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Fadlo R. Khuri
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Journal Articles

Abstract 3261: Gene methylation biomarkers in sputum as a classifier for lung cancer risk

Maria A. Picchi, Shuguang Leng, Guodong Wu, Donna M. Klinge, Cynthia L. Thomas, Elia Casas, Christine A. Stidley, Sandra J. Lee, Seena Aisner, Jill M. Siegfried, Suresh Ramalingam, Fadlo R. Khuri, Daniel D. Karp, Steven A. Belinsky
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3261.
https://doi.org/10.1158/1538-7445.AM2017-3261
Published: 01 July 2017
View articletitled, Abstract 3261: Gene methylation biomarkers in sputum as a classifier for lung cancer risk
Journal Articles

Modulation of Bax and mTOR for Cancer Therapeutics

Rui Li, Chunyong Ding, Jun Zhang, Maohua Xie, Dongkyoo Park, Ye Ding, Guo Chen, Guojing Zhang, Melissa Gilbert-Ross, Wei Zhou, Adam I. Marcus, Shi-Yong Sun, Zhuo G. Chen, Gabriel L. Sica, Suresh S. Ramalingam, Andrew T. Magis, Haian Fu, Fadlo R. Khuri, Walter J. Curran, Taofeek K. Owonikoko, Dong M. Shin, Jia Zhou, Xingming Deng
Journal: Cancer Research
Cancer Res (2017) 77 (11): 3001–3012.
https://doi.org/10.1158/0008-5472.CAN-16-2356
Published: 31 May 2017
View articletitled, Modulation of Bax and mTOR for Cancer Therapeutics
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Includes: Supplementary data
Journal Articles

Abstract 4770: The regulation of pre-ribosomal RNA synthesis by LKB1

Rui Jin, Faken Liu, Xiuju Liu, Henry Huang, Scott C. Wilkinson, Diansheng Zhong, Fadlo R. Khuri, Haian Fu, Adam I. Marcus, Yulong He, Wei Zhou
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4770.
https://doi.org/10.1158/1538-7445.AM2016-4770
Published: 15 July 2016
View articletitled, Abstract 4770: The regulation of pre-ribosomal RNA synthesis by LKB1
Journal Articles

Abstract 1866: HER3 targeting sensitizes HNSCC to cetuximab - evidence from cell line and patient derived xenograft (PDX) models

Dongsheng Wang, Guoqing Qian, hongzheng zhang, kelly R. Magliocca, sreenivas nannapaneni, zhengjia chen, mihir R. patel, Mark W. El-Deiry, J.trad Wadsworth, dong M. Shin, fadlo R. khuri, Nabil F. Saba, Zhuo G. chen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1866.
https://doi.org/10.1158/1538-7445.AM2016-1866
Published: 15 July 2016
View articletitled, Abstract 1866: HER3 targeting sensitizes HNSCC to cetuximab - evidence from cell line and patient derived xenograft (PDX) models
Journal Articles

Abstract LB-348: Developing a personalized anti-metastatic therapy to treat KRAS, LKB1-mutant lung adenocarcinoma

Melissa Gilbert-Ross, Jessica Konen, Junghui Koo, John Shupe, Gabriel L. Sica, Zhengjia Chen, Brian S. Robinson, Madhusmita Behera, Michael R. Rossi, Geoffrey H. Smith, Charles E. Hill, Suresh M. Ramalingam, Haian Fu, Fadlo R. Khuri, Wei Zhou, Adam Marcus
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-348.
https://doi.org/10.1158/1538-7445.AM2016-LB-348
Published: 15 July 2016
View articletitled, Abstract LB-348: Developing a personalized anti-metastatic therapy to treat KRAS, LKB1-mutant lung adenocarcinoma
Journal Articles

Abstract B45: An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma

Melissa Gilbert-Ross, Jessica Konen, John Shupe, Junghui Koo, Gabriel L. Sica, Suresh S. Ramalingam, Haian Fu, Fadlo R. Khuri, Wei Zhou, Adam I. Marcus
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): B45.
https://doi.org/10.1158/1538-7445.TUMMET15-B45
Published: 26 May 2016
View articletitled, Abstract B45: An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma
Journal Articles

