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Eric K. Rowinsky
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Journal Articles

Abstract CT146: RGX-104, a first-in-class immunotherapy targeting the liver-X receptor (LXR): Initial results from the phase 1b RGX-104 plus docetaxel combination dose escalation cohorts

Emerson Lim, Erika P. Hamilton, Rebecca Redman, Michael A. Postow, Russell J. Schilder, Monica M. Mita, Alain C. Mita, Bartosz Chmielowski, James Strauss, Angela Jain, Shubham Pant, Olivier Rixe, Tomislav Dragovich, R. Donald Harvey, Igor Puzanov, Kevin B. Kim, Eric K. Rowinsky, Michael Szarek, Foster Gonsalves, Isabel Kurth, Celia Andreu, Robert W. Busby, David Darst, Masoud Tavazoie, Syed Raza, Narayan Lebaka16, Robert Wasserman, Gerald Falchook
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT146.
https://doi.org/10.1158/1538-7445.AM2020-CT146
Published: 15 August 2020
View articletitled, Abstract CT146: RGX-104, a first-in-class immunotherapy targeting the liver-X receptor (LXR): Initial results from the phase 1b RGX-104 plus docetaxel combination dose escalation cohorts
Journal Articles

Abstract P2-06-07: StemScreen®, an innovative platform technology for the identification of novel cancer stem cell-directed compounds

Janice Chen, Hai Li, Marcie A Glicksman, Charles Karan, Christopher Brooks, Eric K Rowinsky
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P2-06-07.
https://doi.org/10.1158/1538-7445.SABCS14-P2-06-07
Published: 01 May 2015
View articletitled, Abstract P2-06-07: StemScreen®, an innovative platform technology for the identification of novel cancer stem cell-directed compounds
Journal Articles

Abstract 4189: Utilization of Champions Tumorgraft™ models to identify putative biomarkers and signatures of response

Jay A. Friedman, Theodore H. Hewit, Manuel Hidalgo, Eric K. Rowinsky, David Sidransky, Elizabeth M. Bruckheimer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4189.
https://doi.org/10.1158/1538-7445.AM2011-4189
Published: 15 April 2011
View articletitled, Abstract 4189: Utilization of Champions Tumorgraft™ models to identify putative biomarkers and signatures of response
Journal Articles

Phase I study of BMS-247550, an epothilone B analog, administered weekly for 3 weeks followed by a one-week break in patients (pts) with advanced malignancies

Alejandro D. Ricart, Anthony W. Tolcher, Quincy S. Chu, Johann S. De Bono, Muralidhar Beeram, Desiree Hao, Monica Mita, Alain Mita, Geoffrey Weiss, Chris H. Takimoto, Eric K. Rowinsky
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 685.
Published: 15 April 2006
View articletitled, Phase I study of BMS-247550, an epothilone B analog, administered weekly for 3 weeks followed by a one-week break in patients (pts) with advanced malignancies
Journal Articles

The current status of mTOR inhibitors in the clinic: Are they living up to their potential or have we failed them?

Eric K. Rowinsky
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1469.
Published: 01 May 2005
View articletitled, The current status of mTOR inhibitors in the clinic: Are they living up to their potential or have we failed them?
Journal Articles

Analysis of dose proportionality testing methods in phase I clinical trials of anticancer agents

Emiliano Calvo, Haider Zafar, Andrew Goetz, Peter L. Bonate, Johan S. De Bono, Amita Patnaik, Bahram Fourezesh, Anthony W. Tolcher, Eric K. Rowinsky, Chris H. Takimoto
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 973–974.
Published: 01 May 2005
View articletitled, Analysis of dose proportionality testing methods in phase I clinical trials of anticancer agents
Journal Articles

A Phase I, pharmacokinetic (PK) study of HGS-ETR1, an agonist monoclonal antibody to TRAIL-R1, in patients with advanced solid tumors

Monica M. Mita, Anthony W. Tolcher, Amita Patnaik, Monique Hill, Norma Lynn Fox, Alfred Corey, Lara Blake, Kristine M. Padavic, Neal J. Meropol, Eric K. Rowinsky, Roger B. Cohen
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 128.
Published: 01 May 2005
View articletitled, A Phase I, pharmacokinetic (PK) study of HGS-ETR1, an agonist monoclonal antibody to TRAIL-R1, in patients with advanced solid tumors
Journal Articles

Enhanced Antitumor Activity of 6-Hydroxymethylacylfulvene in Combination with Irinotecan and 5-Fluorouracil in the HT29 Human Colon Tumor Xenograft Model

Carolyn D. Britten, Susan G. Hilsenbeck, S. Gail Eckhardt, Jennifer Marty, Gina Mangold, John R. MacDonald, Eric K. Rowinsky, Daniel D. Von Hoff, Steve Weitman
Journal: Cancer Research
Cancer Res (1999) 59 (5): 1049–1053.
Published: 01 March 1999
View articletitled, Enhanced Antitumor Activity of 6-Hydroxymethylacylfulvene in Combination with Irinotecan and 5-Fluorouracil in the HT29 Human Colon Tumor Xenograft Model
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Journal Articles

Phase I and Pharmacological Study of the Novel Topoisomerase I Inhibitor 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) Administered as a Ninety-Minute Infusion Every 3 Weeks

