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Journal Articles

Abstract 3015: EGFR x MET tsAb: Differentiated MET biparatopic design with optimal MET inhibitory activity to pursue best-in-class opportunity

Yanzhou Zhang, Ming Jiang, Hongyu Chen, Mengran Qian, Renke Li, Huang Yan, Huan Li, Xiaona Sun, Sujuan Huang, Xuechun Zhang, Ming Fang, Yue Wu, Fan Wang, Mingchao Kang, Xiaomin Song, Xi Wu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3015.
https://doi.org/10.1158/1538-7445.AM2025-3015
Published: 21 April 2025
View articletitled, Abstract 3015: EGFR x MET tsAb: Differentiated MET biparatopic design with optimal MET inhibitory activity to pursue best-in-class opportunity
Journal Articles

Abstract 5731: BGB-C354, a novel B7H3 ADC with high DAR stability and strong bystander effect, demonstrates robust antitumor activity in preclinical models

Xiao Ding, Charng-Sheng Tsai, Mei-Hsuan Tsai, Maggie Tang, Liu Xue, Chi Guan, Meiling Tan, Yiren Xiao, Yuanyuan Xie, Kunpeng Lyu, Xiaotong Chen, Wenhao Li, Qi Liu, Yun Chen, Jie Pan, Wenjin Yao, Yang Lyu, Kaiying Jia, Chang Song, Weiwei Song, Ce Wang, Fan Wang, Zhitao Wan, Mingming Guo, Beibei Jiang, Xiaomin Song, Wei Jin, Qiansheng Ren, Yu Shen, Zhirong Shen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5731.
https://doi.org/10.1158/1538-7445.AM2025-5731
Published: 21 April 2025
View articletitled, Abstract 5731: BGB-C354, a novel B7H3 ADC with high DAR stability and strong bystander effect, demonstrates robust antitumor activity in preclinical models
Journal Articles

Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma

Yu Kong, Fan Wang, Renwei Jing, Qian Zhao, Xuejiao Lv, Yingying Zhao, Ye Yuan, Xianyou Xia, Yu Sun, Yujie Tong, Han Yan, Qian Li, Ting Li, Lei Cao, Deng Liu, Dawei Huo, Shao-Kai Sun, Francisco Morís, Yujie Tang, Xudong Wu
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2227
Published: 07 March 2025
View articletitled, Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma
Open the PDF for Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma in another window
Includes: Supplementary data
Journal Articles

Abstract 6385: St. Jude Survivorship Portal: Sharing and analyzing large clinical and genomic datasets from pediatric cancer survivors

Gavriel Matt, Edgar Sioson, Jian Wang, Congyu Lu, Airen Zaldívar Peraza, Karishma Gangwani, Robin Paul, Colleen Reilly, Aleksandar Acić, Kyla Shelton, Qi Liu, Stephanie Sandor, Clay McLeod, Weiyu Qiu, Jaimin Patel, Fan Wang, Cindy Im, Zhaoming Wang, Carmen L. Wilson, Nickhill Bhakta, Kirsten Ness, Gregory T. Armstrong, Melissa M. Hudson, Leslie L. Robison, Jinghui Zhang, Yutaka Yasui, Xin Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6385.
https://doi.org/10.1158/1538-7445.AM2024-6385
Published: 22 March 2024
View articletitled, Abstract 6385: St. Jude Survivorship Portal: Sharing and analyzing large clinical and genomic datasets from pediatric cancer survivors
Journal Articles

Abstract 2110: Characterization of the correlation between BTK degradation and tumor growth inhibition of the BTK target protein degraders using PK/PD modeling

Yue Wu, Shuran Li, Fan Wang, Nan Hu, Longbo Yin, Xiaomin Song, Jiye Zhang, Aiying Xu, Shasha Yang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2110.
https://doi.org/10.1158/1538-7445.AM2024-2110
Published: 22 March 2024
View articletitled, Abstract 2110: Characterization of the correlation between BTK degradation and tumor growth inhibition of the BTK target protein degraders using PK/PD modeling
Journal Articles