Abstract B15: RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis

Gina Alesi, Lingtao Jin, Dan Li, Kelly Magliocca, Yibin Kang, Zhuo G. Chen, Dong M. Shin, Fadlo R. Khuri, Sumin Kang
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): B15.
https://doi.org/10.1158/1538-7445.TUMMET15-B15
Published: 26 May 2016
View articletitled, Abstract B15: RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis
Journal Articles

Abstract CT303: A phase I pharmacokinetic and pharmacodynamic evaluation of the combination of everolimus and buparlisib for concurrent mTOR and PI3K pathway blockade in patients with advanced solid tumors

Taofeek Kunle Owonikoko, R.Donald Harvey, Colleen Lewis, Zhengjia Chen, John S. Kauh, Meredith Renfroe, Rijalda Deovic, Gabriel L. Sica, Bradley C. Carthon, Wayne Bernard Harris, Bassel F. El-Rayes, Suresh S. Ramalingam, Fadlo R. Khuri
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT303.
https://doi.org/10.1158/1538-7445.AM2015-CT303
Published: 01 August 2015
View articletitled, Abstract CT303: A phase I pharmacokinetic and pharmacodynamic evaluation of the combination of everolimus and buparlisib for concurrent mTOR and PI3K pathway blockade in patients with advanced solid tumors
Journal Articles

Abstract 29: Potent curcumin analog FLLL12 induces apoptosis in lung cancer cells through death receptor-5-dependent pathway

Abedul Haque, Mohammad A. Rahman, James R. Fuchs, Zhuo G. Chen, Fadlo R. Khuri, Dong M. Shin, A.R.M. Ruhul Amin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 29.
https://doi.org/10.1158/1538-7445.AM2015-29
Published: 01 August 2015
View articletitled, Abstract 29: Potent curcumin analog FLLL12 induces apoptosis in lung cancer cells through death receptor-5-dependent pathway
Journal Articles

Abstract 1317: Biomarker evaluation for PD-1 targeted therapies in non-small cell lung cancer (NSCLC) patients

Alice O. Kamphorst, Rathi N. Pillai, Shu Yang, Rama Akondy, Lydia Koenig, Ke Yu, Megan McCausland, Gabriel Sica, Fadlo R. Khuri, Taofeek K. Owonikoko, Suresh S. Ramalingam, Rafi Ahmed
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1317.
https://doi.org/10.1158/1538-7445.AM2015-1317
Published: 01 August 2015
View articletitled, Abstract 1317: Biomarker evaluation for PD-1 targeted therapies in non-small cell lung cancer (NSCLC) patients
Journal Articles

Cables1 Complex Couples Survival Signaling to the Cell Death Machinery

Zhi Shi, Hae R. Park, Yuhong Du, Zijian Li, Kejun Cheng, Shi-Yong Sun, Zenggang Li, Haian Fu, Fadlo R. Khuri
Journal: Cancer Research
Cancer Res (2015) 75 (1): 147–158.
https://doi.org/10.1158/0008-5472.CAN-14-0036
Published: 04 January 2015
View articletitled, Cables1 Complex Couples Survival Signaling to the Cell Death Machinery
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Includes: Supplementary data
Journal Articles

Abstract 922: Evaluating markers of cisplatin sensitivity and survival in small cell lung cancer

Taofeek Kunle Owonikoko, Guojing Zhang, Gabriel L. Sica, Zhengjia Chen, Jeffrey M. Switchenko, Sungjin Kim, Anthony A. Gal, Suresh S. Ramalingam, Xingming Deng, Michael R. Rossi, Jeanne Kowalski, Fadlo R. Khuri
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 922.
https://doi.org/10.1158/1538-7445.AM2014-922
Published: 01 October 2014
View articletitled, Abstract 922: Evaluating markers of cisplatin sensitivity and survival in small cell lung cancer
Journal Articles

Abstract 349: mTOR complex 2 (mTORC2) positively regulates Mcl-1 stability by suppressing GSK3-dependent and FBXW7-mediated proteasomal degradation of Mcl-1

