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Frank B. Furnari
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Journal Articles

Abstract 1125: Elucidating the transcriptomic response to EGFR-targeted therapy in EGFR-driven glioblastoma

Benjamin Lin, Julia Ziebro, Kasey R. Skinner, Abigail Shelton, Erin Smithberger, Ryan Bash, Frank B. Furnari, Ryan Miller
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1125.
https://doi.org/10.1158/1538-7445.AM2022-1125
Published: 15 June 2022
View articletitled, Abstract 1125: Elucidating the transcriptomic response to EGFR-targeted therapy in EGFR-driven glioblastoma
Journal Articles

Abstract 1857: Glioblastoma growth is suppressed dual inhibition of EGFR and CDK6 kinases

Erin Smithberger, Abigail K. Shelton, Ryan E. Bash, Madison K. Butler, Alex R. Flores, Allie Stamper, Steven P. Angus, Michael P. East, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, Ryan Miller
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1857.
https://doi.org/10.1158/1538-7445.AM2022-1857
Published: 15 June 2022
View articletitled, Abstract 1857: Glioblastoma growth is suppressed dual inhibition of EGFR and CDK6 kinases
Journal Articles

Abstract 3248: Acquired resistance to targeted inhibitors in EGFR-driven glioblastoma: Identification of dual kinase targets

Abigail K. Shelton, Erin Smithberger, Madison Butler, Allie Stamper, Ryan E. Bash, Steve P. Angus, Michael P. East, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, Ryan Miller
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3248.
https://doi.org/10.1158/1538-7445.AM2022-3248
Published: 15 June 2022
View articletitled, Abstract 3248: Acquired resistance to targeted inhibitors in EGFR-driven glioblastoma: Identification of dual kinase targets
Journal Articles

Abstract 1300: Identification of efficacious treatment for glioblastoma (GBM) by applying computational drug sensitivity imputation to novel GBM avatars and GBM clinical datasets

Danielle Maeser, Robert Gruener, Robert Galvin, Tomoyuki Koga, Frank B. Furnari, David Largaespada, Clark C. Chen, Stephanie R. Huang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1300.
https://doi.org/10.1158/1538-7445.AM2021-1300
Published: 01 July 2021
View articletitled, Abstract 1300: Identification of efficacious treatment for glioblastoma (GBM) by applying computational drug sensitivity imputation to novel GBM avatars and GBM clinical datasets
Journal Articles

Abstract 3019: Dynamic kinome profiling of EGFRvIII-driven murine astrocyte models of glioblastoma reveals targets for dual kinase inhibitor therapy

Erin Smithberger, Abigail K. Shelton, Madison K. Butler, Alex R. Flores, Ryan E. Bash, Steven P. Angus, Noah Sciaky, Harshil D. Dhruv, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, C. Ryan Miller
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3019.
https://doi.org/10.1158/1538-7445.AM2019-3019
Published: 01 July 2019
View articletitled, Abstract 3019: Dynamic kinome profiling of EGFRvIII-driven murine astrocyte models of glioblastoma reveals targets for dual kinase inhibitor therapy
Journal Articles

Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Tao Sun, Rameshwar Patil, Anna Galstyan, Dmytro Klymyshyn, Hui Ding, Alexandra Chesnokova, Webster K. Cavenee, Frank B. Furnari, Vladimir A. Ljubimov, Ekaterina S. Shatalova, Shawn Wagner, Debiao Li, Adam N. Mamelak, Serguei I. Bannykh, Chirag G. Patil, Jeremy D. Rudnick, Jethro Hu, Zachary B. Grodzinski, Arthur Rekechenetskiy, Vida Falahatian, Alexander V. Lyubimov, Yongmei L. Chen, Lai S. Leoh, Tracy R. Daniels-Wells, Manuel L. Penichet, Eggehard Holler, Alexander V. Ljubimov, Keith L. Black, Julia Y. Ljubimova
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (6): 1239–1251.
https://doi.org/10.1158/0008-5472.CAN-18-2725
Published: 15 March 2019
View articletitled, Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk
Open the PDF for Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2372: Kinome profiling of non-germline, genetically engineered mouse models of glioblastoma driven by Cdkn2a, Egfr, and/or Pten mutations reveals genotype-dependent kinase targets

Erin Smithberger, Alex R. Flores, Madison K. Butler, Harshil D. Dhruv, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, C. Ryan Miller
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2372.
https://doi.org/10.1158/1538-7445.AM2018-2372
Published: 01 July 2018
View articletitled, Abstract 2372: Kinome profiling of non-germline, genetically engineered mouse models of glioblastoma driven by Cdkn2a, Egfr, and/or Pten mutations reveals genotype-dependent kinase targets
Journal Articles

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc( — )

Kenji Tsuchihashi, Shogo Okazaki, Mitsuyo Ohmura, Miyuki Ishikawa, Oltea Sampetrean, Nobuyuki Onishi, Hiroaki Wakimoto, Momoko Yoshikawa, Ryo Seishima, Yoshimi Iwasaki, Takayuki Morikawa, Shinya Abe, Ayumi Takao, Misato Shimizu, Takashi Masuko, Motoo Nagane, Frank B. Furnari, Tetsu Akiyama, Makoto Suematsu, Eishi Baba, Koichi Akashi, Hideyuki Saya, Osamu Nagano
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (10): 2954–2963.
https://doi.org/10.1158/0008-5472.CAN-15-2121
Published: 12 May 2016
View articletitled, The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc( — )
Open the PDF for The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc( — ) in another window
Includes: Supplementary data
Journal Articles

Abstract 3478: A multi-orthogonal strategy for targeting EGFRvIII expressing glioblastomas

Ying Shen, Jie Li, Frank B Furnari, Arshad Desai, Hong-Zhuan Chen, Clark Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3478.
https://doi.org/10.1158/1538-7445.AM2015-3478
Published: 01 August 2015
View articletitled, Abstract 3478: A multi-orthogonal strategy for targeting EGFRvIII expressing glioblastomas
Journal Articles

A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma

Jill Wykosky, Jingjing Hu, German G. Gomez, Tiffany Taylor, Genaro R. Villa, Donald Pizzo, Scott R. VandenBerg, Amy Haseley Thorne, Clark C. Chen, Paul S. Mischel, Steven L. Gonias, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2015) 75 (2): 394–404.
https://doi.org/10.1158/0008-5472.CAN-14-2004
Published: 14 January 2015
View articletitled, A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma
Open the PDF for A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract A4: Guanylate binding protein‐1 promotes glioma cell invasion through induction of MMP1 expression

Ming Li, Frank B. Furnari, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A4.
https://doi.org/10.1158/0008-5472.FBCR09-A4
Published: 28 October 2014
View articletitled, Abstract A4: Guanylate binding protein‐1 promotes glioma cell invasion through induction of MMP1 expression
Journal Articles

Abstract B05: The tumor suppressor gene pten regulates gene expression through histone H3.3 deposition and Daxx interaction

Jorge A. Benitez, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): B05.
https://doi.org/10.1158/1538-7445.CEC13-B05
Published: 13 May 2014
View articletitled, Abstract B05: The tumor suppressor gene pten regulates gene expression through histone H3.3 deposition and Daxx interaction
Journal Articles

Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity

German G. Gomez, Stefano Volinia, Carlo M. Croce, Ciro Zanca, Ming Li, Ryan Emnett, David H. Gutmann, Cameron W. Brennan, Frank B. Furnari, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2014) 74 (5): 1429–1439.
https://doi.org/10.1158/0008-5472.CAN-13-2117
Published: 02 March 2014
View articletitled, Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Open the PDF for Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity in another window
Includes: Supplementary data
Journal Articles

Heterogeneity Maintenance in Glioblastoma: A Social Network

Rudy Bonavia, Maria-del-Mar Inda, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2011) 71 (12): 4055–4060.
https://doi.org/10.1158/0008-5472.CAN-11-0153
Published: 14 June 2011
View articletitled, Heterogeneity Maintenance in Glioblastoma: A Social Network
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Journal Articles

Abstract 3126: Tumor heterogeneity in glioblastoma is an active process driven by a mutant EGFR-induced paracrine circuit

Maria-del-Mar Inda, Rudy Bonavia, Dinah WY Sah, Scott Vandenberg, Cameron Brennan, Terrance G. Johns, Philipp Hadwiger, Pamela Tan, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3126.
https://doi.org/10.1158/1538-7445.AM10-3126
Published: 15 April 2010
View articletitled, Abstract 3126: Tumor heterogeneity in glioblastoma is an active process driven by a mutant EGFR-induced paracrine circuit
Journal Articles

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

Kan V. Lu, Shaojun Zhu, Anna Cvrljevic, Tiffany T. Huang, Shawn Sarkaria, David Ahkavan, Julie Dang, Eduard B. Dinca, Seema B. Plaisier, Isaac Oderberg, Yohan Lee, Zugen Chen, Jeremy S. Caldwell, Yongmin Xie, Joseph A. Loo, David Seligson, Arnab Chakravari, Francis Y. Lee, Roberto Weinmann, Timothy F. Cloughesy, Stanley F. Nelson, Gabriele Bergers, Thomas Graeber, Frank B. Furnari, C. David James, Webster K. Cavenee, Terrance G. Johns, Paul S. Mischel
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6889–6898.
https://doi.org/10.1158/0008-5472.CAN-09-0347
Published: 31 August 2009
View articletitled, Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
Open the PDF for Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients in another window
Includes: Supplementary data
Journal Articles

PCAF regulates PI3-kinase signaling by acetylation of PTEN

Koichi Okumura, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1276–1277.
Published: 01 April 2004
View articletitled, PCAF regulates PI3-kinase signaling by acetylation of PTEN
Journal Articles

Mutant Epidermal Growth Factor Receptor Signaling Down-Regulates p27 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Glioblastomas

Yoshitaka Narita, Motoo Nagane, Kazuhiko Mishima, H-J. Su Huang, Frank B. Furnari, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2002) 62 (22): 6764–6769.
Published: 15 November 2002
View articletitled, Mutant Epidermal Growth Factor Receptor Signaling Down-Regulates p27 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Glioblastomas
Open the PDF for Mutant Epidermal Growth Factor Receptor Signaling Down-Regulates p27 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Glioblastomas in another window
Journal Articles

The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells

Frank B. Furnari, H-J. Su Huang, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (1998) 58 (22): 5002–5008.
Published: 01 November 1998
View articletitled, The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells
Open the PDF for The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells in another window
Journal Articles

Absence of PTEN/MMAC1 Germ-Line Mutations in Sporadic Bannayan-Riley-Ruvalcaba Syndrome

John M. Carethers, Frank B. Furnari, Andrew F. Zigman, Joel E. Lavine, Marilyn C. Jones, Gail E. Graham, Ahmad S. Teebi, H-J. Su Huang, Hannah T. Ha, Dharam P. Chauhan, Christina L. Chang, Webster K. Cavenee, C. Richard Boland
Journal: Cancer Research
Cancer Res (1998) 58 (13): 2724–2726.
Published: 01 July 1998
View articletitled, Absence of PTEN/MMAC1 Germ-Line Mutations in Sporadic Bannayan-Riley-Ruvalcaba Syndrome
Open the PDF for Absence of PTEN/MMAC1 Germ-Line Mutations in Sporadic Bannayan-Riley-Ruvalcaba Syndrome in another window