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Journal Articles

Abstract LB129: Preclinical development of a bispecific antibody-trap selectively targeting CD38 and CD47 for treating hematologic malignancies

Wenzhi Tian, Song Li, Dianze Chen, Yanan Yang, Huiqin Guo, Dandan Liu, Ruliang Zhang, Fan Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB129.
https://doi.org/10.1158/1538-7445.AM2024-LB129
Published: 05 April 2024
View article titled, Abstract LB129: Preclinical development of a bispecific antibody-trap selectively targeting CD38 and CD47 for treating hematologic malignancies
Journal Articles

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Chun-Miao Deng, Guo-Geng Zhang, Qin-Wen Liu, Jiao-Jiao Xu, Zhi-Chao Liu, Jing Yang, Tao-Yang Xu, Zhi-Gang Li, Fan Zhang, Bin Li
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1851–1865.
https://doi.org/10.1158/0008-5472.CAN-22-3490
Published: 02 June 2023
View article titled, ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis
Open the PDF for ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 5292: Characterization of androgen receptor properties and interactome in mediating transcriptional condensates in prostate cancer

Nicholas C. Pinette, Shabnam Massah, Sofia Kochkina, Fan Zhang, Maitree Biswas, Joseph Lee, Jörg Gsponer, Nada Lallous
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5292.
https://doi.org/10.1158/1538-7445.AM2023-5292
Published: 04 April 2023
View article titled, Abstract 5292: Characterization of androgen receptor properties and interactome in mediating transcriptional condensates in prostate cancer
Journal Articles

Abstract 1878: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2520, targeting both PD-L1 and CD47 as cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Wenqi Zhu, Yanan Yang, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang, Frank Gan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1878.
https://doi.org/10.1158/1538-7445.AM2023-1878
Published: 04 April 2023
View article titled, Abstract 1878: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2520, targeting both PD-L1 and CD47 as cancer immunotherapy
Journal Articles

Abstract 2938: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2902, targeting both HER2 and CD47 as cancer immunotherapy

Binglei Zhang, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Frank X. Gan, Wenzhi Tian, Fan Zhang, Yongping Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2938.
https://doi.org/10.1158/1538-7445.AM2023-2938
Published: 04 April 2023
View article titled, Abstract 2938: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2902, targeting both HER2 and CD47 as cancer immunotherapy
Journal Articles

Abstract 6341: Preclinical development of a monoclonal antibody targeting CD70 as cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang, Frank X. Gan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6341.
https://doi.org/10.1158/1538-7445.AM2023-6341
Published: 04 April 2023
View article titled, Abstract 6341: Preclinical development of a monoclonal antibody targeting CD70 as cancer immunotherapy
Journal Articles

Abstract 6340: Preclinical development of a monoclonal antibody targeting CD24 as cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang, Frank X. Gan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6340.
https://doi.org/10.1158/1538-7445.AM2023-6340
Published: 04 April 2023
View article titled, Abstract 6340: Preclinical development of a monoclonal antibody targeting CD24 as cancer immunotherapy
Journal Articles

Correction: Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation

Fan Zhang, Lihong Lou, Bo Peng, Xiaotian Song, Ofer Reizes, Alexandru Almasan, Zihua Gong
Journal: Cancer Research
Cancer Res (2022) 82 (15): 2807.
https://doi.org/10.1158/0008-5472.CAN-22-1948
Published: 03 August 2022
View article titled, Correction: Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation
Open the PDF for Correction: Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation in another window
Journal Articles

Abstract 5729: Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression

Fan Zhang, Maitree Biswas, Joseph Lee, Shreyas Lingadahalli, Samantha Wong, Christopher Wells, Neetu Saxena, Bei Sun, Ana K. Parra-Nuñez, Christophe Sanchez, Jane Foo, Novia Chan, Lauren Ung, Nabeel Khan, Umut Berkay Altıntaş, Jennifer M. Bui, Yuzhuo Wang, Ladan Fazli, Paul S. Rennie, Nathan Lack, Artem Cherkasov, Martin E. Gleave, Joerg Gsponer, Nada Lallous
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5729.
https://doi.org/10.1158/1538-7445.AM2022-5729
Published: 15 June 2022
View article titled, Abstract 5729: Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression
Journal Articles

Abstract 2367: Characterizing the reciprocal regulation of an ABI1-dependent androgen receptor axis in prostate cancer

Baylee A. Porter-Hansen, Alaji Bah, Alfonso Urbanucci, Konsta Kukkonen, Fan Zhang, Sonia Kung, Ladan Fazli, Martin E. Gleave, Gennady Bratslavsky, Leszek Kotula
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2367.
https://doi.org/10.1158/1538-7445.AM2022-2367
Published: 15 June 2022
View article titled, Abstract 2367: Characterizing the reciprocal regulation of an ABI1-dependent androgen receptor axis in prostate cancer
Journal Articles

Abstract 6281: Preclinical development of a bispecific antibody-trap selectively targeting CD47 and CD24 for cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6281.
https://doi.org/10.1158/1538-7445.AM2022-6281
Published: 15 June 2022
View article titled, Abstract 6281: Preclinical development of a bispecific antibody-trap selectively targeting CD47 and CD24 for cancer immunotherapy
Journal Articles

