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Journal Articles

Abstract 6244: Design, synthesis, and structure-activity relationships of substituted pyrido[3,2-d]pyrimidines as microtubule targeting agents and anti-cancer agents

Yesha Vijaykumar Shah, Ruoli Bai, Ernest Hamel, Aleem Gangjee

Cancer Res (2023) 83 (7_Supplement): 6244.

https://doi.org/10.1158/1538-7445.AM2023-6244

Published: 04 April 2023

View articletitled, Abstract 6244: Design, synthesis, and structure-activity relationships of substituted pyrido[3,2-d]pyrimidines as microtubule targeting agents and anti-cancer agents

Journal Articles

Abstract 1665: Design, synthesis, biological evaluation of cyclopenta[d]pyrimidines as antitubulin agents and discovery of N-(4-methylthiophenyl) and N-(4-dimethylaminophenyl) substituted N,2-dimethyl-cyclopenta[d]pyrimidines as long acting and poten

Aleem Gangjee, Weiguo Xiang, Susan L. Mooberry, Ernest Hamel

Cancer Res (2015) 75 (15_Supplement): 1665.

https://doi.org/10.1158/1538-7445.AM2015-1665

Published: 01 August 2015

View articletitled, Abstract 1665: Design, synthesis, biological evaluation of cyclopenta[d]pyrimidines as antitubulin agents and discovery of N-(4-methylthiophenyl) and N-(4-dimethylaminophenyl) substituted N,2-dimethyl-cyclopenta[d]pyrimidines as long acting and poten

Journal Articles

Abstract 4553: Substituted monocyclic pyrimidines as potent tubulin inhibitors that circumvent P-glycoprotein mediated resistance

Rishabh Mohan, Aleem Gangjee, Ruoli Bai, Ernest Hamel

Cancer Res (2015) 75 (15_Supplement): 4553.

https://doi.org/10.1158/1538-7445.AM2015-4553

Published: 01 August 2015

View articletitled, Abstract 4553: Substituted monocyclic pyrimidines as potent tubulin inhibitors that circumvent P-glycoprotein mediated resistance

Journal Articles

Abstract 1622: Design and preclinical evaluation of single agents with tubulin and multiple receptor tyrosine kinase inhibition

Aleem Gangjee, Roheeth K. Pavana, Michael Ihnat, Ernest Hamel

Cancer Res (2014) 74 (19_Supplement): 1622.

https://doi.org/10.1158/1538-7445.AM2014-1622

Published: 01 October 2014

View articletitled, Abstract 1622: Design and preclinical evaluation of single agents with tubulin and multiple receptor tyrosine kinase inhibition

Journal Articles

Abstract 836: Potent antitubulin and antitumor activities influenced by the 3-D conformational shape of bicyclic fused pyrimidines

Aleem Gangjee, Weiguo Xiang, Susan L. Mooberry, Ernest Hamel

Cancer Res (2014) 74 (19_Supplement): 836.

https://doi.org/10.1158/1538-7445.AM2014-836

Published: 01 October 2014

View articletitled, Abstract 836: Potent antitubulin and antitumor activities influenced by the 3-D conformational shape of bicyclic fused pyrimidines

Journal Articles

Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential.

Aleem Gangjee, Roheeth K. Pavana, Michael A. Ihnat, Jessica E. Thorpe, Bryan C. Disch, Anja Bastian, Lora C. Bailey-Downs, Ernest Hamel, Rouli Bai

Cancer Res (2013) 73 (8_Supplement): 5682.

https://doi.org/10.1158/1538-7445.AM2013-5682

Published: 15 April 2013

View articletitled, Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential.

Journal Articles

Abstract 4492: Structure-activity relationship study anti-microtubule agents targeting the colchicine site on tubulin that circumvent drug resistance.

Aleem Gangjee, Weiguo Xiang, Susan L. Mooberry, Ernest Hamel

Cancer Res (2013) 73 (8_Supplement): 4492.

https://doi.org/10.1158/1538-7445.AM2013-4492

Published: 15 April 2013

View articletitled, Abstract 4492: Structure-activity relationship study anti-microtubule agents targeting the colchicine site on tubulin that circumvent drug resistance.

Journal Articles

Abstract 2477: Design, synthesis and biological evaluation of substituted monocyclic pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin-mediated resistance.

