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Journal Articles

Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Friederike I. Nollmann, Patricia Perez Galan, Javier Garcia Fernandez, Heidi K. Walter, Johannes P. Magnusson, Federico Medda, Felix Kratz, Stephan D. Koester, Khalid Abu Ajaj, Lara Pes, Serghei Chercheja, Anna Warnecke

Cancer Res (2018) 78 (13_Supplement): 1657.

https://doi.org/10.1158/1538-7445.AM2018-1657

Published: 01 July 2018

View article titled, Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Journal Articles

Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Cancer Res (2018) 78 (13_Supplement): 2661.

https://doi.org/10.1158/1538-7445.AM2018-2661

Published: 01 July 2018

View article titled, Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Journal Articles

Abstract 3708: Targeted delivery of doxorubicin to glioblastomas by thermally sensitive polypeptides

Sonja Dragojevic, Rebecca B. Mackey, Felix Kratz, Drazen Raucher

Cancer Res (2018) 78 (13_Supplement): 3708.

https://doi.org/10.1158/1538-7445.AM2018-3708

Published: 01 July 2018

View article titled, Abstract 3708: Targeted delivery of doxorubicin to glioblastomas by thermally sensitive polypeptides

Journal Articles

Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Stephan D. Koester, Lara Pes, Johannes P. Magnusson, Serghei Chercheja, Federico Medda, Friederike I. Nollmann, Patricia Perez Galan, Javier Garcia Fernandez, Heidi-Kristin Walter, Khalid Abu Ajaj, Anna Warnecke, Felix Kratz

Cancer Res (2018) 78 (13_Supplement): 3703.

https://doi.org/10.1158/1538-7445.AM2018-3703

Published: 01 July 2018

View article titled, Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Journal Articles

Abstract 3106: Targeted delivery via Elastin Like Polypeptide: Biodistribution of a doxorubicin derivative in MDA-MB231 human breast cancer xenografts in mice

Sonja Dragojevic, Jung Su Ryu, Felix Kratz, Drazen Raucher

Cancer Res (2017) 77 (13_Supplement): 3106.

https://doi.org/10.1158/1538-7445.AM2017-3106

Published: 01 July 2017

View article titled, Abstract 3106: Targeted delivery via Elastin Like Polypeptide: Biodistribution of a doxorubicin derivative in MDA-MB231 human breast cancer xenografts in mice

Journal Articles

Abstract 2061: DK049, a novel acid-sensitive prodrug of gemcitabine: design, in vitro properties and in vivo efficacy

David Koester, Javier Garcia, Olga Fuchs, Felix Kratz

Cancer Res (2016) 76 (14_Supplement): 2061.

https://doi.org/10.1158/1538-7445.AM2016-2061

Published: 15 July 2016

View article titled, Abstract 2061: DK049, a novel acid-sensitive prodrug of gemcitabine: design, in vitro properties and in vivo efficacy

Journal Articles

Abstract 2168: Optimizing doxorubicin derivatives delivery using temperature sensitive biopolymers in multidrug resistant breast cancer cells

Sonja Dragojevic, Jung Su Ryu, Felix Kratz, Drazen Raucher

Cancer Res (2016) 76 (14_Supplement): 2168.

https://doi.org/10.1158/1538-7445.AM2016-2168

Published: 15 July 2016

View article titled, Abstract 2168: Optimizing doxorubicin derivatives delivery using temperature sensitive biopolymers in multidrug resistant breast cancer cells

Journal Articles

Abstract 4858: LADR™: A novel linker activated drug release technology for drug delivery

Khalid Abu Ajaj, Stephan David Koester, Friederike Inga Nollmann, Simon Waltzer, Olga Fuchs, André Warnecke, Felix Kratz

Cancer Res (2016) 76 (14_Supplement): 4858.

https://doi.org/10.1158/1538-7445.AM2016-4858

Published: 15 July 2016

View article titled, Abstract 4858: LADR™: A novel linker activated drug release technology for drug delivery

Journal Articles

Abstract 4507: Utilizing the targeting properties of elastin-like polypeptide to safely deliver a potent doxorubicin derivative.

