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Journal Articles

Abstract LB241: FateAI: Analysis of circulating DNA fragmentomics with an artificial intelligence model for cancer screening

Antonio De Falco, Piera Grisolia, Rossella Tufano, Cinzia Graziano, Marianna Scrima, Clara Iannarone, Marco Bocchetti, Michele Falco, Francesca Carlino, Teresa Noviello, Anna Ceccarelli, Gabriella Misso, Chiara Tammaro, Maria Carminia Della Cort, Floriana Morgillo, Fortunato Ciardiello, Maria Rosaria Rizzo, Alfonso Fiorelli, Noemi Maria Giorgiano, Pasquale Vitale, Raffaele Addeo, Michele Orditura, Stefano Forte, Raffaella Giuffrida, Michele Caraglia, Michele Ceccarelli
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB241.
https://doi.org/10.1158/1538-7445.AM2024-LB241
Published: 05 April 2024
View article titled, Abstract LB241: FateAI: Analysis of circulating DNA fragmentomics with an artificial intelligence model for cancer screening
Journal Articles

Abstract CT164: Tisotumab vedotin (TV) in squamous cell carcinoma of head and neck (SCCHN): interim analysis from innovaTV 207

Beatriz Cirauqui, Sebastien Salas, William William, Ariel E. Birnbaum, Kristi Schmidt, Xuesong Guan, Ibrahima Soumaoro, Leonardo Nicacio, Fortunato Ciardiello
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT164.
https://doi.org/10.1158/1538-7445.AM2023-CT164
Published: 14 April 2023
View article titled, Abstract CT164: Tisotumab vedotin (TV) in squamous cell carcinoma of head and neck (SCCHN): interim analysis from innovaTV 207
Journal Articles

Abstract PO-052: A pilot study of miRNA expression profile in surgically resected pancreatic ductal adenocarcinoma: Initial report from a bi-institutional cohort

Luca Pompella, Michela Falco, Carlo Caputo, Anna Grimaldi, Giuseppe Tirino, Severo Campione, Francesca Sparano, Maria Lucia Iacovino, Chiara Carmen Miceli, Carlo Molino, Marco Montella, Renato Franco, Gennaro Galizia, Giovanni Conzo, Vincenzo Napolitano, Annamaria Auricchio, Francesca Cardella, Fortunato Ciardiello, Michele Caraglia, Angela Lombardi, Gabriella Misso, Ferdinando De Vita
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-052.
https://doi.org/10.1158/1538-7445.PANCA21-PO-052
Published: 15 November 2021
View article titled, Abstract PO-052: A pilot study of miRNA expression profile in surgically resected pancreatic ductal adenocarcinoma: Initial report from a bi-institutional cohort
Journal Articles

A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy

Rakesh Kumar, Marc Van de Vijver, Giampaolo Tortora, Fortunato Ciardiello, Tzipora Goldkorn, Wilson H. Miller, Jr, Larry Norton
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4315–4323.
https://doi.org/10.1158/0008-5472.CAN-19-0989
Published: 03 September 2019
View article titled, A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy
Open the PDF for A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy in another window
Journal Articles

Abstract 295: Synergism between oxaliplatin or irinotecan with the PARP inhibitor niraparib in a preclinical model of KRAS/BRAF mutated colorectal cancer is associated with MSI status

Pietro Paolo Vitiello, Davide Ciardiello, Claudia Cardone, Giulia Martini, Valentina Belli, Nunzia Matrone, Luca Poliero, Carola Borrelli, Pasquale Vitale, Nicoletta Zanaletti, Teresa Troiani, Davide Melisi, Fortunato Ciardiello, Erika Martinelli
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 295.
https://doi.org/10.1158/1538-7445.AM2019-295
Published: 01 July 2019
View article titled, Abstract 295: Synergism between oxaliplatin or irinotecan with the PARP inhibitor niraparib in a preclinical model of KRAS/BRAF mutated colorectal cancer is associated with MSI status
Journal Articles

Abstract 2627: Inhibition of TGFβ in colorectal cancer cells is associated with a compensatory activation of AXL and p38 MAPK signaling pathways

Davide Ciardiello, Pietro Paolo Vitiello, Nunzia Matrone, Valentina Belli, Claudia Cardone, Luca Poliero, Carola Borrelli, Gianluca Arrichiello, Giulia Martini, Vincenza Ciaramella, Giusi Barra, Floriana Morgillo, Teresa Troiani, Davide Melisi, Fortunato Ciardiello, Erika Martinelli
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2627.
https://doi.org/10.1158/1538-7445.AM2019-2627
Published: 01 July 2019
View article titled, Abstract 2627: Inhibition of TGFβ in colorectal cancer cells is associated with a compensatory activation of AXL and p38 MAPK signaling pathways
Journal Articles

