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Eric O. Aboagye
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Journal Articles

Abstract 600: Tumour and local lymphoid tissue interaction determines prognosis in high grade serous ovarian cancer

Haonan Lu, Georg Wengert, Hantao Lou, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J. Pinato, Andrea Rockall, Susan J. Copley, Sadaf Ghaem-Maghami, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 600.
https://doi.org/10.1158/1538-7445.AM2023-600
Published: 04 April 2023
View article titled, Abstract 600: Tumour and local lymphoid tissue interaction determines prognosis in high grade serous ovarian cancer
Journal Articles

Abstract PD6-09: Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study

Laura M. Kenny, Gosala S. Gopalakrishnan, Tara D. Barwick, Vijay Vaja, S. Hope McDevitt, Robert Punjani, Neva H. Patel, Rathi Ramakrishnan, Naina R. Patel, Stephen Johnston, Janine Mansi, Gary J. Cook, Fiona J. Gilbert, Franklin I. Aigbirhio, Duncan Hiscock, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD6-09.
https://doi.org/10.1158/1538-7445.SABCS20-PD6-09
Published: 15 February 2021
View article titled, Abstract PD6-09: Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study
Journal Articles

Abstract 4235: Choline metabolism is an early predictor of EGFR-mediated survival in NSCLC

Rosy Favicchio, Nicos Angelopoulos, Diana Brickute, Robin Fortt, Frazer Twyman, Georgios Giamas, Juan Carlos Lacal, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4235.
https://doi.org/10.1158/1538-7445.AM2016-4235
Published: 15 July 2016
View article titled, Abstract 4235: Choline metabolism is an early predictor of EGFR-mediated survival in NSCLC
Journal Articles

Abstract P5-01-02: Evaluation of apoptosis in breast cancer using the novel PET probe [18F]ICMT-11 in patients treated with neoadjuvant FEC chemotherapy: Initial assessment of optimum imaging time and relation to caspase-3 immunostaining

Shairoz Merchant, Eric O Aboagye, Adrian Lim, Kasia Kozlowski, Naina Patel, Jennifer Steel, Susan Cleator, Sami Shousha, Vidhya Varghese, Raoul C Coombes, Laura Kenny
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-01-02.
https://doi.org/10.1158/1538-7445.SABCS14-P5-01-02
Published: 01 May 2015
View article titled, Abstract P5-01-02: Evaluation of apoptosis in breast cancer using the novel PET probe [<sup>18</sup>F]ICMT-11 in patients treated with neoadjuvant FEC chemotherapy: Initial assessment of optimum imaging time and relation to caspase-3 immunostaining
Journal Articles

Alterations of Choline Phospholipid Metabolism in Endometrial Cancer Are Caused by Choline Kinase Alpha Overexpression and a Hyperactivated Deacylation Pathway

Sebastian Trousil, Patrizia Lee, David J. Pinato, James K. Ellis, Roberto Dina, Eric O. Aboagye, Hector C. Keun, Rohini Sharma
Journal: Cancer Research
Cancer Res (2014) 74 (23): 6867–6877.
https://doi.org/10.1158/0008-5472.CAN-13-2409
Published: 30 November 2014
View article titled, Alterations of Choline Phospholipid Metabolism in Endometrial Cancer Are Caused by Choline Kinase Alpha Overexpression and a Hyperactivated Deacylation Pathway
Open the PDF for Alterations of Choline Phospholipid Metabolism in Endometrial Cancer Are Caused by Choline Kinase Alpha Overexpression and a Hyperactivated Deacylation Pathway in another window
Includes: Supplementary data
Journal Articles

A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography

Timothy H. Witney, Laurence Carroll, Israt S. Alam, Anil Chandrashekran, Quang-Dé Nguyen, Roberta Sala, Robert Harris, Ralph J. DeBerardinis, Roshan Agarwal, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2014) 74 (5): 1319–1328.
https://doi.org/10.1158/0008-5472.CAN-13-2768
Published: 02 March 2014
View article titled, A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography
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Includes: Supplementary data
Journal Articles

Abstract 2660: Regulation of 18F-fluorothymidine uptake by thymidine kinase 1 protein phosphorylation.

