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Frances R. Balkwill
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Journal Articles

Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC

Panoraia Kotantaki, Florian Laforêts, Eleni Maniati, Chiara Berlato, Anna Malliouri, Michael John Devlin, Beatrice Malacrida, Samar Elorbany, Ranjit Manchanda, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5957.
https://doi.org/10.1158/1538-7445.AM2023-5957
Published: 04 April 2023
View article titled, Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC
Journal Articles

Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells

Beatrice Malacrida, Samar Elorbany, Eleni Maniati, Florian Laforets, Ranjit Manchanda, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4551.
https://doi.org/10.1158/1538-7445.AM2023-4551
Published: 04 April 2023
View article titled, Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells
Journal Articles

TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer

Laura S.M. Lecker, Chiara Berlato, Eleni Maniati, Robin Delaine-Smith, Oliver M.T. Pearce, Owen Heath, Samuel J. Nichols, Caterina Trevisan, Marian Novak, Jacqueline McDermott, James D. Brenton, Pedro R. Cutillas, Vinothini Rajeeve, Ana Hennino, Ronny Drapkin, Daniela Loessner, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5706–5719.
https://doi.org/10.1158/0008-5472.CAN-21-0536
Published: 15 November 2021
View article titled, TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer

Beatrice Malacrida, Robin Delaine-Smith, Sam Nichols, Eleni Maniati, Roanne L. Jones, Martin M. Knight, Oliver M. Pearce, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2642.
https://doi.org/10.1158/1538-7445.AM2021-2642
Published: 01 July 2021
View article titled, Abstract 2642: Using 3-Dimensional <em>in vitro</em> models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer
Journal Articles

Abstract 2745: Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy

Chiara Berlato, Owen Heath, Eleni Maniati, Ganga Gopinathan, Panoraia Kotantaki, Samar Elorbany, Jacqueline McDermott, Colin Pegrum, Ludmila Szabova, Ruth Perets, Ronny Drapkin, Peter Bailey, Alessandro Annibaldi, Desmond P. Barton, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2745.
https://doi.org/10.1158/1538-7445.AM2021-2745
Published: 01 July 2021
View article titled, Abstract 2745: Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy
Journal Articles

Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma

Naoka Tamura, Nadeem Shaikh, Daniel Muliaditan, Tanya N. Soliman, Jennifer R. McGuinness, Eleni Maniati, Daniela Moralli, Mary-Anne Durin, Catherine M. Green, Frances R. Balkwill, Jun Wang, Kit Curtius, Sarah E. McClelland
Journal: Cancer Research
Cancer Res (2020) 80 (22): 4946–4959.
https://doi.org/10.1158/0008-5472.CAN-19-0852
Published: 13 November 2020
View article titled, Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 4976: Combining measures of immune infiltration uncovers predictors of survival in high-grade serous ovarian cancer

Anne Montfort, Steph J. Owen, Anna M. Piskorz, Anna Supernat, Luiza Moore, Sarwah Al-Khalidi, Steffen Boehm, Paul Pharoah, Jacqueline McDermott, Frances R. Balkwill, James D. Brenton
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4976.
https://doi.org/10.1158/1538-7445.AM2020-4976
Published: 15 August 2020
View article titled, Abstract 4976: Combining measures of immune infiltration uncovers predictors of survival in high-grade serous ovarian cancer
Journal Articles

Abstract 5558: Deconstruction of a human tumor microenvironment

Frances R. Balkwill, Oliver M. Pearce, Robin Delaine-Smith, Eleni Maniati, Sam Nichols, Jun Wang, Conrad Bessant, Martin Knight
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5558.
https://doi.org/10.1158/1538-7445.AM2017-5558
Published: 01 July 2017
View article titled, Abstract 5558: Deconstruction of a human tumor microenvironment
Journal Articles

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

Josephine Walton, Julianna Blagih, Darren Ennis, Elaine Leung, Suzanne Dowson, Malcolm Farquharson, Laura A. Tookman, Clare Orange, Dimitris Athineos, Susan Mason, David Stevenson, Karen Blyth, Douglas Strathdee, Frances R. Balkwill, Karen Vousden, Michelle Lockley, Iain A. McNeish
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (20): 6118–6129.
https://doi.org/10.1158/0008-5472.CAN-16-1272
Published: 13 October 2016
View article titled, CRISPR/Cas9-Mediated <em>Trp53</em> and <em>Brca2</em> Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma
Open the PDF for CRISPR/Cas9-Mediated <em>Trp53</em> and <em>Brca2</em> Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma in another window
Includes: Supplementary data
Journal Articles

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma

Joshua B.N. Dawkins, Jun Wang, Eleni Maniati, James A. Heward, Lola Koniali, Hemant M. Kocher, Sarah A. Martin, Claude Chelala, Frances R. Balkwill, Jude Fitzgibbon, Richard P. Grose
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4861–4871.
https://doi.org/10.1158/0008-5472.CAN-16-0481
Published: 14 August 2016
View article titled, Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma
Open the PDF for Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

