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Francis Y. Lee
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Journal Articles

Abstract 4085: DDR2 inhibition enhances response to anti-PD-1 immunotherapy

Megan M. Tu, Francis Y. Lee, Robert T. Jones, Abigail K. Kimball, Elizabeth Saravia, Robert F. Graziano, Brianne Coleman, Krista Menard, Jun Yan, Erin Michaud, Han Chang, Hany A. Abdel-Hafiz, Andrii I. Rozhok, Jason E. Duex, Neeraj Agarwal, Ana Chauca-Diaz, Linda K. Johnson, Terry L. Ng, John C. Cambier, Eric T. Clambey, James C. Costello, Alan J. Korman, Dan Theodorescu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4085.
https://doi.org/10.1158/1538-7445.AM2019-4085
Published: 01 July 2019
View article titled, Abstract 4085: DDR2 inhibition enhances response to anti-PD-1 immunotherapy
Journal Articles

Abstract 5395: Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor

Brent A. Rupnow, Chiang Yu, Jonathan G. Pabalan, Urvashi V. Roongta, Jonathan S. Lippy, Ashok R. Dongre, Mary T. Obermeier, Aberra Fura, Paul A. Elzinga, Benjamin J. Henley, Joseph Fargnoli, Francis Y. Lee, William R. Foster, Christine M. Tarby, Brian E. Fink, John S. Tokarski, Ashvinikumar V. Gavai, Tai W. Wong, John T. Hunt, Gregory D. Vite, Ashok V. Purandare
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5395.
https://doi.org/10.1158/1538-7445.AM2015-5395
Published: 01 August 2015
View article titled, Abstract 5395: Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor
Journal Articles

Abstract DDT01-03: Discovery of BMS-911543, a highly selective JAK2 inhibitor, as a clinical candidate for the treatment of myeloproliferative disease and other malignancies

Ashok V. Purandare, Honghe Wan, Gretchen Schroeder, Amy Hart, James Grebinski, Jennifer Inghrim, John Tokarski, Dan You, Becky Penhallow, Theresa McDevitt, Ragini Vuppugalla, Yueping Zhang, Stefan Ruepp, George Trainor, Xia Han, Louis Lombardo, Francis Y. Lee, Marco Gottardis, Jennifer Hosbach, Elizabeth Fitzpatrick, Stuart Emanuel, Animesh Pardanani, Terra L. Lasho, Ayalew Tefferi, Matthew V. Lorenzi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): DDT01-03.
https://doi.org/10.1158/1538-7445.AM2011-DDT01-03
Published: 15 April 2011
View article titled, Abstract DDT01-03: Discovery of BMS-911543, a highly selective JAK2 inhibitor, as a clinical candidate for the treatment of myeloproliferative disease and other malignancies
Journal Articles

Extranuclear Functions of ER Impact Invasive Migration and Metastasis by Breast Cancer Cells

Dimple Chakravarty, Sujit S. Nair, Bindu Santhamma, Binoj C. Nair, Long Wang, Abhik Bandyopadhyay, Joseph K. Agyin, Darrell Brann, Lu-Zhe Sun, I-Tien Yeh, Francis Y. Lee, Rajeshwar Rao Tekmal, Rakesh Kumar, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2010) 70 (10): 4092–4101.
https://doi.org/10.1158/0008-5472.CAN-09-3834
Published: 12 May 2010
View article titled, Extranuclear Functions of ER Impact Invasive Migration and Metastasis by Breast Cancer Cells
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Journal Articles

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

Kan V. Lu, Shaojun Zhu, Anna Cvrljevic, Tiffany T. Huang, Shawn Sarkaria, David Ahkavan, Julie Dang, Eduard B. Dinca, Seema B. Plaisier, Isaac Oderberg, Yohan Lee, Zugen Chen, Jeremy S. Caldwell, Yongmin Xie, Joseph A. Loo, David Seligson, Arnab Chakravari, Francis Y. Lee, Roberto Weinmann, Timothy F. Cloughesy, Stanley F. Nelson, Gabriele Bergers, Thomas Graeber, Frank B. Furnari, C. David James, Webster K. Cavenee, Terrance G. Johns, Paul S. Mischel
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6889–6898.
https://doi.org/10.1158/0008-5472.CAN-09-0347
Published: 31 August 2009
View article titled, Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
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Includes: Supplementary data
Journal Articles

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Fei Huang, Ann Greer, Warren Hurlburt, Xia Han, Rameh Hafezi, Gayle M. Wittenberg, Karen Reeves, Jiwen Chen, Douglas Robinson, Aixin Li, Francis Y. Lee, Marco M. Gottardis, Edwin Clark, Lee Helman, Ricardo M. Attar, Ashok Dongre, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2009) 69 (1): 161–170.
https://doi.org/10.1158/0008-5472.CAN-08-0835
Published: 31 December 2008
View article titled, The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
Open the PDF for The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors in another window
Includes: Supplementary data
Journal Articles

