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Frank Lyko
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Journal Articles

Abstract 228: Loss of TET2 and TET3 mediated DNA demethylation drives intestinal tumor formation

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Oliver Gilliam, Ihab Ansari, Nikolaos Georgakopoulos, Manuel Mastel, Rene Jackstadt, Sebastian Belle, Yehudit Bergman, Frank Lyko
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 228.
https://doi.org/10.1158/1538-7445.AM2025-228
Published: 21 April 2025
View articletitled, Abstract 228: Loss of TET2 and TET3 mediated DNA demethylation drives intestinal tumor formation
Journal Articles

Abstract 208: Epigenomic characterization of keratinocyte carcinomas in xeroderma pigmentosum

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Bea Riebesehl, Lea S. Beensen, Felix Bormann, Wilfried Roth, Carlos F. Menck, Thomas G. Hofmann, Frank Lyko, Manuel Rodríguez Paredes
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 208.
https://doi.org/10.1158/1538-7445.AM2025-208
Published: 21 April 2025
View articletitled, Abstract 208: Epigenomic characterization of keratinocyte carcinomas in xeroderma pigmentosum
Journal Articles

Abstract 2755: The m6A epitranscriptomic landscape of bladder cancer is characterized by sequential 3'UTR hypermethylation and global methylation dilution

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Jonas Koch, Felix Bormann, Vitor Coutinho Carneiro, Manuel Neuberger, Katja Nitschke, Malin Nientiedt, Philipp Erben, Maurice S. Michel, Frank Lyko
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2755.
https://doi.org/10.1158/1538-7445.AM2025-2755
Published: 21 April 2025
View articletitled, Abstract 2755: The m6A epitranscriptomic landscape of bladder cancer is characterized by sequential 3'UTR hypermethylation and global methylation dilution
Journal Articles

Abstract 5333: Methylation profiling identifies two subclasses of cutaneous squamous cell carcinoma related to distinct cell types of origin

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Manuel Rodríguez Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Esther Herpel, Ingo Nindl, Thomas G. Hofmann, Marc Winnefeld, Frank Lyko
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5333.
https://doi.org/10.1158/1538-7445.AM2018-5333
Published: 01 July 2018
View articletitled, Abstract 5333: Methylation profiling identifies two subclasses of cutaneous squamous cell carcinoma related to distinct cell types of origin
Journal Articles

Abstract 3305: Cell-of-origin differentiation stages define methylation-based subtypes of human colorectal adenomas and carcinomas

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Felix Bormann, Manuel Rodríguez-Paredes, Felix Lasitschka, Dominic Edelmann, Axel Benner, Yehudit Bergman, Claudia R. Ball, Hanno Glimm, Heinz G. Linhart, Frank Lyko
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3305.
https://doi.org/10.1158/1538-7445.AM2018-3305
Published: 01 July 2018
View articletitled, Abstract 3305: Cell-of-origin differentiation stages define methylation-based subtypes of human colorectal adenomas and carcinomas
Journal Articles

Abstract 4350: Cell-of-origin differentiation stages define methylation-based subtypes of human colorectal cancer

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Felix Bormann, Manuel Rodríguez-Paredes, Yehudit Bergman, Heinz G. Linhart, Frank Lyko
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4350.
https://doi.org/10.1158/1538-7445.AM2017-4350
Published: 01 July 2017
View articletitled, Abstract 4350: Cell-of-origin differentiation stages define methylation-based subtypes of human colorectal cancer
Journal Articles

Abstract 2408: Epigenomic characterization of MSC from myeloid malignancies

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Manuel Rodríguez-Paredes, Stefanie Geyh, Mahshid Gazorpak, Julian Gutekunst, Felix Bormann, Rainer Haas, Thomas Schröder, Frank Lyko
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2408.
https://doi.org/10.1158/1538-7445.AM2017-2408
Published: 01 July 2017
View articletitled, Abstract 2408: Epigenomic characterization of MSC from myeloid malignancies
Journal Articles

Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer

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Monther Abu-Remaileh, Sebastian Bender, Günter Raddatz, Ihab Ansari, Daphne Cohen, Julian Gutekunst, Tanja Musch, Heinz Linhart, Achim Breiling, Eli Pikarsky, Yehudit Bergman, Frank Lyko
Journal: Cancer Research
Cancer Res (2015) 75 (10): 2120–2130.
https://doi.org/10.1158/0008-5472.CAN-14-3295
Published: 13 May 2015
View articletitled, Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer
Open the PDF for Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1036: Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation

Free
Carlo Stresemann, Sabine Hagemann, Cora Mund, Dirk Kuck, Florian Prinz, Bodo Brueckner, Dominik Mumberg, Frank Lyko, Anette Sommer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1036.
https://doi.org/10.1158/1538-7445.AM2012-1036
Published: 15 April 2012
View articletitled, Abstract 1036: Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation
Journal Articles

Abstract 2013: Modulation of cellular uptake and increased therapeutic efficacy of the azacytidine-elaidic acid ester CP-4200 in vitro and in vivo

Free
Bodo Brueckner, Maria Rius, Maria Rivera Markelova, Iduna Fichtner, Petter-Arnt Hals, Marit Liland Sandvold, Frank Lyko
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2013.
https://doi.org/10.1158/1538-7445.AM2011-2013
Published: 15 April 2011
View articletitled, Abstract 2013: Modulation of cellular uptake and increased therapeutic efficacy of the azacytidine-elaidic acid ester CP-4200 in vitro and in vivo
Journal Articles

Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells

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Pedro de Souza Rocha Simonini, Achim Breiling, Nibedita Gupta, Mahdi Malekpour, Mahmoud Youns, Ramesh Omranipour, Fatemeh Malekpour, Stefano Volinia, Carlo M. Croce, Hossein Najmabadi, Sven Diederichs, Özgür Sahin, Doris Mayer, Frank Lyko, Jörg D. Hoheisel, Yasser Riazalhosseini
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9175–9184.
https://doi.org/10.1158/0008-5472.CAN-10-1318
Published: 14 November 2010
View articletitled, Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells
Open the PDF for Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

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Matthias Schaefer, Sabine Hagemann, Katharina Hanna, Frank Lyko
Journal: Cancer Research
Cancer Res (2009) 69 (20): 8127–8132.
https://doi.org/10.1158/0008-5472.CAN-09-0458
Published: 14 October 2009
View articletitled, Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines
Open the PDF for Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines in another window
Journal Articles

The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function

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Bodo Brueckner, Carlo Stresemann, Ruprecht Kuner, Cora Mund, Tanja Musch, Michael Meister, Holger Sültmann, Frank Lyko
Journal: Cancer Research
Cancer Res (2007) 67 (4): 1419–1423.
https://doi.org/10.1158/0008-5472.CAN-06-4074
Published: 16 February 2007
View articletitled, The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function
Open the PDF for The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function in another window
Includes: Supplementary data
Journal Articles

Allelic silencing at 13q14.3: A novel oncogenic mechanism

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Daniel Mertens, Stephan Wolf, Cora Mund, Dirk Kienle, Frank Lyko, Hartmut Döhner, Stephan Stilgenbauer, Peter Lichter
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 382.
Published: 15 April 2006
View articletitled, Allelic silencing at 13q14.3: A novel oncogenic mechanism
Journal Articles

Functional Diversity of DNA Methyltransferase Inhibitors in Human Cancer Cell Lines

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Carlo Stresemann, Bodo Brueckner, Tanja Musch, Helga Stopper, Frank Lyko
Journal: Cancer Research
Cancer Res (2006) 66 (5): 2794–2800.
https://doi.org/10.1158/0008-5472.CAN-05-2821
Published: 01 March 2006
View articletitled, Functional Diversity of DNA Methyltransferase Inhibitors in Human Cancer Cell Lines
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Journal Articles

Characterization of DNA Demethylation Effects Induced by 5-Aza-2′-Deoxycytidine in Patients with Myelodysplastic Syndrome

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Cora Mund, Björn Hackanson, Carlo Stresemann, Michael Lübbert, Frank Lyko
Journal: Cancer Research
Cancer Res (2005) 65 (16): 7086–7090.
https://doi.org/10.1158/0008-5472.CAN-05-0695
Published: 15 August 2005
View articletitled, Characterization of DNA Demethylation Effects Induced by 5-Aza-2′-Deoxycytidine in Patients with Myelodysplastic Syndrome
Open the PDF for Characterization of DNA Demethylation Effects Induced by 5-Aza-2′-Deoxycytidine in Patients with Myelodysplastic Syndrome in another window
Journal Articles

Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases

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Bodo Brueckner, Regine Garcia Boy, Pawel Siedlecki, Tanja Musch, H. Christian Kliem, Piotr Zielenkiewicz, Sandor Suhai, Manfred Wiessler, Frank Lyko
Journal: Cancer Research
Cancer Res (2005) 65 (14): 6305–6311.
https://doi.org/10.1158/0008-5472.CAN-04-2957
Published: 15 July 2005
View articletitled, Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases
Open the PDF for Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases in another window