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Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Cancer Res (2022) 82 (4_Supplement): P3-09-01.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-01

Published: 15 February 2022

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Journal Articles

Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?

Francisca Vazquez, William R. Sellers

Cancer Res (2021) 81 (23): 5806–5809.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-1784

Published: 01 December 2021

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Journal Articles

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Cancer Res (2021) 81 (15): 3971–3984.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-0791

Published: 01 August 2021

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Includes: Supplementary data

Journal Articles

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Cancer Res (2021) 81 (13_Supplement): NG01.

DOI: https://doi.org/10.1158/1538-7445.AM2021-NG01

Published: 01 July 2021

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Journal Articles

Abstract 96: Gene fusions create partner and collateral dependencies that are essential to cancer cell survival

Cancer Res (2021) 81 (13_Supplement): 96.

DOI: https://doi.org/10.1158/1538-7445.AM2021-96

Published: 01 July 2021

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Journal Articles

Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival

Cancer Res (2021) 81 (13_Supplement): 1950.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1950

Published: 01 July 2021

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Journal Articles

Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers

Cancer Res (2020) 80 (22_Supplement): PO-011.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-011

Published: 13 November 2020

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Journal Articles

Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4

Cancer Res (2020) 80 (16_Supplement): LB-053.

DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-053

Published: 15 August 2020

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Journal Articles

Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines

Tsukasa Shibue, John M. Krill-Burger, Brenton R. Paolella, Benjamin Gaeta, Adhana Asfaw, Joshua M. Dempster, James M. McFarland, David E. Root, Jesse S. Boehm, Aviad Tsherniak, William C. Hahn, Francisca Vazquez

Cancer Res (2020) 80 (16_Supplement): LB-100.

DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-100

Published: 15 August 2020

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Journal Articles

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Cancer Res (2020) 80 (14_Supplement): B10.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B10

Published: 15 July 2020

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Journal Articles

Abstract PR09: A systematic approach to create patient-derived models of rare tumors

Yuen-Yi Tseng, Paula Keskula, Rebecca Deasy, Andrew Hong, Priya Chatterji, Francisca Vazquez, Adam Bass, Barbara Van Hare, David Sandak, Keith Ligon, Jesse Boehm

Cancer Res (2020) 80 (11_Supplement): PR09.

DOI: https://doi.org/10.1158/1538-7445.CAMODELS2020-PR09

Published: 02 June 2020

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Journal Articles

Abstract 2878: CRISPR-Cas9 screens identify the nuclear export factor NXT1 as a novel therapeutic target in MYCN-amplified neuroblastoma

Clare F. Malone, Neekesh V. Dharia, Guillaume Kugener, Brenton Paolella, Michael Rothberg, Mai Abdusamad, Alfredo Gonzalez, Nancy Dumont, Scott Younger, David Root, Francisca Vazquez, Kimberly Stegmaier

Cancer Res (2019) 79 (13_Supplement): 2878.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2878

Published: 01 July 2019

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Journal Articles

Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors

Cancer Res (2019) 79 (13_Supplement): 2867.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2867

Published: 01 July 2019

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Journal Articles

Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing

Samantha Bender, Cong Zhu, Li Wang, Michael Rothberg, Joshua Dempster, Brenton Paolella, Mustafa Kocak, Massami Laird, Jordan Rossen, Karolina Stumbraite, Jordan Bryan, Vickie Wang, John Doench, Francisca Vazquez, Aviad Tsherniak, Todd Golub, Jennifer Roth

Cancer Res (2019) 79 (13_Supplement): 2690.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2690

Published: 01 July 2019

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Journal Articles

Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells

Steven M. Corsello, Ryan D. Spangler, Rohith T. Nagari, Mustafa Kocak, Jordan Rossen, Patrick O'Hearn, Jennifer Roth, Alfredo Gonzalez, Nancy Dumont, John Doench, Jesse S. Boehm, Francisca Vazquez, Aviad Tsherniak, Todd R. Golub

Cancer Res (2019) 79 (13_Supplement): 2948.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2948

Published: 01 July 2019

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Journal Articles

Abstract LB-048: WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan, Tsukasa Shibue, James McFarland, Benjamin Gaeta, Francisca Vazquez, Adam J. Bass

Cancer Res (2019) 79 (13_Supplement): LB-048.

DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-048

Published: 01 July 2019

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Journal Articles

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

Colles Price, Stanley Gill, Zandra V. Ho, Shawn M. Davidson, Erin Merkel, James M. McFarland, Lisa Leung, Andrew Tang, Maria Kost-Alimova, Aviad Tsherniak, Oliver Jonas, Francisca Vazquez, William C. Hahn

Cancer Res (2019) 79 (10): 2564–2579.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-2674

Published: 15 May 2019

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Includes: Supplementary data

Journal Articles

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Cancer Res (2019) 79 (9): 2404–2414.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-3066

Published: 01 May 2019

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Includes: Supplementary data

Journal Articles

Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Brian J. Abraham, Amanda Balboni-Iniguez, Nina Weichert-Leahey, Shuning He, John M. Krill-Burger, David E. Root, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Todd R. Golub, Richard A. Young, A. Thomas Look, Kimberly Stegmaier

Cancer Res (2018) 78 (13_Supplement): 2062.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2062

Published: 01 July 2018

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Journal Articles

Abstract 2352: Defining a pediatric cancer dependency map

Cancer Res (2018) 78 (13_Supplement): 2352.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2352

Published: 01 July 2018

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NARROW

Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Abstract 96: Gene fusions create partner and collateral dependencies that are essential to cancer cell survival

Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival

Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers

Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4

Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Abstract PR09: A systematic approach to create patient-derived models of rare tumors

Abstract 2878: CRISPR-Cas9 screens identify the nuclear export factor NXT1 as a novel therapeutic target in MYCN-amplified neuroblastoma

Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors

Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing

Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells

Abstract LB-048: WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Abstract 2352: Defining a pediatric cancer dependency map

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