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G. David Roodman
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Journal Articles

Abstract 5672: Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

Hayley M. Sabol, Tania Amorim, Cody Ashby, David Halladay, Judith Anderson, Meloney Cregor, Megan Sweet, Intawat Nookaew, Noriyoshi Kurihara, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5672.
https://doi.org/10.1158/1538-7445.AM2022-5672
Published: 15 June 2022
View article titled, Abstract 5672: Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
Journal Articles

Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity

Hayley M. Sabol, Adam J. Ferrari, Manish Adhikari, Tânia Amorim, Kevin McAndrews, Judith Anderson, Michele Vigolo, Rajwinder Lehal, Meloney Cregor, Sharmin Khan, Pedro L. Cuevas, Jill A. Helms, Noriyoshi Kurihara, Venkat Srinivasan, Frank H. Ebetino, Robert K. Boeckman, Jr, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5102–5114.
https://doi.org/10.1158/0008-5472.CAN-21-0524
Published: 01 October 2021
View article titled, Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
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Includes: Supplementary data
Journal Articles

Abstract 693: Effects of a bone-anabolic agent on metastatic bone cancer growth

Teja Vallapuri, Colin Crean, John Chirgwin, G. David Roodman, Attaya Suvannasankha
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 693.
https://doi.org/10.1158/1538-7445.AM2020-693
Published: 15 August 2020
View article titled, Abstract 693: Effects of a bone-anabolic agent on metastatic bone cancer growth
Journal Articles

Abstract 103: Disruption of Notch Signaling targeted to the myeloma bone marrow microenvironment simultaneously inhibits tumor growth and prevents bone loss without inducing gut toxicity

Adam J. Ferrari, Kevin McAndrews, Jessica H. Nelson, James T. Bell, Venkatesan Srinivasan, Frank H. Ebetino, Robert K. Boeckman, Jr, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 103.
https://doi.org/10.1158/1538-7445.AM2019-103
Published: 01 July 2019
View article titled, Abstract 103: Disruption of Notch Signaling targeted to the myeloma bone marrow microenvironment simultaneously inhibits tumor growth and prevents bone loss without inducing gut toxicity
Journal Articles

Abstract LB-360: JNKs-mediated phosphorylation of human stromal xbp1s regulates multiple myeloma growth & osteolysis

Risheng Chen, Guoshuang Xu, Wissam Beaino, Kai Lui, Xuemei Zeng, Nathan Yates, Rong Chong, Konstas Verdelis, G. David Roodman, Denise Toscani, Nicola Giuliani, Yan Lin, Carolyn J. Anderson, Hongjiao Ouyang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-360.
https://doi.org/10.1158/1538-7445.AM2018-LB-360
Published: 01 July 2018
View article titled, Abstract LB-360: JNKs-mediated phosphorylation of human stromal xbp1s regulates multiple myeloma growth & osteolysis
Journal Articles

Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3

Masahiro Hiasa, Tatsuo Okui, Yohance M. Allette, Matthew S. Ripsch, Ge-Hong Sun-Wada, Hiroki Wakabayashi, G. David Roodman, Fletcher A. White, Toshiyuki Yoneda
Journal: Cancer Research
Cancer Res (2017) 77 (6): 1283–1295.
https://doi.org/10.1158/0008-5472.CAN-15-3545
Published: 14 March 2017
View article titled, Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3
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Includes: Supplementary data
Journal Articles

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma

Jesus Delgado-Calle, Judith Anderson, Meloney D. Cregor, Masahiro Hiasa, John M. Chirgwin, Nadia Carlesso, Toshiyuki Yoneda, Khalid S. Mohammad, Lilian I. Plotkin, G. David Roodman, Teresita Bellido
Journal: Cancer Research
Cancer Res (2016) 76 (5): 1089–1100.
https://doi.org/10.1158/0008-5472.CAN-15-1703
Published: 29 February 2016
View article titled, Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma
Open the PDF for Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Monocyte Chemotactic Protein-1 Mediates Prostate Cancer–Induced Bone Resorption

Yi Lu, Zhong Cai, Guozhi Xiao, Evan T. Keller, Atsushi Mizokami, Zhi Yao, G. David Roodman, Jian Zhang
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3646–3653.
https://doi.org/10.1158/0008-5472.CAN-06-1210
Published: 17 April 2007
View article titled, Monocyte Chemotactic Protein-1 Mediates Prostate Cancer–Induced Bone Resorption
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Journal Articles

Immunomodulatory derivatives of thalidomide inhibit osteoclast formation by down regulation of PU.1

Gulsum Anderson, Markus Y. Mapara, David Stirling, G. David Roodman, Suzanne Lentzsch
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1092.
Published: 15 April 2006
View article titled, Immunomodulatory derivatives of thalidomide inhibit osteoclast formation by down regulation of PU.1
Journal Articles

Tumor Necrosis Factor Enhances Parathyroid Hormone-related Protein-induced Hypercalcemia and Bone Resorption without Inhibiting Bone Formation in Vivo

Harry L. Uy, Gregory R. Mundy, Brendan F. Boyce, Beryl M. Story, Colin R. Dunstan, Juan Juan Yin, G. David Roodman, Theresa A. Guise
Journal: Cancer Research
Cancer Res (1997) 57 (15): 3194–3199.
Published: 01 August 1997
View article titled, Tumor Necrosis Factor Enhances Parathyroid Hormone-related Protein-induced Hypercalcemia and Bone Resorption without Inhibiting Bone Formation <em>in Vivo</em>
Open the PDF for Tumor Necrosis Factor Enhances Parathyroid Hormone-related Protein-induced Hypercalcemia and Bone Resorption without Inhibiting Bone Formation <em>in Vivo</em> in another window