Aleem Gangjee, Rishabh Mohan, Ernest Hamel, Ruoli Bai

Cancer Res (2013) 73 (8_Supplement): 2477.

https://doi.org/10.1158/1538-7445.AM2013-2477

Published: 15 April 2013

View articletitled, Abstract 2477: Design, synthesis and biological evaluation of substituted monocyclic pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin-mediated resistance.

Journal Articles

Abstract 3897: Design and preclinical evaluation of single agents with antitubulin and antiangiogenic activity as antitumor agents

Aleem Gangjee, Roheeth Kumar Pavana, Xin Zhang, Michael Ihnat, Ernest Hamel

Cancer Res (2012) 72 (8_Supplement): 3897.

https://doi.org/10.1158/1538-7445.AM2012-3897

Published: 15 April 2012

View articletitled, Abstract 3897: Design and preclinical evaluation of single agents with antitubulin and antiangiogenic activity as antitumor agents

Journal Articles

Abstract 3889: Substituted pyrrolo[2,3-d]pyrimidines as water soluble microtubule targeting agents

Aleem Gangjee, Lu Lin, Susan L. Mooberry, Ernest Hamel

Cancer Res (2012) 72 (8_Supplement): 3889.

https://doi.org/10.1158/1538-7445.AM2012-3889

Published: 15 April 2012

View articletitled, Abstract 3889: Substituted pyrrolo[2,3-d]pyrimidines as water soluble microtubule targeting agents

Journal Articles

Abstract 3244: Design, synthesis and biological evaluation of substituted furo[2,3-d]pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin mediated resistance

Aleem Gangjee, Xin Zhang, Ojas Namjoshi, Ravi Kumar Vyas Devambatla, Ernest Hamel, Susan L. Mooberry

Cancer Res (2011) 71 (8_Supplement): 3244.

https://doi.org/10.1158/1538-7445.AM2011-3244

Published: 15 April 2011

View articletitled, Abstract 3244: Design, synthesis and biological evaluation of substituted furo[2,3-d]pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin mediated resistance

Journal Articles

Abstract #5570: Interaction of [³H]halichondrin B with tubulin

Ruoli Bai, Ernest Hamel

Cancer Res (2009) 69 (9_Supplement): 5570.

Published: 01 May 2009

View articletitled, Abstract #5570: Interaction of [³H]halichondrin B with tubulin

Journal Articles

The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

Adam I. Marcus, Jun Zhou, Aurora O'Brate, Ernest Hamel, Jason Wong, Michael Nivens, Adel El-Naggar, Tso-Pang Yao, Fadlo R. Khuri, Paraskevi Giannakakou

Cancer Res (2005) 65 (9): 3883–3893.

https://doi.org/10.1158/0008-5472.CAN-04-3757

Published: 02 May 2005

View articletitled, The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

Includes: Supplementary data

Journal Articles

Interactions of ILX651 and its metabolite with tubulin

Michael C. Edler, Ruoli Bai, Larry E. Arthaud, Richard F. Luduena, George R. Pettit, Ernest Hamel

Cancer Res (2005) 65 (9_Supplement): 809.

Published: 01 May 2005

View articletitled, Interactions of ILX651 and its metabolite with tubulin

Journal Articles

Tubulin assembly, paclitaxel site binding and cellular effects of the microtubule-stabilizing agent dictyostatin-1 and its synthetic analogues

Charitha Madiraju, Michael C. Edler, Brianne S. Raccor, Raghavan Balachandran, Ernest Hamel, Kenneth A. Giuliano, Andreas Vogt, Youseung Shin, Jean-Hughes Fournier, Yoshikazu Fukui, Arndt M. Bruckner, Dennis P. Curran, Billy W. Day

Cancer Res (2005) 65 (9_Supplement): 932–933.

Published: 01 May 2005

View articletitled, Tubulin assembly, paclitaxel site binding and cellular effects of the microtubule-stabilizing agent dictyostatin-1 and its synthetic analogues

Journal Articles

Farnesyl transferase inhibitors affect microtubule stability and function

Adam I. Marcus, Ernest Hamel, Michael C. Nivens, Jonathan Iaconelli, Fadlo R. Khuri, Paraskevi Giannakakou

Cancer Res (2004) 64 (7_Supplement): 892–893.

Published: 01 April 2004

View articletitled, Farnesyl transferase inhibitors affect microtubule stability and function

Journal Articles

In vitro conditions promoting the formation of both microtubules and spirals by the natural product (-)-rhazinilam

Michael C. Edler, Guangli Yang, William G. Bornmann, Ernest Hamel

Cancer Res (2004) 64 (7_Supplement): 1249–1250.

