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Galen Hostetter
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Journal Articles

Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation

Wei Cui, Zhijun Huang, Seung-Gi Jin, Jennifer Johnson, Kin H. Lau, Galen Hostetter, Gerd P. Pfeifer
Journal: Cancer Research
Cancer Res (2023) 83 (15): 2480–2495.
https://doi.org/10.1158/0008-5472.CAN-23-0269
Published: 01 August 2023
View article titled, Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Open the PDF for Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation in another window
Includes: Supplementary data
Journal Articles

Abstract 1572: FZD6 and RYK, non-canonical Wnt receptors in pancreatic cancer progression

Payton D. Stevens, Emily Sall, Alex Zhong, Galen Hostetter, Zachary Madaj, Jennifer Thalappillil, Alexander Dobin, Youngkyu Park, David A. Tuveson, Bart O. Williams
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1572.
https://doi.org/10.1158/1538-7445.AM2022-1572
Published: 15 June 2022
View article titled, Abstract 1572: FZD6 and RYK, non-canonical Wnt receptors in pancreatic cancer progression
Journal Articles

Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy

Elizabeth R. Plimack, Kerry Campbell, Jean-Pierre J. Issa, Noah M. Hahn, David I. Quinn, Hyo Sik Jang, Galen Hostetter, Peter W. Nichols, Woonbok Chung, Jozef Madzo, Hitoshi Ohtani, Hui Shen, Toshinori Hinoue, Stephen B. Baylin, Peter A. Jones
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT121.
https://doi.org/10.1158/1538-7445.AM2021-CT121
Published: 01 July 2021
View article titled, Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy
Journal Articles

Abstract 5719: Tumor-suppressive stromal activity of pro-fibrogenic microRNA-21 in initiation and progression of K-Ras-driven mouse models of pancreatic cancer

Josh Schipper, Brooke Jackson, Ian Beddows, Elizabeth Kenyon, Katie Powell, Neil Robertson, Galen Hostetter, Matti Kiupel, Anna Moore, Jose Conejo-Garcia, Lorenzo sempere
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5719.
https://doi.org/10.1158/1538-7445.AM2020-5719
Published: 15 August 2020
View article titled, Abstract 5719: Tumor-suppressive stromal activity of pro-fibrogenic microRNA-21 in initiation and progression of K-Ras-driven mouse models of pancreatic cancer
Journal Articles

Abstract 3688: A novel biomarker for pancreatic cancer, sTRA, and CA19-9 define separate subpopulations of PDAC cells with distinctions in behavior and molecular characteristics

Daniel Barnett, Ying Liu, ChongFeng Gao, Luke Wisniewski, Katie Partyka, Anna Barry, Galen Hostetter, Aatur Singhi, Randall E. Brand, Richard R. Drake, Brian B. Haab
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3688.
https://doi.org/10.1158/1538-7445.AM2018-3688
Published: 01 July 2018
View article titled, Abstract 3688: A novel biomarker for pancreatic cancer, sTRA, and CA19-9 define separate subpopulations of PDAC cells with distinctions in behavior and molecular characteristics
Journal Articles

Abstract 1754: A new glycan biomarker for pancreatic cancer complements CA19-9 and identifies a distinct subpopulation of cancer cells

Daniel Barnett, Ying Liu, Katie Partyka, Galen Hostetter, Herbert Zeh, Aatur D. Singhi, Ying Huang, Richard R. Drake, Randall E. Brand, Brian B. Haab
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1754.
https://doi.org/10.1158/1538-7445.AM2017-1754
Published: 01 July 2017
View article titled, Abstract 1754: A new glycan biomarker for pancreatic cancer complements CA19-9 and identifies a distinct subpopulation of cancer cells
Journal Articles

Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus

Matt L. Harlow, Nichole Maloney, Joseph Roland, Maria Jose Guillen Navarro, Matthew K. Easton, Susan M. Kitchen-Goosen, Elissa A. Boguslawski, Zachary B. Madaj, Ben K. Johnson, Megan J. Bowman, Maurizio D'Incalci, Mary E. Winn, Lisa Turner, Galen Hostetter, Carlos María Galmarini, Pablo M. Aviles, Patrick J. Grohar
Journal: Cancer Research
Cancer Res (2016) 76 (22): 6657–6668.
https://doi.org/10.1158/0008-5472.CAN-16-0568
Published: 14 November 2016
View article titled, Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus
Open the PDF for Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus in another window
Includes: Supplementary data
Journal Articles

