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Journal Articles

Abstract 2876: BR116: An antibody drug conjugate targeting CDH17 for gastrointestinal cancer therapy

Xiaobei Zhao, Jie Zhu, Zhenhua Wu, Yiqun Li, Cindy Wu, Lei Nie, Haibin Wang, Gang Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2876.
https://doi.org/10.1158/1538-7445.AM2025-2876
Published: 21 April 2025
View articletitled, Abstract 2876: BR116: An antibody drug conjugate targeting CDH17 for gastrointestinal cancer therapy
Journal Articles

Abstract 6027: Translational medicine studies of BRY812, an anti-LIV-1 antibody drug conjugate for cancer therapeutics

Qinqin Zhuang, Qianqian Tao, Xiaobei Zhao, Jie Zhu, Lei Nie, Gang Chen, Haibin Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6027.
https://doi.org/10.1158/1538-7445.AM2025-6027
Published: 21 April 2025
View articletitled, Abstract 6027: Translational medicine studies of BRY812, an anti-LIV-1 antibody drug conjugate for cancer therapeutics
Journal Articles

Abstract 659: Translational medicine studies of BR111, a biparatopic anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment

Qinqin Zhuang, Yan Sun, Lilv Fan, Qianqian Tao, Xiaobei Zhao, Jie Zhu, Zhenhua Wu, Lei Nie, Gang Chen, Haibin Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 659.
https://doi.org/10.1158/1538-7445.AM2025-659
Published: 21 April 2025
View articletitled, Abstract 659: Translational medicine studies of BR111, a biparatopic anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment
Journal Articles

Abstract 396: Discovery of SHR3591, a highly potent and orally bioavailable AR PROTAC for the treatment of prostate cancer

Minqiang Jia, Limin Zhang, Fanglong Yang, Gang Chen, Shouli Zhao, Weimin Wang, Jiangtao Chi, Wei Peng, Luona Wang, Huishuang Miao, Zhibin Xu, Yuchang Mao, Xun Li, Yi Mao, Shuyu Cai, Jun Feng, Min Hu, Xin Li, Feng He
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 396.
https://doi.org/10.1158/1538-7445.AM2025-396
Published: 21 April 2025
View articletitled, Abstract 396: Discovery of SHR3591, a highly potent and orally bioavailable AR PROTAC for the treatment of prostate cancer
Journal Articles

Extracellular Vesicle–Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression

Pei-pei Hou, Chong-ming Zheng, Si-hong Wu, Xi-xiao Liu, Guang-xin Xiang, Wei-yang Cai, Gang Chen, Yong-liang Lou
Journal: Cancer Research
Cancer Res (2024) 84 (23): 3953–3966.
https://doi.org/10.1158/0008-5472.CAN-24-0832
Published: 02 December 2024
View articletitled, Extracellular Vesicle–Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression
Open the PDF for Extracellular Vesicle–Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 1886: BRY812, an anti-LIV-1 antibody drug conjugate with novel conjugation method for cancer therapeutics

Xiaobei Zhao, Jie Zhu, Yaqiong Zhou, Jing Li, Lei Nie, Haibin Wang, Gang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1886.
https://doi.org/10.1158/1538-7445.AM2024-1886
Published: 22 March 2024
View articletitled, Abstract 1886: BRY812, an anti-LIV-1 antibody drug conjugate with novel conjugation method for cancer therapeutics
Journal Articles

Abstract 1885: Developing a biparatopic anti-ROR1 antibody drug conjugate BR111 for hematological and solid tumor treatment

Xiaobei Zhao, Jie Zhu, zhenhua Wu, Yiqun Li, Jing Li, Yaqiong Zhou, Lei Nie, Haibin Wang, Gang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1885.
https://doi.org/10.1158/1538-7445.AM2024-1885
Published: 22 March 2024
View articletitled, Abstract 1885: Developing a biparatopic anti-ROR1 antibody drug conjugate BR111 for hematological and solid tumor treatment
Journal Articles

