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Abstract 363: Exploiting Rb-deficiency: Dual inhibition of TRIP13 and Aurora A as a path to mitotic catastrophe

Lacin Yapindi, Soma Ghosh, Li Shen, Jing Wang, Faye M. Johnson

Cancer Res (2025) 85 (8_Supplement_1): 363.

https://doi.org/10.1158/1538-7445.AM2025-363

Published: 21 April 2025

View articletitled, Abstract 363: Exploiting Rb-deficiency: Dual inhibition of TRIP13 and Aurora A as a path to mitotic catastrophe

Journal Articles

Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment

Soma Ghosh, Madison P. O’Hara, Tuhina Mazumdar, Lacin Yapindi, Li Shen, Jing Wang, Mitchell J. Frederick, Jagannadha K. Sastry, Faye M. Johnson

Cancer Res (2025) 85 (8_Supplement_1): 3094.

https://doi.org/10.1158/1538-7445.AM2025-3094

Published: 21 April 2025

View articletitled, Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment

Journal Articles

Abstract PR007: The combination of TRIP13 and Aurora kinase A inhibition caused cell cycle specific DNA damage and death in Rb-deficient cancers

Lacin Yapindi, Soma Ghosh, Tuhina Mazumdar, Faye M. Johnson

Cancer Res (2024) 84 (1_Supplement): PR007.

https://doi.org/10.1158/1538-7445.DNAREPAIR24-PR007

Published: 09 January 2024

View articletitled, Abstract PR007: The combination of TRIP13 and Aurora kinase A inhibition caused cell cycle specific DNA damage and death in Rb-deficient cancers

Journal Articles

Abstract 1564: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Soma Ghosh, Tuhina Mazumdar, Lacin Yapindi, Pragya Sinha, Jagannadha Sastry, Faye M. Johnson

Cancer Res (2023) 83 (7_Supplement): 1564.

https://doi.org/10.1158/1538-7445.AM2023-1564

Published: 04 April 2023

View articletitled, Abstract 1564: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Journal Articles

Abstract 5021: Preclinical evaluation of immunomodulatory effects of aurora kinase inhibition in HPV+ cancers

Pragya Sinha, Soma Ghosh, Faye M. Johnson, Jagannadha K. Sastry

Cancer Res (2023) 83 (7_Supplement): 5021.

https://doi.org/10.1158/1538-7445.AM2023-5021

Published: 04 April 2023

View articletitled, Abstract 5021: Preclinical evaluation of immunomodulatory effects of aurora kinase inhibition in HPV+ cancers

Journal Articles

Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1^MUT HNSCC

Pooja A. Shah, Tuhina Mazumdar, Reid T. Powell, Li Shen, Jing Wang, Clifford C. Stephen, Mitchell J. Frederick, Faye M. Johnson

Cancer Res (2023) 83 (7_Supplement): 2847.

https://doi.org/10.1158/1538-7445.AM2023-2847

Published: 04 April 2023

View articletitled, Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1MUT HNSCC

Journal Articles

Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Pooja A. Shah, Vaishnavi Sambandam, Anne M. Fernandez, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Qi Wang, Kazi M. Ahmed, Soma Ghosh, Mitchell J. Frederick, Jing Wang, Faye M. Johnson

Cancer Res (2022) 82 (23): 4444–4456.

https://doi.org/10.1158/0008-5472.CAN-22-1175

Published: 02 December 2022

View articletitled, Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Includes: Supplementary data

Journal Articles

Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T. Powell, Clifford Stephan, Li Shen, Curtis R. Pickering, Jing Wang, Faye M. Johnson

Cancer Res (2022) 82 (12_Supplement): 1858.

https://doi.org/10.1158/1538-7445.AM2022-1858

Published: 15 June 2022

View articletitled, Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

Journal Articles

Abstract 5733: Targeting nonsense-mediated decay restores p53 function in HPV-associated head and neck cancers

