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Journal Articles

Abstract 884: Development of allogeneic persistence-enhanced PB-derived NK cells in treating solid tumors

Free
Chao Wang, Tingting Liu, Qin Wang, Yanxue Gong, Fanxiang Gao, Feng Zhou, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 884.
https://doi.org/10.1158/1538-7445.AM2025-884
Published: 21 April 2025
View articletitled, Abstract 884: Development of allogeneic persistence-enhanced PB-derived NK cells in treating solid tumors
Journal Articles

Abstract 6121: A novel allogeneic anti-DLL3 CAR-NK cell therapy in treating small cell lung cancer

Free
Chao Wang, Tingting Liu, Qin Wang, Yanxue Gong, Ling Chen, Fanxiang Gao, Feng Zhou, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6121.
https://doi.org/10.1158/1538-7445.AM2025-6121
Published: 21 April 2025
View articletitled, Abstract 6121: A novel allogeneic anti-DLL3 CAR-NK cell therapy in treating small cell lung cancer
Journal Articles

Abstract 6120: Combination of a novel allogeneic anti-cMet CAR-NK cell product with therapeutic antibodies in treating solid tumors

Free
Chao Wang, Tingting Liu, Qin Wang, Yanxue Gong, Fanxiang Gao, Feng Zhou, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6120.
https://doi.org/10.1158/1538-7445.AM2025-6120
Published: 21 April 2025
View articletitled, Abstract 6120: Combination of a novel allogeneic anti-cMet CAR-NK cell product with therapeutic antibodies in treating solid tumors
Journal Articles

Abstract 4853: Knockout of hypoxia inducible factor 1 subunit alpha (HIF1a) augments the antitumor activity of EGFR CAR-NK cells

Free
Fanxiang Gao, Tingting Liu, Qin Wang, Yanxue Gong, Chao Wang, Feng Zhou, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4853.
https://doi.org/10.1158/1538-7445.AM2025-4853
Published: 21 April 2025
View articletitled, Abstract 4853: Knockout of hypoxia inducible factor 1 subunit alpha (HIF1a) augments the antitumor activity of EGFR CAR-NK cells
Journal Articles

Abstract 6122: Off-the-shelf BCMA/GPRC5D dual targeted CAR-NK cell therapy combined with Daratumumab in treating multiple myeloma

Free
Chao Wang, Tingting Liu, Qin Wang, Yanxue Gong, Fanxiang Gao, Feng Zhou, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6122.
https://doi.org/10.1158/1538-7445.AM2025-6122
Published: 21 April 2025
View articletitled, Abstract 6122: Off-the-shelf BCMA/GPRC5D dual targeted CAR-NK cell therapy combined with Daratumumab in treating multiple myeloma
Journal Articles

Abstract 2344: Novel multiplex paired-antibody amplified detection (MPAD) assay panel in combination with CA19-9 for early detection of pancreatic cancer using plasma samples

Free
Malcolm MacKenzie, Matthew Preimesberger, Shu Feng Zhou, Ilya Alexandrov
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2344.
https://doi.org/10.1158/1538-7445.AM2025-2344
Published: 21 April 2025
View articletitled, Abstract 2344: Novel multiplex paired-antibody amplified detection (MPAD) assay panel in combination with CA19-9 for early detection of pancreatic cancer using plasma samples
Journal Articles

Abstract LB271: Synergistic anti-tumor efficacy in olaparib-sensitive and -resistant models via simultaneously inhibition of USP1 and PARP

Free
Shuqun Yang, Zhengtao Li, Lei Zhou, Feng Zhou, Xiaokang Qin, Liting Xue, Piaopiao Xu, Jianxing Tang, Wendy Wang, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB271.
https://doi.org/10.1158/1538-7445.AM2024-LB271
Published: 05 April 2024
View articletitled, Abstract LB271: Synergistic anti-tumor efficacy in olaparib-sensitive and -resistant models via simultaneously inhibition of USP1 and PARP
Journal Articles

Abstract 591: Discovery of ZM-2322, a highly selective, potent inhibitor of membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Free
Feng Zhou, Lu Liu, Lei Jiang, Baoying Cheng, Zhentao Li, Dongxing Zhu, Jianbin Xue, Liting Xue, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 591.
https://doi.org/10.1158/1538-7445.AM2024-591
Published: 22 March 2024
View articletitled, Abstract 591: Discovery of ZM-2322, a highly selective, potent inhibitor of membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)
Journal Articles

Abstract 4539: ZM-2311 a novel and highly potent Polθ inhibitor demonstrates synergistically anti-tumor activities in combination with different therapeutics

Free
Feng Zhou, Lu Liu, Lei Jiang, Shuo Qian, Liting Xue, Mengying Li, Zhengtao Li, Zhen Li, Jian Li, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4539.
https://doi.org/10.1158/1538-7445.AM2024-4539
Published: 22 March 2024
View articletitled, Abstract 4539: ZM-2311 a novel and highly potent Polθ inhibitor demonstrates synergistically anti-tumor activities in combination with different therapeutics
Journal Articles

Abstract 5946: ZM-412, a potent and selective KIF18A inhibitor with robust efficacy as monotherapy in CIN-positive tumors and in combination with MMAE-conjugated ADC in CIN-negative tumors

Free
Feng Zhou, Lei Zhou, Ruina Wang, Liting Xue, Xiaokang Qin, Zhengtao Li, Jian Yu, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5946.
https://doi.org/10.1158/1538-7445.AM2024-5946
Published: 22 March 2024
View articletitled, Abstract 5946: ZM-412, a potent and selective KIF18A inhibitor with robust efficacy as monotherapy in CIN-positive tumors and in combination with MMAE-conjugated ADC in CIN-negative tumors
Journal Articles