Abstract LB-177: PM01183 inactivates the EWS/FLI1 transcription factor by redistributing the protein within the nucleus

Matt Harlow, Matthew Easton, Maria Jose Guillén Navarro, Lisa Turner, Galen Hostetter, Carlos Galmarini, Pablo Aviles, Patrick Grohar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-177.
https://doi.org/10.1158/1538-7445.AM2016-LB-177
Published: 15 July 2016
View article titled, Abstract LB-177: PM01183 inactivates the EWS/FLI1 transcription factor by redistributing the protein within the nucleus
Journal Articles

Abstract A34: Characterizing macrophage adaptive function in tumor stroma

Galen Hostetter, Arkadeep Sinha, Brian Haab
Journal: Cancer Research
Cancer Res (2015) 75 (1_Supplement): A34.
https://doi.org/10.1158/1538-7445.CHTME14-A34
Published: 12 January 2015
View article titled, Abstract A34: Characterizing macrophage adaptive function in tumor stroma
Journal Articles

Abstract B60: From plasma peptide to phenotype: An emerging role of quiescin-sulfhydryl oxidase 1 in tumor cell invasion

Benjamin A. Katchman, Kwasi Antwi, Galen Hostetter, Michael Demeure, Aprill Wantanabe, G. Anton Decker, Lawrence J. Miller, Daniel D. Von Hoff, Douglas F. Lake
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): B60.
https://doi.org/10.1158/1538-7445.FBCR11-B60
Published: 28 October 2014
View article titled, Abstract B60: From plasma peptide to phenotype: An emerging role of quiescin-sulfhydryl oxidase 1 in tumor cell invasion
Journal Articles

Abstract 361: Illuminating the effects of tissue degradation to improve the management of tissues used in cancer research or clinical applications

Scott D. Jewell, Eric Collins, John Beck, David Monsma, Dawna Dylewski, Andrew Borgman, Mary Winn, Galen Hostetter
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 361.
https://doi.org/10.1158/1538-7445.AM2014-361
Published: 01 October 2014
View article titled, Abstract 361: Illuminating the effects of tissue degradation to improve the management of tissues used in cancer research or clinical applications
Journal Articles

Transient Induction of ING4 by Myc Drives Prostate Epithelial Cell Differentiation and Its Disruption Drives Prostate Tumorigenesis

Penny L. Berger, Sander B. Frank, Veronique V. Schulz, Eric A. Nollet, Mathew J. Edick, Brittany Holly, Ting-Tung A. Chang, Galen Hostetter, Suwon Kim, Cindy K. Miranti
Journal: Cancer Research
Cancer Res (2014) 74 (12): 3357–3368.
https://doi.org/10.1158/0008-5472.CAN-13-3076
Published: 12 June 2014
View article titled, Transient Induction of ING4 by Myc Drives Prostate Epithelial Cell Differentiation and Its Disruption Drives Prostate Tumorigenesis
Open the PDF for Transient Induction of ING4 by Myc Drives Prostate Epithelial Cell Differentiation and Its Disruption Drives Prostate Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract B60: Analysis of the endocytic receptor MRC2 as a target for mesenchymal pancreatic cancer cells

Arkadeep Sinha, Aprill Watanabe, Jordan Winter, Peter Allen, Galen Hostetter, Brian B. Haab
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): B60.
https://doi.org/10.1158/1538-7445.TIM2013-B60
Published: 01 May 2014
View article titled, Abstract B60: Analysis of the endocytic receptor MRC2 as a target for mesenchymal pancreatic cancer cells
Journal Articles

Hypoxia Triggers Hedgehog-Mediated Tumor–Stromal Interactions in Pancreatic Cancer

