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Francesca Spinella
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Journal Articles

Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy

Laura Rosanò, Roberta Cianfrocca, Piera Tocci, Francesca Spinella, Valeriana Di Castro, Valentina Caprara, Elisa Semprucci, Gabriella Ferrandina, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2014) 74 (24): 7453–7464.
https://doi.org/10.1158/0008-5472.CAN-13-3133
Published: 14 December 2014
View article titled, Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Open the PDF for Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 2684: Inhibition of tumor growth and angiogenesis by SP-2, an anti-LGALS3BP antibody

Enza Piccolo, Sara Trani, Nicola Tinari, Cosmo Rossi, Rossana L. Sorda, Rossano Lattanzio, Maurizia D'Egidio, Annalisa D. Risio, Antonino Grassadonia, Francesca Spinella, Anna Bagnato, Mauro Piantelli, Clara Natoli, Stefano Iacobelli
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2684.
https://doi.org/10.1158/1538-7445.AM2014-2684
Published: 01 October 2014
View article titled, Abstract 2684: Inhibition of tumor growth and angiogenesis by SP-2, an anti-LGALS3BP antibody
Journal Articles

Abstract 756: Endothelin-induced multifunctional complex regulates β-arrestin-1 nuclear activity to promote EMT in chemoresistant ovarian cancer cells.

Laura Rosanò, Roberta Cianfrocca, Piera Tocci, Elisa Semprucci, Francesca Spinella, Valeriana Di Castro, Anna Bagnato
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 756.
https://doi.org/10.1158/1538-7445.AM2013-756
Published: 15 April 2013
View article titled, Abstract 756: Endothelin-induced multifunctional complex regulates β-arrestin-1 nuclear activity to promote EMT in chemoresistant ovarian cancer cells.
Journal Articles

Abstract 3086: α-arrestin-1 acts as a nuclear transcriptional regulator of endothelin A receptor signalling to promote ovarian cancer progression

Laura Rosanò, Roberta Cianfrocca, Piera Tocci, Francesca Spinella, Valeriana Di Castro, Erica Salvati, Anna Maria Biroccio, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3086.
https://doi.org/10.1158/1538-7445.AM2012-3086
Published: 15 April 2012
View article titled, Abstract 3086: α-arrestin-1 acts as a nuclear transcriptional regulator of endothelin A receptor signalling to promote ovarian cancer progression
Journal Articles

Abstract 493: Endothelin-1 induces activation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells

Francesca Spinella, Valentina Caprara, Valeriana DiCastro, Laura Rosanò, Roberta Cianfrocca, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 493.
https://doi.org/10.1158/1538-7445.AM2012-493
Published: 15 April 2012
View article titled, Abstract 493: Endothelin-1 induces activation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells
Journal Articles

Abstract 3473: Endothelin axis autocrine loop is positively regulated by the interplay between ET-1 and hypoxia-inducible factor-1α in melanoma cells

Francesca Spinella, Valentina Caprara, Roberta Cianfrocca, Laura Rosanò, Valeriana DiCastro, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3473.
https://doi.org/10.1158/1538-7445.AM2011-3473
Published: 15 April 2011
View article titled, Abstract 3473: Endothelin axis autocrine loop is positively regulated by the interplay between ET-1 and hypoxia-inducible factor-1α in melanoma cells
Journal Articles

Abstract 707: Acquisition of chemoresistance and epithelial to mesenchymal phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells

Roberta Cianfrocca, Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Alessandro Lucidi, Gabriella Ferrandina, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 707.
https://doi.org/10.1158/1538-7445.AM2011-707
Published: 15 April 2011
View article titled, Abstract 707: Acquisition of chemoresistance and epithelial to mesenchymal phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells
Journal Articles

Abstract 698: β-arrestin-1 as nuclear signalling element essential for endothelin A receptor-induced epithelial to mesenchymal transition and chemoresistance

Laura Rosanò, Roberta Cianfrocca, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 698.
https://doi.org/10.1158/1538-7445.AM2011-698
Published: 15 April 2011
View article titled, Abstract 698: β-arrestin-1 as nuclear signalling element essential for endothelin A receptor-induced epithelial to mesenchymal transition and chemoresistance
Journal Articles

Abstract 1286: Endothelin-1-induced angiogenesis is regulated by PHD2 in a HIF-1α-dependent manner

