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Franziska Michor
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Journal Articles

Abstract PS09-02: Event-free Survival by Residual Cancer Burden (RCB) and Intratumor HER2 Heterogeneity after Neoadjuvant T-DM1 and Pertuzumab for Early-stage HER2-positive Breast Cancer

Otto Metzger, Se Eun Kim, Nabihah Tayob, Giuseppe Viale, Denise Yardley, Aleix Prat, Vandana Abramson, Laura Spring, Adrienne Waks, Eileen Wrabel, Michelle DeMeo, Aditya Bardia, Patrizia Dell'Orto, Leila Russo, Tari King, Franziska Michor, Eric Winer, Kornelia Polyak, Sara Tolaney, Ian Krop
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS09-02.
https://doi.org/10.1158/1538-7445.SABCS23-PS09-02
Published: 02 May 2024
View article titled, Abstract PS09-02: Event-free Survival by Residual Cancer Burden (RCB) and Intratumor HER2 Heterogeneity after Neoadjuvant T-DM1 and Pertuzumab for Early-stage HER2-positive Breast Cancer
Journal Articles

Abstract 5825: Non-genetic determinants driving the evolutional trajectories of drug-tolerant-persisters in KRAS Non-small cell lung cancer

Chendi Li, Christopher J. Graser, Qian Qin, Anahita Nimbalkar, Usman Syed, Barbara Karakyriakou, Sarah Clark, Anne Y. Saiki, Paul E. Hughes, Christopher Ott, Luca Pinello, Franziska Michor, Aaron Hata
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5825.
https://doi.org/10.1158/1538-7445.AM2024-5825
Published: 22 March 2024
View article titled, Abstract 5825: Non-genetic determinants driving the evolutional trajectories of drug-tolerant-persisters in KRAS Non-small cell lung cancer
Journal Articles

Abstract 2392: Use of early dynamics of clinical and laboratory parameters to predict resistance in patients with metastatic urothelial carcinoma receiving post-platinum atezolizumab

Christopher Graser, Thomas O. McDonald, Guru Sonpavde, Franziska Michor
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2392.
https://doi.org/10.1158/1538-7445.AM2024-2392
Published: 22 March 2024
View article titled, Abstract 2392: Use of early dynamics of clinical and laboratory parameters to predict resistance in patients with metastatic urothelial carcinoma receiving post-platinum atezolizumab
Journal Articles

Abstract 4338: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution

Hanghui Ye, Thomas McDonald, Emi Sei, Darlan Conterno Minussi, Min Hu, Chenling Tang, Junke Wang, Kaile Wang, Anna Casasent, Hui Chen, Franziska Michor, Nicholas Navin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4338.
https://doi.org/10.1158/1538-7445.AM2024-4338
Published: 22 March 2024
View article titled, Abstract 4338: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution
Journal Articles

Abstract B008: KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping

Zheqi Li, Guillermo Peluffo, Laura Stevens, Xintao Qiu, Marco Seehawer, Xiao-Yun Huang, Shawn Egri, Malvina Papanastasiou, Natalie Kingston, Clive D'Santos, Eva Papachristou, Jun Nishida, Kyle Evans, Ji-Heui Seo, Kendell Clement, Daniel Temko, Muhammad Ekram, Matthew Rees, Melissa Ronan, Jennifer Roth, Anton Simeonov, Stephen Kales, Ganesha Rai, Madhu Lal-Nag, David Maloney, Ajit Jadhav, Franziska Michor, Alex Meissner, Justin Balko, Jason Carroll, Matthew Freedman, Henry Long, Jacob Jaffe, Kornelia Polyak
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B008.
https://doi.org/10.1158/1538-7445.ADVBC23-B008
Published: 01 February 2024
View article titled, Abstract B008: KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping
Journal Articles

Abstract PR08: Intratumoral heterogeneity drives resistance to Antibody Drug Conjugate therapy: Analysis of the NeoSTAR trial of neoadjuvant Sacituzumab govitecan for localized TNBC

Laura M. Spring, Bogang Wu, Ting Liu, Jacob Geisberg, Simona Cristea, Veerle Bossuyt, Rachel Occhiogrosso Abelman, Nicole Peiris, James Coates, Siang-Boon Koh, Mengran Zhang, Lianne Ryan, Beverly Moy, Steven J. Isakoff, Sara M. Tolaney, Franziska Michor, Aditya Bardia, Leif W. Ellisen
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): PR08.
https://doi.org/10.1158/1538-7445.ADVBC23-PR08
Published: 01 February 2024
View article titled, Abstract PR08: Intratumoral heterogeneity drives resistance to Antibody Drug Conjugate therapy: Analysis of the NeoSTAR trial of neoadjuvant Sacituzumab govitecan for localized TNBC
Journal Articles