Abstract 4904: PD-L1 pathway activation as an escape mechanism of resistance to MEK inhibitor treatment in human colorectal cancer models

Stefania Napolitano, Nunzia Matrone, Valentina Belli, Vincenzo De Falco, Erika Martinelli, Scott Kopetz, Fortunato Ciardiello, Teresa Troiani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4904.
https://doi.org/10.1158/1538-7445.AM2018-4904
Published: 01 July 2018
View article titled, Abstract 4904: PD-L1 pathway activation as an escape mechanism of resistance to MEK inhibitor treatment in human colorectal cancer models
Journal Articles

Abstract 2841: Her2/neu expression as potential marker of regorafenib resistance in CRC

Loredana Vecchione, Stefania Napolitano, Valentina Belli, Erika Martinelli, Nunzia Matrone, Christophe Hapke, Ulrich Keilholz, Josep Tabernero, Fortunato Ciardiello, Teresa Troiani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2841.
https://doi.org/10.1158/1538-7445.AM2018-2841
Published: 01 July 2018
View article titled, Abstract 2841: Her2/neu expression as potential marker of regorafenib resistance in CRC
Journal Articles

Abstract 2619: Genetic landscape of KRAS-NRAS-BRAF-PIK3CA wild type metastatic colorectal cancer patients enrolled in the CAPRI clinical trial

Anna Maria Rachiglio, Matilde Lambiase, Francesca Fenizia, Alessia Iannaccone, Cristin Roma, Claudia Cardone, Antonella De Luca, Erika Martinelli, Evaristo Maiello, Fortunato Ciardiello, Nicola Normanno
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2619.
https://doi.org/10.1158/1538-7445.AM2018-2619
Published: 01 July 2018
View article titled, Abstract 2619: Genetic landscape of KRAS-NRAS-BRAF-PIK3CA wild type metastatic colorectal cancer patients enrolled in the CAPRI clinical trial
Journal Articles

Abstract 5712: Identification of a highly suppressive Treg subset associated with immunotherapy response

Teresa Troiani, Simona Romano, Paolo D'Arrigo, Anna Rea, Martina Tufano, Emilio F. Giunta, Giuseppe Matarrese, Claudio Procaccini, Nunzia Novizio, Vincenza Vigorito, Deriggio Faicchia, Giuseppe Argenziano, Fortunato Ciardiello, Maria F. Romano
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5712.
https://doi.org/10.1158/1538-7445.AM2018-5712
Published: 01 July 2018
View article titled, Abstract 5712: Identification of a highly suppressive Treg subset associated with immunotherapy response
Journal Articles

Abstract CT005: Final results of the HERACLES trial in HER2-amplified colorectal cancer

Salvatore Siena, Andrea Sartore-Bianchi, Livio Trusolino, Cosimo Martino, Katia Bencardino, Sara Lonardi, Vittorina Zagonel, Francesco Leone, Erika Martinelli, Fortunato Ciardiello, Patrizia Racca, Alessio Amatu, Laura Palmeri, Emanuele Valtorta, Silvia Ghezzi, Angelo Vanzulli, Daniele Regge, Silvio Veronese, Alberto Bardelli, Silvia Marsoni
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT005.
https://doi.org/10.1158/1538-7445.AM2017-CT005
Published: 01 July 2017
View article titled, Abstract CT005: Final results of the HERACLES trial in HER2-amplified colorectal cancer
Journal Articles

Abstract CT082: Pertuzumab and trastuzumab-emtansine in HER2-positive colorectal cancer: the HERACLES B trial

Livio Trusolino, Andrea Bertotti, Sara Lonardi, Andrea Sartore-Bianchi, Cosimo Martino, Francesca Cottino, Valentina Vurchio, Emanuele Valtorta, Calogero Lauricella, Daniele Regge, Angelo Vanzulli, Vittorina Zagonel, Francesco Leone, Patrizia Racca, Fortunato Ciardiello, Andrea Ardizzoni, Silvia Marsoni, Salvatore Siena
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT082.
https://doi.org/10.1158/1538-7445.AM2016-CT082
Published: 15 July 2016
View article titled, Abstract CT082: Pertuzumab and trastuzumab-emtansine in HER2-positive colorectal cancer: the HERACLES B trial
Journal Articles

Abstract 937: Molecular analysis of KRAS exon 2 wild type colorectal cancer patients enrolled in the CAPRI clinical trial reveals high degree of tumor heterogeneity

