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Francisca Vazquez
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Journal Articles

Abstract SY14-03: Exploiting dysregulated ribosomal homeostasis in chromosome 9p21.3 deleted cancers and microsatellite unstable cancers

Free
Patricia Borck, Isabella Boyle, Kristina Jankovic, Nolan Bick, Kyla Foster, Anthony Lau, Lucy Parker-Burns, Daniel Lubicki, Ashir Borah, Nicholas Lofaso, Sohani Das Sharma, Riya V. Kishen, Joshua Dempster, Francisca Vazquez, Edmond M. Chan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): SY14-03.
https://doi.org/10.1158/1538-7445.AM2025-SY14-03
Published: 25 April 2025
View articletitled, Abstract SY14-03: Exploiting dysregulated ribosomal homeostasis in chromosome 9p21.3 deleted cancers and microsatellite unstable cancers
Journal Articles

Abstract SY14-02: Mapping synthetic lethal interactions at scale: A functional genomics approach to cancer therapeutic discovery

Free
Francisca Vazquez
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): SY14-02.
https://doi.org/10.1158/1538-7445.AM2025-SY14-02
Published: 25 April 2025
View articletitled, Abstract SY14-02: Mapping synthetic lethal interactions at scale: A functional genomics approach to cancer therapeutic discovery
Journal Articles

Abstract 2397: Order parameter methods for interpretable comparisons across tumors and cell lines

Free
Lauren Golden, Naima Abdirahman, Xiaomeng Zhang, Maria Yampolskaya, Barbara DeKegel, Pankaj Mehta, Francisca Vazquez, Catarina D. Campbell
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2397.
https://doi.org/10.1158/1538-7445.AM2025-2397
Published: 21 April 2025
View articletitled, Abstract 2397: Order parameter methods for interpretable comparisons across tumors and cell lines
Journal Articles

Abstract 2980: Therapeutic potential of combined targeting of casein kinase 1 alpha (CK1 alpha) and CDK7/9 with the inhibitor BTX-A51 in human liposarcomas

Free
Renyan Liu, Nicole L. Solimini, Caoibhne McSweeney, Patrick Bhola, Daryl Griffin, Tim B. Branigan, Michael J. Wagner, Audrey Turchick, Ricardo de Simoes, Joshua M. Dempster, Jie Hao, Xin Wang, Roshen Alharthi, Michael Yorsz, Shaili Soni, Cing-siang Hu, Irit Snir-Alkalay, Francisca Vazquez, Prafulla C. Gokhale, Constantine Mitsiades, Anthony Letai, Yinon Ben-Neriah, George D. Demetri, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2980.
https://doi.org/10.1158/1538-7445.AM2025-2980
Published: 21 April 2025
View articletitled, Abstract 2980: Therapeutic potential of combined targeting of casein kinase 1 alpha (CK1 alpha) and CDK7/9 with the inhibitor BTX-A51 in human liposarcomas
Journal Articles

Abstract LB203: CRISPR anchor screens to identify co-vulnerabilities and drug combinations in DepMap

Free
Jenny Serra-Vinardell, Zoe Posner, Alison Cameron, Yuqi Chen, Negin Karisani, Barbara De Kegel, Joshua M. Dempster, Andrew J. Aguirre, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB203.
https://doi.org/10.1158/1538-7445.AM2024-LB203
Published: 05 April 2024
View articletitled, Abstract LB203: CRISPR anchor screens to identify co-vulnerabilities and drug combinations in DepMap
Journal Articles

Abstract LB234: Identifying cancer vulnerabilities associated with changes in chromatin accessibility by simultaneously profiling hundreds of cancer cell lines with ATAC-seq

Free
Patricia Borck, Kirsty Wienand, Fabiana Duarte, Alvin Qin, Ruochi Zhang, Juliana Babu, Simone Zhang, Samuel Maffa, Max Horlbeck, Rojesh Shrestha, Joshua Dempster, Jennifer Roth, Catarina Campbell, Jason Buenrostro, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB234.
https://doi.org/10.1158/1538-7445.AM2024-LB234
Published: 05 April 2024
View articletitled, Abstract LB234: Identifying cancer vulnerabilities associated with changes in chromatin accessibility by simultaneously profiling hundreds of cancer cell lines with ATAC-seq
Journal Articles

