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Journal Articles

Abstract 5590: Inhibition of the autophagy protein Vps34 induces tumor cell secretion of proinflammatory chemokines

Marie Bernardo, Yu-an Zhang, Martin Graf, Jane Cheng, Fangxian Sun, Virna Cortez-Retamozo, Sukhvinder Sidhu, Eladio Marquez, Donald Jackson, Jack Pollard, Timothy R. Wagenaar, Donald Shaffer
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5590.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5590
Published: 15 June 2022
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Abstract P4-02-08: Amcenestrant in combination with CDK4/6 inhibitor palbociclib demonstrates synergistic anti-tumor activity in ER+ endocrine-resistant breast cancer xenograft models

Maysoun Shomali, Zhuyan Guo, Jane Cheng, Amy Sullivan, Youssef El-Ahmad, Fangxian Sun, Sukhvinder Sidhu, Joon Sang Lee, Hui Cai, Jack Pollard, Laurent Debussche, Chris Soria, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-02-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P4-02-08
Published: 15 February 2022
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Journal Articles

Abstract 2712: Donor selection strategies to optimize humanized mouse models for the evaluation of T cell engagers

Liqing Cheng, Jane Chen, Qunyan Yu, Natalia Malkova, Virna F. Cortez-Retamozo, Fangxian Sun, Sukhvinder Sidhu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2712.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2712
Published: 01 July 2021
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Journal Articles

Abstract 1590: An experimental tumor model resistant to anti-PD-1 is sensitive to local mRNA immunotherapy

Marie Bernardo, Tatiana Tolstykh, Yu-an Zhang, Dinesh S. Bangari, Hui Cao, Kerstin A. Heyl, Joon Sang Lee, Natalia Malkova, Jack Pollard, Hui Qu, Fangxian Sun, Dmitri Wiederschain, Timothy R. Wagenaar
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1590.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1590
Published: 01 July 2021
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Journal Articles

Abstract 739: Preclinical and clinical activity of SAR439859, Amcenestrant, a next generation SERD

Maysoun Shomali, Fangxian Sun, Laurent Besret, Anne Caron, Joon Sang Lee, Youssef El-Ahmed, Laurent Schio, Jack Pollard, Vasiliki Pelekanou, Patrick Cohen, Marina Celanovic, Christina Herold, Chris Soria, Laurent Debussche, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 739.
DOI: https://doi.org/10.1158/1538-7445.AM2021-739
Published: 01 July 2021
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Journal Articles

Abstract PS17-16: Sar439859, a novel selective estrogen receptor degrader (serd), demonstrates effective and broad antitumor activity in wild-type and mutant er-positive breast cancer models

Maysoun Shomali, Fangxian Sun, Mikhail Levit, Jack Pollard, Joon Sang Lee, Laurent Schio, Youssef El-Ahmad, Chris Soria, Patrick Cohen, Laurent Debussche, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-16.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS17-16
Published: 15 February 2021
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Journal Articles

Abstract 1377: Identification and validation of WRN as a novel synthetic lethality target in context of microsatellite instability

Zhihu (Jeff) Ding, Jing Zhang, Chandra Sekhar Pedamallu, Steve Rowley, Jane Cheng, Shujia Dai, Bridget Zhou, Malvika Koundinya, Zhuyan Guo, Stephane Poirier, Joern Hopke, Amanda Lennon, Jennifer Buell, May Cindhuchao, Karen Wong, Emma Wang, Alexei Protopopov, Bailin Zhang, Dietmar Hoffmann, Fangxian Sun, Jack Pollard, Laurent Debussche, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1377.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1377
Published: 15 August 2020
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Journal Articles

Abstract 3452: Pre-clinical development of next generation selective estrogen receptor degrader - SAR439859

Fangxian Sun, Jane Cheng, Amy Sullivan, Natalia Malkova, Maysoun Shomali, Jesseca McManus, Mikhail Levit, Dinesh Bangari, Youssef El-Ahmad, Sukhvinder Sidhu, Laurent Debussche, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3452.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3452
Published: 15 August 2020
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Journal Articles

Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models

Timothy R. Wagenaar, Christian Hotz, Friederike Gieseke, Hui Cao, Jan Diekmann, Mustafa Diken, Christian Grunwitz, Andy Hebert, Karl Hsu, Marie Jordan, Katalin Kariko, Sebastian Kreiter, Andreas N. Kuhn, Mikhail Levit, Natalia Malkova, Serena Masciari, Jack Pollard, Hui Qu, Abderaouf Selmi, Julia Schlereth, Fangxian Sun, Bodo Tillmann, Tatiana Tolstykh, Lena Wicke, Sonja Witzel, Qunyan Yu, Yu-An Zhang, Gang Zheng, Gary Nabel, Joanne Lager, Ugur Sahin, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-130.
DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-130
Published: 01 July 2018
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Journal Articles

Abstract 5550: Translational biomarkers for SAR439459, an anti-TGFβ antibody for cancer immunotherapy

Joachim Theilhaber, Jean Cavallo, Stephen L. Madden, Charlene Manning, Sherry Cao, Parminder Mankoo, Robert Pomponio, Hongjing Qu, Natalia Malkova, Gary Shapiro, Christopher Winter, Dmitri Wiederschain, Michele Sanicola-Nadel, Fangxian Sun, Tun Tun Lin, Richard C. Gregory, Jack Pollard
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5550.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5550
Published: 01 July 2018
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Journal Articles

