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Journal Articles

Abstract 6657: Oncolytic Vaccinia Virus Carrying OPCML Tumor Suppressor is active in Epithelial Ovarian Cancer

Yong Tang, Yingzhao Liu, Mingjing Deng, Fei Huang, Jiahu Wang, Paul Blake, Hani Gabra, Qi Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6657.
https://doi.org/10.1158/1538-7445.AM2024-6657
Published: 22 March 2024
View article titled, Abstract 6657: Oncolytic Vaccinia Virus Carrying OPCML Tumor Suppressor is active in Epithelial Ovarian Cancer
Journal Articles

Abstract 3792: Imetelstat inhibits RNA-editing mediated myeloproliferative neoplasm stem cell self-renewal

Wenxue Ma, Larisa Balaian, Cayla Mason, Raymond Diep, Jessica Pham, Qingfei Jiang, Jeremy Lee, Sheldon Morris, Phoebe Mondala, Ping Chen, Thomas Whisenant, Mary Donohoe, Benjamin Heyman, Edward Ball, Fei Huang, Catriona Jamieson
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3792.
https://doi.org/10.1158/1538-7445.AM2020-3792
Published: 15 August 2020
View article titled, Abstract 3792: Imetelstat inhibits RNA-editing mediated myeloproliferative neoplasm stem cell self-renewal
Journal Articles

HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer

Fei Huang, Qiaoni Shi, Yuzhen Li, Linlin Xu, Chi Xu, Fenfang Chen, Hai Wang, Hongwei Liao, Zai Chang, Fang Liu, Xiang H.-F. Zhang, Xin-Hua Feng, Jing-Dong J. Han, Shiwen Luo, Ye-Guang Chen
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6073–6085.
https://doi.org/10.1158/0008-5472.CAN-18-0136
Published: 01 November 2018
View article titled, HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer
Open the PDF for HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1101: Telomerase inhibitor imetelstat in combination with the BCL-2 inhibitor venetoclax enhances apoptosis in vitro and increases survival in vivo in acute myeloid leukemia

Joshua J. Rusbuldt, Leopoldo Luistro, Diana Chin, Melissa Smith, Amy Wong, Margarita Romero, Aleksandra Rizo, Jacqueline Bussolari, Fei Huang, Amy (Kate) Sasser
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1101.
https://doi.org/10.1158/1538-7445.AM2017-1101
Published: 01 July 2017
View article titled, Abstract 1101: Telomerase inhibitor imetelstat in combination with the BCL-2 inhibitor venetoclax enhances apoptosis <em>in vitro</em> and increases survival <em>in vivo</em> in acute myeloid leukemia
Journal Articles

Abstract 2732: Myelosuppression in patients treated with the telomerase inhibitor imetelstat is not mediated through activation of toll-like receptors

Gabriela M. Baerlocher, Joshua Rusbuldt, Fei Huang, Jacqueline Bussolari
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2732.
https://doi.org/10.1158/1538-7445.AM2016-2732
Published: 15 July 2016
View article titled, Abstract 2732: Myelosuppression in patients treated with the telomerase inhibitor imetelstat is not mediated through activation of toll-like receptors
Journal Articles

Abstract 2731: Impact of hypomethylating agents on hTERT expression and synergistic effect in combination with imetelstat, a telomerase inhibitor, in AML cell lines

Joshua Rusbuldt, Jacqueline Bussolari, Aleksandra Rizo, Fei Huang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2731.
https://doi.org/10.1158/1538-7445.AM2016-2731
Published: 15 July 2016
View article titled, Abstract 2731: Impact of hypomethylating agents on hTERT expression and synergistic effect in combination with imetelstat, a telomerase inhibitor, in AML cell lines
Journal Articles

Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages

Jun-Long Zhao, Fei Huang, Fei He, Chun-Chen Gao, Shi-Qian Liang, Peng-Fei Ma, Guang-Ying Dong, Hua Han, Hong-Yan Qin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (6): 1403–1415.
https://doi.org/10.1158/0008-5472.CAN-15-2019
Published: 14 March 2016
View article titled, Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages
Open the PDF for Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages in another window
Includes: Supplementary data
Journal Articles

Abstract 2163: Increased overall survival in platinum-resistant ovarian cancer: paradigmatic use of novel SINE (selective inhibitor of nuclear export), which restores p53 nuclear localization and activation.

