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Journal Articles

Abstract 4391: A novel dual inhibitor of RAS and β-catenin signaling with advantages over mutant-specific KRAS inhibitors to escape resistance has robust antitumor efficacy and activates antitumor immunity

Gary A. Piazza, Dhana Sekhar Reddy Bandi, Ganji Purnachandra Nagaraju, Kristy L. Berry, Khalda Fadlalla, Md Yeashin Gazi, Upender Manne, Xi Chen, Jeremy B. Foote, Adam B. Keeton, Yulia Y. Maxuitenko, Donald B. Buchsbaum, Bassel F. El Rayes, Gang Zhou

Cancer Res (2025) 85 (8_Supplement_1): 4391.

https://doi.org/10.1158/1538-7445.AM2025-4391

Published: 21 April 2025

View articletitled, Abstract 4391: A novel dual inhibitor of RAS and β-catenin signaling with advantages over mutant-specific KRAS inhibitors to escape resistance has robust antitumor efficacy and activates antitumor immunity

Journal Articles

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

Cancer Res (2025) 85 (5): 956–972.

https://doi.org/10.1158/0008-5472.CAN-24-0323

Published: 03 March 2025

View articletitled, A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

Includes: Supplementary data

Journal Articles

Abstract 2459: ADT-030 is a novel dual-acting RAS/β-catenin inhibitor that potentiates antitumor immunity

Md Yeashin Gazi, Ogacheko Okoko, Xin Wang, Caitlin Brandle, Xi Chen, Khalda Fadlalla, Adam Keeton, Yulia Maxuitenko, Catherine Hedrick, Huidong Shi, Gary Piazza, Gang Zhou

Cancer Res (2024) 84 (6_Supplement): 2459.

https://doi.org/10.1158/1538-7445.AM2024-2459

Published: 22 March 2024

View articletitled, Abstract 2459: ADT-030 is a novel dual-acting RAS/β-catenin inhibitor that potentiates antitumor immunity

Journal Articles

Abstract 18: The polyamine-hypusine axis is a promising avenue to improve T-cell metabolism and persistence for adoptive cell therapy

Mercy Kehinde-Ige, Ogacheko Okoko, Gang Zhou, Huidong Shi

Cancer Res (2024) 84 (6_Supplement): 18.

https://doi.org/10.1158/1538-7445.AM2024-18

Published: 22 March 2024

View articletitled, Abstract 18: The polyamine-hypusine axis is a promising avenue to improve T-cell metabolism and persistence for adoptive cell therapy

Journal Articles

Abstract 6333: Repurposing NSAIDs for chemo-immunotherapy: mechanisms beyond COX inhibition

Ogacheko D. Okoko, Md Y. Gazi, Xin Wang, Caitlin Brandle, Mercy Kehinde-Ige, Gary A. Piazza, Huidong Shi, Gang Zhou

Cancer Res (2023) 83 (7_Supplement): 6333.

https://doi.org/10.1158/1538-7445.AM2023-6333

Published: 04 April 2023

View articletitled, Abstract 6333: Repurposing NSAIDs for chemo-immunotherapy: mechanisms beyond COX inhibition

Journal Articles

Abstract 478: A novel dual-acting RAS/β-catenin inhibitor activates antitumor immunity to potentiate cancer immunotherapy

Md Yeashin Gazi, Ogacheko Okoko, Xin Wang, Caitlin Brandle, Zhi-chun Ding, Amit Mitra, Veronica Ramirez-Alcantara, Xi Chen, Adam Keeton, Yulia Maxuitenko, Gary Piazza, Gang Zhou

Cancer Res (2023) 83 (7_Supplement): 478.

https://doi.org/10.1158/1538-7445.AM2023-478

Published: 04 April 2023

View articletitled, Abstract 478: A novel dual-acting RAS/β-catenin inhibitor activates antitumor immunity to potentiate cancer immunotherapy

Journal Articles

Abstract 3693: Single-cell flux estimation analysis reveals the metabolic states of tumor-specific CD4⁺ T cells

Mercy Kehinde-Ige, Ogacheko Okoko, Zhi-Chun Ding, Gang Zhou, Huidong Shi

Cancer Res (2023) 83 (7_Supplement): 3693.

https://doi.org/10.1158/1538-7445.AM2023-3693

Published: 04 April 2023

View articletitled, Abstract 3693: Single-cell flux estimation analysis reveals the metabolic states of tumor-specific CD4+ T cells