Taly R. Spivak-Kroizman, Galen Hostetter, Richard Posner, Meraj Aziz, Chengcheng Hu, Michael J. Demeure, Daniel Von Hoff, Sunil R. Hingorani, Timothy B. Palculict, Julie Izzo, Galina M. Kiriakova, Mena Abdelmelek, Geoffrey Bartholomeusz, Brian P. James, Garth Powis
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (11): 3235–3247.
https://doi.org/10.1158/0008-5472.CAN-11-1433
Published: 30 May 2013
View article titled, Hypoxia Triggers Hedgehog-Mediated Tumor–Stromal Interactions in Pancreatic Cancer
Open the PDF for Hypoxia Triggers Hedgehog-Mediated Tumor–Stromal Interactions in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4243: Regulation of H3K9 methylation by the demethyltransferase gene JMJD1C in multiple myeloma.

Janine LoBello, Danielle DiPerna, Moly Gale, Aprill Watanabe, Galen Hostetter, Rafael Fonseca, Bodour Salhia
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4243.
https://doi.org/10.1158/1538-7445.AM2013-4243
Published: 15 April 2013
View article titled, Abstract 4243: Regulation of H3K9 methylation by the demethyltransferase gene JMJD1C in multiple myeloma.
Journal Articles

Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer

Yan W. Asmann, Brian M. Necela, Krishna R. Kalari, Asif Hossain, Tiffany R. Baker, Jennifer M. Carr, Caroline Davis, Julie E. Getz, Galen Hostetter, Xing Li, Sarah A. McLaughlin, Derek C. Radisky, Gary P. Schroth, Heather E. Cunliffe, Edith A. Perez, E. Aubrey Thompson
Journal: Cancer Research
Cancer Res (2012) 72 (8): 1921–1928.
https://doi.org/10.1158/0008-5472.CAN-11-3142
Published: 16 April 2012
View article titled, Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Open the PDF for Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3679: Paired tumor and normal whole genome and transcriptome sequencing of transitional cell carcinoma of the upper urinary tract

Irene Cherni, David W. Craig, Lori Phillips, Winnie S. Liang, Angela S. Baker, Tyler Izatt, Ahmet Kurdoglu, Alexis Christoforides, Shripad Sinari, Galen Hostetter, Michael J. Demeure, Daniel D. Von Hoff, John D. Carpten, Glen J. Weiss
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3679.
https://doi.org/10.1158/1538-7445.AM2012-3679
Published: 15 April 2012
View article titled, Abstract 3679: Paired tumor and normal whole genome and transcriptome sequencing of transitional cell carcinoma of the upper urinary tract
Journal Articles

Abstract 5072: Genome sequencing of metastatic colorectal carcinomas to identify potential targets for therapy in patients

Viji Shanmugam, Ramesh K. Ramanathan, Shripad Sinari, Manpreet Chadha, Winnie Liang, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Hollie Benson, Lori Phillips, Angela Baker, Galen Hostetter, Daniel D. Von Hoff, David Craig, John Carpten
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5072.
https://doi.org/10.1158/1538-7445.AM2012-5072
Published: 15 April 2012
View article titled, Abstract 5072: Genome sequencing of metastatic colorectal carcinomas to identify potential targets for therapy in patients
Journal Articles

Abstract 1216: The Fn14 receptor is highly expressed in NSCLC tumors and in NSCLC cell lines harboring EGFR-activating mutations

Nhan L. Tran, Kaushal Asrani, Nathan Jameson, Landon Inge, Emily Cheng, Galen Hostetter, Glen Weiss, Serdar Tuncali, Ross Bremner, Jeffrey A. Winkles
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1216.
https://doi.org/10.1158/1538-7445.AM2011-1216
Published: 15 April 2011
View article titled, Abstract 1216: The Fn14 receptor is highly expressed in NSCLC tumors and in NSCLC cell lines harboring EGFR-activating mutations
Journal Articles

Abstract 2601: ROCK1 as a potential therapeutic target in pancreatic cancer

Clifford Whatcott, Aprill Watanabe, Joseph Demirjian, Michael Barrett, Galen Hostetter, Daniel Von Hoff, Haiyong Han
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2601.
https://doi.org/10.1158/1538-7445.AM2011-2601
Published: 15 April 2011
View article titled, Abstract 2601: ROCK1 as a potential therapeutic target in pancreatic cancer