Anna Maria Rachiglio, Matilde Lambiase, Francesca Fenizia, Claudia Esposito, Cristin Roma, Giuseppe Tonini, Saverio Cinieri, Giuseppe Colucci, Fortunato Ciardiello, Nicola Normanno
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 937.
https://doi.org/10.1158/1538-7445.AM2014-937
Published: 01 October 2014
View article titled, Abstract 937: Molecular analysis of KRAS exon 2 wild type colorectal cancer patients enrolled in the CAPRI clinical trial reveals high degree of tumor heterogeneity
Journal Articles

The role of VEGF receptor signaling in gastrointestinal carcinoma cell migration

Maria Pia Morelli, Todd Pitts, Amy Meyer, Fortunato Ciardiello, Anderson Ryan, S. Gail Eckhardt
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 275.
Published: 01 May 2008
View article titled, The role of VEGF receptor signaling in gastrointestinal carcinoma cell migration
Journal Articles

Optimal dose of cetuximab administered every 2 weeks (q2w): A phase I safety, pharmacokinetics (PK) and pharmacodynamics (PD) study of weekly (q1w) and q2w schedules in patients (pts) with metastatic colorectal cancer (mCRC)

Andres Cervantes, Fortunato Ciardiello, Fernando Rivera, Federico Rojo, Esther Casado, Edith Rodriguez-Braun, Erika Martinelli, Oliver Kisker, Jose Baselga, Josep Tabernero
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): LB-352.
Published: 01 May 2007
View article titled, Optimal dose of cetuximab administered every 2 weeks (q2w): A phase I safety, pharmacokinetics (PK) and pharmacodynamics (PD) study of weekly (q1w) and q2w schedules in patients (pts) with metastatic colorectal cancer (mCRC)
Journal Articles

Potentiation of the antitumor activity of bortezomib, a proteasome inhibitor, by the combination with epidermal growth factor receptor tyrosine kinase inhibitors in human cancer cell lines

Tina Cascone, Maria Pia Morelli, Floriana Morgillo, Stefano Pepe, Gabriella Rodolico, Liberato Berrino, Fortunato Ciardiello
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4011.
Published: 01 May 2007
View article titled, Potentiation of the antitumor activity of bortezomib, a proteasome inhibitor, by the combination with epidermal growth factor receptor tyrosine kinase inhibitors in human cancer cell lines
Journal Articles

Human cancer cell lines resistant to EGFR inhibitors acquire an altered expression of VEGFR-1/Flt-1 and become sensitive to ZD6474

Roberto Bianco, Gennaro Daniele, Terese Gelardi, Concetta Tuccillo, Anderson J. Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 888.
Published: 15 April 2006
View article titled, Human cancer cell lines resistant to EGFR inhibitors acquire an altered expression of VEGFR-1/Flt-1 and become sensitive to ZD6474
Journal Articles

The protein kinase C beta antagonist enzastaurin (LY317615.HCL) inhibits cancer cell growth by multiple mechanisms and is active in EGFR inhibitors-resistant cancer cells

Bianco Roberto, Vincenzo Damiano, Teresa Gelardi, Gennaro Daniele, Rosa Caputo, Davide Melisi, Angelo Raffaele Bianco, Michael Lahn, Fortunato Ciardiello, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 518.
Published: 15 April 2006
View article titled, The protein kinase C beta antagonist enzastaurin (LY317615.HCL) inhibits cancer cell growth by multiple mechanisms and is active in EGFR inhibitors-resistant cancer cells
Journal Articles

Enhancement of cytotoxic activity of gemcitabine and ionizing radiation by combined treatment with the VEGF and EGF receptor tyrosine kinase inhibitor ZD6474 against pancreatic cancer cells in vitro

Cataldo Bianco, Elisa Giovannetti, Romano Danesi, Fortunato Ciardiello, Valentina Mey, Giampaolo Tortora, Urraca Gambardella, Francesco Pasqualetti, Giuseppe Pasqualetti, Sara Nannizzi, Luca Cionini, David Raben, Mario Del Tacca
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1121.
Published: 01 May 2005
View article titled, Enhancement of cytotoxic activity of gemcitabine and ionizing radiation by combined treatment with the VEGF and EGF receptor tyrosine kinase inhibitor ZD6474 against pancreatic cancer cells in vitro
Journal Articles

Antitumor activity of ZD6474, a VEGF and EGF receptor tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor

Fortunato Ciardiello, Marco Romano, Concetta Tuccillo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Ferdinando De Vita, Sabino De Placido, A. R. Bianco, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1048–1049.
Published: 01 April 2004
View article titled, Antitumor activity of ZD6474, a VEGF and EGF receptor tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor