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Filip Janku
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Journal Articles

Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction

Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Agustin Chicas, Frederic Delobel, Brad Demarco, Alexander Flohr, Christopher King, Anne-Laure Laine, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Giorgio Ottaviani, Dave Peck, Sarah Pessa, Nooreen Rubin, Thomas Ryckmans, Martin Schillo, Ambika Singh, Simone Tortoioli, Dominico Vigil, Vladislav Zarayskiy, John Castle, Filip Janku, Owen Wallace, Silvia Buonamici, Bernhard Fasching
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3929.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3929
Published: 15 June 2022
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Abstract 5152: Mutation-agnostic detection of colorectal cancer-specific cell-free DNA using targeted methylation sequencing

Mohamed A. Gouda, Dzifa Y. Duose, Morten Lapin, Stephanie Zalles, Helen J. Huang, Yuanxin Xi, Xiaofeng Zheng, Amira I. Aldesoky, Alshimaa M. Alhanafy, Mohamed A. Shehata, Jing Wang, Scott Kopetz, Funda Meric-Bernstam, Ignacio I. Wistuba, Rajyalakshmi Luthra, Filip Janku
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5152.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5152
Published: 15 June 2022
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Abstract 5161: Exome-scale longitudinal tracking of emerging therapeutic resistance in GIST via analysis of circulating tumor DNA

Charles W. Abbott, Niamh Coleman, Jing Wang, Josette Northcott, Jason Pugh, Dan Norton, Fábio C. Navarro, Lee D. McDaniel, Eric Levy, Rachel Marty Pyke, John Lyle, Jason Harris, Gabor Bartha, Filip Janku, John West, Richard O. Chen, Sean Boyle
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5161.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5161
Published: 15 June 2022
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Abstract 5237: B-Raf V600E harboring non-melanoma cancers treated with Vemurafenib monotherapy and in combination with Everolimus/Sorafenib/Crizotinib/Paclitaxel+ Carboplatin: A pooled analysis of five phase 1/2 studies

Blessie Elizabeth Nelson, Jason Roszik, Filip Janku, David Hong, Shumei Kato, Aung Naing, Sarina Piha-Paul, Siqing Fu, Apostolia Tsimberidou, Maria Cabanillas, Naifa Busaidy, Milind Javle, Lauren Byers, John Heymach, Funda Meric-Bernstam, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5237.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5237
Published: 15 June 2022
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Journal Articles

Abstract 2710: The MD Anderson patient-derived xenograft series for modeling precision oncology in biliary tract cancers

Timothy Philip DiPeri, Kurt W. Evans, Ching-Wei D. Tzeng, Lawrence Kwong, Michael P. Kahle, Xiaofeng Zheng, Dali Li, Hop S. Tran Cao, Thuy Vu, Sunhee Kim, Fei Su, Bryce Kirby, Chetna Wathoo, Gabriela Raso, Yasmin Rizvi, Huamin Wang, Filip Janku, Kenna Shaw, Timothy Yap, Milind Javle, Jordi Rodon, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2710.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2710
Published: 01 July 2021
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Abstract LB041: THOR-707 (SAR444245), a novel not-alpha IL-2 as monotherapy and in combination with pembrolizumab in advanced/metastatic solid tumors: Interim results from HAMMER, an open-label, multicenter phase 1/2 Study

Filip Janku, Raghad Abdul-Karim, Arun Azad, Johanna Bendell, Gerald Falchook, Hui K. Gan, Tira Tan, Judy S. Wang, Cheng Ean CHEE, Lina Ma, Jill Mooney, Neyssa Marina, Giovanni Abbadessa, Marcos Milla, Tarek Meniawy
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB041.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB041
Published: 01 July 2021
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Journal Articles

Abstract CT212: Expanded phase 1/2a study of PLX8394, a novel next generation BRAF inhibitor in patients with advanced, unresectable solid tumors with alterations in BRAF

Filip Janku, Eric Sherman, Rona Yaeger, Aparna Parikh, Ryan Sullivan, Lynn Feun, Macarena De La Fuente, Frank Yung-Chin Tsai, Michael Gordon, Carl Allen, Marc S. Rudoltz, Kathe Balinski, Steven Averbuch, Michael Vidne, Gabi Tarcic
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT212.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT212
Published: 01 July 2021
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Journal Articles

Abstract LB031: Plasma based metabolic profiling in metastatic gastrointestinal stromal tumors (GIST)

Chandrashekhar Honrao, Srihari Raghavendra Rao, Nathalie Teissier, S. Greg Call, Elizabeth M. ODay, Filip Janku
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB031.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB031
Published: 01 July 2021
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Abstract LB057: Whole exome sequencing of tumor tissue and circulating tumor DNA ingastrointestinal stromal tumors (GIST)

Niamh Coleman, Charles Abbot, Neeta Somaiah, Sarina Piha-Paul, Shubham Pant, Jordi Rodon, S. Greg Call, Sean Boyle, Funda Meric-Bernstam, Filip Janku
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB057.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB057
Published: 01 July 2021
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Journal Articles

Abstract CT108: A first-in-human, Phase 1 study of ASTX029, a dual-mechanism inhibitor of ERK1/2, in relapsed/refractory solid tumors

Patricia LoRusso, Drew Rasco, Geoffrey Shapiro, Filip Janku, Alain Mita, Nilofer Azad, Marcia Toguchi, Chris Hindley, Shannon Bradley, Danna Chan, Harold Keer, Kim-Hien Dao, Ryan J. Sullivan, Alexander Spira
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT108.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT108
Published: 01 July 2021
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Journal Articles

Abstract CT123: Population pharmacokinetics of ripretinib in patients with advanced malignancies

Suzanne George, Filip Janku, Ping Chi, Margaret von Mehren, Neeta Somaiah, Hans Gelderblom, Robin L. Jones, Martine Allard, Adekemi Taylor, Xiaoyan Li, Julie Meade, Vienna Reichert, Rodrigo Ruiz-Soto, Jing Wang, Michael C. Heinrich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT123.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT123
Published: 01 July 2021
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Journal Articles

Abstract CT110: Intratumoral injection of SYNB1891, a synthetic biotic designed to activate the innate immune system, demonstrates target engagement in humans including intratumoral STING activation

Filip Janku, Jason J. Luke, Aoife Brennan, Richard Riese, Mary Varterasian, Michael B. Armstrong, Karen L. Kuhn, Anna Sokolovska, James F. Strauss
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT110.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT110
Published: 01 July 2021
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Journal Articles

Abstract 575: Enhancing cell-free DNA mutation detection with novel liquid-phase extraction

Filip Janku, Helen Huang, David Y. Pereira, Masae Kobayashi, Steven G. Call, Kristen T. Woodbury, Felix Chao, Daniel R. Marshak, Ricky Y. Chiu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 575.
DOI: https://doi.org/10.1158/1538-7445.AM2021-575
Published: 01 July 2021
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Journal Articles

Abstract 564: BRAFV600 mutation in circulating tumor DNA can predict outcomes in early-stage melanoma

Mohamed Alaa Gouda, Jiri Polivka, Helen Huang, Inka Treskova, Kristyna Pivovarcikova, Funda Meric-Bernstam, Martin Pesta, Filip Janku
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 564.
DOI: https://doi.org/10.1158/1538-7445.AM2021-564
Published: 01 July 2021
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Journal Articles

Abstract CT034: Phase I study of WNT974 + spartalizumab in patients (pts) with advanced solid tumors

Filip Janku, Filip de Vos, Maria de Miguel, Patrick Forde, Antoni Ribas, Misako Nagasaka, Guillem Argiles, Ana Maria Arance, Aitano Calvo, Marios Giannakis, Maritza Melendez, Jiachang Gong, Sebastian Szpakowski, Rebecca Kan, Susan E. Moody, Maja De Jonge
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT034.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT034
Published: 15 August 2020
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Journal Articles

Abstract 3011: Phase I study of TT-00420, a multiple kinase inhibitor, in patients with triple negative breast cancers and other advanced solid tumors

Sarina A. Piha-Paul, Ecaterina Ileana-Dumbrava, Filip Janku, Daniel D. Karp, Funda Meric-Bernstam, Jordi Rodon, Brenda Ngo, Peng Peng, Frank Wu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3011.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3011
Published: 15 August 2020
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Abstract 3172: Evaluation of cytotoxic T cell infiltration and clinical benefit from PD-L1 checkpoint inhibition among PIK3CA mutant microsatellite stable (MSS) metastatic adenocarcinoma patients

Maliha Nusrat, Coya Tapia, S. Greg Call, David S. Hong, Sarina A. Piha-Paul, Vivek Subbiah, Jordi Rodon, Apostolia M. Tsimberidou, Abha Adat, Yan Wang, Funda Meric-Bernstam, Michael J. Overman, Scott Kopetz, Filip Janku
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3172.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3172
Published: 15 August 2020
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Journal Articles

Abstract 1979: Enhancing cell-free DNA and mutant copy recovery from plasma with novel liquid-liquid extraction

Filip Janku, Helen J. Huang, David Y. Pereira, Masae Kobayashi, Chung Hei Chiu, Steven G. Call, Kristen T. Woodbury, Felix Chao, Daniel R. Marshak, Ricky Y. Chiu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1979.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1979
Published: 15 August 2020
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Journal Articles

Abstract 734: Monitoring of dynamic changes and clonal evolution in circulating tumor DNA from patients with IDH-mutated cholangiocarcinoma treated with IDH inhibitors

Morten Lapin, Helen J. Huang, Milind Javle, Rachna T. Shroff, Shubham Pant, Anjali Raina, Kiran Madwani, Veronica R. Holley, S. Greg Call, Richard B. Lanman, Lawrence Kwong, Funda Meric-Bernstam, Victoria M. Raymond, Filip Janku
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 734.
DOI: https://doi.org/10.1158/1538-7445.AM2020-734
Published: 15 August 2020
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Abstract P1-19-18: Everolimus, letrozole and trastuzumab in hormone receptor-positive, HER2-positive/amplified or mutant metastatic cancer: Evaluating synergy and overcoming resistance

Alexej Ballhausen, Jennifer J Wheler, Daniel D Karp, Sarina A Piha-Paul, Siqing Fu, Shubham Pant, Apostolia M Tsimberidou, David S Hong, Vivek Subbiah, Veronica R Holley, Helen J Huang, Abeena M Brewster, Kimberly H Koenig, Nuhad K Ibrahim, Funda Meric-Bernstam, Filip Janku
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-19-18.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P1-19-18
Published: 15 February 2020
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