Abstract 4687: Primary study on the anticancer role of BAM15 in lung cancer cells

Free
Mei-yin Zhang, Yue-Ning Wang, Yu-Feng Zhou, Shuo-Cheng Wang, Shi-Juan Mai, Hui-Yun Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4687.
https://doi.org/10.1158/1538-7445.AM2024-4687
Published: 22 March 2024
View articletitled, Abstract 4687: Primary study on the anticancer role of BAM15 in lung cancer cells
Journal Articles

Abstract 661: An oral Cbl-b inhibitor with sustained T cell activation demonstrated robust anti-tumor efficacy along with enhanced infiltration and activation of functional T cells

Free
Feng Zhou, Guimei Yang, Yajing Liu, Liting Xue, Weijie Chen, Zhengtao Li, Xiaowu Liu, Jian Li, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 661.
https://doi.org/10.1158/1538-7445.AM2024-661
Published: 22 March 2024
View articletitled, Abstract 661: An oral Cbl-b inhibitor with sustained T cell activation demonstrated robust anti-tumor efficacy along with enhanced infiltration and activation of functional T cells
Journal Articles

Abstract 7278: Discovery of a novel WRN inhibitor, ZM-3329 that efficiently inhibits MSI-H tumor growth

Free
Feng Zhou, Guimei Yang, Yajing Liu, Liting Xue, Yao Guo, Zhengtao Li, Weikun Wang, Jian Li, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7278.
https://doi.org/10.1158/1538-7445.AM2024-7278
Published: 22 March 2024
View articletitled, Abstract 7278: Discovery of a novel WRN inhibitor, ZM-3329 that efficiently inhibits MSI-H tumor growth
Journal Articles

Abstract LB154: Circ0003039 interacts with calreticulin to inhibit the progression of hepatocellular carcinoma by suppressing wnt/beta-catenin signaling pathway

Free
Yue-Ning Wang, Yu-Feng Zhou, Ji Liu, Mei-Yin Zhang, Shuo-Cheng Wang, Shi-Juan Mai, Hui-Yun Wang
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB154.
https://doi.org/10.1158/1538-7445.AM2023-LB154
Published: 14 April 2023
View articletitled, Abstract LB154: Circ0003039 interacts with calreticulin to inhibit the progression of hepatocellular carcinoma by suppressing wnt/beta-catenin signaling pathway
Journal Articles

Abstract 512: Identification of SS008871, a novel Polθ inhibitor that effectively inhibits tumors with homologous recombination deficiency in vitro and in vivo

Free
Feng Zhou, Lu Liu, Lei Jiang, Feng Tang, Zhen Li, Wenqing Yang, Liting Xue, L Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 512.
https://doi.org/10.1158/1538-7445.AM2023-512
Published: 04 April 2023
View articletitled, Abstract 512: Identification of SS008871, a novel Polθ inhibitor that effectively inhibits tumors with homologous recombination deficiency in vitro and in vivo
Journal Articles

Abstract 6201: Identification of SP-002, a highly selective USP1 inhibitor effectively inhibits HRD tumor growth and displays low hematotoxicity risk

Free
Feng Zhou, Zhengtao Li, Lei Zhou, Wei Zhu, Jiyan Zhang, Wenqing Yang, Liting Xue, Xiaokang Qin, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6201.
https://doi.org/10.1158/1538-7445.AM2023-6201
Published: 04 April 2023
View articletitled, Abstract 6201: Identification of SP-002, a highly selective USP1 inhibitor effectively inhibits HRD tumor growth and displays low hematotoxicity risk
Journal Articles

Abstract 1137: Identification of a high selective SMARCA2 degrader which effectively suppresses the SMARCA4-deficient tumors in vitro and in vivo

Free
Feng Zhou, Zhiyong Yu, Ruonan Chen, Feng Tang, Peng Gu, Wenqing Yang, Liting Xue, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1137.
https://doi.org/10.1158/1538-7445.AM2023-1137
Published: 04 April 2023
View articletitled, Abstract 1137: Identification of a high selective SMARCA2 degrader which effectively suppresses the SMARCA4-deficient tumors in vitro and in vivo
Journal Articles

Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile

Free
Yingying Hu, Yayuan Fu, Lei Liu, Wenjing Li, Liting Xue, Zhiyong Yu, Yun Zhang, Meijuan Gao, Yixin Tan, Fudong Wang, Yadan Wu, Jie Li, Zhenzhen Li, Feng Zhou, Wenqing Yang, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6357.
https://doi.org/10.1158/1538-7445.AM2023-6357
Published: 04 April 2023
View articletitled, Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile
Journal Articles

Abstract 3474: Identification of the selective CBL-b inhibitors which effectively prevent T cells from exhaustion and demonstrate synergistic anti-tumor activity in combination with an anti-PD1 antibody

Free
Feng Zhou, Zhengtao Li, Yajing Liu, Guimei Yang, Wansun Mai, Wenqing Yang, Liting Xue, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3474.
https://doi.org/10.1158/1538-7445.AM2023-3474
Published: 04 April 2023
View articletitled, Abstract 3474: Identification of the selective CBL-b inhibitors which effectively prevent T cells from exhaustion and demonstrate synergistic anti-tumor activity in combination with an anti-PD1 antibody
Journal Articles

Abstract 1724: SCR-8388, a potent and selective SOS1::KRAS inhibitor, is effective in KRAS-addicted cancers

Free
Feng Zhou, Guimei Yang, Feng Tang Tang, Yan Zhang, Shengwei Yang, Wenqing Yang, Liting Xue, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1724.
https://doi.org/10.1158/1538-7445.AM2023-1724
Published: 04 April 2023
View articletitled, Abstract 1724: SCR-8388, a potent and selective SOS1::KRAS inhibitor, is effective in KRAS-addicted cancers