Abstract 5775: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER+ breast cancer models

Maysoun Shomali, Youssef El-Ahmad, Frank Halley, Jane Cheng, Michael Weinstein, Muchun Wang, Fangxian Sun, Natalia Malkova, Mikhail Levit, Malvika Koundinya, Zhuyan Gou, Andrew Hebert, Jessica McManus, Dietmar Hoffman, Hui Cao, Joonil Jung, Jack Pollard, Sylvie Vincent, Timothy Ackerson, Francisco Adrian, Chris Winter, Victoria Richon, Hong Chen, Karl Hsu, Joanne Lager, Albane Courjaud, Rosalia Arrebola, Laurent Besret, Pierre-Yves Abecassis, Laurent Schio, Gary McCort, Michel Tabart, Victor Certal, Fabienne Thompson, Bruno Filoche-Rommé, Laurent Debussche, Patrick Cohen, Carlos Garcia-Echeverria, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5775.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5775
Published: 01 July 2018
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Journal Articles

Abstract 2790: The anti-TGFβ neutralizing antibody, SAR439459, blocks the immunosuppressive effects of TGFβ and inhibits the growth of syngeneic tumors in combination with anti-PD1

Richard C. Gregory, Rita Greco, Hongjing Qu, Natalia Malkova, Mikhail Levit, Keli Perron, Waldemar Racki, Fangxian Sun, Gary Shapiro, Christopher Winter, Dmitri Wiederschain, Tun Tun Lin, Jack Pollard
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2790.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2790
Published: 01 July 2018
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Journal Articles

Abstract 2489: Sensitivity of liver cancer cell lines to B-catenin knock-down correlates with pathway activation

Zhihu (Jeff) Ding, Chaomei Shi, Lan Jiang, Tatiana Tolstykh, Hui Cao, Dinesh Bangari, Susan Ryan, Taiguang Jin, Mikhail Levit, Karl Mamaat, Qunyan Yu, Hui Qu, Joern Hopke, May Cindhuchao, Dietmar Hoffmann, Fangxian Sun, Mike Helms, Kerstin Jahn-Hofmann, Sabine Scheidler, Douglas Fang, Liang Schweizer, Jack Pollard, Christopher Winter, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2489.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2489
Published: 01 July 2018
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Journal Articles

Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer

Monsif Bouaboula, Maysoun Shomali, Jane Cheng, Natalia Malkova, Fangxian Sun, Malvika Koundinya, Zhuyan Guo, Stephane Poirier, Mikhail Levit, Dietmar Hoffman, Hui Cao, Laurent Bestret, Francisco Adrian, Christoph Winter, Youssef El-Ahmad, Sylvie Vincent, Frank Halley, Gary McCort, Laurent Schio, Vicky Richon, Hong Cheng, Karl Hsu, Chris Soria, Patrick Cohen, Joanne Lager, Carlos Garcia-Echeverria, Laurent Debussche
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 943.
DOI: https://doi.org/10.1158/1538-7445.AM2018-943
Published: 01 July 2018
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Journal Articles

Abstract 4787: Targeting miR-21 in hepatocellular carcinoma

Sonya Zabludoff, Timothy Wagenaar, Francisco Adrian, Charles Allerson, Heike Arlt, Raffaele Baffa, Bal Bhat, Hui Cao, Scott Davis, Carlos Garcia-Echeverria, Kathrin Heermeier, Shih-Min Huang, Lan Jiang, Eric Marcusson, Christiane Metz-Weidmann, Adam Pavlicek, Jack Pollard, Jennifer Rocnik, Sabine Scheidler, Chaomei Shi, Fangxian Sun, Tatiana Tolstykh, Qunyan Yu, Gang Zheng, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4787.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4787
Published: 01 October 2014
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Journal Articles

Abstract 2435: Anticipating clinical resistance to SAR302503, a JAK2 inhibitor in clinical development for the treatment of myelofibrosis.

Raelene Hurley, Rita Greco, Fangxian Sun, Anlai Wang, Shih-Min A. Huang, Jenny Zhang, Claudia Lebedinsky, Pamela Cohen, Francisco Adrian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2435.
DOI: https://doi.org/10.1158/1538-7445.AM2013-2435
Published: 15 April 2013
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Abstract 1796: SAR302503: A Jak2 inhibitor with antitumor activity in solid tumor models

Rita Greco, Raelene Hurley, Fangxian Sun, Lu Yang, Qunyan Yu, Juliet Williams, Marion Dorsch, Pamela Cohen, Francisco Adrián
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1796.
DOI: https://doi.org/10.1158/1538-7445.AM2012-1796
Published: 15 April 2012
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Journal Articles

The BMX Tec family kinase mediates PI(3)-Kinase-dependent transformation in an epithelial cell line model.

Laura Peiffer, Anastasia Velentza, Auzon Acena, Wenjun Zhou, Fangxian Sun, Nathanael Gray, Markus Warmuth
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5224.
Published: 01 May 2008
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Journal Articles

Optimal cell density plays a critical role in the hollow fiber assay

AnneMarie Culazzo, Fangxian Sun
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): LB-83.
Published: 01 May 2007
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