Abstract 5083: Investigating the development and therapeutic potential of intra-tumoral CXCR6+ effector/effector memory T cells (TEFF/EM) in triple-negative breast cancer

Bryan Jian Wei Lim, Xiao-Fan Wang, Qi-Jing Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5083.
https://doi.org/10.1158/1538-7445.AM2023-5083
Published: 04 April 2023
View articletitled, Abstract 5083: Investigating the development and therapeutic potential of intra-tumoral CXCR6+ effector/effector memory T cells (TEFF/EM) in triple-negative breast cancer
Journal Articles

Abstract 3136: HYENA detects non-coding genes activated by distal enhancers in cancer

Anqi Yu, Ali E. Yesilkanal, Ashish Thakur, Fan Wang, Xiaoyang Wu, Alexander Muir, Xin He, Francois Spitz, Lixing Yang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3136.
https://doi.org/10.1158/1538-7445.AM2023-3136
Published: 04 April 2023
View articletitled, Abstract 3136: HYENA detects non-coding genes activated by distal enhancers in cancer
Journal Articles

Genome-Wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk

Fan Wang, Wonjong Moon, William Letsou, Yadav Sapkota, Zhaoming Wang, Cindy Im, Jessica L. Baedke, Leslie Robison, Yutaka Yasui
Journal: Cancer Research
Cancer Res (2023) 83 (2): 332–345.
https://doi.org/10.1158/0008-5472.CAN-22-1888
Published: 18 January 2023
View articletitled, Genome-Wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk
Open the PDF for Genome-Wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk in another window
Includes: Supplementary data
Journal Articles

LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway

Fengyu Xu, Mengqi Huang, Qingyong Chen, Yi Niu, Yuhang Hu, Ping Hu, Ding Chen, Chi He, Kang Huang, Zhu Zeng, Jiang Tang, Fan Wang, Yong Zhao, Chunyou Wang, Gang Zhao
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5678–5691.
https://doi.org/10.1158/0008-5472.CAN-21-0281
Published: 15 November 2021
View articletitled, LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway
Open the PDF for LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway in another window
Includes: Supplementary data
Journal Articles

Hepatitis B–Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation

Changlu Zhang, Yanan Gao, Chengzhi Du, Geoffrey J. Markowitz, Jing Fu, Zhenxing Zhang, Chunliang Liu, Wenhao Qin, Hongyang Wang, Fan Wang, Pengyuan Yang
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2386–2398.
https://doi.org/10.1158/0008-5472.CAN-20-3453
Published: 01 May 2021
View articletitled, Hepatitis B–Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation
Open the PDF for Hepatitis B–Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation in another window
Includes: Supplementary data
Journal Articles

Abstract 664: BGB-10188, a highly selective PI3Kδ inhibitor with improved safety profile and superior anti-tumor activities in vivo

Xiao Yang, Xiaolong Yang, Xinxin Cui, Dan Su, Yue Wu, Xuebing Sun, Jingyuan Wang, Huichen Bai, Wei Wei, Jing Li, Xi Yuan, Ye Liu, Fan Wang, Zhiwei Wang, Lai Wang, Xuesong Liu, Xiaomin Song
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 664.
https://doi.org/10.1158/1538-7445.AM2020-664
Published: 15 August 2020
View articletitled, Abstract 664: BGB-10188, a highly selective PI3Kδ inhibitor with improved safety profile and superior anti-tumor activities in vivo
Journal Articles

Abstract 3077: Preclinical characterization of BGB-11417, a potent and selective Bcl-2 inhibitor with superior antitumor activities in haematological tumor models

Nan Hu, Yunhang Guo, Hai Xue, Ye Liu, Yin Guo, Fan Wang, Xiaomin Song, Ying Guo, Shuaishuai Chen, Haipeng Xu, Taichang Zhang, Yanwen Ma, Xuebing Sun, Yuan Hong, Yutong Zhu, Aiying Xu, Zhenzhen Cheng, Haimei Xing, Zhiwei Wang, Xuesong Liu, Lai Wang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3077.
https://doi.org/10.1158/1538-7445.AM2020-3077
Published: 15 August 2020
View articletitled, Abstract 3077: Preclinical characterization of BGB-11417, a potent and selective Bcl-2 inhibitor with superior antitumor activities in haematological tumor models
Journal Articles

