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Journal Articles

Abstract RF02-02: BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS-driven PI3Kalpha activity without affecting glucose metabolism

Pedro Beltran, Simanshu Dhirendra, Rui Xu, Ming Chen, Daniel Czyzyk, Sofia Donovan, Siyu Feng, Cindy Feng, Lijuan Fu, Felice Lightstone, Ken Lin, Anna Maciag, Dwight Nissley, Erin Riegler, Kerstin Sinkevicius, Andrew Stephen, James Stice, David Turner, Bin Wang, Keshi Wang, Yue Yang, Cathy Zhang, Frank McCormick, Eli Wallace
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): RF02-02.
https://doi.org/10.1158/1538-7445.SABCS23-RF02-02
Published: 02 May 2024
View articletitled, Abstract RF02-02: BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS-driven PI3Kalpha activity without affecting glucose metabolism
Journal Articles

Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding

Anna E. Maciag, James Stice, Bin Wang, Alok Sharma, Albert Chan, Ken Lin, Devansh Singh, Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P. Smith, Dana Rabara, Zuhui Zhang, Erik K. Larsen, Dom Esposito, John Paul Denson, Michela Ranieri, Mary Meynardie, Sadaf Mehdizadeh, Patrick Alexander, Maria Abreu Blanco, David Turner, Rui Xu, Felice C. Lightstone, Kwok Kin Wong, Dhirendra Simanshu, Keshi Wang, Andrew G. Stephen, Kerstin Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank McCormick, Pedro J. Beltran
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND07.
https://doi.org/10.1158/1538-7445.AM2024-ND07
Published: 05 April 2024
View articletitled, Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
Journal Articles

Abstract 2080: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer

Matthew J. Sale, Neal Mukherjee, Martín Koch, Regina Ruzicka, Robin Jacob, Christoph Albrecht, Teresa Zanin, Thomas Madensky, Robyn L. Schenk, Anke Baum, Kaja Kostyrko, Daniel Gerlach, Marco H. Hofmann, Frank McCormick
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2080.
https://doi.org/10.1158/1538-7445.AM2024-2080
Published: 22 March 2024
View articletitled, Abstract 2080: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer
Journal Articles

Abstract 1715: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer

Matthew J. Sale, Neal Mukherjee, Regina Ruzicka, Robin Jacob, Christoph Albrecht, Teresa Zanin, Tom Madensky, Kaja Kostyrko, Robyn L. Schenk, Anke Baum, Daniel Gerlach, Marco H. Hofmann, Frank McCormick
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1715.
https://doi.org/10.1158/1538-7445.AM2023-1715
Published: 04 April 2023
View articletitled, Abstract 1715: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer
Journal Articles

Abstract 1844: A CD70 antibody-drug conjugate is highly active and induces long term remission in patient-derived xenograft mouse models of cutaneous T cell lymphoma

Chi-Heng Wu, Chen-Yen Yang, Linlin Wang, Ryan Gill, Frank McCormick, Weiyun Z. Ai
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1844.
https://doi.org/10.1158/1538-7445.AM2021-1844
Published: 01 July 2021
View articletitled, Abstract 1844: A CD70 antibody-drug conjugate is highly active and induces long term remission in patient-derived xenograft mouse models of cutaneous T cell lymphoma
Journal Articles

Abstract 3765: c-Kit mediated phosphorylation of Spred1 regulates Neurofibromin-Spred1 interaction

Claire Lorenzo, Lucy C. Young, Alexandra Tannka, Anatoly Urisman, Frank McCormick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3765.
https://doi.org/10.1158/1538-7445.AM2020-3765
Published: 15 August 2020
View articletitled, Abstract 3765: c-Kit mediated phosphorylation of Spred1 regulates Neurofibromin-Spred1 interaction
Journal Articles

Abstract 6425: Sensitivity of oncogenic KRAS-expressing cells to CDK9 inhibition identified by a phenotypic compound screen

Lick P. Lai, Viviane Brel, Kanika Sharma, Julia Frappier, Nadia Le-Henanf, Bertrand Vivet, Nicolas Muzet, Emilie Schell, Renaud Morales, Eamonn Rooney, Matthew Holderfield, Frederic Lacroix, Walter Englaro, Christophe Marcireau, Laurent Debussche, Dwight V. Nissley, Frank Mccormick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6425.
https://doi.org/10.1158/1538-7445.AM2020-6425
Published: 15 August 2020
View articletitled, Abstract 6425: Sensitivity of oncogenic KRAS-expressing cells to CDK9 inhibition identified by a phenotypic compound screen
Journal Articles

