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Journal Articles

Abstract 369: A novel class of multitarget small molecule PI3K-CDK4/6-CDK9-AURAKA/B inhibitor harnesses Warburg effect against non-small cell lung cancer

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Anna V. Ivanina Foureau, Cody C. McHale, Hailey L. Dryden, Krishnaiah Maddeboina, David M. Foureau, Fei Guo, Donald L. Durden, Kathryn F. Mileham
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 369.
https://doi.org/10.1158/1538-7445.AM2025-369
Published: 21 April 2025
View article titled, Abstract 369: A novel class of multitarget small molecule PI3K-CDK4/6-CDK9-AURAKA/B inhibitor harnesses Warburg effect against non-small cell lung cancer
Journal Articles

Abstract 1976: Targeting metabolism in non-small cell lung cancer (NSCLC) with the novel multitarget small molecule PI3K-CDK4/6-CDK9 inhibitor LCI139

Free
Cody C. McHale, Anna V. Ivanina Foureau, Hailey L. Dryden, Krishnaiah Maddeboina, Dhananjaya Pal, Bharath Yada, Page Mangum Arditti, Fei Guo, Kathryn F. Mileham, David M. Foureau, Donald L. Durden
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1976.
https://doi.org/10.1158/1538-7445.AM2024-1976
Published: 22 March 2024
View article titled, Abstract 1976: Targeting metabolism in non-small cell lung cancer (NSCLC) with the novel multitarget small molecule PI3K-CDK4/6-CDK9 inhibitor LCI139
Journal Articles

Abstract 1772: A novel approach for autologous pan-cancer cellular immunotherapy reveals dramatic expansion of ab and gd TCR T cell clonotypes indicative of an antigen-driven response

Free
Frank Borriello, Joshua W. Keegan, Brandon L. Hancock, Fei Guo, James R. Lederer
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1772.
https://doi.org/10.1158/1538-7445.AM2021-1772
Published: 01 July 2021
View article titled, Abstract 1772: A novel approach for autologous pan-cancer cellular immunotherapy reveals dramatic expansion of ab and gd TCR T cell clonotypes indicative of an antigen-driven response
Journal Articles

Abstract 1509: Identification of immunotherapy resistance mechanisms within tumor microenvironment in a mouse model of oral squamous cell carcinoma

Free
Liye Zhou, Yasutaka Nakahori, Fei Guo, Joshua Keegan, Rachel Riley, James A. Lederer, Ravindra Uppaluri
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1509.
https://doi.org/10.1158/1538-7445.AM2019-1509
Published: 01 July 2019
View article titled, Abstract 1509: Identification of immunotherapy resistance mechanisms within tumor microenvironment in a mouse model of oral squamous cell carcinoma
Journal Articles

Abstract LB-466: Genomic Loss of microRNA 491 contributes to IGFBP2 overexpression and stemness in GBM

Free
Xia Li, Yuexin Liu, Ping Ji, Yingxuan Chua, Limei Hu, Fei Guo, Yan Sun, Frederick Lang, Wei Zhang
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-466.
https://doi.org/10.1158/1538-7445.AM2012-LB-466
Published: 15 April 2012
View article titled, Abstract LB-466: Genomic Loss of microRNA 491 contributes to IGFBP2 overexpression and stemness in GBM
Journal Articles

Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin

Free
Fei Guo, Kathy Rocha, Purva Bali, Michael Pranpat, Warren Fiskus, Sandhya Boyapalle, Sandhya Kumaraswamy, Maria Balasis, Benjamin Greedy, E. Simon M. Armitage, Nicholas Lawrence, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2005) 65 (22): 10536–10544.
https://doi.org/10.1158/0008-5472.CAN-05-1799
Published: 15 November 2005
View article titled, Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin
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Journal Articles

Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Free
Fei Guo, Celia Sigua, Purva Bali, Michael Pranpat, Warren Fiskus, Nicholas Lawrence, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 771.
Published: 01 May 2005
View article titled, Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)
Journal Articles

Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Free
Purva Bali, Fei Guo, Warren Fiskus, Michael Pranpat, Celia Sigua, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 769–770.
Published: 01 May 2005
View article titled, Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins
Journal Articles

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Free
Prince George, Purva Bali, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Warren Fiskus, Anna Scuto, Srinivas Annavarapu, Lynn Moscinski, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2004) 64 (10): 3645–3652.
https://doi.org/10.1158/0008-5472.CAN-04-0006
Published: 17 May 2004
View article titled, Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3
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Journal Articles

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Free
Fei Guo, Celia Sigua, Jianguo Tao, Purva Bali, Prince George, Yunqing Li, Sylvie Wittmann, Lynn Moscinski, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2004) 64 (7): 2580–2589.
https://doi.org/10.1158/0008-5472.CAN-03-2629
Published: 01 April 2004
View article titled, Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells
Open the PDF for Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells in another window
Journal Articles

Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-xL and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Free
Fei Guo, Celia Sigua, Purva Bali, Prince George, Ravi Gutti, Yunqing Li, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 135–136.
Published: 01 April 2004
View article titled, Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-xL and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells
Journal Articles

A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Free
Ravi Gutti, Prince George, Purva Bali, Jianguo Tao, Fei Guo, Celia Sigua, Yunqing Li, Lynn Moscinski, Peter Atadja, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 699.
Published: 01 April 2004
View article titled, A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.
Journal Articles

Arsenic Trioxide Inhibits Translation of mRNA of bcr-abl , Resulting in Attenuation of Bcr-Abl Levels and Apoptosis of Human Leukemia Cells

Free
Ramadevi Nimmanapalli, Purva Bali, Erica O’Bryan, Lianne Fuino, Fei Guo, Jie Wu, Peter Houghton, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2003) 63 (22): 7950–7958.
Published: 21 November 2003
View article titled, Arsenic Trioxide Inhibits Translation of mRNA of bcr-abl , Resulting in Attenuation of Bcr-Abl Levels and Apoptosis of Human Leukemia Cells
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Journal Articles

Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis

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Sylvie Wittmann, Purva Bali, Sreenivasa Donapaty, Ramadevi Nimmanapalli, Fei Guo, Hirohito Yamaguchi, Mei Huang, Richard Jove, Hong Gang Wang, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2003) 63 (1): 93–99.
Published: 01 January 2003
View article titled, Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis
Open the PDF for Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis in another window