Carla S. Milagre, Ganga Gopinathan, Gemma Everitt, Richard G. Thompson, Hagen Kulbe, Haihong Zhong, Robert E. Hollingsworth, Richard Grose, David D.L. Bowtell, Daniel Hochhauser, Frances R. Balkwill
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (7): 1255–1264.
https://doi.org/10.1158/0008-5472.CAN-14-1801
Published: 31 March 2015
View article titled, Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer
Open the PDF for Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Hagen Kulbe, Probir Chakravarty, D. Andrew Leinster, Kellie A. Charles, Joseph Kwong, Richard G. Thompson, Jermaine I. Coward, Tiziana Schioppa, Stephen C. Robinson, William M. Gallagher, Laura Galletta, Michael A. Salako, John F. Smyth, Thorsten Hagemann, Donal J. Brennan, David D. Bowtell, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2012) 72 (1): 66–75.
https://doi.org/10.1158/0008-5472.CAN-11-2178
Published: 02 January 2012
View article titled, A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment
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Includes: Supplementary data
Journal Articles

Abstract 5331: Interleukin-6 as a therapeutic target in advanced ovarian cancer

Jermaine Coward, Hagen Kulbe, David Leader, Mary Quigley, David Andrew Leinster, Richard Thompson, Jeffrey Nemeth, Jessica Vermeulen, Iain McNeish, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5331.
https://doi.org/10.1158/1538-7445.AM10-5331
Published: 15 April 2010
View article titled, Abstract 5331: Interleukin-6 as a therapeutic target in advanced ovarian cancer
Journal Articles

Abstract 591: Host cell DNA damage and inflammation responses determine oncolytic adenovirus efficacy in ovarian cancer

Michael A. Salako, Claire M. Connell, Atsushi Shibata, Vilma Graupner, Michelle Lockley, Frances R. Balkwill, Iain A. McNeish
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 591.
https://doi.org/10.1158/1538-7445.AM10-591
Published: 15 April 2010
View article titled, Abstract 591: Host cell DNA damage and inflammation responses determine oncolytic adenovirus efficacy in ovarian cancer
Journal Articles

Arginine depletion upregulates Bax and triggers apoptosis of malignant mesothelioma cells deficient in argininosuccinate synthetase

Peter W. Szlosarek, Astero Klabatsa, Arben Pallaska, Michael Sheaff, Frances R. Balkwill, Dean Fennell
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 521.
Published: 15 April 2006
View article titled, Arginine depletion upregulates Bax and triggers apoptosis of malignant mesothelioma cells deficient in argininosuccinate synthetase
Journal Articles

10th Biennial Helene Harris Memorial Trust Meeting

Frances R. Balkwill, Alan Ashworth, Robert C. Bast, Jonathon S. Berek, Jeff Boyd, Mary L. Disis, Hani Gabra, Martin E. Gore, Thomas C. Hamilton, Ian J. Jacobs, Stan B. Kaye, Elise C. Kohn, Gordon B. Mills, Nicole D. Urban
Journal: Cancer Research
Cancer Res (2006) 66 (6): 2904–2906.
https://doi.org/10.1158/0008-5472.CAN-05-2093
Published: 15 March 2006
View article titled, 10th Biennial Helene Harris Memorial Trust Meeting
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Journal Articles

The Inflammatory Cytokine Tumor Necrosis Factor-α Regulates Chemokine Receptor Expression on Ovarian Cancer Cells

Hagen Kulbe, Thorsten Hagemann, Piotr W. Szlosarek, Frances R. Balkwill, Julia L. Wilson
Journal: Cancer Research
Cancer Res (2005) 65 (22): 10355–10362.
https://doi.org/10.1158/0008-5472.CAN-05-0957
Published: 15 November 2005
View article titled, The Inflammatory Cytokine Tumor Necrosis Factor-α Regulates Chemokine Receptor Expression on Ovarian Cancer Cells
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Journal Articles

Biological activity of infliximab, an anti-TNF-α monoclonal antibody, in the tumor microenvironment of advanced epithelial ovarian patients

Kellie A. Charles, Susan A. Hoare, Thorsten Hagermann, Diane X. Scott, Rona Aird, John F. Smyth, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 166.
Published: 01 May 2005
View article titled, Biological activity of infliximab, an anti-TNF-α monoclonal antibody, in the tumor microenvironment of advanced epithelial ovarian patients
Journal Articles

Chemokine expression profiles of normal and malignant human cervical epithelium

Violet I. F. Slettenaar, Philippe O. Van Trappen, Yaohe Wang, Ayse Ayhan, Frances R. Balkwill, Julia L. Wilson
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1108.
Published: 01 May 2005
View article titled, Chemokine expression profiles of normal and malignant human cervical epithelium
Journal Articles

Tumor necrosis factor-α and the modulation of a proinflammatory microenvironment in ovarian cancer

Peter W. Szlosarek, Matthew J. Grimshaw, George D. Wilbanks, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 408.
Published: 01 April 2004
View article titled, Tumor necrosis factor-α and the modulation of a proinflammatory microenvironment in ovarian cancer