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Journal Articles

Abstract LB431: Discovery and characterization of a highly potent and orally available small-molecule inhibitor for diverse KRAS mutations

Free
Yongxian Zhang, Fei Yang, Zhigang Feng, Meimei Sun, Xinyan Huang, Haibing Deng, Hongping Yu, Yao-chang Xu, Zhui Chen, Haiyan Ying
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB431.
https://doi.org/10.1158/1538-7445.AM2025-LB431
Published: 25 April 2025
View article titled, Abstract LB431: Discovery and characterization of a highly potent and orally available small-molecule inhibitor for diverse KRAS mutations
Journal Articles

Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer

Open Access
Tanvi H. Visal, Recep Bayraktar, Petra den Hollander, Michael A. Attathikhun, Tieling Zhou, Jing Wang, Li Shen, Corina-Elena Minciuna, Meng Chen, Elizve Barrientos-Toro, Harsh Batra, Maria Gabriela Raso, Fei Yang, Edwin R. Parra, Aysegul A. Sahin, George A. Calin, Sendurai A. Mani
Journal: Cancer Research
Cancer Res (2025) 85 (5): 894–911.
https://doi.org/10.1158/0008-5472.CAN-24-0400
Published: 03 March 2025
View article titled, Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer
Open the PDF for Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5099: Prevalence of fibroblast growth factor receptor (FGFR) alterations (alts) and programmed death-ligand 1 (PD-L1) expression (exp) in Chinese solid tumor patients (pts)

Free
Min Qing, Fei Yang, Xiaowei Chen, Xuesong Lyu, Aodi Wang, Yanfei Yu, Shibu Thomas, Longen Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5099.
https://doi.org/10.1158/1538-7445.AM2024-5099
Published: 22 March 2024
View article titled, Abstract 5099: Prevalence of fibroblast growth factor receptor (FGFR) alterations (alts) and programmed death-ligand 1 (PD-L1) expression (exp) in Chinese solid tumor patients (pts)
Journal Articles

Abstract LB328: Discovery & characterization of a next-generation FGFR4 inhibitor overcoming resistant mutations

Free
Haiyan Ying, Nannan Zhang, Haibing Deng, Fei Yang, Wenqun Xin, Bin Shen, Hongping Yu, Zhui Chen, Yao-chang Xu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB328.
https://doi.org/10.1158/1538-7445.AM2023-LB328
Published: 14 April 2023
View article titled, Abstract LB328: Discovery & characterization of a next-generation FGFR4 inhibitor overcoming resistant mutations
Journal Articles

Abstract LB530: A potent and selective small molecule antagonist of PD-L1 ABSK043 demonstrates significant anti-tumor efficacy in combination with other agents in preclinical models

Free
Haiyan Ying, Yongxian Zhang, Fei Yang, Wenqun Xin, Jiaqi Song, Zhui Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB530.
https://doi.org/10.1158/1538-7445.AM2022-LB530
Published: 15 June 2022
View article titled, Abstract LB530: A potent and selective small molecule antagonist of PD-L1 ABSK043 demonstrates significant anti-tumor efficacy in combination with other agents in preclinical models
Journal Articles

Abstract LB525: Discovery and characterization of ABSK111, a selective, CNS-penetrable, and broad-spectrum EGFR inhibitor targeting exon20 insertion, atypical and extracellular mutations

Free
Cheng Dai, Juan Peng, Fei Yang, Haibing Deng, Yuan Zhao, Hongping Yu, Yaochang Xu, Zhui Chen, Shuqun Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB525.
https://doi.org/10.1158/1538-7445.AM2022-LB525
Published: 15 June 2022
View article titled, Abstract LB525: Discovery and characterization of ABSK111, a selective, CNS-penetrable, and broad-spectrum EGFR inhibitor targeting exon20 insertion, atypical and extracellular mutations
Journal Articles

Abstract 1791: Epigenetically upregulating TROP2 enhances therapeutic efficacy of TROP2 ADC sacitizumab govitecan

