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Gabriel N. Hortobagyi
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Journal Articles

Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance

MeiKuang Chen, Yuan Gao, Weiya Xia, Yu-Han Wang, Jennifer K. Litton, Yu-Yi Chu, Funda Meric-Bernstam, Helen Piwnica-Worms, Banu Arun, Jordi Rodon Ahnert, Yongkun Wei, Wei-Chao Chang, Hung-Ling Wang, Coya Tapia, Constance T. Albarracin, Shao-Chun Wang, Ying-Nai Wang, Gabriel N. Hortobagyi, Chunru Lin, Liuqing Yang, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1792.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1792
Published: 15 June 2022
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Journal Articles

Abstract P5-08-14: Maternal embryonic leucine zipper kinase is associated with metastasis in triple-negative breast cancer

Xuemei Xie, Gaurav B. Chauhan, Ramakrishna Edupuganti, Takahiro Kogawa, Jihyun Park, Moises T Tacam, Fnu Vidhu, Diane D. Liu, Juliana M. Taliaferro, Mary Kathryn Pitner, Yu Shen, Naoto T. Ueno, Savitri Krishnamurthy, Gabriel N. Hortobagyi, Debu Tripathy, Steven J. Van Laere, Geoffrey Bartholomeusz, Kevin Dalby, Chandra Bartholomeusz
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-08-14.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-08-14
Published: 15 February 2022
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Journal Articles

Abstract GS2-01: Overall survival subgroup analysis by metastatic site from the phase 3 MONALEESA-2 study of first-line ribociclib + letrozole in postmenopausal patients with advanced HR+/HER2− breast cancer

Joyce O'Shaughnessy, Salomon M Stemmer, Howard A Burris, Yoon-Sim Yap, Gabe Sonke, Lowell Hart, Mario Campone, Katarina Petrakova, Eric P Winer, Wolfgang Janni, Pierfranco Conte, David A Cameron, Fabrice André, Carlos Arteaga, Juan Pablo Zarate, Arunava Chakravartty, Tetiana Taran, Fabienne Le Gac, Paolo Serra, Gabriel N Hortobagyi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS2-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS2-01
Published: 15 February 2022
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Journal Articles

Abstract PD2-05: Genomic profiling of PAM50-based intrinsic subtypes in HR+/HER2- advanced breast cancer (ABC) across the MONALEESA (ML) studies

Aleix Prat, Nadia Solovieff, Faye Su, Aditya Bardia, Patrick Neven, Gabriel N. Hortobagyi, Debu Tripathy, Stephen Chia, Dennis Slamon, Yen-Shen Lu, Tetiana Taran, Agnes Lteif, Carlos L. Arteaga, Fabrice André
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD2-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD2-05
Published: 15 February 2022
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Journal Articles

Abstract PD9-06: Evaluation of the predicted sensitivity to endocrine therapy (SET2,3 index) and the 21-gene Breast Recurrence Score® assay in node-positive postmenopausal breast cancer: Results from an analysis in the SWOG S8814 trial

Corey W. Speers, W. Fraser Symmans, William E. Barlow, Alex Trevarton, Stephanie The, Lili Du, James M. Rae, Steven Shak, Frederick L. Baehner, Priyanka Sharma, Lajos Pusztai, Gabriel N. Hortobagyi, Daneil F Hayes, Kathy S. Albain, Andrew Godwin, Alastair Thompson
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD9-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD9-06
Published: 15 February 2022
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Journal Articles

Abstract PD9-01: Expanding downstaging criteria in AJCC pathologic prognostic staging using OncotypeDx Recurrence Score® assay in T1-2N0 hormone-receptor positive patients enrolled in the TAILORx trial

Olga Kantor, Harold J Burstein, Tari King, Steven Shak, Christy Russell, Armando E Giuliano, Gabriel N Hortobagyi, Eric P Winer, Larissa A Korde, Joseph A Sparano, Elizabeth A Mittendorf
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD9-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD9-01
Published: 15 February 2022
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Journal Articles

