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Frederick F. Lang
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Journal Articles

Abstract CT289: A phase II study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in patients with HER2-positive metastatic solid tumors and metastases to brain (TUCATEMEB)

Ecaterina E. Dumbrava, Amber M. Kennon, Rashmi K. Murthy, Emma J. Montazari, Hussein Tawbi, Jing Li, Frederick F. Lang, Gisela Sanchez, Jianbo Wang, Isabella C. Glitza, Barbara J. O'Brien, Thomas Beckham, Todd Swanson, Martin C. Tom, Uyen M. Vu, Tanisha T. Darko, Tiantian Cai, Komal Shah, Funda Meric-Bernstam, Jordi Rodon
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT289.
https://doi.org/10.1158/1538-7445.AM2024-CT289
Published: 05 April 2024
View articletitled, Abstract CT289: A phase II study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in patients with HER2-positive metastatic solid tumors and metastases to brain (TUCATEMEB)
Journal Articles

Abstract CT292: Phase II study of pembrolizumab in combination with lenvatinib in patients with triple negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and other tumor types and brain metastases

Ecaterina E. Dumbrava, Emma J. Montazari, Uyen M. Vu, Tiantian Cai, Mehmet Altan, Nuhad K. Ibrahim, Debra N. Yeboa, Jing Li, Frederick F. Lang, Gisela Sanchez, Isabella C. Glitza, Barbara J. O'Brien, Rashmi K. Murthy, Jianbo Wang, Tanisha T. Darko, Denisse Velazquez, Komal Shah, Funda Meric-Bernstam, Hussein Tawbi, Jordi Rodon
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT292.
https://doi.org/10.1158/1538-7445.AM2024-CT292
Published: 05 April 2024
View articletitled, Abstract CT292: Phase II study of pembrolizumab in combination with lenvatinib in patients with triple negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and other tumor types and brain metastases
Journal Articles

Abstract 669: Immunophenotyping of human brain tumors reveals myeloid cell mediated anti-glioma axis

Pravesh Gupta, Minghao Dang, Shivangi Oberai, Mekenzie Peshoff, Nancy Milam, Aml Ahmed, Krishna Bojja, Tuan M. Tran, Kathryn Cox, Huma Shehwana, Carlos Kamiya Matsuoka, Jianzhuo Li, Joy Gumin, Alicia Goldman, Sameer A. Seth, Atul Maheshwari, Frederick F. Lang, Nicholas E. Navin, Amy B. Heimberger, Karen Clise Dwyer, Linghua Wang, Krishna P. Bhat
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 669.
https://doi.org/10.1158/1538-7445.AM2023-669
Published: 04 April 2023
View articletitled, Abstract 669: Immunophenotyping of human brain tumors reveals myeloid cell mediated anti-glioma axis
Journal Articles

Abstract 3569: Combining oncolytic adenovirus Delta-24-RGDOX with adoptive T cell therapy in localized treatment induces sustainable regression of disseminated solid tumors through antigen spreading

Hong Jiang, Dong Ho Shin, Yanhua Yi, Xuejun Fan, Joy Gumin, Marta M. Alonso, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3569.
https://doi.org/10.1158/1538-7445.AM2022-3569
Published: 15 June 2022
View articletitled, Abstract 3569: Combining oncolytic adenovirus Delta-24-RGDOX with adoptive T cell therapy in localized treatment induces sustainable regression of disseminated solid tumors through antigen spreading
Journal Articles

Abstract 2540: A multi-dimensional analysis of human gliomas at the single cell level identifies immune suppressive macrophage molecular signatures and a novel immunotherapy target for GBM

Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, Jia-Shiun Leu, William W. Flynn, Ruli Gao, David S. Baskin, Kumar Pichumani, Omkar B. Ijare, Stephanie Wood, Suzanne Powell, David Haviland, Frederick F. Lang, Sujit Prabhu, Kristin Huntoon, Brittany C. Parker Kerrigan, Wen Jiang Jiang, Betty Y. Kim, Joshy George, Kyuson Yun
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2540.
https://doi.org/10.1158/1538-7445.AM2022-2540
Published: 15 June 2022
View articletitled, Abstract 2540: A multi-dimensional analysis of human gliomas at the single cell level identifies immune suppressive macrophage molecular signatures and a novel immunotherapy target for GBM
Journal Articles

Abstract 3565: Viroimmunotherapy for solid tumors results in local and abscopal anti-cancer effects and the remodeling of tumor microenvironment