Abstract 3132: A novel dual drug antibody-drug conjugate targeting hTrop2 has synergetic anti-tumor activity in solid tumor models

Jie Zhu, Xiaobei Zhao, Eileen Li, Hong Xu, Lei Nie, Gang Chen, Haibing Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3132.
https://doi.org/10.1158/1538-7445.AM2024-3132
Published: 22 March 2024
View articletitled, Abstract 3132: A novel dual drug antibody-drug conjugate targeting hTrop2 has synergetic anti-tumor activity in solid tumor models
Journal Articles

Abstract B075: Anti-human LIV-1 antibody drug conjugate for treatment of metastatic prostate cancer

Xiaobei Zhao, Gang Chen
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B075.
https://doi.org/10.1158/1538-7445.PRCA2023-B075
Published: 02 June 2023
View articletitled, Abstract B075: Anti-human LIV-1 antibody drug conjugate for treatment of metastatic prostate cancer
Journal Articles

Abstract CT086: H3.3-K27M neoantigen vaccine elicits CD4+ and CD8+ T cells immunity and improved prognosis against diffuse intrinsic pontine glioma

Yang Zhang, Nan Ji, Gang Chen, Haiyang Wu, Yi Wang, Xiao’ou Li, Wei Xu, Ling Peng, Tian Li, Yi Wang, Li-Feng Zhang, Shengjun Sun, Xiaobing Zhao, Si Li, Peter Alexander, Liwei Zhang, Qi-Jing Li
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT086.
https://doi.org/10.1158/1538-7445.AM2023-CT086
Published: 14 April 2023
View articletitled, Abstract CT086: H3.3-K27M neoantigen vaccine elicits CD4+ and CD8+ T cells immunity and improved prognosis against diffuse intrinsic pontine glioma
Journal Articles

Abstract LB218: Developing a bispecific anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment

Xiaobei Zhao, Jie Zhu, Zhenhua Wu, Jing Li, yaqiong zhou, Lei Nie, Gang Chen
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB218.
https://doi.org/10.1158/1538-7445.AM2023-LB218
Published: 14 April 2023
View articletitled, Abstract LB218: Developing a bispecific anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment
Journal Articles

Abstract 2206: Machine learning radiomics to predict early recurrence of intrahepatic cholangiocarcinoma after curative resection: a multicenter cohort study

Zhiyuan Bo, Bo Chen, Yi Yang, Zhengxiao Zhao, Yi Wang, Gang Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2206.
https://doi.org/10.1158/1538-7445.AM2023-2206
Published: 04 April 2023
View articletitled, Abstract 2206: Machine learning radiomics to predict early recurrence of intrahepatic cholangiocarcinoma after curative resection: a multicenter cohort study
Journal Articles

Abstract LB228: PD-L1/PD-1 and arsenic lung tumorigenesis

Wenhua Xu, Gang Chen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB228.
https://doi.org/10.1158/1538-7445.AM2021-LB228
Published: 01 July 2021
View articletitled, Abstract LB228: PD-L1/PD-1 and arsenic lung tumorigenesis
Journal Articles

MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors

Bin Yang, Xi Li, Yu Fu, Ensong Guo, Youqiong Ye, Fuxia Li, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Jia Huang, Tianyu Qin, Leng Han, Guang Peng, Gordon B. Mills, Chaoyang Sun, Gang Chen
Journal: Cancer Research
Cancer Res (2021) 81 (10): 2714–2729.
https://doi.org/10.1158/0008-5472.CAN-20-2370
Published: 15 May 2021
View articletitled, MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
Open the PDF for MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 4555: Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties

Lauric Haber, Kara Olson, Robert Babb, Marcus Kelly, Alison Crawford, Marc Retter, David DiLillo, Erica Ullman, Jennifer Finney, Lauren Canova, Arpita Pawashe, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda Dorvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Supriya Patel, Richard Tavare, Ya Ping Chen, Gang Chen, William Olson, Gavin Thurston, John Chia-Yang Lin, Aynur Hermann, Jessica Kirshner, Eric J. Smith
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4555.
https://doi.org/10.1158/1538-7445.AM2020-4555
Published: 15 August 2020
View articletitled, Abstract 4555: Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties
Journal Articles

Abstract 38: Large-scale study of NTRK fusions in Chinese solid tumors and using next generation sequencing: A multicenter study

Wen-xian Wang, Chun-wei Xu, Lei Lei, Xiao-jia Wang, You-cai Zhu, Yong Fang, Xiu-yu Cai, Rong-bo Lin, Li Lin, Hong Wang, Mei-yu Fang, Yin-bin Zhang, Shi-jie Lan, Xin Cai, Xin Liu, Xing-xiang Pu, Zong-yang Yu, Bing Wan, Jin-luan Li, Xian-bin Liang, Li-ping Wang, Wu Zhuang, Zi-yan Yang, Gang Chen, Tang-feng Lv, Yong Song
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 38.
https://doi.org/10.1158/1538-7445.AM2020-38
Published: 15 August 2020
View articletitled, Abstract 38: Large-scale study of NTRK fusions in Chinese solid tumors and using next generation sequencing: A multicenter study
Journal Articles

Abstract 6330: DPP4 modulates ACSL4 to promote lipid peroxidation and regulate ferroptosis in pancreatic cancer

Xiang Zhou, Weiming Wang, Baofu Zhang, Zixia Lin, Yi Wang, Gang Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6330.
https://doi.org/10.1158/1538-7445.AM2020-6330
Published: 15 August 2020
View articletitled, Abstract 6330: DPP4 modulates ACSL4 to promote lipid peroxidation and regulate ferroptosis in pancreatic cancer
Journal Articles

Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker

Shihua Dong, Wei Li, Lin Wang, Jie Hu, Yuanlin Song, Baolong Zhang, Xiaoguang Ren, Shimeng Ji, Jin Li, Peng Xu, Ying Liang, Gang Chen, Jia-Tao Lou, Wenqiang Yu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (24): 6101–6112.
https://doi.org/10.1158/0008-5472.CAN-19-1019
Published: 13 December 2019
View articletitled, Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker
Open the PDF for Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker in another window
Includes: Supplementary data
Journal Articles

Abstract 1597: Real-world large-scale study kinase domain duplications across diverse tumor types in Chinese populations

Chun-wei Xu, Wen-xian Wang, Xiao-jia Wang, You-cai Zhu, Qu-xia Zhang, Yong Fang, Xiu-yu Cai, Yu Chen, Li Lin, Hong Wang, Mei-yu Fang, Yin-bin Zhang, Shi-jie Lan, Xin Liu, Xing-xiang Pu, Zong-yang Yu, Bing Wan, Jian-ying Li, Xian-bin Liang, Li-ping Wang, Wu Zhuang, Ling Lin, Gang Chen, Tang-feng Lv, Yong Song
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1597.
https://doi.org/10.1158/1538-7445.AM2019-1597
Published: 01 July 2019
View articletitled, Abstract 1597: Real-world large-scale study kinase domain duplications across diverse tumor types in Chinese populations
Journal Articles

Abstract 101: Human bone marrow-derived endothelial progenitor cells promote the transformation of periostin-positive hepatocellular carcinoma cells into CD36-positive metastasis-initialing cells in pre-metastatic niche

Xiaozai Xie, Pengyi Guo, Haitao Yu, Yi Wang, Gang Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 101.
https://doi.org/10.1158/1538-7445.AM2018-101
Published: 01 July 2018
View articletitled, Abstract 101: Human bone marrow-derived endothelial progenitor cells promote the transformation of periostin-positive hepatocellular carcinoma cells into CD36-positive metastasis-initialing cells in pre-metastatic niche