Abstract 1256: RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

Free
Hannah N. Weinstein, Kevin Hu, Lisa Fish, Yih-An Chen, Paul Allegakoen, Keliana S. Hui, Julia H. Pham, Maria B. Baco, Hanbing Song, Andrew O. Giacomelli, Francisca Vazquez, Mahmoud Ghandi3, Hani Goodarzi, Franklin W. Huang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1256.
https://doi.org/10.1158/1538-7445.AM2024-1256
Published: 22 March 2024
View articletitled, Abstract 1256: RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
Journal Articles

Abstract 3364: PELO is a synthetic lethal target in chromosome 9p21-deleted or MSI cancers

Free
Edmond M. Chan, Patricia Borck, Nolan Bick, Kristina Jankovic, Isabella Boyle, Lucy Parker-Burns, Kyla Foster, Anthony Lau, Ashir Borah, Joshua Dempster, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3364.
https://doi.org/10.1158/1538-7445.AM2024-3364
Published: 22 March 2024
View articletitled, Abstract 3364: PELO is a synthetic lethal target in chromosome 9p21-deleted or MSI cancers
Journal Articles

Abstract 413: Aneuploid cells depend on the RAF/MEK/ERK pathway and on RNA degradation for overcoming DNA damage and transcriptional burden

Free
Marica Rosaria Ippolito, Johanna Zerbib Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Anouk Savir Kadmon, Alice Ratti, Sara Martin, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Francisca Vazquez, Uri Ben-David, Stefano Santaguida
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 413.
https://doi.org/10.1158/1538-7445.AM2024-413
Published: 22 March 2024
View articletitled, Abstract 413: Aneuploid cells depend on the RAF/MEK/ERK pathway and on RNA degradation for overcoming DNA damage and transcriptional burden
Journal Articles

Abstract B014: Charting ovarian cancer dependencies with patient-derived organoids

Free
Ashley Anderson, Tate Bertea, James Neiswender, Lisa Brenan, Megan Wong, Alina Simerzin, Sarah Wie, Isabella Boyle, Lauren Golden, Barbara De Kegel, Josh Dempster, Yuen-Yi Tseng, David Root, Sarah Hill, Andrew Aguirre, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B014.
https://doi.org/10.1158/1538-7445.OVARIAN23-B014
Published: 04 March 2024
View articletitled, Abstract B014: Charting ovarian cancer dependencies with patient-derived organoids
Journal Articles

Abstract LB074: Towards the next generation cancer dependency map

Free
Kirsty Wienand, Samantha Stokes, Philip G. Montgomery, Kelly Sullivan, Joshua M. Dempster, William C. Hahn, Jennifer A. Roth, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB074.
https://doi.org/10.1158/1538-7445.AM2023-LB074
Published: 14 April 2023
View articletitled, Abstract LB074: Towards the next generation cancer dependency map
Journal Articles

Abstract 6088: Charting new cancer dependencies with patient derived organoids

Free
James V. Neiswender, Lisa Brenan, Tate Bertea, Jimmy Guo, Ashley Anderson, Megan Wong, Zoe Posner, Kevin Kapner, Connor Hennessey, Sarah Wie, Isabella Boyle, Barbara De Kegel, Joshua Dempster, Yuen-Yi (Moony) Tseng, David Root, Andrew Aguirre, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6088.
https://doi.org/10.1158/1538-7445.AM2023-6088
Published: 04 April 2023
View articletitled, Abstract 6088: Charting new cancer dependencies with patient derived organoids
Journal Articles

Abstract 5324: Drug repurposing and genetic screening strategies for effective treatment discovery in soft-tissue sarcomas