Estrogen Receptor: A Paradigm for Targeted Therapy

Senthil Damodaran, Gabriel N. Hortobagyi
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5396–5398.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3200
Published: 01 November 2021
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Journal Articles

Abstract 3081: Secretory human ribonuclease 1 functions as Eph receptor A4 ligand to promote breast tumor initiation

Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3081.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3081
Published: 01 July 2021
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Journal Articles

Abstract GS3-05: Classification of triple negative breast cancer (TNBC) by DNA damage immune response (DDIR) signature and homologous recombination deficiency (HRD) status: Analysis of SWOG S9313 adjuvant trial

Shane R Stecklein, William Barlow, Lajos Pusztai, Kirsten Timms, Richard Kennedy, Sunil Badve, Yesim Gökmen-Polar, Peggy Porter, Hannah Linden, Debu Tripathy, Gabriel N Hortobagyi, Andrew K Godwin, Alastair Thompson, Daniel Hayes, Priyanka Sharma
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS3-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-GS3-05
Published: 15 February 2021
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Journal Articles

Abstract PS2-04: Evaluating serum thymidine kinase 1 in hormone receptor positive metastatic breast cancer patients receiving first line endocrine therapy in the SWOG S0226 trial

Costanza Paoletti, William E. Barlow, Mattias Bergqvist, Rita S. Mehta, Julie R. Gralow, Gabriel N. Hortobagyi, Kathy S. Albain, Lajos Pusztai, Priyanka Sharma, Andrew K. Godwin, Alastair M. Thompson, Daniel F. Hayes, James Rae
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS2-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS2-04
Published: 15 February 2021
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Journal Articles

Abstract P5-06-10: Validation of prognostic stage and anatomic stage in the American joint committee on cancer 8th edition for inflammatory breast cancer

Kumiko Kida, Kenneth R Hess, Bora Lim, Toshiaki Iwase, Sudpreeda Chainitikun, Maryanne E Sapon, Vicente Valero, Anthony Lucci, Carisa Le-Petross, Wendy A Woodward, Savitri Krishnamurthy, Gabriel N Hortobagyi, Debu Tripathy, Naoto T Ueno
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-06-10.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P5-06-10
Published: 15 February 2020
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Journal Articles

Abstract P2-18-02: Fractures in women with breast cancer receiving high-dose bisphosphonates to prevent breast cancer metastases as part of the SWOG S0307 trial (ClinicalTrials.gov Identifier: NCT00127205)

Rachel L (MD) Yung, Jieling Miao, Alexander HG Paterson, Mark Clemons, Elizabeth C Dees, James N Ingle, Carla I Falkson, William Barlow, Gabriel N Hortobagyi, Julie R Gralow
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-18-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-18-02
Published: 15 February 2020
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Journal Articles

Abstract 1776: Impact of homologous recombination deficiency (HRD) biomarkers on outcomes in triple-negative breast cancer (TNBC) patients treated with AC chemotherapy (SWOG S9313)

Priyanka Sharma, William Barlow, Andrew K. Godwin, Harsh Pathak, Kamilla Isakova, Anne R. Hartman, Kristen M. Timms, Hannah M. Linden, Debu Tripathy, Gabriel N. Hortobagyi, Daniel F. Hayes
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1776.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1776
Published: 01 July 2017
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Journal Articles

Abstract CT045: Ribociclib + letrozole for first-line treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC): efficacy by baseline tumor markers

Fabrice Andre, Salomon M. Stemmer, Mario Campone, Katarina Petrakova, Shani Paluch-Shimon, Yoon-Sim Yap, Norbert Marschner, Arlene Chan, Cristian Villanueva, Lowell L. Hart, Carlos L. Arteaga, Gabe S. Sonke, Eva-Maria Grischke, Emilio Alba, Arnd Nusch, Denise A. Yardley, Erik Jakobsen, Sibel Blau, Sara M. Tolaney, Faye Su, Wei He, Caroline Germa, Gabriel N. Hortobagyi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT045.
DOI: https://doi.org/10.1158/1538-7445.AM2017-CT045
Published: 01 July 2017
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Journal Articles

