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Journal Articles

Abstract LB074: Targeting chromatin remodeling disrupts immune suppression by pathologically activated neutrophils in cancer

Fan Yang, Yi Bao, Lanbo Xiao, Yuanyuan Qiao, Yizhi Cao, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB074.
https://doi.org/10.1158/1538-7445.AM2025-LB074
Published: 25 April 2025
View articletitled, Abstract LB074: Targeting chromatin remodeling disrupts immune suppression by pathologically activated neutrophils in cancer
Journal Articles

Abstract 1317: Lung-specific CRISPR/Cas9 delivery using sulfonium lipid nanoparticles effectively suppresses lung metastases by targeting ATAD3A

Fanghui Chen, David O. Popoola, Fan Yang, Wei Zhen, Yamin Li, Yong Teng
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1317.
https://doi.org/10.1158/1538-7445.AM2025-1317
Published: 21 April 2025
View articletitled, Abstract 1317: Lung-specific CRISPR/Cas9 delivery using sulfonium lipid nanoparticles effectively suppresses lung metastases by targeting ATAD3A
Journal Articles

Abstract 650: Enhancing antitumor immunity by inducing PANoptosis using a new generation of vesicular stomatitis virus

Fanghui Chen, Liwei Lang, Sijia Tang, Fan Yang, Nabil F. Saba, Ming Luo, Yong Teng
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 650.
https://doi.org/10.1158/1538-7445.AM2025-650
Published: 21 April 2025
View articletitled, Abstract 650: Enhancing antitumor immunity by inducing PANoptosis using a new generation of vesicular stomatitis virus
Journal Articles

Abstract 5730: Discovery of a novel antibody-drug conjugate linker-payload with a distinct killing mechanism via prolonged unfolded protein response activation

Rui Liu, Yushi Chi, Yongqiang Shan, Chenqiang Jia, Yingying Zhang, Xiayan Zhang, Wentao Zhang, Xuemei Tian, Yifan Zhang, Fan Yang, Dongmei Han, Simon Hsu, Jiamin Su, Jijun Yuan, Wan-Jen Yang, Xiaoling Yuan, Zhiyu Ma, Chen Hu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5730.
https://doi.org/10.1158/1538-7445.AM2025-5730
Published: 21 April 2025
View articletitled, Abstract 5730: Discovery of a novel antibody-drug conjugate linker-payload with a distinct killing mechanism via prolonged unfolded protein response activation
Journal Articles

Abstract 2818: Targeting PIKfyve sensitizes gastroenteropancreatic neuroendocrine tumor to mTOR inhibition by disrupting ferritinophagy and lipid homeostasis

Yizhi Cao, Yitong Yin, Caleb Cheng, Shannon VanAkon, Sarah Nicole Yee, Jacinda Jiali Liu, Yang Zheng, Andrej Coleski, Radha Paturu, Somnath Mahapatra, Fan Yang, Rupam Bhattacharyya, Rahul Mannan, Yuanyuan Qiao, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2818.
https://doi.org/10.1158/1538-7445.AM2025-2818
Published: 21 April 2025
View articletitled, Abstract 2818: Targeting PIKfyve sensitizes gastroenteropancreatic neuroendocrine tumor to mTOR inhibition by disrupting ferritinophagy and lipid homeostasis
Journal Articles

Therapeutic Targeting of the GLS1–c-Myc Positive Feedback Loop Suppresses Glutaminolysis and Inhibits Progression of Head and Neck Cancer

Jianqiang Yang, Fanghui Chen, Liwei Lang, Fan Yang, Zhenzhen Fu, Juan Martinez, Amber Cho, Nabil F. Saba, Yong Teng
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3223–3234.
https://doi.org/10.1158/0008-5472.CAN-24-0254
Published: 01 October 2024
View articletitled, Therapeutic Targeting of the GLS1–c-Myc Positive Feedback Loop Suppresses Glutaminolysis and Inhibits Progression of Head and Neck Cancer
Open the PDF for Therapeutic Targeting of the GLS1–c-Myc Positive Feedback Loop Suppresses Glutaminolysis and Inhibits Progression of Head and Neck Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO3-24-05: Cysteine metabolism related ferroptosis sensitivity in trastuzumab resistant HER2 positive breast cancer

Yongmei Yin, Yijia Hua, Ningjun Duan, Chunxiao Sun, Fan Yang
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-24-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-24-05
Published: 02 May 2024
View articletitled, Abstract PO3-24-05: Cysteine metabolism related ferroptosis sensitivity in trastuzumab resistant HER2 positive breast cancer
Journal Articles

Abstract PO1-16-03: GDP-mannose enhances the efficacy of PARP inhibitors and immunotherapy in triple-negative breast cancer

Yi Xiao, Jiahan Ding, Yi-Zhou Jiang, Zhi-Ming Shao, Genhong Di, Fan Yang, Xiaoqing Song
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-16-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-16-03
Published: 02 May 2024
View articletitled, Abstract PO1-16-03: GDP-mannose enhances the efficacy of PARP inhibitors and immunotherapy in triple-negative breast cancer
Journal Articles

Abstract PO1-04-04: Inetetamab combined with pyrotinib and oral vinorelbine for patients with HER2-positive metastatic breast cancer: a single-arm phase 2 trial

Xiang Huang, Nan Jin, Chunxiao Sun, Xueqi Yan, Fan Yang, Yan Liang, Wei Li, Yongmei Yin
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-04-04.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-04-04
Published: 02 May 2024
View articletitled, Abstract PO1-04-04: Inetetamab combined with pyrotinib and oral vinorelbine for patients with HER2-positive metastatic breast cancer: a single-arm phase 2 trial
Journal Articles

Abstract 4214: Tissue-engineered 3D model for elucidating the role of the bone niche in osteosarcoma therapy response