Junghui Koo, Ping Yue, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 349.
https://doi.org/10.1158/1538-7445.AM2014-349
Published: 01 October 2014
View articletitled, Abstract 349: mTOR complex 2 (mTORC2) positively regulates Mcl-1 stability by suppressing GSK3-dependent and FBXW7-mediated proteasomal degradation of Mcl-1
Journal Articles

Abstract 2758: Development of small molecule Bax agonists for lung cancer treatment

Meiguo Xin, Rui Li, Dongkyoo Park, Taofeek K. Owonikoko, Gabriel L. Sica, Patrick E. Corsino, Jia Zhou, Chunyong Ding, Andrew T. Magis, Suresh S. Ramalingam, Walter J. Curran, Fadlo R. Khuri, Xingming Deng
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2758.
https://doi.org/10.1158/1538-7445.AM2014-2758
Published: 01 October 2014
View articletitled, Abstract 2758: Development of small molecule Bax agonists for lung cancer treatment
Journal Articles

Abstract 1227: Preserved histological and molecular phenotypes following serial in vivo propagation of patient-derived xenografts of small cell lung cancer

Taofeek Kunle Owonikoko, Guojing Zhang, Gabriel L. Sica, Hyun S. Kim, Onyinye C. Ogee-Nwankwo, Suresh S. Ramalingam, Michael R. Rossi, Fadlo R. Khuri
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1227.
https://doi.org/10.1158/1538-7445.AM2014-1227
Published: 01 October 2014
View articletitled, Abstract 1227: Preserved histological and molecular phenotypes following serial in vivo propagation of patient-derived xenografts of small cell lung cancer
Journal Articles

Abstract 2288: Pharmacological inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs cancer cell response to DR5 activation-induced apoptosis

You-Take Oh, Ping Yue, Taofeek K. Owonikoko, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2288.
https://doi.org/10.1158/1538-7445.AM2014-2288
Published: 01 October 2014
View articletitled, Abstract 2288: Pharmacological inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs cancer cell response to DR5 activation-induced apoptosis
Journal Articles

Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth

Junghui Koo, Ping Yue, Anthony A. Gal, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2014) 74 (9): 2555–2568.
https://doi.org/10.1158/0008-5472.CAN-13-2946
Published: 30 April 2014
View articletitled, Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth
Open the PDF for Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth in another window
Includes: Supplementary data
Journal Articles

Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase

Maohua Xie, Yun Yen, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, Walter J. Curran, Paul W. Doetsch, Xingming Deng
Journal: Cancer Research
Cancer Res (2014) 74 (1): 212–223.
https://doi.org/10.1158/0008-5472.CAN-13-1536-T
Published: 05 January 2014
View articletitled, Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
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Includes: Supplementary data
Journal Articles

Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer

Dongkyoo Park, Andrew T. Magis, Rui Li, Taofeek K. Owonikoko, Gabriel L. Sica, Shi-Yong Sun, Suresh S. Ramalingam, Fadlo R. Khuri, Walter J. Curran, Xingming Deng
Journal: Cancer Research
Cancer Res (2013) 73 (17): 5485–5496.
https://doi.org/10.1158/0008-5472.CAN-12-2272
Published: 02 September 2013
View articletitled, Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Open the PDF for Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-194: Window of opportunity preoperative interrogation of mTOR pathway in patients with resectable non-small cell lung cancer (NSCLC).

Taofeek Kunle Owonikoko, Daniel L. Miller, Seth Force, Gabriel Sica, Scott Kono, Madhusmita Behera, Jennifer Mendel, Zhengjia Chen, Allan Pickens, Robert W. Fu, William F. Auffermann, Jaqueline Rogerio, William E. Torres, Haian Fu, John Hohneker, Shi-Yong Sun, Anthony A. Gal, Suresh S. Ramalingam, Fadlo R. Khuri
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-194.
https://doi.org/10.1158/1538-7445.AM2013-LB-194
Published: 15 April 2013
View articletitled, Abstract LB-194: Window of opportunity preoperative interrogation of mTOR pathway in patients with resectable non-small cell lung cancer (NSCLC).