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Journal Articles

Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

Anna-Mariya Kukuyan, Eleonora Sementino, Yuwaraj Kadariya, Craig W. Menges, Mitchell Cheung, Yinfei Tan, Kathy Q. Cai, Michael J. Slifker, Suraj Peri, Andres J. Klein-Szanto, Frank J. Rauscher, III, Joseph R. Testa

Cancer Res (2019) 79 (16): 4113–4123.

https://doi.org/10.1158/0008-5472.CAN-18-4093

Published: 15 August 2019

View article titled, Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

Includes: Supplementary data

Journal Articles

Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains

Hongzhuang Peng, Jeremy Prokop, Jayashree Karar, Kyewon Park, Li Cao, J. William Harbour, Anne M. Bowcock, S. Bruce Malkowicz, Mitchell Cheung, Joseph R. Testa, Frank J. Rauscher, III

Cancer Res (2018) 78 (5): 1200–1213.

https://doi.org/10.1158/0008-5472.CAN-17-2876

Published: 28 February 2018

View article titled, Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains

Includes: Supplementary data

Journal Articles

Abstract 667: Immunoprofiling circulating blood as a means to early detection of solid tumors

Amit Kumar, Dimitry Gabrilovich, Frank J. Rauscher, George Dominguez, Cyrus Sholevar, John Roop, Anthony Campisi, Alexander Polo

Cancer Res (2017) 77 (13_Supplement): 667.

https://doi.org/10.1158/1538-7445.AM2017-667

Published: 01 July 2017

View article titled, Abstract 667: Immunoprofiling circulating blood as a means to early detection of solid tumors

Journal Articles

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations

Yuwaraj Kadariya, Mitchell Cheung, Jinfei Xu, Jianming Pei, Eleonora Sementino, Craig W. Menges, Kathy Q. Cai, Frank J. Rauscher, Andres J. Klein-Szanto, Joseph R. Testa

Cancer Res (2016) 76 (9): 2836–2844.

https://doi.org/10.1158/0008-5472.CAN-15-3371

Published: 01 May 2016

View article titled, Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations

Includes: Supplementary data

Journal Articles

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

Jill A. Ohar, Mitchell Cheung, Jacqueline Talarchek, Suzanne E. Howard, Timothy D. Howard, Mary Hesdorffer, Hongzhuang Peng, Frank J. Rauscher, Joseph R. Testa

Cancer Res (2016) 76 (2): 206–215.

https://doi.org/10.1158/0008-5472.CAN-15-0295

Published: 14 January 2016

View article titled, Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

Journal Articles

Abstract 2752: Prevalence of BAP1 germline mutations in asbestos-exposed malignant mesothelioma cases and controls

Mitchell Cheung, Jacqueline Talarchek, Suzanne E. Howard, Timothy Howard, Hongzhuang Peng, Mary Hesdorffer, Frank J. Rauscher, Jill A. Ohar, Joseph Testa

Cancer Res (2015) 75 (15_Supplement): 2752.

https://doi.org/10.1158/1538-7445.AM2015-2752

Published: 01 August 2015

View article titled, Abstract 2752: Prevalence of BAP1 germline mutations in asbestos-exposed malignant mesothelioma cases and controls

Journal Articles

Abstract A13: MSX1-induced neural crest-like reprograming promotes melanoma progression

Markus V. Heppt, Wang X. Joshua, Denitsa M. Hristova, Zhi Wei, Martin Irmler, Carola Berking, Robert Besch, Johannes Beckers, Frank J. Rauscher, III, David E. Fisher, Meenhard Herlyn, Mizuho Fukunaga-Kalabis

Cancer Res (2015) 75 (14_Supplement): A13.

https://doi.org/10.1158/1538-7445.MEL2014-A13

Published: 16 July 2015

View article titled, Abstract A13: MSX1-induced neural crest-like reprograming promotes melanoma progression

Journal Articles

Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase

Cancer Res (2014) 74 (19_Supplement): 992.

