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Abstract 1539: LKB1 down-modulation by miR-17 biologically and clinically mirrors LKB1-mutated NSCLC

Cristina Borzi, Monica Ganzinelli, Elisa Caiola, Marika Colombo, Giovanni Centonze, Mattia Boeri, Laura Caleca, Ugo Pastorino, Mirko Marabese, Massimo Milione, Massimo Broggini, Marina C. Garassino, Gabriella Sozzi, Massimo Moro

Cancer Res (2022) 82 (12_Supplement): 1539.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1539

Published: 15 June 2022

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Abstract 962: A hybrid epithelial-mesenchymal phenotype identifies lung cancer cells with high metastatic potential due to increased stemness properties and escape from NK immunosurveillance

Giulia Bertolini, Monica Parodi, Massimo Milione, Fabio Murianni, Giovanni Centonze, Giulia Taiè, Gabriella Sozzi, Massimo Vitale, Luca Roz

Cancer Res (2022) 82 (12_Supplement): 962.

DOI: https://doi.org/10.1158/1538-7445.AM2022-962

Published: 15 June 2022

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Journal Articles

Abstract 3377: Immunosuppressive features characterize tumor tissues and peripheral blood of lung cancer patients

Mattia Boeri, Veronica Huber, Orazio Fortunato, Ugo Pastorino, Licia Rivoltini, Gabriella Sozzi

Cancer Res (2022) 82 (12_Supplement): 3377.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3377

Published: 15 June 2022

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Journal Articles

Abstract 1106: Cisplatin-induced activation of SDF-1/CXCR4 axis sustains lung cancer metastasis by promoting co-recruitment of metastasis initiating cells and inflammatory monocytes

Giulia Bertolini, Valeria Cancila, Orazio Fortunato, Giuseppe Lo Russo, Monica Tortoreto, Giovanni Centonze, Massimo Milione, Claudio Tripodo, Stefania Scala, Gabriella Sozzi, Luca Roz

Cancer Res (2020) 80 (16_Supplement): 1106.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1106

Published: 15 August 2020

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Journal Articles

Abstract 5098: Cues from extracellular matrix produced by fibroblasts prime lung cancer cells for distant dissemination

Giuliana Pollaci, Francesca Giovinazzo, Ornella Rondinone, Antonina Bruccoleri, Federica Facchinetti, Monica Tortoreto, Ugo Pastorino, Giulia Bertolini, Gabriella Sozzi, Luca Roz

Cancer Res (2020) 80 (16_Supplement): 5098.

DOI: https://doi.org/10.1158/1538-7445.AM2020-5098

Published: 15 August 2020

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Journal Articles

Abstract 1605: Extracellular vesicles from metastatic non-small cell lung cancer induce the angiogenic switch in natural killer cells

Matteo Gallazzi, Orazio Fortunato, Ugo Pastorino, Gabriella Sozzi, Douglas Noonan, Adriana Albini, Antonino Bruno

Cancer Res (2020) 80 (16_Supplement): 1605.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1605

Published: 15 August 2020

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Journal Articles

Abstract 1912: Inhibition of Exportin-1 function reverses the pro-tumorigenic potential of lung fibrotic microenvironments

Antonina Bruccoleri, Ornella Rondinone, Francesca Andriani, Federica Facchinetti, Monica Tortoreto, Gabriella Sozzi, Giulia Bertolini, Luca Roz

Cancer Res (2019) 79 (13_Supplement): 1912.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1912

Published: 01 July 2019

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Journal Articles

Abstract 4981: Circulating mir-320 promotes immunosuppressive macrophages M2 phenotype associated with lung cancer progression

Orazio Fortunato, Cristina Borzi, Massimo Milione, Giovanni Centonze, Davide Conte, Mattia Boeri, Massimo Moro, Federica Facchinetti, Luca Roz, Veronica Huber, Chiara Camisaschi, Chiara Castelli, Licia Rivoltini, Valeria Cancila, Claudio Tripodo, Ugo Pastorino, Gabriella Sozzi

Cancer Res (2018) 78 (13_Supplement): 4981.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4981

