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Felix K. Niggli
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Journal Articles

Abstract B19: Identification of physiologically relevant EWS-FLI1 target genes in Ewing’s sarcoma via CRISPRa screening

Vadim Saratov, Qui A. Ngo, Gloria Pedot, Felix K. Niggli, Beat W. Schaefer
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B19.
https://doi.org/10.1158/1538-7445.PEDCA19-B19
Published: 15 July 2020
View article titled, Abstract B19: Identification of physiologically relevant EWS-FLI1 target genes in Ewing’s sarcoma via CRISPRa screening
Journal Articles

Abstract 3109: Protein stability screen to identify compounds destabilizing EWS-FLI1 in Ewing sarcoma

Gloria Pedot, Felix K. Niggli, Beat W. Schaefer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3109.
https://doi.org/10.1158/1538-7445.AM2019-3109
Published: 01 July 2019
View article titled, Abstract 3109: Protein stability screen to identify compounds destabilizing EWS-FLI1 in Ewing sarcoma
Journal Articles

Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth

Tim Hensel, Chiara Giorgi, Oxana Schmidt, Hsi-Yu Yen, Katja Steiger, Simone Fulda, Felix K. Niggli, Wilko Weigert, Shudong Wang, Beat W. Schäfer, Stefan Burdach, Günther H.S. Richter
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): PR13.
https://doi.org/10.1158/1538-7445.PEDCA17-PR13
Published: 01 October 2018
View article titled, Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth
Journal Articles

Abstract 478: EWS/FLI1 transcription is modulated by the PI3K pathway via SP1 in Ewing sarcoma

Chiara Giorgi, Alexander Boro, Laura A. Lopez-Garcia, Beat W. Schaefer, Felix K. Niggli
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 478.
https://doi.org/10.1158/1538-7445.AM2015-478
Published: 01 August 2015
View article titled, Abstract 478: EWS/FLI1 transcription is modulated by the PI3K pathway via SP1 in Ewing sarcoma
Journal Articles

Abstract 4966: Identification of deubiquitinating enzyme USP19 as a regulator of EWS/FLI1 protein turnover in Ewing sarcoma

Maria E. Gierisch, Laura A. Lopez-Garcia, Franziska Pfistner, Felix K. Niggli, Beat W. Schaefer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4966.
https://doi.org/10.1158/1538-7445.AM2015-4966
Published: 01 August 2015
View article titled, Abstract 4966: Identification of deubiquitinating enzyme USP19 as a regulator of EWS/FLI1 protein turnover in Ewing sarcoma
Journal Articles

Abstract 271: Validation of Polo-like Kinase 1 as a novel therapeutic target in alveolar rhabdomyosarcoma

Verena Thalhammer, David Herrero-Martin, Regina Hecker, Felix K. Niggli, Beat W. Schäfer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 271.
https://doi.org/10.1158/1538-7445.AM2012-271
Published: 15 April 2012
View article titled, Abstract 271: Validation of Polo-like Kinase 1 as a novel therapeutic target in alveolar rhabdomyosarcoma
Journal Articles

Abstract 5342: Assessing EWS/FLI1 activity as a read-out for small-molecule drug screening in Ewing's sarcoma

Florian Rechfeld, Aleksandar Boro, Felix K. Niggli, Beat W. Schäfer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5342.
https://doi.org/10.1158/1538-7445.AM2011-5342
Published: 15 April 2011
View article titled, Abstract 5342: Assessing EWS/FLI1 activity as a read-out for small-molecule drug screening in Ewing's sarcoma
Journal Articles

Abstract #2191: Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumor lymphatic-homing peptide LyP-1

Hendrik Witt, Katarina Hajdin, Oliver Greiner, Kristina Iljin Iljin, Felix K. Niggli, Beat W. Schäfer, Michele Bernasconi
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2191.
Published: 01 May 2009
View article titled, Abstract #2191: Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumor lymphatic-homing peptide LyP-1
Journal Articles

Phosphorylation Regulates Transcriptional Activity of PAX3/FKHR and Reveals Novel Therapeutic Possibilities

Ralf Amstutz, Marco Wachtel, Heinz Troxler, Peter Kleinert, Margret Ebauer, Torsten Haneke, Christoph Oehler-Jänne, Doriano Fabbro, Felix K. Niggli, Beat W. Schäfer
Journal: Cancer Research
Cancer Res (2008) 68 (10): 3767–3776.
https://doi.org/10.1158/0008-5472.CAN-07-2447
Published: 15 May 2008
View article titled, Phosphorylation Regulates Transcriptional Activity of PAX3/FKHR and Reveals Novel Therapeutic Possibilities
Open the PDF for Phosphorylation Regulates Transcriptional Activity of PAX3/FKHR and Reveals Novel Therapeutic Possibilities in another window
Journal Articles

Regulation of chimaeric oncogenic transcription factor activity by a tyrosine kinase inhibitor

Beat W. Schafer, Marco Wachtel, Ralf Amstutz, Heinz Troxler, Peter Kleinert, Doriano Fabbro, Felix K. Niggli
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 887.
Published: 15 April 2006
View article titled, Regulation of chimaeric oncogenic transcription factor activity by a tyrosine kinase inhibitor
Journal Articles

Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1

Marco Wachtel, Marcel Dettling, Eva Koscielniak, Sabine Stegmaier, Jörn Treuner, Katja Simon-Klingenstein, Peter Bühlmann, Felix K. Niggli, Beat W. Schäfer
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5539–5545.
https://doi.org/10.1158/0008-5472.CAN-04-0844
Published: 16 August 2004
View article titled, Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1
Open the PDF for Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1 in another window
Includes: Supplementary data