Abstract 5133: Optimized RAS top-down proteomic assay reveals expanded proteoform landscape in malignant cells

Caroline DeHart, Kanika Sharma, Dominic Esposito, Anna Maciag, Dwight Nissley, Frank McCormick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5133.
https://doi.org/10.1158/1538-7445.AM2020-5133
Published: 15 August 2020
View articletitled, Abstract 5133: Optimized RAS top-down proteomic assay reveals expanded proteoform landscape in malignant cells
Journal Articles

Abstract 1087: NF1 regulates the RAS-related GTPases, RRAS and RRAS2, independent of RAS activity

Jillian M. Silva, Lizzeth Canche, Frank McCormick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1087.
https://doi.org/10.1158/1538-7445.AM2020-1087
Published: 15 August 2020
View articletitled, Abstract 1087: NF1 regulates the RAS-related GTPases, RRAS and RRAS2, independent of RAS activity
Journal Articles

Abstract 1470: UGP2 is a critical regulator of protein glycosylation in pancreatic cancer

Andrew L. Wolfe, Jacqueline Galeas, Eneda Toska, Qing Zhou, Angel Ku, Richard P. Koche, Sourav Bandyopadhyay, Carlito B. Lebrilla, Maurizio Scaltriti, Frank McCormick, Sung Eun Kim
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1470.
https://doi.org/10.1158/1538-7445.AM2020-1470
Published: 15 August 2020
View articletitled, Abstract 1470: UGP2 is a critical regulator of protein glycosylation in pancreatic cancer
Journal Articles

Abstract 238: Targeting glutaminolysis potentiates the efficacy of chemotherapy in RAS-driven pancreatic cancers

Suman Mukhopadhyay, Debanjan Goswami, Dwight V. Nissley, Frank McCormick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 238.
https://doi.org/10.1158/1538-7445.AM2020-238
Published: 15 August 2020
View articletitled, Abstract 238: Targeting glutaminolysis potentiates the efficacy of chemotherapy in RAS-driven pancreatic cancers
Journal Articles

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

Suman Mukhopadhyay, Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin, Serguei V. Kozlov, Dwight V. Nissley, Frank McCormick
Journal: Cancer Research
Cancer Res (2020) 80 (8): 1630–1643.
https://doi.org/10.1158/0008-5472.CAN-19-1363
Published: 15 April 2020
View articletitled, Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers
Open the PDF for Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 3373: Identification of KRAS membrane bound states using an integrated computational and experimental approach

Andrew G. Stephen, Animesh Agarwal, Angel E. Garcia, Gnana S. Gnanakaran, Jeevapani Hettige, Christopher Neale, Timothy Travers, Harsh Bhatia, Peer-Timo Bremer, Tim Carpenter, Jim Glosli, Helgi Ingolfsson, Piyush Karande, Felice Lightstone, Tomas Oppelstrup, Liam Stanton, Shiv Sundram, Xiaohua Zhang, Debsindhu Bhowmik, Arvind Ramanathan, Christopher Stanley, Debanjan Goswami, Gulcin Gulten, Frantz Jean-Francios, Dhirendra Simanshu, Tommy Turbyville, Rebika Shrestha, Que Van, Frank McCormick, Dwight Nissley, Fred Streitz, Constance Agamasu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3373.
https://doi.org/10.1158/1538-7445.AM2019-3373
Published: 01 July 2019
View articletitled, Abstract 3373: Identification of KRAS membrane bound states using an integrated computational and experimental approach
Journal Articles

Abstract LB-265: ARAF activates RAS by antagonizing its interaction with NF1

Wenjing Su, Rona Yaeger, Na Na, Jaclyn Hechtman, Viktoriya Paroder, Sandra Misale, Sae-Won Han, Omar I. Abdel-Wahab, Frank McCormick, Neal Rosen, Zhan Yao
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-265.
https://doi.org/10.1158/1538-7445.AM2019-LB-265
Published: 01 July 2019
View articletitled, Abstract LB-265: ARAF activates RAS by antagonizing its interaction with NF1
Journal Articles