Leslie R. Walker, Eddie Perkins, Khalid Abu Ajaj, Felix Kratz, Drazen Raucher

Cancer Res (2013) 73 (8_Supplement): 4507.

https://doi.org/10.1158/1538-7445.AM2013-4507

Published: 15 April 2013

View article titled, Abstract 4507: Utilizing the targeting properties of elastin-like polypeptide to safely deliver a potent doxorubicin derivative.

Journal Articles

Abstract 1760: Development of bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B

Katrin Hochdörffer, Cynthia Schäfer-Obodozie, Christoph Schächtele, Felix Kratz

Cancer Res (2012) 72 (8_Supplement): 1760.

https://doi.org/10.1158/1538-7445.AM2012-1760

Published: 15 April 2012

View article titled, Abstract 1760: Development of bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B

Journal Articles

Abstract 2763: Combination therapy of an acid-sensitive albumin-binding prodrug of doxorubicin (INNO-206) and an albumin-binding prodrug of methotrexate (AW054) that is cleaved by cathepsin B and plasmin induces complete remissions against pancreatic cancer in vivo (MiaPaca-2)

Felix Kratz, Samar S E E A Azab, Rainer Zeisig, Iduna Fichtner, Andre Warnecke

Cancer Res (2012) 72 (8_Supplement): 2763.

https://doi.org/10.1158/1538-7445.AM2012-2763

Published: 15 April 2012

View article titled, Abstract 2763: Combination therapy of an acid-sensitive albumin-binding prodrug of doxorubicin (INNO-206) and an albumin-binding prodrug of methotrexate (AW054) that is cleaved by cathepsin B and plasmin induces complete remissions against pancreatic cancer in vivo (MiaPaca-2)

Journal Articles

Abstract 2756: Combination therapy of doxorubicin and the acid-sensitive albumin-binding prodrug of doxorubicin INNO-206 induces complete regressions in a xenograft pancreatic carcinoma model demonstrating excellent tolerability

Felix Kratz, Samar S E E A Azab, Rainer Zeisig, Iduna Fichtner, Andre Warnecke

Cancer Res (2012) 72 (8_Supplement): 2756.

https://doi.org/10.1158/1538-7445.AM2012-2756

Published: 15 April 2012

View article titled, Abstract 2756: Combination therapy of doxorubicin and the acid-sensitive albumin-binding prodrug of doxorubicin INNO-206 induces complete regressions in a xenograft pancreatic carcinoma model demonstrating excellent tolerability

Journal Articles

Abstract 3800: Nitric oxide acts a promoter of the enhanced permeation and retention effect in a xenograft pancreatic carcinoma model

André Warnecke, Reiner Zeisig, Iduna Fichtner, Felix Kratz

Cancer Res (2012) 72 (8_Supplement): 3800.

https://doi.org/10.1158/1538-7445.AM2012-3800

Published: 15 April 2012

View article titled, Abstract 3800: Nitric oxide acts a promoter of the enhanced permeation and retention effect in a xenograft pancreatic carcinoma model

Journal Articles

Abstract 4771: Improved antitumor efficacy of an acid-sensitive doxorubicin derivative delivered by thermally responsive elastin-like polypeptides

Leslie R. Walker, Felix Kratz, Drazen Raucher

Cancer Res (2012) 72 (8_Supplement): 4771.

https://doi.org/10.1158/1538-7445.AM2012-4771

Published: 15 April 2012

View article titled, Abstract 4771: Improved antitumor efficacy of an acid-sensitive doxorubicin derivative delivered by thermally responsive elastin-like polypeptides

Journal Articles

Abstract 779: Prodrug-mediated reversal of multidrug resistance in breast cancer cells

Khalid Abu Ajaj, Yeonju Lee, Ralph Graser, Felix Kratz

Cancer Res (2012) 72 (8_Supplement): 779.

https://doi.org/10.1158/1538-7445.AM2012-779

Published: 15 April 2012

View article titled, Abstract 779: Prodrug-mediated reversal of multidrug resistance in breast cancer cells

Journal Articles

Abstract 3226: In vitro evaluation of a thermally targeted conjugate of a highly potent doxorubicin derivative

Teuta Opacak-Bernardi, Leslie Robinson, Khalid Abu Ajaj, Felix Kratz, Drazen Raucher

Cancer Res (2011) 71 (8_Supplement): 3226.

https://doi.org/10.1158/1538-7445.AM2011-3226

Published: 15 April 2011

View article titled, Abstract 3226: In vitro evaluation of a thermally targeted conjugate of a highly potent doxorubicin derivative

