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Fabrizio Pane
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Journal Articles

Abstract 310: BCR-ABL1 transcript detection in patients with Philadelphia-positive Acute Lymphoblastic Leukemia (ALL) using a new and high sensitive nanofluidic method

Annalisa Lonetti, Ilaria Iacobucci, Anna Ferrari, Cristina Papayannidis, Mariachiara Abbenante, Viviana Guadagnuolo, Stefania Paolini, Fabrizio Pane, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 310.
https://doi.org/10.1158/1538-7445.AM2011-310
Published: 15 April 2011
View article titled, Abstract 310: <em>BCR-ABL1</em> transcript detection in patients with Philadelphia-positive Acute Lymphoblastic Leukemia (ALL) using a new and high sensitive nanofluidic method
Journal Articles

Abstract 5448: Pharmacogenetics of drug transporters may be useful to identify chronic myeloid leukemia patients who are less likely to achieve molecular responses to imatinib: Implications for treatment optimization in the era of new tyrosine kinase inhibitors

Simona Soverini, Sabrina Angelini, Matt Barnett, Gloria Ravegnini, Fabrizio Pane, Timothy P. Hughes, Deborah White, Dong-Wook Kim, Giuseppe Saglio, Gianantonio Rosti, Richard Woodman, Richard Woodman, Patrizia Hrelia, Guido Biasco, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5448.
https://doi.org/10.1158/1538-7445.AM2011-5448
Published: 15 April 2011
View article titled, Abstract 5448: Pharmacogenetics of drug transporters may be useful to identify chronic myeloid leukemia patients who are less likely to achieve molecular responses to imatinib: Implications for treatment optimization in the era of new tyrosine kinase inhibitors
Journal Articles

Abstract 656: High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)

Ilaria Iacobucci, Emanuela Ottaviani, Viviana Guadagnuolo, Annalisa Lonetti, Nicoletta Testoni, Cristina Papayannidis, Stefania Paolini, Daniela Cilloni, Francesca Messa, Anna Candoni, Francesca Arruga, Giuseppe Saglio, Michela Rondoni, Fabrizio Pane, Hasan Syed Khizer, Michele Baccarani, Francesco Lo Coco, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 656.
https://doi.org/10.1158/1538-7445.AM10-656
Published: 15 April 2010
View article titled, Abstract 656: High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)
Journal Articles

Abstract 651: Whole transcriptome sequencing of Philadelphia positive acute lymphoblastic leukemia (ALL) by RNA-seq: an exhaustive overview of novel point mutations, gene expression and alternative splicing profiles

Ilaria Iacobucci, Alberto Ferrarini, Marco Sazzini, Annalisa Lonetti, Enrico Giacomelli, Luciano Xumerle, Anna Ferrari, Cristina Papayannidis, Emanuela Ottaviani, Stefania Paolini, Francesca Messa, Daniela Cilloni, Antonella Vitale, Fabrizio Pane, Simona Soverini, Giuseppe Saglio, Robin Foà, Michele Baccarani, Massimo Delledonne, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 651.
https://doi.org/10.1158/1538-7445.AM10-651
Published: 15 April 2010
View article titled, Abstract 651: Whole transcriptome sequencing of Philadelphia positive acute lymphoblastic leukemia (ALL) by RNA-seq: an exhaustive overview of novel point mutations, gene expression and alternative splicing profiles
Journal Articles

Abstract 251: Disabled gene is involved in CML progression and its expression level at diagnosis can predict major molecular response (MMR) to imatinib therapy

Francesca Arruga, Francesca Messa, Monica Pradotto, Roberto Bernardoni, Enrico Bracco, Sonia Carturan, Chiara Maffè, Emanuela Messa, Chiara Zanone, Antonia Rotolo, Elisabetta Greco, Ilaria Iacobucci, Elisabetta Signorino, Valentina Gaidano, Fabrizio Pane, Thea Kalebic, Giovanni Martinelli, Michele Baccarani, Giuseppe Saglio, Daniela Cilloni
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 251.
https://doi.org/10.1158/1538-7445.AM10-251
Published: 15 April 2010
View article titled, Abstract 251: Disabled gene is involved in CML progression and its expression level at diagnosis can predict major molecular response (MMR) to imatinib therapy
Journal Articles

Abstract 1805: Improving on Imatinib for targeted therapy of chronic myeloid leukemia: First line treatment with Nilotinib 800 mg daily results in unprecedentedly high rate of rapid, “deep” and stable molecular responses - Results of a phase 2 trial of the GIMEMA CML working party