Abstract 4271: Most expression quantitative trait loci discovered in tumors cannot be attributed to cancer cells

Paul Geeleher, Fan Wang, Zheny Zhang, Robert L. Grossman, Cathal Seoighe, R. Stephanie Huang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4271.
https://doi.org/10.1158/1538-7445.AM2018-4271
Published: 01 July 2018
View articletitled, Abstract 4271: Most expression quantitative trait loci discovered in tumors cannot be attributed to cancer cells
Journal Articles

Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy

Yang Zhao, Chenran Zhang, Liquan Gao, Xinhe Yu, Jianhao Lai, Dehua Lu, Rui Bao, Yanpu Wang, Bing Jia, Fan Wang, Zhaofei Liu
Journal: Cancer Research
Cancer Res (2017) 77 (21): 6021–6032.
https://doi.org/10.1158/0008-5472.CAN-17-1655
Published: 31 October 2017
View articletitled, Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
Open the PDF for Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 3059: UHRF1 deficiency exerts anti-tumor immune responses in non-small cell lung cancer

Handan Xiang, Junying Chen, Xiao-Fan Wang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3059.
https://doi.org/10.1158/1538-7445.AM2017-3059
Published: 01 July 2017
View articletitled, Abstract 3059: UHRF1 deficiency exerts anti-tumor immune responses in non-small cell lung cancer
Journal Articles

Abstract 5035: IDWAS: Imputing drug response in large cohorts of cancer patients to discover novel predictive biomarkers

Paul Geeleher, Zhenyu Zhang, Fan Wang, Aritro Nath, Steven Bhutra, Robert Grossman, R. Stephanie Huang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5035.
https://doi.org/10.1158/1538-7445.AM2017-5035
Published: 01 July 2017
View articletitled, Abstract 5035: IDWAS: Imputing drug response in large cohorts of cancer patients to discover novel predictive biomarkers
Journal Articles

Abstract 2039: Exploring the longitudinal transcriptomic landscape of tyrosine kinase inhibitor treatment response in chronic myeloid leukemia patients

Aritro Nath, Fan Wang, Divya Lenkala, Bonnie LaCroix, Nancy Glavin, Kristen Kipping-Johnson, Paul Geeleher, Michael Thirman, Lucy Godley, Gordana Raca, Richard Larson, R. Stephanie Huang.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2039.
https://doi.org/10.1158/1538-7445.AM2016-2039
Published: 15 July 2016
View articletitled, Abstract 2039: Exploring the longitudinal transcriptomic landscape of tyrosine kinase inhibitor treatment response in chronic myeloid leukemia patients
Journal Articles

Abstract 4070: Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice

Zhengxue Liu, Tanima R. Kundu, Isao Matsuura, Guannan Wang, Yong Lin, You-Rong Lou, Nicola J. Barnard, Xiao-Fan Wang, Mou-Tuan Huang, Nanjoo Suh, Fang Liu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4070.
https://doi.org/10.1158/1538-7445.AM2016-4070
Published: 15 July 2016
View articletitled, Abstract 4070: Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
Journal Articles

Abstract 2100: Imputation of drug sensitivity levels in The Cancer Genome Atlas using machine learning identifies novel predictors of chemotherapeutic response

Paul Geeleher, R. Stephanie Huang, Fan Wang, Gladys Morrison
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2100.
https://doi.org/10.1158/1538-7445.AM2016-2100
Published: 15 July 2016
View articletitled, Abstract 2100: Imputation of drug sensitivity levels in The Cancer Genome Atlas using machine learning identifies novel predictors of chemotherapeutic response
Journal Articles

Abstract 2009: Role of FOXO1 in oncogenic program of B cell precursor acute lymphoblastic leukemia (BCP-ALL)

Fan Wang, Alexey Ushmorov, Thomas Wirth
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2009.
https://doi.org/10.1158/1538-7445.AM2016-2009
Published: 15 July 2016
View articletitled, Abstract 2009: Role of FOXO1 in oncogenic program of B cell precursor acute lymphoblastic leukemia (BCP-ALL)