Free
Mushriq Al-Jazrawe, Kathryn Cebula, Elisabeth A. Abeyta, Haley S. Curtis, Jane K. McIninch, Jaime H. Cheah, James Berstler, Lisa Miller, James Neiswender, Lisa Brenan, Mike Burger, Francisca Vazquez, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5324.
https://doi.org/10.1158/1538-7445.AM2023-5324
Published: 04 April 2023
View articletitled, Abstract 5324: Drug repurposing and genetic screening strategies for effective treatment discovery in soft-tissue sarcomas
Journal Articles

Abstract A052: Systematic dissection of transcriptional states in pancreatic cancer

Free
Jimmy A. Guo, Jennifer Su, Ananya Jambhale, Julien Dilly, Connor J. Hennessey, Carina Shiau, Patrick Yu, Steven Wang, Junning Wang, Laleh Abbassi, James Neiswender, Tate Bertea, Annan Yang, Qijia Yu, Peter Westcott, Jason Schenkel, Daniel Y. Kim, Hannah I. Hoffman, Grissel Cervantes Jaramillo, Giselle A. Uribe, Westley W. Wu, Arnav Mehta, David Ting, Julian A. Pacheco, Amy Deik, Clary Clish, Francisca Vazquez, Brian Wolpin, Aviv Regev, William A. Freed-Pastor, Joseph D. Mancias, Tyler Jacks, William L. Hwang, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A052.
https://doi.org/10.1158/1538-7445.PANCA22-A052
Published: 15 November 2022
View articletitled, Abstract A052: Systematic dissection of transcriptional states in pancreatic cancer
Journal Articles

Abstract 1897: Systematic methods to identify cancer vulnerabilities from genome-wide loss-of-function screens: An interactive framework for target discovery

Free
John M. Krill-Burger, Ashir A. Borah, Brenton R. Paolella, James M. McFarland, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1897.
https://doi.org/10.1158/1538-7445.AM2022-1897
Published: 15 June 2022
View articletitled, Abstract 1897: Systematic methods to identify cancer vulnerabilities from genome-wide loss-of-function screens: An interactive framework for target discovery
Journal Articles

Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers

Free
Daniel Bondeson, Brenton Paolella, Adhana Asfaw, Michael Rothberg, Thomas Skipper, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allie Warren, Joshua Dempster, J Michael Krill-Burger, Maria Ericsson, Andrew Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John Doench, Federica Piccioni, David Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James McFarland, Francisca Vazquez, Todd Golub
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1028.
https://doi.org/10.1158/1538-7445.AM2022-1028
Published: 15 June 2022
View articletitled, Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers
Journal Articles

Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Free
Lisa D. Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A. Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M. Dempster, John M. Krill-Burger, Federica Piccioni, Namrata D. Udeshi, Meagan E. Olive, Steven A. Carr, David E. Root, James M. McFarland, Francisca Vazquez, William C. Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 73.
https://doi.org/10.1158/1538-7445.AM2022-73
Published: 15 June 2022
View articletitled, Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Journal Articles

Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Free
Lisa D Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M Dempster, John M Krill-Burger, Federica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-01.
https://doi.org/10.1158/1538-7445.SABCS21-P3-09-01
Published: 15 February 2022
View articletitled, Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Journal Articles

Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?

Available to Purchase
Francisca Vazquez, William R. Sellers
Journal: Cancer Research
Cancer Res (2021) 81 (23): 5806–5809.
https://doi.org/10.1158/0008-5472.CAN-21-1784
Published: 01 December 2021
View articletitled, Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?
Open the PDF for Are CRISPR Screens Providing the Next Generation of Therapeutic Targets? in another window
Journal Articles

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Open Access
Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, Jake R. Conway, Neekesh V. Dharia, Saif Alimohamed, Brian J. Haas, Kyuho Han, Jihye Park, Felix Dietlein, Meng Xiao He, Alma Imamovic, Clement Ma, Michael C. Bassik, Jesse S. Boehm, Francisca Vazquez, Alexander Gusev, David Liu, Katherine A. Janeway, James M. McFarland, Kimberly Stegmaier, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2021) 81 (15): 3971–3984.
https://doi.org/10.1158/0008-5472.CAN-21-0791
Published: 01 August 2021
View articletitled, Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival
Open the PDF for Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival in another window
Includes: Supplementary data