Journal Articles

Abstract 2569: Combination of the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin produces complete remissions in an ovarian A2780 xenograft model

Felix Kratz, Iduna Fichtner, Ralph Graeser

Cancer Res (2011) 71 (8_Supplement): 2569.

https://doi.org/10.1158/1538-7445.AM2011-2569

Published: 15 April 2011

View article titled, Abstract 2569: Combination of the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin produces complete remissions in an ovarian A2780 xenograft model

Journal Articles

Abstract 1726: Overcoming multi-drug resistance with Paclitaxel-loaded polymer nanoparticles

Yeonju Lee, Ralph Graeser, Felix Kratz, Kurt Ernst Geckeler

Cancer Res (2011) 71 (8_Supplement): 1726.

https://doi.org/10.1158/1538-7445.AM2011-1726

Published: 15 April 2011

View article titled, Abstract 1726: Overcoming multi-drug resistance with Paclitaxel-loaded polymer nanoparticles

Journal Articles

Abstract 3502: Activity of combinations of anticancer agents in pancreatic carcinoma cell lines

Christina Schwarting, Julia Belgardt, Andre Warnecke, Felix Kratz, Ralph Graeser

Cancer Res (2011) 71 (8_Supplement): 3502.

https://doi.org/10.1158/1538-7445.AM2011-3502

Published: 15 April 2011

View article titled, Abstract 3502: Activity of combinations of anticancer agents in pancreatic carcinoma cell lines

Journal Articles

Abstract 4436: Biological evaluation of folate prodrugs with a highly toxic derivative of doxorubicin

Khalid Abu Ajaj, Naser El-Abadla, Pia Welker, Samar Azab, Reiner Zeisig, Iduna Fichtner, Felix Kratz

Cancer Res (2011) 71 (8_Supplement): 4436.

https://doi.org/10.1158/1538-7445.AM2011-4436

Published: 15 April 2011

View article titled, Abstract 4436: Biological evaluation of folate prodrugs with a highly toxic derivative of doxorubicin

NARROW

Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Abstract 3708: Targeted delivery of doxorubicin to glioblastomas by thermally sensitive polypeptides

Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Abstract 3106: Targeted delivery via Elastin Like Polypeptide: Biodistribution of a doxorubicin derivative in MDA-MB231 human breast cancer xenografts in mice

Abstract 2061: DK049, a novel acid-sensitive prodrug of gemcitabine: design, in vitro properties and in vivo efficacy

Abstract 2168: Optimizing doxorubicin derivatives delivery using temperature sensitive biopolymers in multidrug resistant breast cancer cells

Abstract 4858: LADR™: A novel linker activated drug release technology for drug delivery

Abstract 4507: Utilizing the targeting properties of elastin-like polypeptide to safely deliver a potent doxorubicin derivative.

Abstract 1760: Development of bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B

Abstract 2763: Combination therapy of an acid-sensitive albumin-binding prodrug of doxorubicin (INNO-206) and an albumin-binding prodrug of methotrexate (AW054) that is cleaved by cathepsin B and plasmin induces complete remissions against pancreatic cancer in vivo (MiaPaca-2)

Abstract 2756: Combination therapy of doxorubicin and the acid-sensitive albumin-binding prodrug of doxorubicin INNO-206 induces complete regressions in a xenograft pancreatic carcinoma model demonstrating excellent tolerability

Abstract 3800: Nitric oxide acts a promoter of the enhanced permeation and retention effect in a xenograft pancreatic carcinoma model

Abstract 4771: Improved antitumor efficacy of an acid-sensitive doxorubicin derivative delivered by thermally responsive elastin-like polypeptides

Abstract 779: Prodrug-mediated reversal of multidrug resistance in breast cancer cells

Abstract 3226: In vitro evaluation of a thermally targeted conjugate of a highly potent doxorubicin derivative

Abstract 2569: Combination of the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin produces complete remissions in an ovarian A2780 xenograft model

Abstract 1726: Overcoming multi-drug resistance with Paclitaxel-loaded polymer nanoparticles

Abstract 3502: Activity of combinations of anticancer agents in pancreatic carcinoma cell lines

Abstract 4436: Biological evaluation of folate prodrugs with a highly toxic derivative of doxorubicin

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