Journal Articles

Abstract 268: Antitumor CD4⁺ T cells reprogram tumor metabolism to drive progressive tumor regression

Caitlin Brandle, Ogacheko D. Okoko, Md Yeashin Gazi, Xin Wang, Mercy Kehinde-Ige, Huidong Shi, Gang Zhou

Cancer Res (2023) 83 (7_Supplement): 268.

https://doi.org/10.1158/1538-7445.AM2023-268

Published: 04 April 2023

View articletitled, Abstract 268: Antitumor CD4+ T cells reprogram tumor metabolism to drive progressive tumor regression

Journal Articles

Abstract 1633: ADT-030, a novel dual-acting RAS and β-catenin inhibitor with robust antitumor activity

Veronica Ramirez-Alcantara, Xi Chen, Michele A. Schuler, Dennis Otali, William Grizzle, Kristy Berry, Antonio Ward, Ivan Babic, Elmar Nurmemmedov, Gang Zhou, Chengguo Xing, Greg Gorman, Lori Coward, Yulia Maxuitenko, Adam B. Keeton, Gary A. Piazza

Cancer Res (2023) 83 (7_Supplement): 1633.

https://doi.org/10.1158/1538-7445.AM2023-1633

Published: 04 April 2023

View articletitled, Abstract 1633: ADT-030, a novel dual-acting RAS and β-catenin inhibitor with robust antitumor activity

Journal Articles

Correction: YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma

Cancer Res (2022) 82 (24): 4694.

https://doi.org/10.1158/0008-5472.CAN-22-3444

Published: 16 December 2022

View articletitled, Correction: YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma

Journal Articles

Abstract 5322: The antitumor activity and immumodulatory effect of a novel phosphodiesterase 10 inhibitor

Md Yeashin Gazi, Caitlin Brandle, Ogacheko Okoko, Xi Chen, Adam Keeton, Yulia Maxuitenko, Gary Piazza, Gang Zhou

Cancer Res (2022) 82 (12_Supplement): 5322.

https://doi.org/10.1158/1538-7445.AM2022-5322

Published: 15 June 2022

View articletitled, Abstract 5322: The antitumor activity and immumodulatory effect of a novel phosphodiesterase 10 inhibitor

Journal Articles

Abstract 4095: Adding fuel to the fire: Augmenting the efficacy of adoptive T-cell therapy with pro-oxidants

Nada Aboelella, Gang Zhou, Kateryna Fesenkova, Zhi-chun Ding

Cancer Res (2019) 79 (13_Supplement): 4095.

https://doi.org/10.1158/1538-7445.AM2019-4095

Published: 01 July 2019

View articletitled, Abstract 4095: Adding fuel to the fire: Augmenting the efficacy of adoptive T-cell therapy with pro-oxidants

Journal Articles

Abstract 2315: Alteration of tumor metabolism by CD4+ T cells leads to TNF-α-dependent intensification of oxidative stress and tumor cell death

Zhichun Ding, Tsadik Habtetsion, Gang Zhou

Cancer Res (2019) 79 (13_Supplement): 2315.

https://doi.org/10.1158/1538-7445.AM2019-2315

Published: 01 July 2019

View articletitled, Abstract 2315: Alteration of tumor metabolism by CD4+ T cells leads to TNF-α-dependent intensification of oxidative stress and tumor cell death

Journal Articles

Abstract 2350: Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Chunwan Lu, John D. Klement, Mohammed L. Ibrahim, Priscilla S. Redd, Gang Zhou, Kebin Liu

Cancer Res (2019) 79 (13_Supplement): 2350.

https://doi.org/10.1158/1538-7445.AM2019-2350

Published: 01 July 2019

View articletitled, Abstract 2350: Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Journal Articles

YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma

Cancer Res (2019) 79 (7): 1451–1464.

https://doi.org/10.1158/0008-5472.CAN-18-2238

Published: 01 April 2019

View articletitled, YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma

Includes: Supplementary data

Journal Articles

Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Jing Meng, Shuang Chen, Jing-Xia Han, Baoxin Qian, Xiao-Rui Wang, Wei-Long Zhong, Yuan Qin, Heng Zhang, Wan-Feng Gao, Yue-Yang Lei, Wei Yang, Lan Yang, Chao Zhang, Hui-Juan Liu, Yan-Rong Liu, Hong-Gang Zhou, Tao Sun, Cheng Yang

Cancer Res (2018) 78 (15): 4150–4162.

