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Eugene P. Frenkel
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Journal Articles

Relationship between sun exposure and methylation in malignant and non malignant skin lesions.

Ubaradka G. Sathyanarayana, Angela Yen Moore, Lin Li, Asha Padar, Kuntal Majmudar, Victor Stastny, Prakash Makarla, Makoto Suzuki, John D. Minna, Ziding Feng, Eugene P. Frenkel, Adi F. Gazdar
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1187.
Published: 15 April 2006
View article titled, Relationship between sun exposure and methylation in malignant and non malignant skin lesions.
Journal Articles

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuki Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 329.
Published: 01 May 2005
View article titled, PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates
Journal Articles

PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuji Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6673–6678.
https://doi.org/10.1158/0008-5472.CAN-04-1822
Published: 16 September 2004
View article titled, PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates
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Journal Articles

Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate

Zhijian Yang, Xinghua Sun, Shukuan Li, Yuying Tan, Xiaoen Wang, Nan Zhang, Shigeo Yagi, Tomoaki Takakura, Yoshinao Kobayashi, Akio Takimoto, Takayuki Yoshioka, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5775–5778.
https://doi.org/10.1158/0008-5472.CAN-04-1406
Published: 16 August 2004
View article titled, Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate
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Journal Articles

Synergistic induction of coxsackie and adenovirus receptor expression by histone deacteylase inhibitor and ipriflavone in bladder cancer cells

Rey-Chen Pong, Ryan Roark, Eugene P. Frenkel, Arthur I. Sagalowsky, Jer-Tsong Hsieh
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 271–272.
Published: 01 April 2004
View article titled, Synergistic induction of coxsackie and adenovirus receptor expression by histone deacteylase inhibitor and ipriflavone in bladder cancer cells
Journal Articles

Deregulation of genes related to TGF-β signaling pathway via aberrant methylation in human cancers

Hisayuki Shigematsu, Makoto Suzuki, Takao Takahashi, David S. Shames, Noriaki Sunaga, Eugene P. Frenkel, Takehiko Fujisawa, John D. Minna, Adi F. Gazdar
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 965.
Published: 01 April 2004
View article titled, Deregulation of genes related to TGF-β signaling pathway via aberrant methylation in human cancers
Journal Articles

5-Azacytidine and depsipeptide control the growth of bladder cancer, in vitro and in vivo

Jose A. Karam, Elie A. Benaim, Eugene P. Frenkel, Jer-Tsong Hsieh
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 369.
Published: 01 April 2004
View article titled, 5-Azacytidine and depsipeptide control the growth of bladder cancer, <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Molecular Detection of Noninvasive and Invasive Bladder Tumor Tissues and Exfoliated Cells by Aberrant Promoter Methylation of Laminin-5 Encoding Genes

Ubaradka G. Sathyanarayana, Riichiroh Maruyama, Asha Padar, Makoto Suzuki, Jolanta Bondaruk, Arthur Sagalowsky, John D. Minna, Eugene P. Frenkel, H. Barton Grossman, Bogdan Czerniak, Adi F. Gazdar
Journal: Cancer Research
Cancer Res (2004) 64 (4): 1425–1430.
https://doi.org/10.1158/0008-5472.CAN-03-0701
Published: 18 February 2004
View article titled, Molecular Detection of Noninvasive and Invasive Bladder Tumor Tissues and Exfoliated Cells by Aberrant Promoter Methylation of Laminin-5 Encoding Genes
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Journal Articles

In Vivo Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akio Takimoto, Kenji Mitsushima, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8377–8383.
Published: 16 December 2003
View article titled, <em>In Vivo</em> Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation
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Journal Articles

Synergy between Methionine Stress and Chemotherapy in the Treatment of Brain Tumor Xenografts in Athymic Mice

Demetrius M. Kokkinakis, Robert M. Hoffman, Eugene P. Frenkel, Jacquelynn B. Wick, Qinghong Han, Mingxu Xu, Yuying Tan, S. Clifford Schold
Journal: Cancer Research
Cancer Res (2001) 61 (10): 4017–4023.
Published: 01 May 2001
View article titled, Synergy between Methionine Stress and Chemotherapy in the Treatment of Brain Tumor Xenografts in Athymic Mice
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Journal Articles

Growth of Human Lung Tumor in the Brain of the Nude Rat as a Model to Evaluate Antitumor Agent Delivery across the Blood-Brain Barrier

Edward A. Neuwelt, Eugene P. Frenkel, Anthony N. D'Agostino, Desmond N. Carney, John D. Minna, Peggy A. Barnett, Christopher I. McCormick
Journal: Cancer Research
Cancer Res (1985) 45 (6): 2827–2833.
Published: 01 June 1985
View article titled, Growth of Human Lung Tumor in the Brain of the Nude Rat as a Model to Evaluate Antitumor Agent Delivery across the Blood-Brain Barrier
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Journal Articles

Pharmacology and Neurotoxicity of cis-Diamminedichloroplatinum, Bleomycin, 5-Fluorouracil, and Cyclophosphamide Administration following Osmotic Blood-Brain Barrier Modification

Edward A. Neuwelt, Peggy A. Barnett, Mark Glasberg, Eugene P. Frenkel
Journal: Cancer Research
Cancer Res (1983) 43 (11): 5278–5285.
Published: 01 November 1983
View article titled, Pharmacology and Neurotoxicity of <em>cis</em>-Diamminedichloroplatinum, Bleomycin, 5-Fluorouracil, and Cyclophosphamide Administration following Osmotic Blood-Brain Barrier Modification
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Journal Articles

Selective Toxicity of 6-Hydroxydopamine and Ascorbate for Human Neuroblastoma in Vitro: A Model for Clearing Marrow Prior to Autologous Transplant

C. Patrick Reynolds, Debra A. Reynolds, Eugene P. Frenkel, R. Graham Smith
Journal: Cancer Research
Cancer Res (1982) 42 (4): 1331–1336.
Published: 01 April 1982
View article titled, Selective Toxicity of 6-Hydroxydopamine and Ascorbate for Human Neuroblastoma <em>in Vitro</em>: A Model for Clearing Marrow Prior to Autologous Transplant
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Journal Articles

Pharmacology and Toxicity of Intracarotid Adriamycin Administration Following Osmotic Blood-Brain Barrier Modification

Edward A. Neuwelt, Michael Pagel, Peggy Barnett, Mark Glassberg, Eugene P. Frenkel
Journal: Cancer Research
Cancer Res (1981) 41 (11_Part_1): 4466–4470.
Published: 01 November 1981
View article titled, Pharmacology and Toxicity of Intracarotid Adriamycin Administration Following Osmotic Blood-Brain Barrier Modification
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Journal Articles

Induced Ribotide Reductive Conversion Defect by Hydroxyurea and Its Relationship to Megaloblastosis

Eugene P. Frenkel, Clinton Arthur
Journal: Cancer Research
Cancer Res (1967) 27 (6_Part_1): 1016–1019.
Published: 01 June 1967
View article titled, Induced Ribotide Reductive Conversion Defect by Hydroxyurea and Its Relationship to Megaloblastosis
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