Anoikis, Initiated by Mcl-1 Degradation and Bim Induction, Is Deregulated during Oncogenesis

Nicholas T. Woods, Hirohito Yamaguchi, Francis Y. Lee, Kapil N. Bhalla, Hong-Gang Wang
Journal: Cancer Research
Cancer Res (2007) 67 (22): 10744–10752.
https://doi.org/10.1158/0008-5472.CAN-07-3148
Published: 15 November 2007
View article titled, Anoikis, Initiated by Mcl-1 Degradation and Bim Induction, Is Deregulated during Oncogenesis
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Includes: Supplementary data
Journal Articles

Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival

Audrey C. Shor, Elizabeth A. Keschman, Francis Y. Lee, Carlos Muro-Cacho, G. Douglas Letson, Jonathan C. Trent, W. Jack Pledger, Richard Jove
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2800–2808.
https://doi.org/10.1158/0008-5472.CAN-06-3469
Published: 15 March 2007
View article titled, Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival
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Journal Articles

Dasatinib (BMS-354825) Selectively Induces Apoptosis in Lung Cancer Cells Dependent on Epidermal Growth Factor Receptor Signaling for Survival

Lanxi Song, Mark Morris, Tapan Bagui, Francis Y. Lee, Richard Jove, Eric B. Haura
Journal: Cancer Research
Cancer Res (2006) 66 (11): 5542–5548.
https://doi.org/10.1158/0008-5472.CAN-05-4620
Published: 01 June 2006
View article titled, Dasatinib (BMS-354825) Selectively Induces Apoptosis in Lung Cancer Cells Dependent on Epidermal Growth Factor Receptor Signaling for Survival
Open the PDF for Dasatinib (BMS-354825) Selectively Induces Apoptosis in Lung Cancer Cells Dependent on Epidermal Growth Factor Receptor Signaling for Survival in another window
Includes: Supplementary data
Journal Articles

Combined activity of dasatinib (BMS-354825) and oxaliplatin in an orthotopic model of metastatic colorectal carcinoma

Donald P. Lesslie, III, Nila U. Parikh, Ami Shah, Justin M. Summy, Jose G. Trevino, David Hong, Nicholas J. Donato, Francis Y. Lee, Gary E. Gallick
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1114.
Published: 15 April 2006
View article titled, Combined activity of dasatinib (BMS-354825) and oxaliplatin in an orthotopic model of metastatic colorectal carcinoma
Journal Articles

Preclinical studies of ixabepilone (BMS-247550) demonstrate optimal antitumor activity against both chemotherapy-sensitive and -resistant tumor types

Francis Y. Lee, Amy Camuso, Stephen Castenada, Krista Fager, Christine Flefleh, Ivan Inigo, Kathy Johnson, David Kan, Kelly McGlinchey, Russ Peterson, Richard Smykla, Mei-Li Wen, Craig Fairchild, Robert Kramer
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 119.
Published: 15 April 2006
View article titled, Preclinical studies of ixabepilone (BMS-247550) demonstrate optimal antitumor activity against both chemotherapy-sensitive and -resistant tumor types
Journal Articles

Inhibition of c-Src expression and kinase activity inhibit progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.

Justin M. Summy, Jose G. Trevino, Donald P. Lesslie, Nila U. Parikh, David S. Hong, Francis Y. Lee, Nicholas J. Donato, Cheryl H. Baker, Gary E. Gallick
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1198.
Published: 15 April 2006
View article titled, Inhibition of c-Src expression and kinase activity inhibit progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.
Journal Articles

In vitro and In vivo Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417

Paul Haluska, Joan M. Carboni, David A. Loegering, Francis Y. Lee, Mark Wittman, Mark G. Saulnier, David B. Frennesson, Kimberly R. Kalli, Cheryl A. Conover, Ricardo M. Attar, Scott H. Kaufmann, Marco Gottardis, Charles Erlichman
Journal: Cancer Research
Cancer Res (2006) 66 (1): 362–371.
https://doi.org/10.1158/0008-5472.CAN-05-1107
Published: 05 January 2006
View article titled, <em>In vitro</em> and <em>In vivo</em> Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417
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Journal Articles

Dasatinib (BMS-354825), a Dual SRC/ABL Kinase Inhibitor, Inhibits the Kinase Activity of Wild-Type, Juxtamembrane, and Activation Loop Mutant KIT Isoforms Associated with Human Malignancies

