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Journal Articles

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

Open Access
Sunyana Gadal, Jacob A. Boyer, Simon F. Roy, Noah A. Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus W. Bosenberg, Neal Rosen
Journal: Cancer Research
Cancer Res (2025) 85 (9): 1611–1627.
https://doi.org/10.1158/0008-5472.CAN-24-2220
Published: 02 May 2025
View articletitled, Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
Open the PDF for Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5185: Intratumoral Escherichia is associated with response to single-agent immune checkpoint inhibition in patients with advanced non-small cell lung cancer

Free
Arielle Elkrief, Anita S. Bowman, Ayyuce Begum Bektas, Wenfei Kang, Katia Manova-Todorova, Jacklynn V. Egger, Hira Rizvi, Daniel Kelly, Eric Chan, Eric Rosiek, Fan Ning, Gregory J. Riely, Álvaro Quintanal Villalonga, Snjezana Dogan, Umesh Bhanot, Mithat Gonen, Matthew D. Hellmann, Adam J. Schoenfeld, Charles M. Rudin, Marc Ladanyi, Chad M. Vanderbilt
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5185.
https://doi.org/10.1158/1538-7445.AM2023-5185
Published: 04 April 2023
View articletitled, Abstract 5185: Intratumoral Escherichia is associated with response to single-agent immune checkpoint inhibition in patients with advanced non-small cell lung cancer
Journal Articles

Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations

Free
Sunyana Gadal, Jacob A. Boyer, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Elisa De Stanchina, Rona Yeager, Marcus Bosenberg, Katia M. Todorova, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2422.
https://doi.org/10.1158/1538-7445.AM2022-2422
Published: 15 June 2022
View articletitled, Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations
Journal Articles

Abstract 1451: AN3025: A novel anti-human TNFR2 antibody that exhibits immune activation and strong anti-tumor activity in vivo

Free
Yonglin Chen, Manxue Jia, Sherry Xu, Yanhui Zhao, Eric Chan, Meng Zhang, Emma Chen, Yi Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1451.
https://doi.org/10.1158/1538-7445.AM2021-1451
Published: 01 July 2021
View articletitled, Abstract 1451: AN3025: A novel anti-human TNFR2 antibody that exhibits immune activation and strong anti-tumor activity in vivo
Journal Articles

Abstract 1476: Vessel normalization following LDH-A knockdown in murine breast tumors

Free
Inna Serganova, Kiranmayi Vemuri, Ivan Cohen, Matthew Lubin, Sheryl Roberts, Masatomo Maeda, Mayuresh Mane, Henry Mann, Thomas Reiner, Eric Chan, Dmitry Yarilin, Katia Manova-Todorova, Roberta Zappasodi, Taha Merghoub, Jason Koutcher, Ronald Blasberg
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1476.
https://doi.org/10.1158/1538-7445.AM2020-1476
Published: 15 August 2020
View articletitled, Abstract 1476: Vessel normalization following LDH-A knockdown in murine breast tumors
Journal Articles

Abstract 4291: A novel image-based cytometry method for autophagy detection in living cells

Free
Leo Li-Ying Chan, Dee Shen, Alisha R. Wilkinson, Wayne Patton, Ning Lai, Eric Chan, Dmitry Kuksin, Bo Lin, Jean Qiu
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4291.
https://doi.org/10.1158/1538-7445.AM2014-4291
Published: 01 October 2014
View articletitled, Abstract 4291: A novel image-based cytometry method for autophagy detection in living cells
Journal Articles

Abstract 4621: The histone methyltransferase EZH2 catalytic activity is required for cell growth in diffuse large B-cell lymphoma.

Free
James E. Audia, Patrick Trojer, Shivani Garapaty, Fei Lan, Vidya Balasubramanian, Eric Chan, Charles Hatton, Robert Campbell, Richard Cummings, Emmanuel Normant, Barbara Bryant, Brian Albrecht, Jean Christophe Harmange, Les Dakin, Victor Gehling, Chris Nasveschuk, Rishi Vaswani, Andrew Cook
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4621.
https://doi.org/10.1158/1538-7445.AM2013-4621
Published: 15 April 2013
View articletitled, Abstract 4621: The histone methyltransferase EZH2 catalytic activity is required for cell growth in diffuse large B-cell lymphoma.
Journal Articles

Abstract 3774: A novel drug discovery assay for analyzing autophagy in living cells

Free
Dee Shen, Eric Chan, Praveen Pande, Jack Coleman, Wayne F. Patton
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3774.
https://doi.org/10.1158/1538-7445.AM2011-3774
Published: 15 April 2011
View articletitled, Abstract 3774: A novel drug discovery assay for analyzing autophagy in living cells
Journal Articles

Abstract 2876: A novel multi-parametric assay of cell death pathways: Autophagy, apoptosis, and necrosis

Free
Dee Shen, Eric Chan, Praveen Pande, Wayne F. Patton
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2876.
https://doi.org/10.1158/1538-7445.AM2011-2876
Published: 15 April 2011
View articletitled, Abstract 2876: A novel multi-parametric assay of cell death pathways: Autophagy, apoptosis, and necrosis
Journal Articles

Abstract 5346: A novel immunotoxin comprising quadruple RNase tethered to an internalizing anti-TROP-2 humanized MAb shows potent cytotoxicity against diverse solid tumors in vitro

Free
Thomas M. Cardillo, Edmund A. Rossi, Roberto Arrojo, Eric Chan, David M. Goldenberg, Chien-Hsing Chang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5346.
https://doi.org/10.1158/1538-7445.AM10-5346
Published: 15 April 2010
View articletitled, Abstract 5346: A novel immunotoxin comprising quadruple RNase tethered to an internalizing anti-TROP-2 humanized MAb shows potent cytotoxicity against diverse solid tumors in vitro
Journal Articles

Abstract 5345: Potent ribonuclease-based immunotoxins comprising quadruple ranpirnase (Rap) site-specifically conjugated to B-cell lymphoma-targeting antibodies

Free
Edmund A. Rossi, Eric Chan, Thomas M. Cardillo, Preeti Trisal, David M. Goldenberg, Chien-Hsing Chang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5345.
https://doi.org/10.1158/1538-7445.AM10-5345
Published: 15 April 2010
View articletitled, Abstract 5345: Potent ribonuclease-based immunotoxins comprising quadruple ranpirnase (Rap) site-specifically conjugated to B-cell lymphoma-targeting antibodies
Journal Articles

A modular method to prepare novel tetrameric cytokines, IFN, G-CSF, and EPO, with improved pharmacokinetics by the Dock-and-Lock (DNL) platform technology

Free
Chien-Hsing Chang, Edmund Rossi, Meiyu Loo, Diane Nordstrom, Eric Chan, Thomas Cardillo, David Goldenberg
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4906.
Published: 01 May 2008
View articletitled, A modular method to prepare novel tetrameric cytokines, IFN, G-CSF, and EPO, with improved pharmacokinetics by the Dock-and-Lock (DNL) platform technology