Roberta Sala, Quang-De Nguyen, Chirag Patel, David Mann, Joachim H. G. Steinke, Ramon Vilar, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2660.
https://doi.org/10.1158/1538-7445.AM2013-2660
Published: 15 April 2013
View article titled, Abstract 2660: Regulation of 18F-fluorothymidine uptake by thymidine kinase 1 protein phosphorylation.
Journal Articles

Abstract 5274: Noninvasive early assessment of tumor response to the SMAC mimetic TL32711 with a caspase-3/7-specific PET imaging radiotracer

Quang-Dé Nguyen, Graham Smith, Laurence S. Carroll, Martin A. Graham, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5274.
https://doi.org/10.1158/1538-7445.AM2011-5274
Published: 15 April 2011
View article titled, Abstract 5274: Noninvasive early assessment of tumor response to the SMAC mimetic TL32711 with a caspase-3/7-specific PET imaging radiotracer
Journal Articles

The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

Olivier E. Pardo, John Latigo, Rosemary E. Jeffery, Emma Nye, Richard Poulsom, Bradley Spencer-Dene, Nick R. Lemoine, Gordon W. Stamp, Eric O. Aboagye, Michael J. Seckl
Journal: Cancer Research
Cancer Res (2009) 69 (22): 8645–8651.
https://doi.org/10.1158/0008-5472.CAN-09-1576
Published: 11 November 2009
View article titled, The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth <em>In vitro</em> and <em>In vivo</em>
Open the PDF for The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth <em>In vitro</em> and <em>In vivo</em> in another window
Includes: Supplementary data
Journal Articles

[18F]Fluoromethyl-[1,2-2H4]-Choline: A Novel Radiotracer for Imaging Choline Metabolism in Tumors by Positron Emission Tomography

Julius Leyton, Graham Smith, Yongjun Zhao, Meg Perumal, Quang-De Nguyen, Edward Robins, Erik Årstad, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7721–7728.
https://doi.org/10.1158/0008-5472.CAN-09-1419
Published: 01 October 2009
View article titled, [<sup>18</sup>F]Fluoromethyl-[1,2-<sup>2</sup>H<sub>4</sub>]-Choline: A Novel Radiotracer for Imaging Choline Metabolism in Tumors by Positron Emission Tomography
Open the PDF for [<sup>18</sup>F]Fluoromethyl-[1,2-<sup>2</sup>H<sub>4</sub>]-Choline: A Novel Radiotracer for Imaging Choline Metabolism in Tumors by Positron Emission Tomography in another window
Includes: Supplementary data
Journal Articles

The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Simak Ali, Dean A. Heathcote, Sebastian H.B. Kroll, Ashutosh S. Jogalekar, Bodo Scheiper, Hetal Patel, Jan Brackow, Alekasandra Siwicka, Matthew J. Fuchter, Manikandan Periyasamy, Robert S. Tolhurst, Seshu K. Kanneganti, James P. Snyder, Dennis C. Liotta, Eric O. Aboagye, Anthony G.M. Barrett, R. Charles Coombes
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6208–6215.
https://doi.org/10.1158/0008-5472.CAN-09-0301
Published: 29 July 2009
View article titled, The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Open the PDF for The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity in another window
Includes: Supplementary data
Journal Articles

A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients

Lula Rosso, Cathryn S. Brock, James M. Gallo, Azeem Saleem, Patricia M. Price, Federico E. Turkheimer, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2009) 69 (1): 120–127.
https://doi.org/10.1158/0008-5472.CAN-08-2356
Published: 31 December 2008
View article titled, A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients
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Journal Articles

Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945

Radhakrishna G. Pillai, Martin Forster, Meg Perumal, Fraser Mitchell, Julius Leyton, Franklin I. Aibgirhio, Oksana Golovko, Ann L. Jackman, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2008) 68 (10): 3827–3834.
https://doi.org/10.1158/0008-5472.CAN-08-0135
Published: 15 May 2008
View article titled, Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945
Open the PDF for Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945 in another window
Includes: Supplementary data
Journal Articles

Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using Renilla Luciferase Bioluminescence and 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography Imaging

Julius Leyton, Michelle Lockley, Joeri L. Aerts, Sarah K. Baird, Eric O. Aboagye, Nicholas R. Lemoine, Iain A. McNeish
Journal: Cancer Research
Cancer Res (2006) 66 (18): 9178–9185.
https://doi.org/10.1158/0008-5472.CAN-06-1539
Published: 18 September 2006
View article titled, Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using <em>Renilla</em> Luciferase Bioluminescence and 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine Positron Emission Tomography Imaging
Open the PDF for Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using <em>Renilla</em> Luciferase Bioluminescence and 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine Positron Emission Tomography Imaging in another window
Includes: Supplementary data
Journal Articles