Marcus M. Schittenhelm, Sharon Shiraga, Arin Schroeder, Amie S. Corbin, Diana Griffith, Francis Y. Lee, Carsten Bokemeyer, Michael W.N. Deininger, Brian J. Druker, Michael C. Heinrich
Journal: Cancer Research
Cancer Res (2006) 66 (1): 473–481.
https://doi.org/10.1158/0008-5472.CAN-05-2050
Published: 05 January 2006
View article titled, Dasatinib (BMS-354825), a Dual SRC/ABL Kinase Inhibitor, Inhibits the Kinase Activity of Wild-Type, Juxtamembrane, and Activation Loop Mutant KIT Isoforms Associated with Human Malignancies
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Journal Articles

Action of the Src Family Kinase Inhibitor, Dasatinib (BMS-354825), on Human Prostate Cancer Cells

Sangkil Nam, Donghwa Kim, Jin Q. Cheng, Shumin Zhang, Ji-Hyun Lee, Ralf Buettner, Janni Mirosevich, Francis Y. Lee, Richard Jove
Journal: Cancer Research
Cancer Res (2005) 65 (20): 9185–9189.
https://doi.org/10.1158/0008-5472.CAN-05-1731
Published: 17 October 2005
View article titled, Action of the Src Family Kinase Inhibitor, Dasatinib (BMS-354825), on Human Prostate Cancer Cells
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Journal Articles

In vitro Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants

Thomas O'Hare, Denise K. Walters, Eric P. Stoffregen, Taiping Jia, Paul W. Manley, Jürgen Mestan, Sandra W. Cowan-Jacob, Francis Y. Lee, Michael C. Heinrich, Michael W.N. Deininger, Brian J. Druker
Journal: Cancer Research
Cancer Res (2005) 65 (11): 4500–4505.
https://doi.org/10.1158/0008-5472.CAN-05-0259
Published: 01 June 2005
View article titled, <em>In vitro</em> Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants
Open the PDF for <em>In vitro</em> Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants in another window
Includes: Supplementary data
Journal Articles

Tumor Development by Transgenic Expression of a Constitutively Active Insulin-Like Growth Factor I Receptor

Joan M. Carboni, Adrian V. Lee, Darryl L. Hadsell, Bruce R. Rowley, Francis Y. Lee, David K. Bol, Amy E. Camuso, Marco Gottardis, Ann F. Greer, Ching Ping Ho, Warren Hurlburt, Aixin Li, Mark Saulnier, Upender Velaparthi, Cindy Wang, Mei-Li Wen, Richard A. Westhouse, Mark Wittman, Kurt Zimmermann, Brent A. Rupnow, Tai W. Wong
Journal: Cancer Research
Cancer Res (2005) 65 (9): 3781–3787.
https://doi.org/10.1158/0008-5472.CAN-04-4602
Published: 02 May 2005
View article titled, Tumor Development by Transgenic Expression of a Constitutively Active Insulin-Like Growth Factor I Receptor
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Journal Articles

BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo

Francis Y. Lee, Louis Lombardo, Amy Camuso, Stephen Castaneda, Krista Fager, Christine Flefleh, Ivan Inigo, Kathy Johnson, David Kan, Roger Luo, Kelly McGlinchey, Suhong Pang, Russell Peterson, Mei-Li Wen, Robert Wild, Craig Fairchild, Tai Wong, Robert Borzilleri, Robert Kramer
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 159.
Published: 01 May 2005
View article titled, BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo
Journal Articles

Pharmacodynamic biomarker

Feng Roger Luo, Zheng Yang, Amy Camuso, Krista Fager, Kelly McGlinchey, Christine Flefleh, Mei-Li Wen, Richard Smykla, David Kan, Ivan Inigo, Stephen Castaneda, Robert Borzilleri, Louis Lombardo, Robert Wild, John Hunt, Robert Kramer, Francis Y. Lee
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 987–988.
Published: 01 May 2005
View article titled, Pharmacodynamic biomarker
Journal Articles

BMS-536924, a potent, small molecule inhibitor of the IGF-1 receptor in vitro and in vivo

Joan M. Carboni, Mark Wittman, Ricardo Attar, Praveen Balimane, Stephen Castaneda, Janet Dell, Marco Gottardis, Ann Greer, Ching-Ping Ho, Chen-Yi Hung, Warren Hurlburt, Ivan Inigo, David Kan, Francis Y. Lee, Aixin Li, Tai-An Lin, Becky Penhallow, Mark Saulnier, Upender Velaparthi, Zheng Yang, Kurt Zimmermann
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1406.
Published: 01 May 2005
View article titled, BMS-536924, a potent, small molecule inhibitor of the IGF-1 receptor <em>in vitro</em> and <em>in vivo</em>