Abstract LB-165: Personalized prognostic prediction models for breast cancer recurrence and survival incorporating multidimensional data

Xifeng Wu, Yuanqing Ye, Carlos H. Barcenas, Wong-Ho Chow, Qing H. Meng, Mariana Chavez Mac Gregor, Michelle Hildebrandt, Hua Zhao, Xiangjun Gu, Yang Deng, Elizabeth A. Wagar, Francisco J. Esteva, Debu Tripathy, Gabriel N. Hortobagyi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-165.
DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-165
Published: 01 July 2017
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Journal Articles

Abstract 4736: ADAMs: potential biomarkers and oncotargets in breast cancer

Shuying Liu, Michael Z. Gilcrease, Huiqin Chen, Wenbin Liu, Fan Zhang, Kim-Anh Do, Gordon B. Mills, William F. Symmans, Naoto T. Ueno, Ana M. Gonzales-Angulo, Gabriel N. Hortobagyi, Debasish Tripathy
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4736.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4736
Published: 01 July 2017
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Journal Articles

Abstract 3413: Supplement use and chemotherapy-induced peripheral neuropathy in breast cancer patients treated on SWOG study S0221

Gary R. Zirpoli, Susan E. McCann, Lara E. Sucheston-Campbell, Dawn L. Hershman, Gregory Ciupak, Warren Davis, Joseph M. Unger, Halle C.F. Moore, James A. Stewart, Claudine Isaacs, Timothy J. Hobday, Muhammad Salim, Robert B. Livingston, Gabriel N. Hortobagyi, Julie R. Gralow, Daniel F. Hayes, G. Thomas Budd, Kathy S. Albain, Christine B. Ambrosone
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3413.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3413
Published: 15 July 2016
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Journal Articles

Abstract 2032: Germline genetic variants in GATA3 and breast cancer treatment outcomes in SWOG 8897 trial

Victoria L. Larsen, William E. Barlow, Jun J. Yang, Qianqian Zhu, Laura F. Hutchins, Susan A. Kadlubar, Kathy S. Albain, Robert B. Livingston, James M. Rae, I-Tien Yeh, Peter M. Ravdin, Silvana Martino, Alan P. Lyss, C. Kent Osborne, Gabriel N. Hortobagyi, Daniel F. Hayes, Christine B. Ambrosone, Song Yao
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2032.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2032
Published: 15 July 2016
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Journal Articles

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

Chia-Wei Li, Weiya Xia, Seung-Oe Lim, Jennifer L. Hsu, Longfei Huo, Yun Wu, Long-Yuan Li, Chien-Chen Lai, Shih-Shin Chang, Yi-Hsin Hsu, Hui-Lung Sun, Jongchan Kim, Hirohito Yamaguchi, Dung-Fang Lee, Hongmei Wang, Yan Wang, Chao-Kai Chou, Jung-Mao Hsu, Yun-Ju Lai, Adam M. LaBaff, Qingqing Ding, How-Wen Ko, Fuu-Jen Tsai, Chang-Hai Tsai, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1451–1462.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-1941
Published: 14 March 2016
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Includes: Supplementary data
Journal Articles

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

Seung-Oe Lim, Chia-Wei Li, Weiya Xia, Heng-Huan Lee, Shih-Shin Chang, Jia Shen, Jennifer L. Hsu, Daniel Raftery, Danijel Djukovic, Haiwei Gu, Wei-Chao Chang, Hung-Ling Wang, Mong-Liang Chen, Longfei Huo, Chung-Hsuan Chen, Yun Wu, Aysegul Sahin, Samir M. Hanash, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (5): 1284–1296.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2478
Published: 29 February 2016
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Includes: Supplementary data