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Frederic J. de Sauvage
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Journal Articles

Abstract LB-136: Characterization of residual Basal Cell Carcinoma after vismodegib treatment

Brian Biehs, Gerrit J. Dijkgraaf, Bruno Alicke, Franklin Peale, Stephen E. Gould, Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-136.
https://doi.org/10.1158/1538-7445.AM2017-LB-136
Published: 01 July 2017
View article titled, Abstract LB-136: Characterization of residual Basal Cell Carcinoma after vismodegib treatment
Journal Articles

Abstract 4428: Oncogenic ERBB3 mutations in human cancers

Bijay S. Jaiswal, Noelyn M. Kljavin, Eric Stawiski, Steffen Durinck, Subhra Chaudhuri, Charles Eigenbrot, Gabriele Schaefer, Frederic J. de Sauvage, Somasekar Seshagiri
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4428.
https://doi.org/10.1158/1538-7445.AM2014-4428
Published: 01 October 2014
View article titled, Abstract 4428: Oncogenic ERBB3 mutations in human cancers
Journal Articles

Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Genee Y. Lee, Peter M. Haverty, Li Li, Noelyn M. Kljavin, Richard Bourgon, James Lee, Howard Stern, Zora Modrusan, Somasekar Seshagiri, Zemin Zhang, David Davis, David Stokoe, Jeffrey Settleman, Frederic J. de Sauvage, Richard M. Neve
Journal: Cancer Research
Cancer Res (2014) 74 (11): 3114–3126.
https://doi.org/10.1158/0008-5472.CAN-13-2683
Published: 29 May 2014
View article titled, Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
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Includes: Supplementary data
Journal Articles

PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition

Ciara Metcalfe, Bruno Alicke, Ailey Crow, Marlea Lamoureux, Gerrit J.P. Dijkgraaf, Franklin Peale, Stephen E. Gould, Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2013) 73 (23): 7034–7042.
https://doi.org/10.1158/0008-5472.CAN-13-1222
Published: 01 December 2013
View article titled, PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
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Includes: Supplementary data
Journal Articles

Abstract SY37-03: Targeting developmental pathways in colon cancer cells and stem cells

Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): SY37-03.
https://doi.org/10.1158/1538-7445.AM2012-SY37-03
Published: 15 April 2012
View article titled, Abstract SY37-03: Targeting developmental pathways in colon cancer cells and stem cells
Journal Articles

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

Ciara Metcalfe, Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2011) 71 (15): 5057–5061.
https://doi.org/10.1158/0008-5472.CAN-11-0923
Published: 28 July 2011
View article titled, Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
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Journal Articles

Abstract PL04-03: Targeting the hedgehog pathway in meduloblastoma and basal cell carcinoma

Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): PL04-03.
https://doi.org/10.1158/1538-7445.AM2011-PL04-03
Published: 15 April 2011
View article titled, Abstract PL04-03: Targeting the hedgehog pathway in meduloblastoma and basal cell carcinoma
Journal Articles

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Gerrit J. P. Dijkgraaf, Bruno Alicke, Lasse Weinmann, Thomas Januario, Kristina West, Zora Modrusan, Dan Burdick, Richard Goldsmith, Kirk Robarge, Dan Sutherlin, Suzie J. Scales, Stephen E. Gould, Robert L. Yauch, Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2011) 71 (2): 435–444.
https://doi.org/10.1158/0008-5472.CAN-10-2876
Published: 13 January 2011
View article titled, Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
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Includes: Supplementary data
Journal Articles

Abstract 305: Frequent PIK3R1 somatic mutations promote oncogenic signaling

Bijay S. Jaiswal, Vasantharajan Janakiraman, Subhra Chaudhuri, Howard M. Stern, Noelyn M. Kljavin, Weiru Wang, Zhengyan Kan, Krista Bowman, Jiansheng Wu, Joshua Kaminker, Peng Yue, Frederic J. de Sauvage, Jonathan Backer, Somasekar Seshagiri
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 305.
https://doi.org/10.1158/1538-7445.AM10-305
Published: 15 April 2010
View article titled, Abstract 305: Frequent PIK3R1 somatic mutations promote oncogenic signaling
Journal Articles