Abstract 2142: Immune determinants of CAR-T expansion in solid tumor patients receiving GD2 CAR-T cell therapy

Tara Murty, Sabina Kaczanowska, Ahmad Alimadadi, Cristina Contreras, Caroline Duault, Priyanka Balasubrahmanyan, Warren Reynolds, Norma Gutierrez, Reema Baskar, Catherine Wu, Franziska Michor, Jennifer Altreuter, Yang Liu, Aashna Jhaveri, Vandon Duong, Hima Anbunathan, Radim Moravec, Joyce Hong, Roshni Biswas, Stephen Van Nostrand, James Lindsay, Mina Pichavant, Elena Sotillo, Bita Sahaf, Sean Bendall, Holden Maecker, Steven Highfill, David Stroncek, Melinda Merchant, John Glod, Catherine Hedrick, Crystal Mackall, Sneha Ramakrishna, Rosandra Kaplan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2142.
https://doi.org/10.1158/1538-7445.AM2023-2142
Published: 04 April 2023
View article titled, Abstract 2142: Immune determinants of CAR-T expansion in solid tumor patients receiving GD2 CAR-T cell therapy
Journal Articles

Abstract 3165: ImmuneSig: A deep learning framework to develop gene expression signature of immune checkpoint inhibitor therapy

Yang Liu, Aashna Jhaveri, Sudhenshna Bodapati, Cheryl Wong, Franziska Michor
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3165.
https://doi.org/10.1158/1538-7445.AM2023-3165
Published: 04 April 2023
View article titled, Abstract 3165: ImmuneSig: A deep learning framework to develop gene expression signature of immune checkpoint inhibitor therapy
Journal Articles

Abstract GS3-07: GS3-07 Clonal evolution and mechanisms of acquired resistance to CDK4/6 inhibitors in ER-wild type and ER-mutant breast cancer

Cristina Guarducci, Simona Cristea, Avery Feit, Sergey Naumenko, Agostina Nardone, Wen Ma, Douglas Russo, Gabriella Cohen Feit, Ariel Feiglin, Francisco Hermida-Prado, Shira Sherman, Myles Brown, Franziska Michor, Rinath Jeselsohn
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): GS3-07.
https://doi.org/10.1158/1538-7445.SABCS22-GS3-07
Published: 01 March 2023
View article titled, Abstract GS3-07: GS3-07 Clonal evolution and mechanisms of acquired resistance to CDK4/6 inhibitors in ER-wild type and ER-mutant breast cancer
Journal Articles

JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States

Laura E. Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl, Zheqi Li, Anne Trinh, Marco Seehawer, Bojana Jovanović, Maša Alečković, Callahan M. Wilde, Renee C. Geck, Shaokun Shu, Natalie L. Kingston, Nicholas W. Harper, Vanessa Almendro, Alanna L. Pyke, Shawn B. Egri, Malvina Papanastasiou, Kendell Clement, Ningxuan Zhou, Sarah Walker, Jacqueline Salas, So Yeon Park, David A. Frank, Alexander Meissner, Jacob D. Jaffe, Piotr Sicinski, Alex Toker, Franziska Michor, Henry W. Long, Beth A. Overmoyer, Kornelia Polyak
Journal: Cancer Research
Cancer Res (2023) 83 (2): 264–284.
https://doi.org/10.1158/0008-5472.CAN-22-0423
Published: 18 January 2023
View article titled, JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States
Open the PDF for JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States in another window
Includes: Supplementary data
Journal Articles

Abstract A018: KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping

Zheqi Li, Guillermo Peluffo, Laura E. Stevens, Xintao Qiu, Shawn B. Egri, Malvina Papanastasiou, Natalie Kingston, Clive S. D'Santos, Eva Papachristou, Kyle Evans, Ji-Heui Seo, Kendell Clement, Daniel Temko, Muhammad Ekram, Anton Simeonov, Stephen C. Kales, Ganesha Rai, Madhu Lal-Nag, David J. Maloney, Ajit Jadhav, Franziska Michor, Alex Meissner, Jason S. Carroll, Matthew L. Freedman, Henry W. Long, Jacob D. Jaffe, Kornelia Polyak
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): A018.
https://doi.org/10.1158/1538-7445.CancEpi22-A018
Published: 01 December 2022
View article titled, Abstract A018: KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping
Journal Articles