Arie C. Van Wieren, Sagar Sahoni, Teresa Nguyen, Ashley Ossimetha, Yisel Rivera-Molina, Hong Jiang, Dong Ho Shin, Debora Kim, Xuejun Fan, Yanhua Yi, Natalie M. Melendez-Vazquez, Filipa Godoy-Vitorino, Joy Gumin, Frederick F. Lang, Marta M. Alonso, Juan Fueyo, Candelaria Gomez-Manzano
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3565.
https://doi.org/10.1158/1538-7445.AM2022-3565
Published: 15 June 2022
View articletitled, Abstract 3565: Viroimmunotherapy for solid tumors results in local and abscopal anti-cancer effects and the remodeling of tumor microenvironment
Journal Articles

Abstract 4184: RNA-seq analyses reveal remodeling of tumor microenvironment and reversal of glioma resistance to oncolytic viruses by targeting immunometabolism

Teresa T. Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay K. Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F. Lang, Christopher Alvarez-Breckenridge, Marta M. Alonso, Filipa Godoy-Vitorino, Lijie Zhai, Erik Ladomersky, Kristen L. Lauing, Derek A. Wainwright, Juan Fueyo, Candelaria Gomez-Manzano
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4184.
https://doi.org/10.1158/1538-7445.AM2022-4184
Published: 15 June 2022
View articletitled, Abstract 4184: RNA-seq analyses reveal remodeling of tumor microenvironment and reversal of glioma resistance to oncolytic viruses by targeting immunometabolism
Journal Articles

Abstract B29: Systemic antimelanoma immunity induced by oncolytic adenovirus Delta-24-RGDOX

Hong Jiang, Dong Ho Shin, Caroline Carrillo, Verlene Henry, Xuejun Fan, Teresa T. Nguyen, Yisel Rivera-Molina, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B29.
https://doi.org/10.1158/1538-7445.MEL2019-B29
Published: 02 October 2020
View articletitled, Abstract B29: Systemic antimelanoma immunity induced by oncolytic adenovirus Delta-24-RGDOX
Journal Articles

Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587

Javier Figueroa, Lynette M. Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J. Bean, George A. Calin, Juan Fueyo, Edgar T. Walters, Raghu Kalluri, Roel G. Verhaak, Frederick F. Lang
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5808–5819.
https://doi.org/10.1158/0008-5472.CAN-16-2524
Published: 31 October 2017
View articletitled, Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587
Open the PDF for Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587 in another window
Includes: Supplementary data
Journal Articles

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination

Hong Jiang, Yisel Rivera-Molina, Candelaria Gomez-Manzano, Karen Clise-Dwyer, Laura Bover, Luis M. Vence, Ying Yuan, Frederick F. Lang, Carlo Toniatti, Mohammad B. Hossain, Juan Fueyo
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (14): 3894–3907.
https://doi.org/10.1158/0008-5472.CAN-17-0468
Published: 13 July 2017
View articletitled, Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination
Open the PDF for Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination in another window
Includes: Supplementary data
Journal Articles

Abstract 2668: The exosomes derived from BM-hMSCs home to glioma and deliver synthetic microRNA mimics after systemic administration

Shinji Yamashita, Tal Shahar, Anwar Hossain, Brittany Parker Kerrigan, Joy Gumin, Shoudong Li, Feng Gao, Kouji Yamasaki, Yuzaburo Shimizu, Frederick F. Lang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2668.
https://doi.org/10.1158/1538-7445.AM2016-2668
Published: 15 July 2016
View articletitled, Abstract 2668: The exosomes derived from BM-hMSCs home to glioma and deliver synthetic microRNA mimics after systemic administration
Journal Articles

Abstract 1646: A glioblastoma methylation assay (GaMA) developedfrom genomic analysis of glioma spheroid cultures predicts response toradiation therapy in patients with glioblastoma

Qianghu Wang, Ravesanker Ezhilarasan, Eskil Eskilsson, Joy Gumin, Jie Yang, Mona Jaffari, Ming Tang, Kenneth D. Aldape, Frederick F. Lang, Roel G.W. Verhaak, Erik P. Sulman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2016-1646
Published: 15 July 2016
View articletitled, Abstract 1646: A glioblastoma methylation assay (GaMA) developedfrom genomic analysis of glioma spheroid cultures predicts response toradiation therapy in patients with glioblastoma
Journal Articles