Published: 01 April 2004

View articletitled, In vitro conditions promoting the formation of both microtubules and spirals by the natural product (-)-rhazinilam

Journal Articles

Hypoestoxide, a Natural Nonmutagenic Diterpenoid with Antiangiogenic and Antitumor Activity: Possible Mechanisms of Action

Emmanuel A. Ojo-Amaize, Emeka J. Nchekwube, Howard B. Cottam, Ruoli Bai, Pascal Verdier-Pinard, Vellalore N. Kakkanaiah, Judith A. Varner, Lorenzo Leoni, Joseph I. Okogun, Akinbo A. Adesomoju, Olusola A. Oyemade, Ernest Hamel

Cancer Res (2002) 62 (14): 4007–4014.

Published: 15 July 2002

View articletitled, Hypoestoxide, a Natural Nonmutagenic Diterpenoid with Antiangiogenic and Antitumor Activity: Possible Mechanisms of Action

Journal Articles

Regulation of Ornithine Decarboxylase Induction by Deguelin, a Natural Product Cancer Chemopreventive Agent

Clarissa Gerhäuser, Sang Kook Lee, Jerry W. Kosmeder, Robert M. Moriarty, Ernest Hamel, Rajendra G. Mehta, Richard C. Moon, John M. Pezzuto

Cancer Res (1997) 57 (16): 3429–3435.

Published: 01 August 1997

View articletitled, Regulation of Ornithine Decarboxylase Induction by Deguelin, a Natural Product Cancer Chemopreventive Agent

Journal Articles

Inhibition of Angiogenesis and Breast Cancer in Mice by the Microtubule Inhibitors 2-Methoxyestradiol and Taxol

Nancy Klauber, Sareh Parangi, Evelyn Flynn, Ernest Hamel, Robert J. D'Amato

Cancer Res (1997) 57 (1): 81–86.

Published: 01 January 1997

View articletitled, Inhibition of Angiogenesis and Breast Cancer in Mice by the Microtubule Inhibitors 2-Methoxyestradiol and Taxol

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Abstract 6244: Design, synthesis, and structure-activity relationships of substituted pyrido[3,2-d]pyrimidines as microtubule targeting agents and anti-cancer agents

Abstract 1665: Design, synthesis, biological evaluation of cyclopenta[d]pyrimidines as antitubulin agents and discovery of N-(4-methylthiophenyl) and N-(4-dimethylaminophenyl) substituted N,2-dimethyl-cyclopenta[d]pyrimidines as long acting and poten

Abstract 4553: Substituted monocyclic pyrimidines as potent tubulin inhibitors that circumvent P-glycoprotein mediated resistance

Abstract 1622: Design and preclinical evaluation of single agents with tubulin and multiple receptor tyrosine kinase inhibition

Abstract 836: Potent antitubulin and antitumor activities influenced by the 3-D conformational shape of bicyclic fused pyrimidines

Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential.

Abstract 4492: Structure-activity relationship study anti-microtubule agents targeting the colchicine site on tubulin that circumvent drug resistance.

Abstract 2477: Design, synthesis and biological evaluation of substituted monocyclic pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin-mediated resistance.

Abstract 3897: Design and preclinical evaluation of single agents with antitubulin and antiangiogenic activity as antitumor agents

Abstract 3889: Substituted pyrrolo[2,3-d]pyrimidines as water soluble microtubule targeting agents

Abstract 3244: Design, synthesis and biological evaluation of substituted furo[2,3-d]pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin mediated resistance

Abstract #5570: Interaction of [³H]halichondrin B with tubulin

The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

Interactions of ILX651 and its metabolite with tubulin

Tubulin assembly, paclitaxel site binding and cellular effects of the microtubule-stabilizing agent dictyostatin-1 and its synthetic analogues

Farnesyl transferase inhibitors affect microtubule stability and function

In vitro conditions promoting the formation of both microtubules and spirals by the natural product (-)-rhazinilam

Hypoestoxide, a Natural Nonmutagenic Diterpenoid with Antiangiogenic and Antitumor Activity: Possible Mechanisms of Action

Regulation of Ornithine Decarboxylase Induction by Deguelin, a Natural Product Cancer Chemopreventive Agent

Inhibition of Angiogenesis and Breast Cancer in Mice by the Microtubule Inhibitors 2-Methoxyestradiol and Taxol

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