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Gabriela Chiosis
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Journal Articles

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas

M. Nieves Calvo-Vidal, Nahuel Zamponi, Jan Krumsiek, Max A. Stockslager, Maria V. Revuelta, Jude M. Phillip, Rossella Marullo, Ekaterina Tikhonova, Nikita Kotlov, Jayeshkumar Patel, Shao Ning Yang, Lucy Yang, Tony Taldone, Catherine Thieblemont, John P. Leonard, Peter Martin, Giorgio Inghirami, Gabriela Chiosis, Scott R. Manalis, Leandro Cerchietti
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5202–5216.
https://doi.org/10.1158/0008-5472.CAN-21-2734
Published: 15 October 2021
View article titled, Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas
Open the PDF for Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas in another window
Includes: Supplementary data
Journal Articles

Abstract LB-003: OncoMatch: Unbiased, quantitative assessment of cancer model fidelity for drug sensitivity and mechanism of action elucidation

Mariano J. Alvarez, Yan Pengrong, Mary L. Alpaugh, Michaela Bowden, Ewa T. Sicinska, Chensheng W. Zhou, Charles Karan, Ronald B. Realubit, Prabhjot S. Mundi, Adina Grunn, Jager Dirk, John A. Chabot, Antonio T. Fojo, Paul E. Oberstein, Hanina Hibshoosh, Jeffrey W. Milsom, Matthew H. Kulke, Massimo Loda, Gabriela Chiosis, Diane L. Reidy-Lagunes, Andrea Califano
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-003.
https://doi.org/10.1158/1538-7445.AM2020-LB-003
Published: 15 August 2020
View article titled, Abstract LB-003: OncoMatch: Unbiased, quantitative assessment of cancer model fidelity for drug sensitivity and mechanism of action elucidation
Journal Articles

Abstract 3370: Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

Hatice Ulku Osmanbeyoglu, Fumiko Shimizu, Angela Rynne-Vidal, Tsz-Lun Yeung, Petar Jelinic, Samuel C. Mok, Gabriela Chiosis, Douglas A. Levine, Christina Leslie
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3370.
https://doi.org/10.1158/1538-7445.AM2019-3370
Published: 01 July 2019
View article titled, Abstract 3370: Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers
Journal Articles

Abstract 4716: Tumor-specific regulation of receptor tyrosine kinases by Grp94

Pengrong Yan, Hardik Patel, Pallav Patel, Stefan Ochiana, Weilin Sun, Smit Shah, Paola Finotti, Cynthia Leifer, Zihai Li, Daniel Gewirth, Tony Taldone, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4716.
https://doi.org/10.1158/1538-7445.AM2015-4716
Published: 01 August 2015
View article titled, Abstract 4716: Tumor-specific regulation of receptor tyrosine kinases by Grp94
Journal Articles

Abstract 2831: Development of selective GRP94 inhibitors for the treatment of cancer

Stefan O. Ochiana, Tony Taldone, Hardik J. Patel, Pallav Patel, Yan Pengrong, Weilin Sun, Anna Rodina, Smit Shah, Daniel T. Gewirth, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2831.
https://doi.org/10.1158/1538-7445.AM2015-2831
Published: 01 August 2015
View article titled, Abstract 2831: Development of selective GRP94 inhibitors for the treatment of cancer
Journal Articles

Abstract 1435: Role of PRKD2 in HSP90- and hypoxia-mediated epithelial-to-mesenchymal transition

Ninel Azoitei, Alexander Becher, Kristina Diepold, Susanne Bobrovich, Cornelia Brunner, Gabriela Chiosis, Stefan Fröhling, van Lint Johan, Claudia Scholl, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1435.
https://doi.org/10.1158/1538-7445.AM2015-1435
Published: 01 August 2015
View article titled, Abstract 1435: Role of PRKD2 in HSP90- and hypoxia-mediated epithelial-to-mesenchymal transition
Journal Articles

Abstract SY30-02: Understanding the proteome through the chaperome: From mechanisms to diagnostics and drugs

Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): SY30-02.
https://doi.org/10.1158/1538-7445.AM2015-SY30-02
Published: 01 August 2015
View article titled, Abstract SY30-02: Understanding the proteome through the chaperome: From mechanisms to diagnostics and drugs
Journal Articles

Abstract 1733: Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells

Anna A. Rodina, Tony Taldone, Yanlong Kang, Pallav Patel, John Koren, Pengrong Yan, Erica DaGama Gomes, Chenghua Yang, Maulik Patel, Liza Shrestha, Stefan Ochiana, Ronnie Maharaj, Alexander Gozman, Marc Cox, Hediye Erdjument-Bromage, Ronald Hendrickson, Leandro Cerchietti, Ari Melnick, Monica Guzman, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1733.
https://doi.org/10.1158/1538-7445.AM2015-1733
Published: 01 August 2015
View article titled, Abstract 1733: Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells
Journal Articles

Abstract 1740: Allosteric Hsp70-family inhibitors as targeted anticancer therapeutics

John Koren, Chao Xu, Anna Rodina, Liza Shrestha, Tony Taldone, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1740.
https://doi.org/10.1158/1538-7445.AM2015-1740
Published: 01 August 2015
View article titled, Abstract 1740: Allosteric Hsp70-family inhibitors as targeted anticancer therapeutics
Journal Articles

Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy

Tony Taldone, Nagavarakishore Pillarsetty, Mark PS Dunphy, John F. Gerecitano, Eloisi Caldas-Lopes, Brad Beattie, Radu I. Peter, Yanlong Kang, Anna Rodina, Pengrong Yan, Erica M. DaGama Gomes, Alexander Bolaender, Christina Pressl, Blesida Punzalan, Anson Ku, Thomas Ku, Smit Shah, Mohammad Uddin, Mei H. Chen, Elmer Santos, Jacek Koziorowski, Adriana Corben, Shanu Modi, Komal Jhaveri, Oscar Lin, Efsevia Vakiani, Yelena Janjigian, Pat Zanzonico, Clifford Hudis, Steven M. Larson, Jason S. Lewis, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5444.
https://doi.org/10.1158/1538-7445.AM2015-5444
Published: 01 August 2015
View article titled, Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy
Journal Articles

HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization

Ninel Azoitei, Kristina Diepold, Cornelia Brunner, Arefeh Rouhi, Felicitas Genze, Alexander Becher, Hans Kestler, Johan van Lint, Gabriela Chiosis, John Koren, III, Stefan Fröhling, Claudia Scholl, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7125–7136.
https://doi.org/10.1158/0008-5472.CAN-14-1017
Published: 30 November 2014
View article titled, HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Open the PDF for HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization in another window
Includes: Supplementary data
Journal Articles

Abstract 3329: Investigations into the tumor specific regulation of HER2 by Grp94 in breast cancer

Pengrong Yan, Hardik Patel, Chenghua Yang, Tony Taldone, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3329.
https://doi.org/10.1158/1538-7445.AM2014-3329
Published: 01 October 2014
View article titled, Abstract 3329: Investigations into the tumor specific regulation of HER2 by Grp94 in breast cancer
Journal Articles

Abstract 5129: Role of PRKD2 in HSP90 inhibition-mediated suppression of cancer growth

Ninel Azoitei, Kristina Diepold, Felicitas Genze, Arefeh Rouhi, Susanne Brobovich, Stefan Froehling, Gabriela Chiosis, Cornelia Brunner, Johan van Lint, Marcus Cronauer, Claudia Scholl, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5129.
https://doi.org/10.1158/1538-7445.AM2014-5129
Published: 01 October 2014
View article titled, Abstract 5129: Role of PRKD2 in HSP90 inhibition-mediated suppression of cancer growth
Journal Articles

Abstract 2045: Oncoproteomic analysis of diffuse large B cell lymphomas reveals rationale for combination treatments.