Published: 01 July 2018

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Journal Articles

Abstract 5090: Exportin-1 enables pro-tumorigenic metabolic reprogramming of lung fibroblasts through relocalization of p53 and p62/SQSTM1

Antonina Bruccoleri, Francesca Andriani, Federica Facchinetti, Ugo Pastorino, Gabriella Sozzi, Luca Roz

Cancer Res (2018) 78 (13_Supplement): 5090.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5090

Published: 01 July 2018

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Journal Articles

Abstract 2753: Mutational profiles from targeted NGS combine with miRNA-based liquid biopsy to predict survival in LDCT screening-detected lung cancers

Mattia Boeri, Carla Verri, Cristina Borzi, Todd Holscher, Matteo Dugo, Andrea Devecchi, Elisa Romeo, Stefano Sestini, Paola Suatoni, Ugo Pastorino, Gabriella Sozzi

Cancer Res (2017) 77 (13_Supplement): 2753.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2753

Published: 01 July 2017

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Journal Articles

Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

Elena Tassi, Giulia Grazia, Claudia Vegetti, Ilaria Bersani, Giulia Bertolini, Alessandra Molla, Paola Baldassari, Francesca Andriani, Luca Roz, Gabriella Sozzi, Ugo Pastorino, Roberta Mortarini, Andrea Anichini

Cancer Res (2017) 77 (4): 851–861.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-1387

Published: 14 February 2017

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Includes: Supplementary data

Journal Articles

Abstract 948: Microenvironmental origin of circulating miRNAs in lung cancer

Orazio Fortunato, Cristina Borzi, Davide Conte, Giovanni Centonze, Mattia Boeri, Carla Verri, Linda Calzolari, Ugo Pastorino, Gabriella Sozzi

Cancer Res (2016) 76 (14_Supplement): 948.

DOI: https://doi.org/10.1158/1538-7445.AM2016-948

Published: 15 July 2016

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Journal Articles

Abstract 3351: Differential glycosylation of extracellular matrix specifically modulates lung cancer initiating cells subsets

Giulia Bertolini, Cecilia Gardelli, Francesca Andriani, Massimo Moro, Laura Russo, Laura Cipolla, Gabriella Sozzi, Luca Roz

Cancer Res (2016) 76 (14_Supplement): 3351.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3351

Published: 15 July 2016

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Journal Articles

Abstract 5085: Cancer-associated fibroblasts transcriptional pattern reveals common changes in extracellular matrix-related genes across different cancer types

Francesca Andriani, Marta Giussani, Federica Facchinetti, Maurizio Callari, Elda Tagliabue, Ugo Pastorino, Luca Roz, Gabriella Sozzi, Gabriella Sozzi

Cancer Res (2016) 76 (14_Supplement): 5085.

DOI: https://doi.org/10.1158/1538-7445.AM2016-5085

Published: 15 July 2016

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Journal Articles

Microenvironment-Modulated Metastatic CD133⁺/CXCR4⁺/EpCAM⁻ Lung Cancer–Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

Giulia Bertolini, Lucia D'Amico, Massimo Moro, Elena Landoni, Paola Perego, Rosalba Miceli, Laura Gatti, Francesca Andriani, Donald Wong, Roberto Caserini, Monica Tortoreto, Massimo Milione, Riccardo Ferracini, Luigi Mariani, Ugo Pastorino, Ilaria Roato, Gabriella Sozzi, Luca Roz

Cancer Res (2015) 75 (17): 3636–3649.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-3781

Published: 31 August 2015

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Includes: Supplementary data

Journal Articles

Abstract 1395: Conversion to stem cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer

Francesca Andriani, Giulia Bertolini, Federica Facchinetti, Erika Baldoli, Massimo Moro, Patrizia Casalini, Roberto Caserini, Ugo Pastorino, Gabriella Sozzi, Luca Roz

Cancer Res (2015) 75 (15_Supplement): 1395.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1395

Published: 01 August 2015

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Journal Articles

Abstract 932: A plasma microRNAs test predicts prognosis and disease status at follow-up in screening-detected lung cancer patients

Gabriella Sozzi, Stefano Sestini, Mattia Boeri, Carla Verri, Alfonso Marchiano', Carlotta Galeone, Nicola Sverzellati, Carlo La Vecchia, Ugo Pastorino

Cancer Res (2015) 75 (15_Supplement): 932.