Abstract 6280: Preclinical development of a bispecific antibody-trap selectively targeting CD47 and HER2 for the treatment of breast as well as gastric cancer

Wenzhi Tian, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6280.
https://doi.org/10.1158/1538-7445.AM2022-6280
Published: 15 June 2022
View article titled, Abstract 6280: Preclinical development of a bispecific antibody-trap selectively targeting CD47 and HER2 for the treatment of breast as well as gastric cancer
Journal Articles

Abstract 395: Characterizing the role of chaperone-mediated autophagy in prostate cancer treatment resistance

Nicholas Nikesitch, Eliana Beraldi, Fan Zhang, Hans Adomat, Robert Bell, Ladan Fazli, Christopher Wells, Nicholas Pinette, Yuzhuo Wang, Martin Gleave
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 395.
https://doi.org/10.1158/1538-7445.AM2022-395
Published: 15 June 2022
View article titled, Abstract 395: Characterizing the role of chaperone-mediated autophagy in prostate cancer treatment resistance
Journal Articles

Abstract 6013: TST005, a bifunctional fusion protein of PD-L1/TGF-βRII, demonstrates potent anti-tumor activities with good safety profiles

Huanhuan Guo, Xinlai Yao, Chunming Wang, Linlin Mao, Hongjun Li, Shuang Lu, Di Sun, Chengwei Jiang, Shenjie Zhang, Lisa Zheng, Fan Zhang, Fei Teng, Steven Yu, Yi Gu, Xueming Qian
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6013.
https://doi.org/10.1158/1538-7445.AM2022-6013
Published: 15 June 2022
View article titled, Abstract 6013: TST005, a bifunctional fusion protein of PD-L1/TGF-βRII, demonstrates potent anti-tumor activities with good safety profiles
Journal Articles

Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation

Fan Zhang, Lihong Lou, Bo Peng, Xiaotian Song, Ofer Reizes, Alexandru Almasan, Zihua Gong
Journal: Cancer Research
Cancer Res (2020) 80 (5): 999–1010.
https://doi.org/10.1158/0008-5472.CAN-19-2205
Published: 02 March 2022
View article titled, Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation
Open the PDF for Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation in another window
Includes: Supplementary data
Journal Articles

Abstract 2470: Defining the reciprocal regulation of Abi1 and the androgen receptor in prostate cancer

Baylee A. Porter, Alaji Bah, Alfonso Urbanucci, Fan Zhang, Sonia Kung, Ladan Fazli, Martin Gleave, Gennady Bratslavsky, Leszek Kotula
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2470.
https://doi.org/10.1158/1538-7445.AM2021-2470
Published: 01 July 2021
View article titled, Abstract 2470: Defining the reciprocal regulation of Abi1 and the androgen receptor in prostate cancer
Journal Articles

Abstract 917: The preclinical characterization of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein

Hongjun Li, Chunming Wang, Huanhuan Guo, Xinlai Yao, Weiwei Sun, Di Sun, Yupeng Zhu, Xiangyu Xu, Zhenzhi Yan, Chengwei Jiang, Shengjie Zhang, Xiwen Wu, Yingdi Luo, Yadong Dai, Lisa Zheng, Fan Zhang, Fei Teng, Xueming Qian, Yi Gu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 917.
https://doi.org/10.1158/1538-7445.AM2021-917
Published: 01 July 2021
View article titled, Abstract 917: The preclinical characterization of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein
Journal Articles

Abstract 340: ABI1 and androgen dependence in prostate cancer

Leszek Kotula, Baylee A. Porter, Xiang Li, Maria A. Ortiz, Rakesh Khanna, Fan Zhang, Sonia H. Kung, Ladan Fazli, Martin E. Gleave, Gennady Bratslavsky, Jeffrey S. Ross
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 340.
https://doi.org/10.1158/1538-7445.AM2020-340
Published: 15 August 2020
View article titled, Abstract 340: ABI1 and androgen dependence in prostate cancer
Journal Articles

LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY

Rui Zhang, Fan Zhang, Zeguo Sun, Pengpeng Liu, Xiao Zhang, Yingnan Ye, Beiqi Cai, Martin J. Walsh, Xiubao Ren, Xishan Hao, Weijia Zhang, Jinpu Yu
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4453–4465.
https://doi.org/10.1158/0008-5472.CAN-19-0076
Published: 03 September 2019
View article titled, LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Open the PDF for LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY in another window
Includes: Supplementary data
Journal Articles

Abstract 4770: Programming tumor-clearing macrophages with targeted in situ gene therapy

Fan Zhang, Miacheal E. Coon, Neha N. Parayath, Sirrka B. Stephan, Smitha P. Pillai, Matthias T. Stephan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4770.
https://doi.org/10.1158/1538-7445.AM2019-4770
Published: 01 July 2019
View article titled, Abstract 4770: Programming tumor-clearing macrophages with targeted in situ gene therapy