Giovanni Martinelli, Angela Poerio, Simona Soverini, Giuseppe Saglio, Fabrizio Pane, Fausto Castagnetti, Adele Capucci, Mario Tiribelli, Fabio Stagno, Francesca Palandri, Gabriele Gugliotta, Alfonso Zaccaria, Tamara Intermesoli, Bruno Martino, Guido Biasco, Monica Bocchia, Michele Cedrone, Nicoletta Testoni, Marilina Amabile, Ilaria Iacobucci, Massimo Breccia, Giuliana Alimena, Luciano Levato, Michele Baccarani, Gianantonio Rosti
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1805.
https://doi.org/10.1158/1538-7445.AM10-1805
Published: 15 April 2010
View article titled, Abstract 1805: Improving on Imatinib for targeted therapy of chronic myeloid leukemia: First line treatment with Nilotinib 800 mg daily results in unprecedentedly high rate of rapid, “deep” and stable molecular responses - Results of a phase 2 trial of the GIMEMA CML working party
Journal Articles

Abstract 1600: Molecular Characterization of PAX5 alterations in Adult BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL)

Annalisa Lonetti, Ilaria Iacobucci, Cristina Papayannidis, Anna Ferrari, Viviana Guadagnuolo, Daniela Cilloni, Francesca Messa, Stefania Paolini, Sabina Chiaretti, Simona Soverini, Giuseppe Saglio, Fabrizio Pane, Michele Baccarani, Robin Foà, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1600.
https://doi.org/10.1158/1538-7445.AM10-1600
Published: 15 April 2010
View article titled, Abstract 1600: Molecular Characterization of <em>PAX5</em> alterations in Adult <em>BCR-ABL1</em>-Positive Acute Lymphoblastic Leukemia (ALL)
Journal Articles

Abstract #5619: Expression of different isoforms of the B-cell mutator activation-induced cytidine deaminase (AID) in BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL) Patients

Annalisa Lonetti, Ilaria Iacobucci, Anna Ferrari, Monica Messina, Daniela Cilloni, Simona Soverini, Sabina Chiaretti, Emanuela Ottaviani, Nicoletta Testoni, Cristina Papayannidis, Francesca Messa, Federica Salmi, Antonella Vitale, Francesca Arruga, Fabrizio Pane, Pier Paolo Piccaluga, Alessandra Gnani, Stefania Paolini, Carla De Giovanni, Giuseppe Saglio, Michele Baccarani, Robin Foà, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5619.
Published: 01 May 2009
View article titled, Abstract #5619: Expression of different isoforms of the B-cell mutator activation-induced cytidine deaminase (AID) in <em>BCR-ABL1</em>-Positive Acute Lymphoblastic Leukemia (ALL) Patients
Journal Articles

Abstract #1287: IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

Ilaria Iacobucci, Annalisa Lonetti, Anna Ferrari, Clelia Tiziana Storlazzi, Emanuela Ottaviani, Sabina Chiaretti, Monica Messina, Daniela Cilloni, Carmen Baldazzi, Cristina Papayannidis, Francesca Messa, Annalisa Astolfi, Luciana Impera, Antonella Vitale, Francesca Arruga, Fabrizio Pane, Pier Paolo Piccaluga, Sabrina Colarossi, Simona Soverini, Marco Vignetti, Stefania Paolini, Giuseppe Saglio, Michele Baccarani, Robin Foà, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1287.
Published: 01 May 2009
View article titled, Abstract #1287: <em>IKZF1</em> (Ikaros) Deletions are a frequent event in <em>BCR-ABL1</em> Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report
Journal Articles

Abstract #4514: Innovative phase I-II study of concomitant and consecutive treatment with Dasatinib and MK-0457 in refractory Ph+ CML and ALL patients

Cristina Papayannidis, Ilaria Iacobucci, Simona Soverini, Stefania Paolini, Sandra Santucci, Daniela Cilloni, Francesca Messa, Fabrizio Pane, Vittorio Meneghini, Panagiota Giannoulia, Emanuela Ottaviani, Nicoletta Testoni, Barbara Lama, Maria Pantaleo, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4514.
Published: 01 May 2009
View article titled, Abstract #4514: Innovative phase I-II study of concomitant and consecutive treatment with Dasatinib and MK-0457 in refractory Ph+ CML and ALL patients
Journal Articles

Consistent Up-regulation of Stat3 Independently of Jak2 Mutations in a New Murine Model of Essential Thrombocythemia

Vitalyi Senyuk, Ciro Roberto Rinaldi, Donglan Li, Francesca Cattaneo, Aleksandra Stojanovic, Fabrizio Pane, Xiaoping Du, Nadim Mahmud, Jerome Dickstein, Giuseppina Nucifora
Journal: Cancer Research
Cancer Res (2009) 69 (1): 262–271.
https://doi.org/10.1158/0008-5472.CAN-08-2534
Published: 31 December 2008
View article titled, Consistent Up-regulation of Stat3 Independently of Jak2 Mutations in a New Murine Model of Essential Thrombocythemia
Open the PDF for Consistent Up-regulation of Stat3 Independently of Jak2 Mutations in a New Murine Model of Essential Thrombocythemia in another window
Journal Articles

Genome wide analysis of Philadelphia positive (Ph+) acute lymphoblastic leukemia (ALL) reveals a recurring deletion of VPREB1 gene which affects B-cell differentiation