DOI: https://doi.org/10.1158/1538-7445.AM2015-932

Published: 01 August 2015

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Journal Articles

Abstract 1216: Effects of phenformin in LKB1/KRAS mutated non-small cell lung cancer patient derived xenograft

Massimo Moro, Luca Roz, Roberto Caserini, Ugo Pastorino, Gabriella Sozzi

Cancer Res (2014) 74 (19_Supplement): 1216.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1216

Published: 01 October 2014

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Journal Articles

Abstract 2852: SNAI2 expression by cancer-associated fibroblasts is a negative prognostic factor in non-small cell lung cancer

Francesca Andriani, Giorgia Leone, Elena Landoni, Federica Facchinetti, Tiziana Caputo, Erika Baldoli, Rosalba Miceli, Luigi Mariani, Ugo Pastorino, Giuseppe Pelosi, Gabriella Sozzi, Luca Roz

Cancer Res (2014) 74 (19_Supplement): 2852.

DOI: https://doi.org/10.1158/1538-7445.AM2014-2852

Published: 01 October 2014

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Journal Articles

Abstract 4867: Microenvironment stimuli elicited by fibroblasts contribute to epithelial mesenchymal transition and acquisition of stemness phenotype in lung cancer

Francesca Andriani, Tiziana Caputo, Giulia Bertolini, Federica Facchinetti, Erika Baldoli, Massimo Moro, Roberto Caserini, Gabriella Sozzi, Luca Roz

Cancer Res (2014) 74 (19_Supplement): 4867.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4867

Published: 01 October 2014

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NARROW

Abstract 1539: LKB1 down-modulation by miR-17 biologically and clinically mirrors LKB1-mutated NSCLC

Abstract 962: A hybrid epithelial-mesenchymal phenotype identifies lung cancer cells with high metastatic potential due to increased stemness properties and escape from NK immunosurveillance

Abstract 3377: Immunosuppressive features characterize tumor tissues and peripheral blood of lung cancer patients

Abstract 1106: Cisplatin-induced activation of SDF-1/CXCR4 axis sustains lung cancer metastasis by promoting co-recruitment of metastasis initiating cells and inflammatory monocytes

Abstract 5098: Cues from extracellular matrix produced by fibroblasts prime lung cancer cells for distant dissemination

Abstract 1605: Extracellular vesicles from metastatic non-small cell lung cancer induce the angiogenic switch in natural killer cells

Abstract 1912: Inhibition of Exportin-1 function reverses the pro-tumorigenic potential of lung fibrotic microenvironments

Abstract 4981: Circulating mir-320 promotes immunosuppressive macrophages M2 phenotype associated with lung cancer progression

Abstract 5090: Exportin-1 enables pro-tumorigenic metabolic reprogramming of lung fibroblasts through relocalization of p53 and p62/SQSTM1

Abstract 2753: Mutational profiles from targeted NGS combine with miRNA-based liquid biopsy to predict survival in LDCT screening-detected lung cancers

Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

Abstract 948: Microenvironmental origin of circulating miRNAs in lung cancer

Abstract 3351: Differential glycosylation of extracellular matrix specifically modulates lung cancer initiating cells subsets

Abstract 5085: Cancer-associated fibroblasts transcriptional pattern reveals common changes in extracellular matrix-related genes across different cancer types

Microenvironment-Modulated Metastatic CD133⁺/CXCR4⁺/EpCAM⁻ Lung Cancer–Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

Abstract 1395: Conversion to stem cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer

Abstract 932: A plasma microRNAs test predicts prognosis and disease status at follow-up in screening-detected lung cancer patients

Abstract 1216: Effects of phenformin in LKB1/KRAS mutated non-small cell lung cancer patient derived xenograft

Abstract 2852: SNAI2 expression by cancer-associated fibroblasts is a negative prognostic factor in non-small cell lung cancer

Abstract 4867: Microenvironment stimuli elicited by fibroblasts contribute to epithelial mesenchymal transition and acquisition of stemness phenotype in lung cancer

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