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Francis J. Giles
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Journal Articles

Abstract 3418: A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: The salivary gland tumor cohort

Young Kwang Chae, Megan Othus, Sandip Pravin Patel, James P. Ohr, Francis P. Worden, Jennifer M. Suga, Aung Naing, Sarah E. Fenton, Hyunseok Kang, Sewan Gurung, Christine M. McLeod, Francis J. Giles, Helen X. Chen, Elad Sharon, Edward Mayerson, Melissa Plets, Christopher Ryan, Charles D. Blanke, Razelle Kurzrock
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3418.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3418
Published: 15 August 2020
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Abstract 5292: Glycogen synthase kinase-3 beta (GSK-3b) genomic alterations and increased programmed death-ligand 1 (PD-L1) expression in advanced malignancies

Brittany A. Borden, Joanne Xiu, Yasmine Baca, Pilar Ramos, Francis J. Giles, Andrew Mazar, Fabio Tavora, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5292.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5292
Published: 15 August 2020
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Abstract B09: GSK-3β blockade with 9-ING-41 in pancreas cancer: The 1801 phase 1/2 study

Benedito A. Carneiro, Malika Dhawan, Brittany Borden, Ludimila Cavalcante, Howard Safran, Andrey Ugolkov, Andrew P. Mazar, Daniel D. Billadeau, Francis J. Giles, Pamela Munster
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B09.
DOI: https://doi.org/10.1158/1538-7445.PANCA19-B09
Published: 13 December 2019
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Abstract 4812: 9-ING-41, a novel inhibitor of glycogen synthase kinase-3beta (GSK-3β), is active as a single agent and within combination therapies in bladder cancer cell lines

Hiroo Kuroki, Tsutomu Anraku, Vladimir Bilim, Masayuki Tasaki, Daniel Schmitt, Andrew Mazer, Francis J. Giles, Andrey Ugolkov, Yoshihiko Tomita
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4812.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4812
Published: 01 July 2019
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Journal Articles

Abstract 2553: PSMA-specific, TGF-ß-insensitive CD8+ T cells derived from metastatic castration resistant prostate cancer (mCRPC) patients induce apoptosis of PSMA positive prostate cancer (PCa)

Qiang Zhang, Brian Helfand, Ximing Yang, Benedito Carneiro, Francis J. Giles, Timothy Kuzel, Chung Lee, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2553.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2553
Published: 01 July 2018
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Journal Articles

Abstract 1127: Aberrant nuclear expression of GSK-3beta in human head and neck carcinoma

Maria Matsangou, Andrey Ugolkov, Timothy J. Taxter, Sandeep Samant, Andrew P. Mazar, Francis J. Giles
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1127.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1127
Published: 01 July 2017
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Abstract 1114: Combining anti-androgen therapy and PARP inhibition results in synergistic cytotoxicity of metastatic castration-resistant prostate cancer (mCRPC) cells

Sahithi Pamarthy, Vinay Sagar, Rajita J. Vatapalli, Zachary Reinstein, Muhammad Zayd Ansari, Benedito A. Carneiro Filho, Francis J. Giles, Sarki A. Abdulkadir
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1114.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1114
Published: 01 July 2017
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Abstract 5935: Higher tumor mutation burden (TMB) is associated with the presence of DNA repair gene mutations, T-cell infiltration, and favorable survival outcome in ovarian carcinoma

Young Kwang Chae, William H. Bae, Sabina Murshudova, Jonathan F. Anker, Young Suk Kim, Mario J. Pineda, Wilberto Nieves-Neira, Daniela Matei, John R. Lurain, Shohreh Shahabi, Francis J. Giles
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5935.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5935
Published: 01 July 2017
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Journal Articles

Abstract 665: Molecular and clinical analyses of patients with gynecologic malignancies treated with PD-1 directed immunotherapy

Young Kwang Chae, Sabina Murshudova, William H. Bae, Jonathan F. Anker, Mario J. Pineda, Wilberto Nieves-Neira, Daniela E. Matei, John R. Lurain, Shohreh Shahabi, Francis J. Giles
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 665.
DOI: https://doi.org/10.1158/1538-7445.AM2017-665
Published: 01 July 2017
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Abstract 658: Association of tumor mutational burden (TMB) with DNA repair mutations and response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer (NSCLC)

Andrew A. Davis, Young Kwang Chae, Sarita Agte, Alan Pan, Nisha Mohindra, Victoria Villaflor, Kirtee Raparia, Francis J. Giles
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 658.
DOI: https://doi.org/10.1158/1538-7445.AM2017-658
Published: 01 July 2017
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Journal Articles