Free
Ming Zhao, Timothy P. DiPeri, Gabriela Raso, Yasmeen Q. Rizvi, Xiaofeng Zheng, Kurt Evans, Argun Akcakanat, Fei Yang, Debu Tripathy, Ecaterina Ileana Dumbrava, Senthil Damodaran, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1791.
https://doi.org/10.1158/1538-7445.AM2022-1791
Published: 15 June 2022
View article titled, Abstract 1791: Epigenetically upregulating TROP2 enhances therapeutic efficacy of TROP2 ADC sacitizumab govitecan
Journal Articles

Abstract 1768: Anti-tumor activity and biomarker analysis for datopotamab deruxtecan in breast cancer PDX models

Free
Erkan Yuca, Kurt Evans, Argun Akcakanat, Gabriela Raso, Yasmeen Q. Rizvi, Fei Yang, Lauren Byers, Senthil Damodaran, Okajima Daisuke, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1768.
https://doi.org/10.1158/1538-7445.AM2022-1768
Published: 15 June 2022
View article titled, Abstract 1768: Anti-tumor activity and biomarker analysis for datopotamab deruxtecan in breast cancer PDX models
Journal Articles

Abstract P2-13-10: First-in-human HER2-targeted bispecific antibody KN026 for the treatment of patients with HER2-positive metastatic breast cancer: Results from a phase I study

Free
Jian Zhang, Dongmei Ji, Li Cai, Herui Yao, Min Yan, Xiaojia Wang, Weina Shen, Yiqun Du, Hui Pang, Xiuping Lai, Huiai Zeng, Jian Huang, Yan Sun, Xinxin Peng, Junfang Xu, Jing Yang, Fei Yang, Ting Xu, Xichun Hu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-13-10.
https://doi.org/10.1158/1538-7445.SABCS21-P2-13-10
Published: 15 February 2022
View article titled, Abstract P2-13-10: First-in-human HER2-targeted bispecific antibody KN026 for the treatment of patients with HER2-positive metastatic breast cancer: Results from a phase I study
Journal Articles

Abstract PD10-08: Remodeling the inflammatory breast cancer tumor microenvironment to enhance immunotherapy: Novel therapeutic development

Free
Xiaoping Wang, Takashi Semba, Ganiraju C. Manyam, Jing Wang, Shan Shao, Francois Bertucci, Pascal Finetti, Savitri Krishnamurthy, Lan ThiHanh Phi, Troy Pearson, Jared K. Burks, Evan N. Cohen, James M. Reuben, Fei Yang, Hu Min, Nicholas Navin, Toshiaki Iwase, Yichao Shen, Xiang Zhang, Debu Tripathy, Naoto T. Ueno
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD10-08.
https://doi.org/10.1158/1538-7445.SABCS21-PD10-08
Published: 15 February 2022
View article titled, Abstract PD10-08: Remodeling the inflammatory breast cancer tumor microenvironment to enhance immunotherapy: Novel therapeutic development
Journal Articles

Abstract PS18-37: Loss of Trop2 protein in metaplastic carcinoma of breast by IHC

Free
Fei Yang, Yasmeen Rizvi, Erkan Yuca, Ming Zhao, Kurt Evans, Xiaofeng Zheng, Aysegul Sahin, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS18-37.
https://doi.org/10.1158/1538-7445.SABCS20-PS18-37
Published: 15 February 2021
View article titled, Abstract PS18-37: Loss of Trop2 protein in metaplastic carcinoma of breast by IHC
Journal Articles

Abstract 3022: Using translational tumor growth inhibition modeling approach and population PK analysis to predict efficacious doses for KN026, a HER2 bispecific antibody

Free
Dongmei Ji, Yuan Xiong, Jing Yang, Pilin Wang, Jiarong Wang, Fei Yang, Junfang Xu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3022.
https://doi.org/10.1158/1538-7445.AM2020-3022
Published: 15 August 2020
View article titled, Abstract 3022: Using translational tumor growth inhibition modeling approach and population PK analysis to predict efficacious doses for KN026, a HER2 bispecific antibody
Journal Articles

Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer

Free
Sunil Acharya, Jun Yao, Ping Li, Chenyu Zhang, Frank J. Lowery, Qingling Zhang, Hua Guo, Jingkun Qu, Fei Yang, Ignacio I. Wistuba, Helen Piwnica-Worms, Aysegul A. Sahin, Dihua Yu
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4211–4226.
https://doi.org/10.1158/0008-5472.CAN-18-3803
Published: 15 August 2019
View article titled, Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer
Open the PDF for Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3761: Regulation of metastasis by CD8 T lymphocytes

Free
Robiya Joseph, Rama Soundararajan, Suhas Vasaikar, Fei Yang, Sevinj Isgandarova, Lin Tian, Monika Haemmerle, Barbara Mino, Tieling Zhou, Geraldine Vidhya Raja, Esmeralda Ramirez Pena, Petra Den Hollander, Neeraja Bhangre, Crystal Shin, Melisa Martinez, Jaime Rodriguez Canales, Jeffrey Chang, Anil Sood, Ignacio Ivan Wistuba, Don L. Gibbons, Jeffrey M. Rosen, Ghanashyam Acharya, Navin Varadarajan, Xiang H. Zhang, Sendurai A. Mani
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3761.
https://doi.org/10.1158/1538-7445.AM2019-3761
Published: 01 July 2019
View article titled, Abstract 3761: Regulation of metastasis by CD8 T lymphocytes
Journal Articles

Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1

Free
Ying Xiang, Kai Yan, Qian Zheng, Haiqiang Ke, Jie Cheng, Wenjun Xiong, Xin Shi, Lei Wei, Min Zhao, Fei Yang, Ping Wang, Xing Lu, Li Fu, Xuemei Lu, Feng Li
Journal: Cancer Research
Cancer Res (2019) 79 (1): 86–98.
https://doi.org/10.1158/0008-5472.CAN-18-1310
Published: 02 January 2019
View article titled, Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1
Open the PDF for Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1 in another window
Includes: Supplementary data
Journal Articles

Abstract 634: SOX11 is a potential clinical marker for hormone receptor negative ductal carcinoma in situ

Free
Kazuharu Kai, Wei Lu, Fei Yang, Ximing Tang, Ignacio I. Wistuba, Subrata Sen, Alastair Thompson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 634.
https://doi.org/10.1158/1538-7445.AM2018-634
Published: 01 July 2018
View article titled, Abstract 634: SOX11 is a potential clinical marker for hormone receptor negative ductal carcinoma in situ
Journal Articles

Abstract 5172: A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

Free
Emily Powell, Jiansu Shao, Hector Picon, Christopher Bristow, Zhongqi Ge, Caitlin Grzeskowiak, Michael Peoples, Frederick Robinson, Sabrina Jeter-Jones, Christopher Schlosberg, Fei Yang, Yun Wu, Ignacio Wistuba, Stacy Moulder, Fraser Symmans, Kenneth Scott, John Edwards, Han Liang, Timothy Heffernan, Helen Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5172.
https://doi.org/10.1158/1538-7445.AM2018-5172
Published: 01 July 2018
View article titled, Abstract 5172: A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis
Journal Articles

A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

Free
Alexis A. Kurmis, Fei Yang, Timothy R. Welch, Nicholas G. Nickols, Peter B. Dervan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (9): 2207–2212.
https://doi.org/10.1158/0008-5472.CAN-16-2503
Published: 30 April 2017
View article titled, A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 1130: Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models.

Free
Nicholas G. Nickols, Fei Yang, Benjamin C. Li, Georgi K. Marinov, Jonathan W. Said, Peter B. Dervan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1130.
https://doi.org/10.1158/1538-7445.AM2013-1130
Published: 15 April 2013
View article titled, Abstract 1130: Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models.
Journal Articles

Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy

Free
Fei Yang, Ximing Tang, Erick Riquelme, Carmen Behrens, Monique B. Nilsson, Uma Giri, Marileila Varella-Garcia, Lauren A. Byers, Heather Y. Lin, Jing Wang, Maria G. Raso, Luc Girard, Kevin Coombes, J. Jack Lee, Roy S. Herbst, John D. Minna, John V. Heymach, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5512–5521.
https://doi.org/10.1158/0008-5472.CAN-10-2614
Published: 11 August 2011
View article titled, Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy
Open the PDF for Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy in another window
Includes: Supplementary data