Abstract 1505: Radiogenomics defines key genomic network driving GBM invasion

Rivka R. Colen, Markus Luedi, Sanjay K. Singh, Islam Hassan, Joy Gumin, Erik P. Sulman, Frederick F. Lang, Pascal O. Zinn
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1505.
https://doi.org/10.1158/1538-7445.AM2016-1505
Published: 15 July 2016
View articletitled, Abstract 1505: Radiogenomics defines key genomic network driving GBM invasion
Journal Articles

Abstract 4795: A novel gene fusion in glioblastoma and a radiation response methylation signature identified by genomic characterization of glioma sphere-forming cells

Qianghu Wang, Ravesanker Ezhilarasan, Lindsey D. Goodman, Joy Gumin, Siyuan Zheng, Kosuke Yoshihara, Peng Sun, Jie Yang, Tim Heffernan, Giulio Draetta, Kenneth D. Aldape, Frederick F. Lang, Roel G.W. Verhaak, Erik P. Sulman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4795.
https://doi.org/10.1158/1538-7445.AM2015-4795
Published: 01 August 2015
View articletitled, Abstract 4795: A novel gene fusion in glioblastoma and a radiation response methylation signature identified by genomic characterization of glioma sphere-forming cells
Journal Articles

Abstract 3483: Synergistic combination therapy with molecular targeted drugs in glioma stem-like cells

Takashi Shingu, Lindsay Holmes, Verlene Henry, Khatri Latha, Anupama E. Gururaj, Laura A. Gibson, Tiffany Doucette, Frederick F. Lang, Ganesh Rao, Liang Yuan, Erik P. Sulman, Nicholas P. Farrell, Waldemar Priebe, Kenneth R. Hess, Yaoqi A. Wang, Jian Hu, Oliver Bogler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3483.
https://doi.org/10.1158/1538-7445.AM2015-3483
Published: 01 August 2015
View articletitled, Abstract 3483: Synergistic combination therapy with molecular targeted drugs in glioma stem-like cells
Journal Articles

Abstract 280: Delta-24-RGDOX: making cancer more “visible” to the immune system

Hong Jiang, Xuejun Fan, Karen Clise-Dwyer, Laura Bover, Joy Gumin, Kathryn E. Ruisaard, Farah J. Mukheef, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 280.
https://doi.org/10.1158/1538-7445.AM2015-280
Published: 01 August 2015
View articletitled, Abstract 280: Delta-24-RGDOX: making cancer more “visible” to the immune system
Journal Articles

FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells

Ai-hua Gong, Ping Wei, Sicong Zhang, Jun Yao, Ying Yuan, Ai-dong Zhou, Frederick F. Lang, Amy B. Heimberger, Ganesh Rao, Suyun Huang
Journal: Cancer Research
Cancer Res (2015) 75 (11): 2337–2348.
https://doi.org/10.1158/0008-5472.CAN-14-2800
Published: 31 May 2015
View articletitled, FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells
Open the PDF for FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells in another window
Includes: Supplementary data
Journal Articles

miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Jun Wei, Fei Wang, Ling-Yuan Kong, Shuo Xu, Tiffany Doucette, Sherise D. Ferguson, Yuhui Yang, Kayla McEnery, Krishan Jethwa, Olsi Gjyshi, Wei Qiao, Nicholas B. Levine, Frederick F. Lang, Ganesh Rao, Gregory N. Fuller, George A. Calin, Amy B. Heimberger
Journal: Cancer Research
Cancer Res (2013) 73 (13): 3913–3926.
https://doi.org/10.1158/0008-5472.CAN-12-4318
Published: 30 June 2013
View articletitled, miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma
Open the PDF for miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma in another window
Includes: Supplementary data
Journal Articles

Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells

Jun Fu, Dimpy Koul, Jun Yao, Shuzhen Wang, Ying Yuan, Howard Colman, Erik. P. Sulman, Frederick. F. Lang, W.K. Alfred Yung
Journal: Cancer Research
Cancer Res (2013) 73 (10): 3062–3074.
https://doi.org/10.1158/0008-5472.CAN-12-2033
Published: 12 May 2013
View articletitled, Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells
Open the PDF for Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4909: Olig2 phosphorylation by CDK2 implicated in glioma proliferation.

Jun Fu, Dimpy Koul, Siyuan Zheng, Vivek Singh, Jun Yao, Yanhua Zheng, Zhimin Lu, Erik P. Sulman, Frederick F. Lang, Alfred W.K Yung
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4909.
https://doi.org/10.1158/1538-7445.AM2013-4909
Published: 15 April 2013
View articletitled, Abstract 4909: Olig2 phosphorylation by CDK2 implicated in glioma proliferation.