Abena Darkwah Peasah, Callan Monette, Jeehee Lee, Michelle Tai, E. Alejandro Sweet-Cordero, Fan Yang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4214.
https://doi.org/10.1158/1538-7445.AM2024-4214
Published: 22 March 2024
View articletitled, Abstract 4214: Tissue-engineered 3D model for elucidating the role of the bone niche in osteosarcoma therapy response
Journal Articles

Abstract 7046: Proteogenomic and immunologic profiles of head and neck cancer patients of African ancestry

Fan Yang, Fanghui Chen, Chloe Shay, Nabil F. Saba, Yong Teng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7046.
https://doi.org/10.1158/1538-7445.AM2024-7046
Published: 22 March 2024
View articletitled, Abstract 7046: Proteogenomic and immunologic profiles of head and neck cancer patients of African ancestry
Journal Articles

Abstract 3061: A positive feedback loop between GLS1 and c-Myc drives tumor aggressiveness

Jianqiang Yang, Fanghui Chen, Fan Yang, Yong Teng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3061.
https://doi.org/10.1158/1538-7445.AM2024-3061
Published: 22 March 2024
View articletitled, Abstract 3061: A positive feedback loop between GLS1 and c-Myc drives tumor aggressiveness
Journal Articles

Abstract 3859: HSP90 blockade activates antitumor immunity by suppressing tumor glycolytic flux in head and neck squamous cell carcinoma

Fanghui Chen, Chris Tang, Fan Yang, Asari Ekpenyong, Richard Qin, Nabil F. Saba, Yong Teng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3859.
https://doi.org/10.1158/1538-7445.AM2024-3859
Published: 22 March 2024
View articletitled, Abstract 3859: HSP90 blockade activates antitumor immunity by suppressing tumor glycolytic flux in head and neck squamous cell carcinoma
Journal Articles

Abstract 4939: Computational pathology approach for prognostic advancements and therapeutic benefits in gastrointestinal cancer: A multi-centric retrospective study

Taojun Zhang, Zepang Sun, Zhe Li, M. Usman Ahmad, Md Tauhidul Islam, Fan Yang, Zhenhui Li, Yuming Jiang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4939.
https://doi.org/10.1158/1538-7445.AM2024-4939
Published: 22 March 2024
View articletitled, Abstract 4939: Computational pathology approach for prognostic advancements and therapeutic benefits in gastrointestinal cancer: A multi-centric retrospective study
Journal Articles

Abstract 6772: A 3D model of breast cancer-bone metastasis to mimic dysregulation of bone remodeling and drug response

Michelle Tai, Eva C. González Díaz, Callan E. Monette, Joy Wu, Fan Yang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6772.
https://doi.org/10.1158/1538-7445.AM2024-6772
Published: 22 March 2024
View articletitled, Abstract 6772: A 3D model of breast cancer-bone metastasis to mimic dysregulation of bone remodeling and drug response
Journal Articles

Abstract 865: Single-cell sequencing identification of malignant cell subpopulations linked to recurrence in hepatocellular carcinoma

Yucheng Dong, Xin Guo, Xuezhu Wang, Fan Yang, Yongchang Zheng, Yang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 865.
https://doi.org/10.1158/1538-7445.AM2024-865
Published: 22 March 2024
View articletitled, Abstract 865: Single-cell sequencing identification of malignant cell subpopulations linked to recurrence in hepatocellular carcinoma
Journal Articles

Abstract 4387: Total toxicity burden of FDA approved immune checkpoint inhibitors in USA

Fan Yang, Chloe Shay, Zhaohui Qin, Nabil Saba, Yong Teng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4387.
https://doi.org/10.1158/1538-7445.AM2023-4387
Published: 04 April 2023
View articletitled, Abstract 4387: Total toxicity burden of FDA approved immune checkpoint inhibitors in USA
Journal Articles

Abstract P6-11-13: Ferroptosis Heterogeneity in Triple-Negative Breast Cancer Reveals an Innovative Immunotherapy Combination Strategy

Fan Yang, Yi Xiao, Jia-Han Ding, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-11-13.
https://doi.org/10.1158/1538-7445.SABCS22-P6-11-13
Published: 01 March 2023
View articletitled, Abstract P6-11-13: Ferroptosis Heterogeneity in Triple-Negative Breast Cancer Reveals an Innovative Immunotherapy Combination Strategy
Journal Articles

Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification

Bingteng Xie, Yang Pu, Fan Yang, Wei Chen, Wei Yue, Jihong Ma, Na Zhang, Yuening Jiang, Jiegen Wu, Yihan Lin, Xin Liang, Chu Wang, Peng Zou, Mo Li
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2576–2592.
https://doi.org/10.1158/0008-5472.CAN-22-0225
Published: 18 July 2022
View articletitled, Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification
Open the PDF for Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5916: Tumor-informed patient-specific panel outperforms tumor-naïve and tumor-informed fixed panel for circulating tumor DNA (ctDNA)-based postoperative monitoring of non-small cell lung cancer (NSCLC)

Kezhong Chen, Haifeng Shen, Shuailai Wu, Pengfei Zhu, Chenyang Wang, Analyn Lizaso, Guannan Kang, Yang Wang, Juan Lv, Shuai Fang, Wenjun Wu, Fujun Qiu, Yuan Sun, Qiang Lu, Heng Zhao, Shannon Chuai, Fan Yang, Zhihong Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5916.
https://doi.org/10.1158/1538-7445.AM2022-5916
Published: 15 June 2022
View articletitled, Abstract 5916: Tumor-informed patient-specific panel outperforms tumor-naïve and tumor-informed fixed panel for circulating tumor DNA (ctDNA)-based postoperative monitoring of non-small cell lung cancer (NSCLC)