Abstract 5585: TGF-ß insensitive PSMA-specific CD8+ T cells derived from metastatic castration resistant prostate cancer (MCRPC) patients enhance the tumor killing ability

Qiang Zhang, Timothy Kuzel, Brian Helfand, Ximing J. Yang, Weijun Qin, Chung Lee, Benedito Carneiro, Francis J. Giles
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5585.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5585
Published: 01 July 2017
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Abstract 5233: Concordance of genomic alterations by next generation sequencing (NGS) in tumor tissue vs. cell-free DNA

Young Kwang Chae, Andrew A. Davis, Benedito A. Carneiro, Sunandana Chandra, Nisha Mohindra, Aparna Kalyan, Jason Kaplan, Maria Matsangou, Leonidas C. Platanias, Massimo Cristofanilli, Francis J. Giles
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5233.
DOI: https://doi.org/10.1158/1538-7445.AM2016-5233
Published: 15 July 2016
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Journal Articles

Abstract B18: EL102: A novel dual inhibitor which demonstrates additive prostate cancer inhibitory activity in combination with docetaxel in vitro and in mouse models

Aidan Toner, Fiona McLaughlin, Jill McMahon, Francis J. Giles, Frank Sullivan, Laura Breen, Martin Clynes, Joe D. Lewis, Sharon A. Glynn
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): B18.
DOI: https://doi.org/10.1158/1538-7445.PRCA2012-B18
Published: 09 May 2013
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Abstract A62: Human endogenous retrovirus activation in prostate cancer: Association with disease progression

Ronan Downey, Amy Burke, Francis J. Giles, Frank Sullivan, Feng Wang-Johanning, Blanaid Mee, Eoin Gaffney, Sharon Anneve Glynn
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): A62.
DOI: https://doi.org/10.1158/1538-7445.PRCA2012-A62
Published: 09 May 2013
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Abstract 1361: A Phase I trial of VB-111, a tissue and condition specific vascular disruptive anti-angiogenic agent, based on novel Vascular Targeting System™, VTS™, for treatment of patients with advanced metastatic cancer

Pierre Triozzi, Andrew Brenner, Francis J. Giles, Yael C. Cohen, Eyal Breitbart, Livnat Bangio, Ernest C. Borden
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1361.
DOI: https://doi.org/10.1158/1538-7445.AM10-1361
Published: 15 April 2010
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Abstract 669: Sunitinib enhances TRAIL-induced apoptosis in preclinical colon cancer models

Devalingam Mahalingam, Sanjay Bansal, Ernest Medina, Kevin Kelly, Ronan Swords, Robbert Cool, Steven de Jong, Jennifer S. Carew, Francis J. Giles, Steffan T. Nawrocki
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 669.
DOI: https://doi.org/10.1158/1538-7445.AM10-669
Published: 15 April 2010
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EXEL-0862, a novel tyrosine kinase inhibitor, inhibits KIT activation and induces apoptosis in human mast cells bearing mutated codon 816 c-kit in vitro and ex vivo: Therapeutic implications

Jingxuan Pan, Hagop M. Kantarjian, Manshouri Taghi, Cem Akin, Peter Lamb, Jorge E. Cortes, Francis J. Giles, Srdan Verstovsek
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 952.
Published: 15 April 2006
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Journal Articles

AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has significant activity in adult patients (pts) with imatinib-resistant bcr-abl positive chronic myeloid leukemia (CML)

Francis J. Giles, Oliver Ottmann, Jorge Cortes, Barbara Wassman, Lydia Wunderle, Susan O’Brien, Dan Jones, Andreas Hochhaus, Srdan Verstovsek, Patricia Rae, Kristine Rose, Leila Alland, Margaret Dugan, Paul Manley, Miloslav Beran, Maher Albitar, Hagop Kantarjian
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 935.
Published: 01 May 2005
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Journal Articles

Cloretazine™, a novel sulfonylhydrazine alkylating agent, combined with cytarabine is an active regimen in patients with refractory hematologic malignancies

Francis J. Giles, Susan O’Brien, Srdan Verstovsek, Jorge Cortes, Debra Thomas, Stephan Faderl, Alessandra Ferrajoli, Farhad Ravandi-Kashani, Steven Kornblau, Guillermo Garcia-Manero, Ann Cahill, Mario Sznol, Hagop Kantarjian
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 935.
Published: 01 May 2005
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