Redistribution of Nucleoside Transporters to the Cell Membrane Provides a Novel Approach for Imaging Thymidylate Synthase Inhibition by Positron Emission Tomography

Meg Perumal, Radhakrishna G. Pillai, Henryk Barthel, Julius Leyton, John R. Latigo, Martin Forster, Fraser Mitchell, Ann L. Jackman, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2006) 66 (17): 8558–8564.
https://doi.org/10.1158/0008-5472.CAN-06-0898
Published: 01 September 2006
View article titled, Redistribution of Nucleoside Transporters to the Cell Membrane Provides a Novel Approach for Imaging Thymidylate Synthase Inhibition by Positron Emission Tomography
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Journal Articles

In vivo Biological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography

Julius Leyton, John P. Alao, Marco Da Costa, Alexandra V. Stavropoulou, John R. Latigo, Meg Perumal, Radhakrishna Pillai, Qimin He, Peter Atadja, Eric W.-F. Lam, Paul Workman, David M. Vigushin, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2006) 66 (15): 7621–7629.
https://doi.org/10.1158/0008-5472.CAN-05-3962
Published: 02 August 2006
View article titled, <em>In vivo</em> Biological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine Positron Emission Tomography
Open the PDF for <em>In vivo</em> Biological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine Positron Emission Tomography in another window
Journal Articles

E1A CR2 deletion mutant adenoviral vectors in ovarian cancer: combination with apoptosis inducers and monitoring with [18F] FLT-PET imaging

Sarah K. Baird, Michelle Lockley, Julius Leyton, Eric O. Aboagye, Nicholas R. Lemoine, Iain A. McNeish
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 704–705.
Published: 15 April 2006
View article titled, E1A CR2 deletion mutant adenoviral vectors in ovarian cancer: combination with apoptosis inducers and monitoring with [18F] FLT-PET imaging
Journal Articles

Quantification of Cellular Proliferation in Tumor and Normal Tissues of Patients with Breast Cancer by [18F]Fluorothymidine-Positron Emission Tomography Imaging: Evaluation of Analytical Methods

Laura M. Kenny, David M. Vigushin, Adil Al-Nahhas, Safiye Osman, Sajinder K. Luthra, Sami Shousha, R. Charles Coombes, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2005) 65 (21): 10104–10112.
https://doi.org/10.1158/0008-5472.CAN-04-4297
Published: 01 November 2005
View article titled, Quantification of Cellular Proliferation in Tumor and Normal Tissues of Patients with Breast Cancer by [<sup>18</sup>F]Fluorothymidine-Positron Emission Tomography Imaging: Evaluation of Analytical Methods
Open the PDF for Quantification of Cellular Proliferation in Tumor and Normal Tissues of Patients with Breast Cancer by [<sup>18</sup>F]Fluorothymidine-Positron Emission Tomography Imaging: Evaluation of Analytical Methods in another window
Journal Articles

Early Detection of Tumor Response to Chemotherapy by 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography: The Effect of Cisplatin on a Fibrosarcoma Tumor Model In vivo

Julius Leyton, John R. Latigo, Meg Perumal, Harmandeep Dhaliwal, Qimin He, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2005) 65 (10): 4202–4210.
https://doi.org/10.1158/0008-5472.CAN-04-4008
Published: 16 May 2005
View article titled, Early Detection of Tumor Response to Chemotherapy by 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine Positron Emission Tomography: The Effect of Cisplatin on a Fibrosarcoma Tumor Model <em>In vivo</em>
Open the PDF for Early Detection of Tumor Response to Chemotherapy by 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine Positron Emission Tomography: The Effect of Cisplatin on a Fibrosarcoma Tumor Model <em>In vivo</em> in another window
Journal Articles

Early detection of tumor response to LAQ824 by 3’-Deoxy-3’-[18F]fluorothymidine by positron emission tomography in HCT116 tumor bearing mice

Julius Leyton, John P. Alao, John R. Latigo, Meg Perumal, Qimin He, David M. Vigushin, Peter Atadja, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 900.
Published: 01 May 2005
View article titled, Early detection of tumor response to LAQ824 by 3’-Deoxy-3’-[<sup>18</sup>F]fluorothymidine by positron emission tomography in HCT116 tumor bearing mice