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Francesco Sassi
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Journal Articles

Abstract 420: On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells

Free
Gabriele Picco, Yanhua Rao, Angham Al Saedi, Samantha J. Walker, Shriram Bhosle, Yang Lee, Sara F. Vieira, Gilberto Valdes Garcia, Kieron May, Francesco Sassi, Mamta Sharma, Cansu Dincer, Inigo Barrio Hernandez, Theo Bell, Anastasia Kavasakali, Maria Garcia-Casado, Ray Shenje, Cuthbert Martyr, Edward Brnardic, Nanhua Deng, Hristina Grigorova Dimitrova, Emre Karakoc, Emma Hitch, Katrina McCarten, Zoe Hewitson, Howard Lightfoot, Syd Barthorpe, Michael P. DeMartino, Phil Landis, Emanuel Gonçalves, Andrea Bertotti, Livio Trusolino, Geeta Sharma, Matthew A. Coelho, Jonathan Houseley, Benjamin Schwartz, Mathew J. Garnett
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 420.
https://doi.org/10.1158/1538-7445.AM2025-420
Published: 21 April 2025
View articletitled, Abstract 420: On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells
Journal Articles

Abstract 3697: Exploiting patient-derived xenografts and organoids to tackle apoptotic dependencies in EGFR-inhibited colorectal tumours

Free
Simonetta Maria Leto, Irene Catalano, Martina Ferri, Valentina Vurchio, Francesca Cottino, Eugenia Rosalinda Zanella, Francesco Sassi, Giorgia Migliardi, Andrea Bertotti, Livio Trusolino
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3697.
https://doi.org/10.1158/1538-7445.AM2022-3697
Published: 15 June 2022
View articletitled, Abstract 3697: Exploiting patient-derived xenografts and organoids to tackle apoptotic dependencies in EGFR-inhibited colorectal tumours
Journal Articles

Abstract 1821: Genome-wide genetic screens define the drug resistance landscape of BRAF mutant colon cancer

Free
Jonathan Brammeld, Marco Ranzani, Elizabeth A. Coker, Stacey Price, Theodoros I. Roumeliotis, Barbara Lupo, Mi Petljak, Steven P. Williams, Francesco Iorio, Francesco Sassi, Nanne Aben, Kosuke Yusa, Livio Trusolino, Lodewyk Wessels, David J. Adams, Mathew Garnett, Bissan Al-Lazikani, Jyoti S. Choudhary, Andrea Bertotti, Ultan McDermott
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1821.
https://doi.org/10.1158/1538-7445.AM2018-1821
Published: 01 July 2018
View articletitled, Abstract 1821: Genome-wide genetic screens define the drug resistance landscape of BRAF mutant colon cancer
Journal Articles

Abstract LB-293: Targeting the PI3K pathway to intercept cetuximab tolerance in metastatic colorectal cancer

Free
Barbara Lupo, Paolo Gagliardi, Francesco Sassi, Eugenia Rosalinda Zanella, Francesca Cottino, Andrea Bertotti, Livio Trusolino
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-293.
https://doi.org/10.1158/1538-7445.AM2017-LB-293
Published: 01 July 2017
View articletitled, Abstract LB-293: Targeting the PI3K pathway to intercept cetuximab tolerance in metastatic colorectal cancer
Journal Articles

Abstract LB-213: NEDD8 pathway inhibition is effective in preclinical models of poorly differentiated, clinically aggressive colorectal cancer

Free
Gabriele Picco, Francesco Sassi, Claudio Isella, Federica Di Nicolantonio, Anna Sapino, Alberto Bardelli, Livio Trusolino, Andrea Bertotti, Enzo Medico
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-213.
https://doi.org/10.1158/1538-7445.AM2016-LB-213
Published: 15 July 2016
View articletitled, Abstract LB-213: NEDD8 pathway inhibition is effective in preclinical models of poorly differentiated, clinically aggressive colorectal cancer
Journal Articles

Abstract 2290: Effective immunotherapy with cytokine-induced killer cells against autologous melanoma cancer stem cells