https://doi.org/10.1158/0008-5472.CAN-17-3009

Published: 31 July 2018

View articletitled, Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Includes: Supplementary data

Journal Articles

Abstract 1533: CD4+ T cells reprogram tumor metabolism and drive oxidative stress-induced tumor destruction

Gang Zhou, Tsadik Habtetsion, Zhi-Chun Ding

Cancer Res (2018) 78 (13_Supplement): 1533.

https://doi.org/10.1158/1538-7445.AM2018-1533

Published: 01 July 2018

View articletitled, Abstract 1533: CD4+ T cells reprogram tumor metabolism and drive oxidative stress-induced tumor destruction

Journal Articles

Abstract 3992: Immune regulation of disseminated tumor cell clearance versus metastatic growth

Hasan Korkaya, Eunmi Lee, Raziye Piranioglu, Maria Ouzounova, Abdeljabar El-Andaloussi, Iskander Asm, Ahmet K. Korkaya, Gang Zhou, Ali Arbab, Paulo Rodriguez

Cancer Res (2017) 77 (13_Supplement): 3992.

https://doi.org/10.1158/1538-7445.AM2017-3992

Published: 01 July 2017

View articletitled, Abstract 3992: Immune regulation of disseminated tumor cell clearance versus metastatic growth

Journal Articles

Abstract 2956: Chemical library screen identifies compounds that target S100A8/S100A9 complex and MDSC accumulation

Eunmi Lee, Maria Ouzounova, Raziye Piranlioglu, Abdeljabar El Andaloussi, Sena Arbag, Gang Zhou, Hasan Korkaya

Cancer Res (2017) 77 (13_Supplement): 2956.

https://doi.org/10.1158/1538-7445.AM2017-2956

Published: 01 July 2017

View articletitled, Abstract 2956: Chemical library screen identifies compounds that target S100A8/S100A9 complex and MDSC accumulation

Journal Articles

Abstract 1555: MDSC mediated spatiotemporal tumor plasticity in breast cancer metastasis

Hasan Korkaya, Eunmi Lee, Maria Ouzounova, Raziye Piranlioglu, Abdeljabar El-Andaloussi, Ena Novakovic, Alicia Hudson, Sumeyye Korkaya, Mhmet F. Demirci, Gang Zhou

Cancer Res (2016) 76 (14_Supplement): 1555.

https://doi.org/10.1158/1538-7445.AM2016-1555

Published: 15 July 2016

View articletitled, Abstract 1555: MDSC mediated spatiotemporal tumor plasticity in breast cancer metastasis

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Abstract 4391: A novel dual inhibitor of RAS and β-catenin signaling with advantages over mutant-specific KRAS inhibitors to escape resistance has robust antitumor efficacy and activates antitumor immunity

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

Abstract 2459: ADT-030 is a novel dual-acting RAS/β-catenin inhibitor that potentiates antitumor immunity

Abstract 18: The polyamine-hypusine axis is a promising avenue to improve T-cell metabolism and persistence for adoptive cell therapy

Abstract 6333: Repurposing NSAIDs for chemo-immunotherapy: mechanisms beyond COX inhibition

Abstract 478: A novel dual-acting RAS/β-catenin inhibitor activates antitumor immunity to potentiate cancer immunotherapy

Abstract 3693: Single-cell flux estimation analysis reveals the metabolic states of tumor-specific CD4⁺ T cells

Abstract 268: Antitumor CD4⁺ T cells reprogram tumor metabolism to drive progressive tumor regression

Abstract 1633: ADT-030, a novel dual-acting RAS and β-catenin inhibitor with robust antitumor activity

Correction: YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma

Abstract 5322: The antitumor activity and immumodulatory effect of a novel phosphodiesterase 10 inhibitor

Abstract 4095: Adding fuel to the fire: Augmenting the efficacy of adoptive T-cell therapy with pro-oxidants

Abstract 2315: Alteration of tumor metabolism by CD4+ T cells leads to TNF-α-dependent intensification of oxidative stress and tumor cell death

Abstract 2350: Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma

Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Abstract 1533: CD4+ T cells reprogram tumor metabolism and drive oxidative stress-induced tumor destruction

Abstract 3992: Immune regulation of disseminated tumor cell clearance versus metastatic growth

Abstract 2956: Chemical library screen identifies compounds that target S100A8/S100A9 complex and MDSC accumulation

Abstract 1555: MDSC mediated spatiotemporal tumor plasticity in breast cancer metastasis

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