Ying Chen, Eva Kalir, Catalina Camacho-Vanegas, Fei Huang, Elena Pereira, Yosef Landesman, Dilara McCauley, Mansoor Raza Mirza, Michael Kauffman, Sharon Shacham, Peter R. Dottino, John A. Martignetti
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2163.
https://doi.org/10.1158/1538-7445.AM2013-2163
Published: 15 April 2013
View article titled, Abstract 2163: Increased overall survival in platinum-resistant ovarian cancer: paradigmatic use of novel SINE (selective inhibitor of nuclear export), which restores p53 nuclear localization and activation.
Journal Articles

Abstract 5396: Interferon-α receptor dependent and independent inhibition of type I interferon production in plasmacytoid dendritic cells from mice and melanoma patients

Xue-Fei Huang, Alexander Gelbard, Haiyan S. Li, Tania G. Rodríguez-Cruz, Yanyan Lou, Chengwen Liu, Yared Hailemichael, Vashisht G Yennu Nanda, Michael A. Davies, Yong-Jun Liu, Stephanie S. Watowich, Willem W. Overwijk
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5396.
https://doi.org/10.1158/1538-7445.AM2012-5396
Published: 15 April 2012
View article titled, Abstract 5396: Interferon-α receptor dependent and independent inhibition of type I interferon production in plasmacytoid dendritic cells from mice and melanoma patients
Journal Articles

Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

Xiaonan Hou, Fei Huang, Luciana F. Macedo, Sean C. Harrington, Karen A. Reeves, Ann Greer, Friedrich Graf Finckenstein, Angela Brodie, Marco M. Gottardis, Joan M. Carboni, Paul Haluska
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7597–7607.
https://doi.org/10.1158/0008-5472.CAN-11-1080
Published: 15 December 2011
View article titled, Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
Open the PDF for Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4125: Identification of candidate predictive biomarkers for the cdc7 kinase inhibitor BMS-863233/XL413

William J. Geese, Guan Xing, Beihong Hu, Heshani DeSilva, Simone Oppenheimer, Craig Fairchild, Bruce Rowley, Petra Ross-MacDonald, Joseph Fargnoli, Adrian Woolfson, Fei Huang
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4125.
https://doi.org/10.1158/1538-7445.AM2011-4125
Published: 15 April 2011
View article titled, Abstract 4125: Identification of candidate predictive biomarkers for the cdc7 kinase inhibitor BMS-863233/XL413
Journal Articles

Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model

Fei Huang, Warren Hurlburt, Ann Greer, Karen A. Reeves, Stephen Hillerman, Han Chang, Joseph Fargnoli, Friedrich Graf Finckenstein, Marco M. Gottardis, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2010) 70 (18): 7221–7231.
https://doi.org/10.1158/0008-5472.CAN-10-0391
Published: 14 September 2010
View article titled, Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model
Open the PDF for Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model in another window
Includes: Supplementary data
Journal Articles

Abstract 3752: Folate receptor expression prevalence across multiple tumor types and concordance between matched primary and metastatic tumor pairs

Hewei Li, Qiuyan Wu, Guan Xing, Vic Teslenko, Jan Van Tornout, Christoph M. Ahlers, Fei Huang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3752.
https://doi.org/10.1158/1538-7445.AM10-3752
Published: 15 April 2010
View article titled, Abstract 3752: Folate receptor expression prevalence across multiple tumor types and concordance between matched primary and metastatic tumor pairs
Journal Articles

Abstract 363: Therapeutic targeting of insulin receptor-A with a dual IGF-1R/IR inhibitor: Overcoming a potential escape mechanism from IGF-1R-specific signaling inhibition in insulin receptor-A transfected cancer cells