Abstract IA013: Genetic heterogeneity and tumor microenvironment in glioblastoma

Kacper A. Walentynowicz, Dalit Engelhardt, Shreya Yadav, Ugoma Onubogu, Roberto Salatino, Cristina Vincentelli, Thomas O. McDonald, Franziska Michor, Michalina Janiszewska
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): IA013.
https://doi.org/10.1158/1538-7445.EVODYN22-IA013
Published: 15 May 2022
View article titled, Abstract IA013: Genetic heterogeneity and tumor microenvironment in glioblastoma
Journal Articles

Abstract PO-133: Breast tumors maintain a reservoir of subclonal diversity during primary expansion

Darlan Conterno Minussi, Michael Nicholson, Hanghui Ye, Alexander Davis, Kaile Wang, Emi Sei, Haowei Du, Mashiat Rabbani, Cheng Peng, Min Hu, Shanshan Bai, Thomas McDonald, Aislyn Schalck, Anna Casasent, Angelica Barrera, Hui Chen, Bora Lim, Banu Arun, Funda Meric-Bernstam, Franziska Michor, Nicholas Navin
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-133.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-133
Published: 03 November 2020
View article titled, Abstract PO-133: Breast tumors maintain a reservoir of subclonal diversity during primary expansion
Journal Articles

Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance

Itziar Irurzun-Arana, Thomas O. McDonald, Iñaki F. Trocóniz, Franziska Michor
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3372–3382.
https://doi.org/10.1158/0008-5472.CAN-20-0056
Published: 14 August 2020
View article titled, Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance
Open the PDF for Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract B16: Mathematical modeling identifies optimum palbociclib dosing schedules for the treatment of estrogen receptor-positive (ER+) breast cancer patients

Shayna Stein, Agostina Nardone, Weihan Liu, Gabriella Cohen, Cristina Guarducci, Myles Brown, Rinath Jeselsohn, Franziska Michor
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): B16.
https://doi.org/10.1158/1538-7445.CAMODELS2020-B16
Published: 02 June 2020
View article titled, Abstract B16: Mathematical modeling identifies optimum palbociclib dosing schedules for the treatment of estrogen receptor-positive (ER+) breast cancer patients
Journal Articles

Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

Jacqueline H. Starrett, Alexis A. Guernet, Maria Emanuela Cuomo, Kamrine E. Poels, Iris K. van Alderwerelt van Rosenburgh, Amy Nagelberg, Dylan Farnsworth, Kristin S. Price, Hina Khan, Kumar Dilip Ashtekar, Mmaserame Gaefele, Deborah Ayeni, Tyler F. Stewart, Alexandra Kuhlmann, Susan M. Kaech, Arun M. Unni, Robert Homer, William W. Lockwood, Franziska Michor, Sarah B. Goldberg, Mark A. Lemmon, Paul D. Smith, Darren A.E. Cross, Katerina Politi
Journal: Cancer Research
Cancer Res (2020) 80 (10): 2017–2030.
https://doi.org/10.1158/0008-5472.CAN-19-3819
Published: 15 May 2020
View article titled, Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance <em>EGFR</em> Mutations
Open the PDF for Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance <em>EGFR</em> Mutations in another window
Includes: Supplementary data
Journal Articles

Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution

Shaon Chakrabarti, Franziska Michor
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (14): 3908–3921.
https://doi.org/10.1158/0008-5472.CAN-16-2871
Published: 13 July 2017
View article titled, Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution
Open the PDF for Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution in another window
Includes: Supplementary data
Journal Articles

Abstract LB-280: The landscape of somatic microsatellite indels across cancer: detection and identification of driver events

Yosef E. Maruvka, Kent W. Mouw, Rosa Karlic, Rasanna Parasuraman, Atanas Kamburov, Paz Polak, Nicholas J. Haradhvala, Julian M. Hess, Esther Rheinbay, Yehuda Brody, Lior Z. Braunstein, Alan D’Andrea, Michael S. Lawrence, Adam Bass, Andre Bernards, Franziska Michor, Gad Getz
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-280.
https://doi.org/10.1158/1538-7445.AM2017-LB-280
Published: 01 July 2017
View article titled, Abstract LB-280: The landscape of somatic microsatellite indels across cancer: detection and identification of driver events
Journal Articles

Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk

Daniel Temko, Yu-Kang Cheng, Kornelia Polyak, Franziska Michor
Journal: Cancer Research
Cancer Res (2017) 77 (11): 2800–2809.
https://doi.org/10.1158/0008-5472.CAN-16-2504
Published: 31 May 2017
View article titled, Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk
Open the PDF for Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk in another window
Journal Articles

Abstract IA05: Evolution of glioblastoma subtypes

Franziska Michor
Journal: Cancer Research
Cancer Res (2015) 75 (23_Supplement): IA05.
https://doi.org/10.1158/1538-7445.BRAIN15-IA05
Published: 09 December 2015
View article titled, Abstract IA05: Evolution of glioblastoma subtypes