Free
Loretta Gammaitoni, Lidia Giraudo, Marco Macagno, Giulia Cattaneo, Valeria Leuci, Francesco Sassi, Alessandro Zaccagna, Alberto Pisacane, Valentina Coha, Fabrizio Carnevale-Schianca, Massimo Aglietta, Dario Sangiolo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2290.
https://doi.org/10.1158/1538-7445.AM2016-2290
Published: 15 July 2016
View articletitled, Abstract 2290: Effective immunotherapy with cytokine-induced killer cells against autologous melanoma cancer stem cells
Journal Articles

Abstract IA28: Preclinical strategies to target resistance in colorectal cancer: Opportunities and challenges

Free
Livio Trusolino, Francesco Sassi
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): IA28.
https://doi.org/10.1158/1538-7445.FBCR15-IA28
Published: 07 April 2016
View articletitled, Abstract IA28: Preclinical strategies to target resistance in colorectal cancer: Opportunities and challenges
Journal Articles

Abstract 659: Sustained inhibition of HER3 and EGFR is necessary to induce regression of HER2-amplified gastrointestinal carcinomas

Free
Simonetta Maria Leto, Francesco Sassi, Irene Catalano, Giorgia Migliardi, Eugenia Rosalinda Zanella, Andrea Bertotti, Livio Trusolino
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 659.
https://doi.org/10.1158/1538-7445.AM2015-659
Published: 01 August 2015
View articletitled, Abstract 659: Sustained inhibition of HER3 and EGFR is necessary to induce regression of HER2-amplified gastrointestinal carcinomas
Journal Articles

MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors

Available to Purchase
Paolo Luraghi, Gigliola Reato, Elia Cipriano, Francesco Sassi, Francesca Orzan, Viola Bigatto, Francesca De Bacco, Elena Menietti, May Han, William M. Rideout, III, Timothy Perera, Andrea Bertotti, Livio Trusolino, Paolo M. Comoglio, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2014) 74 (6): 1857–1869.
https://doi.org/10.1158/0008-5472.CAN-13-2340-T
Published: 13 March 2014
View articletitled, MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors
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Includes: Supplementary data
Journal Articles

Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas

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Dario Sangiolo, Giulia Mesiano, Loretta Gammaitoni, Valeria Leuci, Maja Todorovic, Lidia Giraudo, Cristina Cammarata, Carmine Dell'Aglio, Lorenzo D'Ambrosio, Alberto Pisacane, Ivana Sarotto, Sara Miano, Ivana Ferrero, Fabrizio Carnevale-Schianca, Ymera Pignochino, Francesco Sassi, Andrea Bertotti, Wanda Piacibello, Franca Fagioli, Massimo Aglietta, Giovanni Grignani
Journal: Cancer Research
Cancer Res (2014) 74 (1): 119–129.
https://doi.org/10.1158/0008-5472.CAN-13-1559
Published: 05 January 2014
View articletitled, Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas
Open the PDF for Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas in another window
Journal Articles

Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Available to Purchase
Miriam Martini, Mariangela Russo, Simona Lamba, Elisa Vitiello, Emily Hannah Crowley, Francesco Sassi, Davide Romanelli, Milo Frattini, Antonio Marchetti, Alberto Bardelli
Journal: Cancer Research
Cancer Res (2013) 73 (6): 1912–1921.
https://doi.org/10.1158/0008-5472.CAN-12-3074
Published: 14 March 2013
View articletitled, Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Open the PDF for Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract 230: Modeling tumor progression and identifying genotype-drug interactions by the sequential introduction of cancer mutations into the genome of human normal cells

Free
Davide Zecchin, Margherita Gallicchio, Valentina Boscaro, Francesco Sassi, Enzo Medico, Federica Di Nicolantonio, Alberto Bardelli
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 230.
https://doi.org/10.1158/1538-7445.AM2011-230
Published: 15 April 2011
View articletitled, Abstract 230: Modeling tumor progression and identifying genotype-drug interactions by the sequential introduction of cancer mutations into the genome of human normal cells