https://doi.org/10.1158/1538-7445.AM2014-992

Published: 01 October 2014

View article titled, Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase

Journal Articles

Abstract LB-323: Control of DNA repair and genome stability by the colon microbiome: The EPEC bacterially encoded NLEE virulence effector protein methylates and inactivates the human ZRANB3 DNA repair helicase

Jayashree Karar, Hongzhuang Peng, Li Zhang, Qing Yao, Ilan Rosenshine, Feng Shao, Frank J. Rauscher

Cancer Res (2014) 74 (19_Supplement): LB-323.

https://doi.org/10.1158/1538-7445.AM2014-LB-323

Published: 01 October 2014

View article titled, Abstract LB-323: Control of DNA repair and genome stability by the colon microbiome: The EPEC bacterially encoded NLEE virulence effector protein methylates and inactivates the human ZRANB3 DNA repair helicase

Journal Articles

Abstract 1061: High resolution DNA recognition by the Snail zinc finger protein: Testing of a molecular dynamics based model defines the atomic level interactions required for high affinity binding, E-box specificity and reveals potential strategies for small molecule control of EMT transcriptional programs

Yuanjie Liu, Jeremy W. Prokop, Hongzhuang Peng, Frank J. Rauscher

Cancer Res (2014) 74 (19_Supplement): 1061.

https://doi.org/10.1158/1538-7445.AM2014-1061

Published: 01 October 2014

View article titled, Abstract 1061: High resolution DNA recognition by the Snail zinc finger protein: Testing of a molecular dynamics based model defines the atomic level interactions required for high affinity binding, E-box specificity and reveals potential strategies for small molecule control of EMT transcriptional programs

Journal Articles

Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

Jiangzhi Chen, Hong Xu, Xiuqun Zou, Jiamin Wang, Yi Zhu, Hao Chen, Baiyong Shen, Xiaxing Deng, Aiwu Zhou, Y. Eugene Chin, Frank J. Rauscher, III, Chenghong Peng, Zhaoyuan Hou

Cancer Res (2014) 74 (16): 4353–4363.

https://doi.org/10.1158/0008-5472.CAN-14-0181

Published: 13 August 2014

View article titled, Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

Includes: Supplementary data

Journal Articles

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

Jinfei Xu, Yuwaraj Kadariya, Mitchell Cheung, Jianming Pei, Jacqueline Talarchek, Eleonora Sementino, Yinfei Tan, Craig W. Menges, Kathy Q. Cai, Samuel Litwin, Hongzhuang Peng, Jayashree Karar, Frank J. Rauscher, Joseph R. Testa

Cancer Res (2014) 74 (16): 4388–4397.

https://doi.org/10.1158/0008-5472.CAN-14-1328

Published: 13 August 2014

View article titled, Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

Includes: Supplementary data

Journal Articles

LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Cancer Res (2014) 74 (5): 1390–1403.

https://doi.org/10.1158/0008-5472.CAN-13-1275

Published: 02 March 2014

View article titled, LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Includes: Supplementary data

Journal Articles

Abstract 5219: The LIM protein LIMD2 functions as an effector and biomarker for metastasis in multiple tumor types

Hongzhuang Peng, Zhaoyuan Hou, Mei He, Electron Kebebew, Torben F. Orntoft, Meenhard Herlyn, Andrew J. Caton, William J. Fredericks, Bruce Malkowicz, Frank J. Rauscher

Cancer Res (2011) 71 (8_Supplement): 5219.

https://doi.org/10.1158/1538-7445.AM2011-5219

Published: 15 April 2011

View article titled, Abstract 5219: The LIM protein LIMD2 functions as an effector and biomarker for metastasis in multiple tumor types

Journal Articles

Abstract 966: Snail mediated transcriptional repression and EMT requires zinc-finger and SNAG domain directed phosphorylation: Identification of the kinases and evaluation as therapeutic targets