Paracrine Hedgehog Signaling in Cancer

Jan-Willem Theunissen, Frederic J. de Sauvage
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6007–6010.
https://doi.org/10.1158/0008-5472.CAN-09-0756
Published: 29 July 2009
View article titled, Paracrine Hedgehog Signaling in Cancer
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Journal Articles

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Andrew G. Polson, Jill Calemine-Fenaux, Pamela Chan, Wesley Chang, Erin Christensen, Suzanna Clark, Frederic J. de Sauvage, Dan Eaton, Kristi Elkins, J. Michael Elliott, Gretchen Frantz, Reina N. Fuji, Alane Gray, Kristin Harden, Gladys S. Ingle, Noelyn M. Kljavin, Hartmut Koeppen, Christopher Nelson, Saileta Prabhu, Helga Raab, Sarajane Ross, Jean-Philippe Stephan, Suzie J. Scales, Susan D. Spencer, Richard Vandlen, Bernd Wranik, Shang-Fan Yu, Bing Zheng, Allen Ebens
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2358–2364.
https://doi.org/10.1158/0008-5472.CAN-08-2250
Published: 17 March 2009
View article titled, Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection
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Includes: Supplementary data
Journal Articles

Abstract LB-138: Efficacy data of GDC-0449, a systemic Hedgehog pathway antagonist, in a first-in-human, first-in-class Phase I study with locally advanced, multifocal or metastatic basal cell carcinoma patients

Daniel D Von Hoff, Charles M Rudin, Patricia M LoRusso, Mitesh J Borad, Ronald L Korn, Elisabeth I Heath, Robert Yauch, Walter C Darbonne, Edward E Kadel, III, Kenn L Zerivitz, Lisa E Nelson, Howard Mackey, James C Marsters, Jr., Frederic J de Sauvage, Jennifer A Low
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-138.
https://doi.org/10.1158/1538-7445.AM2008-LB-138
Published: 15 May 2008
View article titled, Abstract LB-138: Efficacy data of GDC-0449, a systemic Hedgehog pathway antagonist, in a first-in-human, first-in-class Phase I study with locally advanced, multifocal or metastatic basal cell carcinoma patients
Journal Articles

Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers

Daniel Gray, Adrian M. Jubb, Deborah Hogue, Patrick Dowd, Noelyn Kljavin, Sothy Yi, Wei Bai, Gretchen Frantz, Zemin Zhang, Hartmut Koeppen, Frederic J. de Sauvage, David P. Davis
Journal: Cancer Research
Cancer Res (2005) 65 (21): 9751–9761.
https://doi.org/10.1158/0008-5472.CAN-04-4531
Published: 01 November 2005
View article titled, Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers
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Includes: Supplementary data
Journal Articles

Dissecting the Oncogenic Potential of Gli2: Deletion of an NH2-Terminal Fragment Alters Skin Tumor Phenotype

Hong Sheng, Sara Goich, Aiqin Wang, Marina Grachtchouk, Lori Lowe, Rong Mo, Kui Lin, Frederic J. de Sauvage, Hiroshi Sasaki, Chi-chung Hui, Andrzej A. Dlugosz
Journal: Cancer Research
Cancer Res (2002) 62 (18): 5308–5316.
Published: 15 September 2002
View article titled, Dissecting the Oncogenic Potential of Gli2: <subtitle>Deletion of an NH<sub>2</sub>-Terminal Fragment Alters Skin Tumor Phenotype</subtitle>
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Journal Articles

Dynamics of Notch Expression during Murine Prostate Development and Tumorigenesis

Jianyong Shou, Sarajane Ross, Hartmut Koeppen, Frederic J. de Sauvage, Wei-Qiang Gao
Journal: Cancer Research
Cancer Res (2001) 61 (19): 7291–7297.
Published: 01 October 2001
View article titled, Dynamics of Notch Expression during Murine Prostate Development and Tumorigenesis
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