Stephen M. Hillerman, Ann F. Greer, Warren Hurlburt, Fei Huang, Karen Reeves, Rolf Ryseck, Friedrich Graf Finckenstein, Arindam Dhar, Robert A. Kramer, Marco M. Gottardis, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 363.
https://doi.org/10.1158/1538-7445.AM10-363
Published: 15 April 2010
View article titled, Abstract 363: Therapeutic targeting of insulin receptor-A with a dual IGF-1R/IR inhibitor: Overcoming a potential escape mechanism from IGF-1R-specific signaling inhibition in insulin receptor-A transfected cancer cells
Journal Articles

Abstract 2697: Analysis of the correlation between gene expression of IGF-pathway components and benefit from cetuximab (Erbitux™) in metastatic colorectal cancer patients

Fei Huang, Li-An Xu, Shirin Khambata-Ford
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2697.
https://doi.org/10.1158/1538-7445.AM10-2697
Published: 15 April 2010
View article titled, Abstract 2697: Analysis of the correlation between gene expression of IGF-pathway components and benefit from cetuximab (Erbitux™) in metastatic colorectal cancer patients
Journal Articles

KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model

Analisa DiFeo, Fei Huang, Jaya Sangodkar, Esteban A. Terzo, Devin Leake, Goutham Narla, John A. Martignetti
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4733–4741.
https://doi.org/10.1158/0008-5472.CAN-08-4282
Published: 01 June 2009
View article titled, KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model
Open the PDF for KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model in another window
Includes: Supplementary data
Journal Articles

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Fei Huang, Ann Greer, Warren Hurlburt, Xia Han, Rameh Hafezi, Gayle M. Wittenberg, Karen Reeves, Jiwen Chen, Douglas Robinson, Aixin Li, Francis Y. Lee, Marco M. Gottardis, Edwin Clark, Lee Helman, Ricardo M. Attar, Ashok Dongre, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2009) 69 (1): 161–170.
https://doi.org/10.1158/0008-5472.CAN-08-0835
Published: 31 December 2008
View article titled, The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
Open the PDF for The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors in another window
Includes: Supplementary data
Journal Articles

Essential role of KLF6-SV1 in regulating tumor cell apoptosis and greatly increasing median and overall ovarian cancer survival: identification and pre-clinical targeting of a novel prosurvival/anti-apoptotic protein

Analisa DiFeo, Goutham Narla, Fei Huang, Esteban Terzo, Devin Leake, John Martignetti
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2549.
Published: 01 May 2008
View article titled, Essential role of KLF6-SV1 in regulating tumor cell apoptosis and greatly increasing median and overall ovarian cancer survival: identification and pre-clinical targeting of a novel prosurvival/anti-apoptotic protein
Journal Articles

KLF6-SV1 accelerates prostate cancer progression and metastasis

Goutham Narla, Analisa DiFeo, Yolanda Fernandez, Saravana Dhanasekaran, Fei Huang, Jaya Sangodkar, Eldad Hod, Devin Leake, Scott Friedman, Simon Hall, Arul Chinnaiyan, William Gerald, Mark Rubin, John Martignetti
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 349.
Published: 01 May 2008
View article titled, KLF6-SV1 accelerates prostate cancer progression and metastasis
Journal Articles

Aurora-A, a Negative Prognostic Marker, Increases Migration and Decreases Radiosensitivity in Cancer Cells

Zhong Guan, Xian-ren Wang, Xiao-feng Zhu, Xue-fei Huang, Jie Xu, Li-hui Wang, Xiang-bo Wan, Zi-jie Long, Jian-nan Liu, Gong-kan Feng, Wenlin Huang, Yi-xin Zeng, Fu-jin Chen, Quentin Liu
Journal: Cancer Research
Cancer Res (2007) 67 (21): 10436–10444.
https://doi.org/10.1158/0008-5472.CAN-07-1379
Published: 01 November 2007
View article titled, Aurora-A, a Negative Prognostic Marker, Increases Migration and Decreases Radiosensitivity in Cancer Cells
Open the PDF for Aurora-A, a Negative Prognostic Marker, Increases Migration and Decreases Radiosensitivity in Cancer Cells in another window
Includes: Supplementary data