Francesca Spinella, Laura Rosanò, Valentina Caprara, Valeriana DiCastro, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1286.
https://doi.org/10.1158/1538-7445.AM10-1286
Published: 15 April 2010
View article titled, Abstract 1286: Endothelin-1-induced angiogenesis is regulated by PHD2 in a HIF-1α-dependent manner
Journal Articles

Abstract 2363: Positive inter-regulation between β-catenin and endothelin signaling in ovarian cancer cells: Epigenetic regulation of gene transcription

Laura Rosanò, Roberta Cianfrocca, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2363.
https://doi.org/10.1158/1538-7445.AM10-2363
Published: 15 April 2010
View article titled, Abstract 2363: Positive inter-regulation between β-catenin and endothelin signaling in ovarian cancer cells: Epigenetic regulation of gene transcription
Journal Articles

Abstract 2551: Acquisition of epithelial-mesenchymal transition phenotype of chemoresistant ovarian cancer cells is linked with activation of the endothelin signaling pathway

Roberta Cianfrocca, Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Gabriella Ferrandina, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2551.
https://doi.org/10.1158/1538-7445.AM10-2551
Published: 15 April 2010
View article titled, Abstract 2551: Acquisition of epithelial-mesenchymal transition phenotype of chemoresistant ovarian cancer cells is linked with activation of the endothelin signaling pathway
Journal Articles

Abstract #5311: A nuclear function of \#946; -arrestin-1 in endothelin A receptor signaling in human ovarian carcinoma cells: Therapeutic implications

Laura Rosanò, Stefano Masi, Roberta Cianfrocca, Francesca Spinella, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5311.
Published: 01 May 2009
View article titled, Abstract #5311: A nuclear function of \#946; -arrestin-1 in endothelin A receptor signaling in human ovarian carcinoma cells: Therapeutic implications
Journal Articles

Abstract #4024: The endothelin axis promotes lymphangiogenesis

Francesca Spinella, Emirena Garrafa, Valeriana DiCastro, Laura Rosanò, Maria Rita Nicotra, Arnaldo Caruso, Pier Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4024.
Published: 01 May 2009
View article titled, Abstract #4024: The endothelin axis promotes lymphangiogenesis
Journal Articles

Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade

Francesca Spinella, Emirena Garrafa, Valeriana Di Castro, Laura Rosanò, Maria Rita Nicotra, Arnaldo Caruso, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2669–2676.
https://doi.org/10.1158/0008-5472.CAN-08-1879
Published: 17 March 2009
View article titled, Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade
Open the PDF for Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade in another window
Includes: Supplementary data
Journal Articles

Endothelin-1 induces hypoxia-inducible factor-1α stabilization through prolyl hydroxylase (PHD2) inhibition in human melanoma cells

Francesca Spinella, Valentina Caprara, Laura Rosano, Valeriana Di Vastro, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2062.
Published: 01 May 2008
View article titled, Endothelin-1 induces hypoxia-inducible factor-1α stabilization through prolyl hydroxylase (PHD2) inhibition in human melanoma cells
Journal Articles

Emerging role of endothelin axis in lymphangiogenesis

Francesca Spinella, Emirena Garrafa, Arnaldo Caruso, Valeriana Di Castro, Laura Rosano, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 375.
Published: 01 May 2008
View article titled, Emerging role of endothelin axis in lymphangiogenesis
Journal Articles

Endothelin A receptor promotes ovarian cancer metastasis: implications for an effective targeted-therapy

Laura Rosano, Stefano Masi, Roberta Cianfrocca, Francesca Spinella, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2574.
Published: 01 May 2008
View article titled, Endothelin A receptor promotes ovarian cancer metastasis: implications for an effective targeted-therapy
Journal Articles

Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity

Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Giampaolo Tortora, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2007) 67 (13): 6351–6359.
https://doi.org/10.1158/0008-5472.CAN-07-0883
Published: 06 July 2007
View article titled, Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity
Open the PDF for Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity in another window
Journal Articles

β-Arrestin 1 as messenger of endothelin A receptor to mediate β-catenin signaling and epithelial to mesenchymal transition in human ovarian cancer cells

Laura Rosano, Francesca Spinella, Valeriana Di Castro, Stefano Masi, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5636.
Published: 01 May 2007
View article titled, β-Arrestin 1 as messenger of endothelin A receptor to mediate β-catenin signaling and epithelial to mesenchymal transition in human ovarian cancer cells
Journal Articles

Endothelins regulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1α in melanoma progression

Francesca Spinella, Laura Rosano, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2150.
Published: 01 May 2007
View article titled, Endothelins regulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1α in melanoma progression