Francesco De Rosa, Ilaria Iacobucci, Emanuela Ottaviani, Annalisa Astolfi, Annalisa Lonetti, Nicoletta Testoni, Tiziana Storlazzi, Luciana Impera, Simona Soverini, Stefania Paolini, Pier Paolo Piccaluga, Cristina Papayannidis, Panagiota Giannoulia, Daniela Cilloni, Andrea Pession, Fabrizio Pane, Antonella Vitale, Robin Foa, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1462.
Published: 01 May 2008
View article titled, Genome wide analysis of Philadelphia positive (Ph+) acute lymphoblastic leukemia (ALL) reveals a recurring deletion of VPREB1 gene which affects B-cell differentiation
Journal Articles

The Bcr-Abl kinase promotes aberrant expression of spliced oncogenic Ikaros isoforms in Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL) patients treated with tyrosine kinase inhibitors

Ilaria Iacobucci, Annalisa Lonetti, Emanuela Ottaviani, Daniela Cilloni, Francesca Messa, Stefania Paolini, Cristina Papayannidis, Pier Paolo Piccaluga, Panagiota Giannoulia, Simona Soverini, Marilina Amabile, Giuseppe Saglio, Fabrizio Pane, Giorgio Berton, Anna Baruzzi, Antonella Vitale, Robin Foa, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5515.
Published: 01 May 2008
View article titled, The Bcr-Abl kinase promotes aberrant expression of spliced oncogenic Ikaros isoforms in Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL) patients treated with tyrosine kinase inhibitors
Journal Articles

High-resolution genomic profiling of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) patients identified novel recurrent copy number variations involved in both pathogenesis and resistance to tyrosine kinase inhibitors

Ilaria Iacobucci, Emanuela Ottaviani, Annalisa Astolfi, Francesco De Rosa, Annalisa Lonetti, Nicoletta Testoni, Tiziana Storlazzi, Luciana Impera, Simona Soverini, Stefania Paolini, Pier Paolo Piccaluga, Cristina Papayannidis, Panagiota Giannoulia, Daniela Cilloni, Andrea Pession, Fabrizio Pane, Antonella Vitale, Robin Foa, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2213.
Published: 01 May 2008
View article titled, High-resolution genomic profiling of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) patients identified novel recurrent copy number variations involved in both pathogenesis and resistance to tyrosine kinase inhibitors
Journal Articles

Expression of a dominant-negative IKAROS splice variant IK6 in Ph-positive acute lymphoblastic leukemia: Implications for a new mechanisms     of resistance to tyrosine kinase inhibitors

Giovanni Martinelli, Ilaria Iacobucci, Simona Soverini, Emanuela Ottaviani, Stefania Paolini, Pier Paolo Piccaluga, Tiziana Grafone, Rondoni Michela, Marilina Amabile, Angela Poerio, Sabrina Colarossi, Alessandra Gnani, Daniela Cilloni, Giuseppe Saglio, Fabrizio Pane, Gianantonio Rosti, Michele Baccarani
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2638.
Published: 01 May 2007
View article titled, Expression of a dominant-negative IKAROS splice variant IK6 in Ph-positive acute lymphoblastic leukemia: Implications for a new mechanisms     of resistance to tyrosine kinase inhibitors
Journal Articles

Imatinib treatment of Philadelphia positive (Ph+) chronic myeloid leukemia (CML). For late chronic phase patients who achieve a complete cytogenetic response 5-year survival     is as high as for early chronic phase patients

Ilaria Iacobucci, Giovanni Martinelli, Marilina Amabile, Angela Poerio, Simona Soverini, Fausto Castagnetti, Sabrina Colarossi, Alessandra Gnani, Nicoletta Testoni, Massimo Breccia, Elisabetta Abruzzese, Bruno Martino, Daniela Cilloni, Giuseppe Saglio, Fabrizio Pane, Gianantonio Rosti, Guido Biasco, Michele Baccarani
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2639.
Published: 01 May 2007
View article titled, Imatinib treatment of Philadelphia positive (Ph+) chronic myeloid leukemia (CML). For late chronic phase patients who achieve a complete cytogenetic response 5-year survival     is as high as for early chronic phase patients
Journal Articles

Imatinib mesylate can induce molecular complete remission in idiopathic hypereosinophilic syndrome (HES): A phase II multicentric Italian clinical trial

Giovanni Martinelli, Daniela Cilloni, Michela Rondoni, Francesca Messa, Emanuela Ottaviani, Enrico Gottardi, Pier Paolo Piccaluga, Michele Malagola, Simona Soverini, Serena Merante, Giuliana Alimena, Costanza Bosi, Antonio Devivo, Gianantonio Rosti, Giugliano Emilia, Fabrizio Pane, Barbara Izzo, Nicoletta Testoni, Stefania Paolini, Francesca Rancati, Renato Bassan, Cristina Mecucci, Michele Baccarani, Giuseppe Saglio
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 274–275.
Published: 15 April 2006
View article titled, Imatinib mesylate can induce molecular complete remission in idiopathic hypereosinophilic syndrome (HES): A phase II multicentric Italian clinical trial