Jayanthi Gudikote, Tina Cascone, Alissa Poteete, Piyada Sitthideatphaiboon, Sonia Patel, Yan Yang, Fahao Zhang, Lerong Li, Li Shen, Monique Nilsson, Phillip Jones, Jing Wang, Jean-Christophe Bourdon, Faye M. Johnson, John V. Heymach

Cancer Res (2022) 82 (12_Supplement): 5733.

https://doi.org/10.1158/1538-7445.AM2022-5733

Published: 15 June 2022

View articletitled, Abstract 5733: Targeting nonsense-mediated decay restores p53 function in HPV-associated head and neck cancers

Journal Articles

Abstract 3251: Aurora kinase B expression shields HNSCC from PI3K inhibition-induced apoptosis through downstream mediators AKT and PDK1

Pooja A. Shah, Anne M. Fernandez, Vaishnavi Sambandam, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Jing Wang, Faye M. Johnson

Cancer Res (2022) 82 (12_Supplement): 3251.

https://doi.org/10.1158/1538-7445.AM2022-3251

Published: 15 June 2022

View articletitled, Abstract 3251: Aurora kinase B expression shields HNSCC from PI3K inhibition-induced apoptosis through downstream mediators AKT and PDK1

Journal Articles

Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC

Pooja A. Shah, Tuhina Mazumdar, Reid T. Powell, Li Shen, Jing Wang, Clifford C. Stephen, Mitchell J. Frederick, Faye M. Johnson

Cancer Res (2021) 81 (13_Supplement): 369.

https://doi.org/10.1158/1538-7445.AM2021-369

Published: 01 July 2021

View articletitled, Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC

Journal Articles

Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers

Tuhina Mazumdar, Li Shen, Wei Xu, Soma Ghosh, Reid T. Powell, Clifford Stephan, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson

Cancer Res (2021) 81 (13_Supplement): 368.

https://doi.org/10.1158/1538-7445.AM2021-368

Published: 01 July 2021

View articletitled, Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers

Journal Articles

Abstract 1662: In vivo drug response evaluation in anaplastic thyroid cancer patient-derived tumor xenografts following high-throughput screening

Anastasios Maniakas, Abdallah S. Mohamed, Ying C. Henderson, Hu Hei, Shaohua Peng, Diana Bell, Michelle D. Williams, Steve Scherer, David A. Wheeler, Gary L. Clayman, Mark Zafereo, Jennifer R. Wang, Maria E. Cabanillas, Clifford Stephan, Faye M. Johnson, Stephen Y. Lai

Cancer Res (2020) 80 (16_Supplement): 1662.

https://doi.org/10.1158/1538-7445.AM2020-1662

Published: 15 August 2020

View articletitled, Abstract 1662: In vivo drug response evaluation in anaplastic thyroid cancer patient-derived tumor xenografts following high-throughput screening

Journal Articles

Abstract 4942: Variations in HPV function are associated with patient outcome and identify new candidate therapeutic approaches

Frederico O. Gleber-Netto, Meng Gao, Xiayu Rao, Christopher P. Vellano, Joseph R. Marszalek, Jing Wang, Faye M. Johnson, Curtis R. Pickering

Cancer Res (2019) 79 (13_Supplement): 4942.

https://doi.org/10.1158/1538-7445.AM2019-4942

Published: 01 July 2019

View articletitled, Abstract 4942: Variations in HPV function are associated with patient outcome and identify new candidate therapeutic approaches

Journal Articles

Abstract 4621: Risk stratification and biomarker discovery in HPV-positive oropharynx squamous cell carcinoma determined by HPV and human gene expression profile associations

Frederico O. Gleber-Netto, Xiayu Rao, Kelly Erikson, Keiko Akagi, Faye M. Johnson, Jing Wang, Joseph Califano, Maura L. Gillison, Jeffrey N. Myers, Curtis R. Pickering

Cancer Res (2018) 78 (13_Supplement): 4621.