Rebecca L. Goldstein, Leandro C. Cerchietti, Gabriela Chiosis, Ari Melnick
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2045.
https://doi.org/10.1158/1538-7445.AM2013-2045
Published: 15 April 2013
View article titled, Abstract 2045: Oncoproteomic analysis of diffuse large B cell lymphomas reveals rationale for combination treatments.
Journal Articles

Abstract 2752: Novel inhibitor of HSP90- PU-H71 exhibits significant activity in Ewing sarcoma pre-clinical models.

Srikanth R. Ambati, Eloisi Caldas Lopes, Ullas Mony, Kohji Kosugi, Andre Moreira, Paul Meyers, Gabriela Chiosis, Malcolm Moore
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2752.
https://doi.org/10.1158/1538-7445.AM2013-2752
Published: 15 April 2013
View article titled, Abstract 2752: Novel inhibitor of HSP90- PU-H71 exhibits significant activity in Ewing sarcoma pre-clinical models.
Journal Articles

Abstract 5598: A comprehensive study to analyze tumor sensitivity to HSP90 inhibition therapy.

Matthew Riolo, Shanu Modi, Adriana Corben, Clifford Hudis, Mary Alpaugh, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5598.
https://doi.org/10.1158/1538-7445.AM2013-5598
Published: 15 April 2013
View article titled, Abstract 5598: A comprehensive study to analyze tumor sensitivity to HSP90 inhibition therapy.
Journal Articles

Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex

Anna Rodina, Kamalika Moulick, James Ahn, Hongliang Zong, Leandro Cerchietti, Erica Gomes DaGama, Eloisi Caldas-Lopes, Kristin Beebe, Fabiana Perna, Katerina Hatzi, Ly Vu, Xinyang Zhao, Danuta Zatorska, Tony Taldone, Peter Smith-Jones, Mary Alpaugh, Steven Gross, Nagavarakishore Pillarsetty, Thomas Ku, Jason Lewis, Steven Larson, Ross Levine, Hediye Erdjument-Bromage, Monica Guzman, Stephen Nimer, Ari Melnick, Len Neckers, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3029.
https://doi.org/10.1158/1538-7445.AM2012-3029
Published: 15 April 2012
View article titled, Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex
Journal Articles

Abstract 3895: Rational design of small molecule inhibitors that bind to an allosteric pocket on human heat shock protein 70 (Hsp70)

Tony Taldone, Pallav D. Patel, Yanlong Kang, Anna Rodina, Tanaji T. Talele, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3895.
https://doi.org/10.1158/1538-7445.AM2012-3895
Published: 15 April 2012
View article titled, Abstract 3895: Rational design of small molecule inhibitors that bind to an allosteric pocket on human heat shock protein 70 (Hsp70)
Journal Articles

Abstract 4829: A purine scaffold Hsp90 inhibitor has antitumor activity in KSHV-associated malignancies by suppressing vFLIP

Utthara Nayar, Pin Lu, Jelena Vider, Rebecca L. Goldstein, Gianna Ballon, Leandro Cerchietti, Gabriela Chiosis, Y L. Wang, Ethel Cesarman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4829.
https://doi.org/10.1158/1538-7445.AM2012-4829
Published: 15 April 2012
View article titled, Abstract 4829: A purine scaffold Hsp90 inhibitor has antitumor activity in KSHV-associated malignancies by suppressing vFLIP
Journal Articles

Abstract 2773: HSP90 inhibitors target KRAS mutant human tumors through degradation of STK33

Ninel Azoitei, Christopher M. Hoffmann, Jana M. Ellegast, Claudia R. Ball, Kerstin Obermayer, Ulrike Gößele, Britta Koch, Katrin Faber, Felicitas Genze, Mark Schrader, Hans A. Kestler, Hartmut Döhner, Gabriela Chiosis, Hanno Glimm, Stefan Fröhling, Claudia Scholl
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2773.
https://doi.org/10.1158/1538-7445.AM2012-2773
Published: 15 April 2012
View article titled, Abstract 2773: HSP90 inhibitors target KRAS mutant human tumors through degradation of STK33