Abstract 960: Structures of oncogenic KRAS mutants in the active state and complexed with RasGAP provide new insights into targeting RAS-driven cancer

Timothy Tran, Srisathiyanarayanan Dharmaiah, Wupeng Yan, Albert Chan, Timothy Waybright, William Gillette, Dominic Esposito, Andrew Stephen, Dwight Nissley, Frank McCormick, Dhirendra K. Simanshu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 960.
https://doi.org/10.1158/1538-7445.AM2019-960
Published: 01 July 2019
View articletitled, Abstract 960: Structures of oncogenic KRAS mutants in the active state and complexed with RasGAP provide new insights into targeting RAS-driven cancer
Journal Articles

Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC

Khyati N. Shah, Roma Bhatt, Julia Rotow, Julia Rohrberg, Victor Olivas, Victoria E. Wang, Jonathan Kuhn, Sophie Dumont, Frank Mccormick, Andrei Goga, Collin M. Blakely, Trever G. Bivona, Sourav Bandyopadhyay
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2902.
https://doi.org/10.1158/1538-7445.AM2019-2902
Published: 01 July 2019
View articletitled, Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC
Journal Articles

Abstract 1768: Biochemical and structural analysis of the Neurofibromin (NF1) protein and a potential role for protein destabilization in Rasopathy diseases

Mukul Sherekar, Sae-Won Han, Simon Messing, Matthew Drew, William Gillette, Claire Lorenzo, Frank McCormick, Dominic Esposito
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1768.
https://doi.org/10.1158/1538-7445.AM2019-1768
Published: 01 July 2019
View articletitled, Abstract 1768: Biochemical and structural analysis of the Neurofibromin (NF1) protein and a potential role for protein destabilization in Rasopathy diseases
Journal Articles

Abstract 5520: Oncogenic RTK signaling inhibits Spred1/NF1 to sustain constitutive Ras/MAPK signaling

Evan Markegard, Ellen L. Mercado, Pau Castel, Jillian Silva, Jacqueline Galeas, Kathy Li, Anatoly Urisman, Frank McCormick
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5520.
https://doi.org/10.1158/1538-7445.AM2018-5520
Published: 01 July 2018
View articletitled, Abstract 5520: Oncogenic RTK signaling inhibits Spred1/NF1 to sustain constitutive Ras/MAPK signaling
Journal Articles

Abstract 3302: The molecular landscape of oncogenic signaling pathways in The Cancer Genome Atlas

Francisco Sanchez-Vega, Marco Mina, Joshua Armenia, Walid K. Chatila, Augustin Luna, Konnor La, Sofia Dimitriadoy, David L. Liu, Havish S. Kantheti, Zachary Heins, Angelica Ochoa, Benjamin Gross, Jianjiong Gao, Hongxin Zhang, Ritika Kundra, Cyriac Kandoth, Istemi Bahceci, Leonard Dervishi, Ugur Dogrusoz, Wanding Zhou, Hui Shen, Peter W. Laird, Alice H. Berger, Trever G. Bivona, Alexander J. Lazar, Gary Hammer, Thomas Giordano, Lawrence Kwong, Grant McArthur, Chenfei Huang, Mitchell J. Frederick, Frank McCormick, Matthew Meyerson, The Cancer Genome Atlas Research Network, Eliezer Van Allen, Andrew D. Cherniack, Giovanni Ciriello, Chris Sander, Nikolaus Schultz
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3302.
https://doi.org/10.1158/1538-7445.AM2018-3302
Published: 01 July 2018
View articletitled, Abstract 3302: The molecular landscape of oncogenic signaling pathways in The Cancer Genome Atlas
Journal Articles

Abstract 3104: Establishment of an oral tongue squamous cell carcinoma cell line from a never-smoking patient

Steven J. Wang, Saurabh Asthana, Annemieke van Zante, Adam B. Olshen, Frank McCormick, Osamu Tetsu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3104.
https://doi.org/10.1158/1538-7445.AM2018-3104
Published: 01 July 2018
View articletitled, Abstract 3104: Establishment of an oral tongue squamous cell carcinoma cell line from a never-smoking patient