https://doi.org/10.1158/1538-7445.AM2018-4621

Published: 01 July 2018

View articletitled, Abstract 4621: Risk stratification and biomarker discovery in HPV-positive oropharynx squamous cell carcinoma determined by HPV and human gene expression profile associations

Journal Articles

Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells

Vaishnavi Sambandam, Li Shen, Pan Tong, Shaohua Peng, Tuhina Mazumdar, Ratnakar Singh, Curtis R. Pickering, Jeffrey N. Myers, Jing Wang, Mitchell Frederick, Faye M. Johnson

Cancer Res (2018) 78 (13_Supplement): 2977.

https://doi.org/10.1158/1538-7445.AM2018-2977

Published: 01 July 2018

View articletitled, Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells

Journal Articles

Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

Tuhina Mazumdar, Nene N. Kalu, Shaohua Peng, Pan Tong, Li Shen, Jing Wang, Jeffrey N. Myers, Curtis R. Pickering, David Brunell, Clifford C. Stephan, Faye M. Johnson

Cancer Res (2018) 78 (13_Supplement): 4646.

https://doi.org/10.1158/1538-7445.AM2018-4646

Published: 01 July 2018

View articletitled, Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

Journal Articles

Abstract 895: Noncanonical c-Met activation mediates de novo and acquired resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer

Ratnakar Singh, Pavitra Viswanath, Shaohua Peng, Vaishnavi Sambandam, Li Shen, Lerong Li, Jing Wang, Bingliang Fang, Faye M. Johnson

Cancer Res (2018) 78 (13_Supplement): 895.

https://doi.org/10.1158/1538-7445.AM2018-895

Published: 01 July 2018

View articletitled, Abstract 895: Noncanonical c-Met activation mediates de novo and acquired resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer

Journal Articles

CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Cancer Res (2018) 78 (3): 781–797.

https://doi.org/10.1158/0008-5472.CAN-17-2802

Published: 31 January 2018

View articletitled, CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Includes: Supplementary data

Journal Articles

Abstract 3816: Mutations of the lim protein ajuba mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell cycle inhibitors

Ming Zhang, Singh Ratnakar, Shaohua Peng, Mazumdar Tuhina, Shen Li, Pan Tong, Curtis Pickering, Jeffrey N. Myers, Jing Wang, Faye M. Johnson

Cancer Res (2017) 77 (13_Supplement): 3816.

https://doi.org/10.1158/1538-7445.AM2017-3816

Published: 01 July 2017

View articletitled, Abstract 3816: Mutations of the lim protein ajuba mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell cycle inhibitors

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Abstract 363: Exploiting Rb-deficiency: Dual inhibition of TRIP13 and Aurora A as a path to mitotic catastrophe

Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment

Abstract PR007: The combination of TRIP13 and Aurora kinase A inhibition caused cell cycle specific DNA damage and death in Rb-deficient cancers

Abstract 1564: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Abstract 5021: Preclinical evaluation of immunomodulatory effects of aurora kinase inhibition in HPV+ cancers

Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1^MUT HNSCC

Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

Abstract 5733: Targeting nonsense-mediated decay restores p53 function in HPV-associated head and neck cancers

Abstract 3251: Aurora kinase B expression shields HNSCC from PI3K inhibition-induced apoptosis through downstream mediators AKT and PDK1

Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC

Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers

Abstract 1662: In vivo drug response evaluation in anaplastic thyroid cancer patient-derived tumor xenografts following high-throughput screening

Abstract 4942: Variations in HPV function are associated with patient outcome and identify new candidate therapeutic approaches

Abstract 4621: Risk stratification and biomarker discovery in HPV-positive oropharynx squamous cell carcinoma determined by HPV and human gene expression profile associations

Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells

Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

Abstract 895: Noncanonical c-Met activation mediates de novo and acquired resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer

CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Abstract 3816: Mutations of the lim protein ajuba mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell cycle inhibitors

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