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Gareth J. Thomas
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Journal Articles

ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Massimiliano Mellone, Klaudia Piotrowska, Giulia Venturi, Lija James, Aleksandra Bzura, Maria A. Lopez, Sonya James, Chuan Wang, Matthew J. Ellis, Christopher J. Hanley, Josephine F. Buckingham, Kerry L. Cox, Gareth Hughes, Viia Valge-Archer, Emma V. King, Stephen A. Beers, Vincent Jaquet, George D.D. Jones, Natalia Savelyeva, Emre Sayan, Jason L. Parsons, Stephen Durant, Gareth J. Thomas
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4571–4585.
https://doi.org/10.1158/0008-5472.CAN-22-0435
Published: 16 December 2022
View article titled, ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
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Includes: Supplementary data
Journal Articles

Editor's Note: miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Lei Zhang, Karen Pickard, Veronika Jenei, Marc D. Bullock, Amanda Bruce, Richard Mitter, Gavin Kelly, Christos Paraskeva, John Strefford, John Primrose, Gareth J. Thomas, Graham Packham, Alex H. Mirnezami
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1669.
https://doi.org/10.1158/0008-5472.CAN-22-0501
Published: 15 April 2022
View article titled, Editor's Note: miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
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Journal Articles

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Kirsty Ford, Christopher J. Hanley, Massimiliano Mellone, Cedric Szyndralewiez, Freddy Heitz, Philippe Wiesel, Oliver Wood, Maria Machado, Maria-Antoinette Lopez, Anusha-Preethi Ganesan, Chuan Wang, Ankur Chakravarthy, Tim R. Fenton, Emma V. King, Pandurangan Vijayanand, Christian H. Ottensmeier, Aymen Al-Shamkhani, Natalia Savelyeva, Gareth J. Thomas
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (9): 1846–1860.
https://doi.org/10.1158/0008-5472.CAN-19-3158
Published: 04 May 2020
View article titled, NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
Open the PDF for NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 3762: Single-cell analysis of cancer-associated fibroblast heterogeneity in non-small cell lung cancer: Mapping molecular phenotypes in tumors

Sara Waise, Christopher J. Hanley, Rachel Parker, Christian H. Ottensmeier, Matthew Rose-Zerilli, Gareth J. Thomas
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3762.
https://doi.org/10.1158/1538-7445.AM2019-3762
Published: 01 July 2019
View article titled, Abstract 3762: Single-cell analysis of cancer-associated fibroblast heterogeneity in non-small cell lung cancer: Mapping molecular phenotypes in tumors
Journal Articles

HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology

Andrew G. Schache, Ned G. Powell, Kate S. Cuschieri, Max Robinson, Sam Leary, Hisham Mehanna, Davy Rapozo, Anna Long, Heather Cubie, Elizabeth Junor, Hannah Monaghan, Kevin J. Harrington, Christopher M. Nutting, Ulrike Schick, Andy S. Lau, Navdeep Upile, Jon Sheard, Kath Brougham, Catharine M.L. West, Ken Oguejiofor, Steve Thomas, Andy R. Ness, Miranda Pring, Gareth J. Thomas, Emma V. King, Dennis J. McCance, Jacqueline A. James, Michael Moran, Phil Sloan, Richard J. Shaw, Mererid Evans, Terry M. Jones
Journal: Cancer Research
Cancer Res (2016) 76 (22): 6598–6606.
https://doi.org/10.1158/0008-5472.CAN-16-0633
Published: 14 November 2016
View article titled, HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology
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Includes: Supplementary data
Journal Articles

Abstract B15: Targeting NOX4 in the tumor microenvironment inhibits myofibroblast differentiation and suppresses tumor progression

Christopher J. Hanley, Massimiliano Mellone, Gareth J. Thomas
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): B15.
https://doi.org/10.1158/1538-7445.TME16-B15
Published: 28 July 2016
View article titled, Abstract B15: Targeting NOX4 in the tumor microenvironment inhibits myofibroblast differentiation and suppresses tumor progression
Journal Articles

Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Christian H. Ottensmeier, Kate L. Perry, Elena L. Harden, Jana Stasakova, Veronika Jenei, Jason Fleming, Oliver Wood, Jeongmin Woo, Christopher H. Woelk, Gareth J. Thomas, Stephen M. Thirdborough
Journal: Cancer Research
Cancer Res (2016) 76 (14): 4136–4148.
https://doi.org/10.1158/0008-5472.CAN-15-3121
Published: 14 July 2016
View article titled, Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Open the PDF for Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Lei Zhang, Karen Pickard, Veronika Jenei, Marc D. Bullock, Amanda Bruce, Richard Mitter, Gavin Kelly, Christos Paraskeva, John Strefford, John Primrose, Gareth J. Thomas, Graham Packham, Alex H. Mirnezami
Journal: Cancer Research
Cancer Res (2013) 73 (21): 6435–6447.
https://doi.org/10.1158/0008-5472.CAN-12-3308
Published: 31 October 2013
View article titled, miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
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Includes: Supplementary data
Journal Articles

αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

Daniel Marsh, Sarah Dickinson, Graham W. Neill, John F. Marshall, Ian R. Hart, Gareth J. Thomas
Journal: Cancer Research
Cancer Res (2008) 68 (9): 3295–3303.
https://doi.org/10.1158/0008-5472.CAN-08-0174
Published: 01 May 2008
View article titled, αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation
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Includes: Supplementary data
Journal Articles

Antibody-Mediated Blockade of Integrin αvβ6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor-β–Regulated Mechanism

Louise A. Koopman Van Aarsen, Diane R. Leone, Steffan Ho, Brian M. Dolinski, Patricia E. McCoon, Doreen J. LePage, Rebecca Kelly, Glenna Heaney, Paul Rayhorn, Carl Reid, Kenneth J. Simon, Gerald S. Horan, Nianjun Tao, Humphrey A. Gardner, Marilyn M. Skelly, Allen M. Gown, Gareth J. Thomas, Paul H. Weinreb, Stephen E. Fawell, Shelia M. Violette
Journal: Cancer Research
Cancer Res (2008) 68 (2): 561–570.
https://doi.org/10.1158/0008-5472.CAN-07-2307
Published: 15 January 2008
View article titled, Antibody-Mediated Blockade of Integrin α<sub>v</sub>β<sub>6</sub> Inhibits Tumor Progression <em>In vivo</em> by a Transforming Growth Factor-β–Regulated Mechanism
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Journal Articles

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

Alan G. Ramsay, Melanie D. Keppler, Mona Jazayeri, Gareth J. Thomas, Maddy Parsons, Shelia Violette, Paul Weinreb, Ian R. Hart, John F. Marshall
Journal: Cancer Research
Cancer Res (2007) 67 (11): 5275–5284.
https://doi.org/10.1158/0008-5472.CAN-07-0318
Published: 01 June 2007
View article titled, HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin α<sub>v</sub>β<sub>6</sub>
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Includes: Supplementary data
Journal Articles

Cyclooxygenase-2 Inhibition Suppresses αvβ6 Integrin–Dependent Oral Squamous Carcinoma Invasion

Maria L. Nystrom, Diana McCulloch, Paul H. Weinreb, Shelia M. Violette, Paul M. Speight, John F. Marshall, Ian R. Hart, Gareth J. Thomas
Journal: Cancer Research
Cancer Res (2006) 66 (22): 10833–10842.
https://doi.org/10.1158/0008-5472.CAN-06-1640
Published: 15 November 2006
View article titled, Cyclooxygenase-2 Inhibition Suppresses α<sub>v</sub>β<sub>6</sub> Integrin–Dependent Oral Squamous Carcinoma Invasion
Open the PDF for Cyclooxygenase-2 Inhibition Suppresses α<sub>v</sub>β<sub>6</sub> Integrin–Dependent Oral Squamous Carcinoma Invasion in another window
Includes: Supplementary data
Journal Articles

Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation

Marisol Quintero, Peter A. Brennan, Gareth J. Thomas, Salvador Moncada
Journal: Cancer Research
Cancer Res (2006) 66 (2): 770–774.
https://doi.org/10.1158/0008-5472.CAN-05-0333
Published: 19 January 2006
View article titled, Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation
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