Frank J. Rauscher, Zhaoyuan Hou, Hongzhuang Peng, David E. White, Colleen Wood

Cancer Res (2011) 71 (8_Supplement): 966.

https://doi.org/10.1158/1538-7445.AM2011-966

Published: 15 April 2011

View article titled, Abstract 966: Snail mediated transcriptional repression and EMT requires zinc-finger and SNAG domain directed phosphorylation: Identification of the kinases and evaluation as therapeutic targets

Journal Articles

Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program

Dmitri G. Negorev, Olga V. Vladimirova, Andrew V. Kossenkov, Elena V. Nikonova, Renee M. Demarest, Anthony J. Capobianco, Michael K. Showe, Frank J. Rauscher, III, Louise C. Showe, Gerd G. Maul

Cancer Res (2010) 70 (23): 9991–10001.

https://doi.org/10.1158/0008-5472.CAN-10-1483

Published: 06 December 2010

View article titled, Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program

Includes: Supplementary data

Journal Articles

14-3-3 Binding Sites in the Snail Protein Are Essential for Snail-Mediated Transcriptional Repression and Epithelial-Mesenchymal Differentiation

Zhaoyuan Hou, Hongzhuang Peng, David E. White, Pu Wang, Paul M. Lieberman, Thanos Halazonetis, Frank J. Rauscher, III

Cancer Res (2010) 70 (11): 4385–4393.

https://doi.org/10.1158/0008-5472.CAN-10-0070

Published: 01 June 2010

View article titled, 14-3-3 Binding Sites in the Snail Protein Are Essential for Snail-Mediated Transcriptional Repression and Epithelial-Mesenchymal Differentiation

Journal Articles

Abstract 3923: ATM and KAP1 are required for nonhomologous end-joining in transcriptionally active chromatin

Amy J. Hawkins, David E. White, Sarah E. Golding, Konstantin Akopiants, Frank J. Rauscher, Lawrence F. Povirk, Kristoffer Valerie

Cancer Res (2010) 70 (8_Supplement): 3923.

https://doi.org/10.1158/1538-7445.AM10-3923

Published: 15 April 2010

View article titled, Abstract 3923: ATM and KAP1 are required for nonhomologous end-joining in transcriptionally active chromatin

Journal Articles

In Memoriam: Carl G. Baker (1920–2009)

Frank J. Rauscher, III

Cancer Res (2009) 69 (11): 4935–4936.

https://doi.org/10.1158/0008-5472.CAN-09-7000

Published: 01 June 2009

View article titled, In Memoriam: Carl G. Baker (1920–2009)

Journal Articles

The Year Ahead

Frank J. Rauscher, III

Cancer Res (2009) 69 (1): 1.

https://doi.org/10.1158/0008-5472.CAN-69-1-ED

Published: 31 December 2008

View article titled, The Year Ahead

NARROW

Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains

Abstract 667: Immunoprofiling circulating blood as a means to early detection of solid tumors

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

Abstract 2752: Prevalence of BAP1 germline mutations in asbestos-exposed malignant mesothelioma cases and controls

Abstract A13: MSX1-induced neural crest-like reprograming promotes melanoma progression

Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase

Abstract LB-323: Control of DNA repair and genome stability by the colon microbiome: The EPEC bacterially encoded NLEE virulence effector protein methylates and inactivates the human ZRANB3 DNA repair helicase

Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Abstract 5219: The LIM protein LIMD2 functions as an effector and biomarker for metastasis in multiple tumor types

Abstract 966: Snail mediated transcriptional repression and EMT requires zinc-finger and SNAG domain directed phosphorylation: Identification of the kinases and evaluation as therapeutic targets

Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program

14-3-3 Binding Sites in the Snail Protein Are Essential for Snail-Mediated Transcriptional Repression and Epithelial-Mesenchymal Differentiation

Abstract 3923: ATM and KAP1 are required for nonhomologous end-joining in transcriptionally active chromatin

In Memoriam: Carl G. Baker (1920–2009)

The Year Ahead

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