Eric K. Rowinsky, Louise B. Grochow, David S. Ettinger, Susan E. Sartorius, Barbara G. Lubejko, Tian-Ling Chen, Michael K. Rock, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1994) 54 (2): 427–436.
Published: 01 January 1994
View articletitled, Phase I and Pharmacological Study of the Novel Topoisomerase I Inhibitor 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) Administered as a Ninety-Minute Infusion Every 3 Weeks
Open the PDF for Phase I and Pharmacological Study of the Novel Topoisomerase I Inhibitor 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) Administered as a Ninety-Minute Infusion Every 3 Weeks in another window
Journal Articles

Phase I and Pharmacological Study of the Pulmonary Cytotoxin 4-Ipomeanol on a Single Dose Schedule in Lung Cancer Patients: Hepatotoxicity Is Dose Limiting in Humans

Eric K. Rowinsky, Dennis A. Noe, David S. Ettinger, Michaele C. Christian, Barbara G. Lubejko, Elliot K. Fishman, Susan E. Sartorius, Michael R. Boyd, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1993) 53 (8): 1794–1801.
Published: 01 April 1993
View articletitled, Phase I and Pharmacological Study of the Pulmonary Cytotoxin 4-Ipomeanol on a Single Dose Schedule in Lung Cancer Patients: Hepatotoxicity Is Dose Limiting in Humans
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Journal Articles

Effect of P-Glycoprotein Expression on the Accumulation and Cytotoxicity of Topotecan (SK&F 104864), a New Camptothecin Analogue

Carolyn B. Hendricks, Eric K. Rowinsky, Louise B. Grochow, Ross C. Donehower, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (1992) 52 (8): 2268–2278.
Published: 01 April 1992
View articletitled, Effect of P-Glycoprotein Expression on the Accumulation and Cytotoxicity of Topotecan (SK&F 104864), a New Camptothecin Analogue
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Journal Articles

Phase I and Pharmacokinetic Study of Hepsulfam (NSC 329680)

Carolyn B. Hendricks, Louise B. Grochow, Eric K. Rowinsky, Arlene A. Forastiere, William P. McGuire, David S. Ettinger, Susan Sartorius, Barbara Lubejko, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1991) 51 (21): 5781–5785.
Published: 01 November 1991
View articletitled, Phase I and Pharmacokinetic Study of Hepsulfam (NSC 329680)
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Journal Articles

Phase I and Pharmacokinetic Study of Brequinar Sodium (NSC 368390)

Dennis A. Noe, Eric K. Rowinsky, Huey-Shin L. Shen, Barbara V. Clarke, Louise B. Grochow, William B. McGuire, Alexander Hantel, David B. Adams, Martin D. Abeloff, David S. Ettinger, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1990) 50 (15): 4595–4599.
Published: 01 August 1990
View articletitled, Phase I and Pharmacokinetic Study of Brequinar Sodium (NSC 368390)
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Journal Articles

Phase I Study and Pharmacodynamics of Piroxantrone (NSC 349174), a New Anthrapyrazole

Alexander Hantel, Ross C. Donehower, Eric K. Rowinsky, Estil Vance, Barbara V. Clarke, William P. McGuire, David S. Ettinger, Dennis A. Noe, Louise B. Grochow
Journal: Cancer Research
Cancer Res (1990) 50 (11): 3284–3288.
Published: 01 June 1990
View articletitled, Phase I Study and Pharmacodynamics of Piroxantrone (NSC 349174), a New Anthrapyrazole
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Journal Articles

Development of Polyploidization in Taxol-resistant Human Leukemia Cells in Vitro

John R. Roberts, David C. Allison, Ross C. Donehower, Eric K. Rowinsky
Journal: Cancer Research
Cancer Res (1990) 50 (3): 710–716.
Published: 01 February 1990
View articletitled, Development of Polyploidization in Taxol-resistant Human Leukemia Cells in Vitro
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Journal Articles

Phase I and Pharmacodynamic Study of Taxol in Refractory Acute Leukemias

Eric K. Rowinsky, Philip J. Burke, Judith E. Karp, Robert W. Tucker, David S. Ettinger, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1989) 49 (16): 4640–4647.
Published: 01 August 1989
View articletitled, Phase I and Pharmacodynamic Study of Taxol in Refractory Acute Leukemias
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Journal Articles

Microtubule Changes and Cytotoxicity in Leukemic Cell Lines Treated with Taxol

Eric K. Rowinsky, Ross C. Donehower, Richard J. Jones, Robert W. Tucker
Journal: Cancer Research
Cancer Res (1988) 48 (14): 4093–4100.
Published: 01 July 1988
View articletitled, Microtubule Changes and Cytotoxicity in Leukemic Cell Lines Treated with Taxol
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Journal Articles

Prolonged Infusion of Hexamethylene Bisacetamide: A Phase I and Pharmacological Study

Eric K. Rowinsky, David S. Ettinger, William P. McGuire, Dennis A. Noe, Louise B. Grochow, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1987) 47 (21): 5788–5795.
Published: 01 November 1987
View articletitled, Prolonged Infusion of Hexamethylene Bisacetamide: A Phase I and Pharmacological Study
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