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Journal Articles

Abstract 5512: Combining RAS(ON) G12C-selective and RAS(ON) multi-selective inhibitors overcomes sotorasib resistance driven byKRASG12C amplification or NRASG13R mutation

Free
Hitendra Singh Solanki, Denis Imbody, Bina Desai, Daria Miroshnychenko, Bhaswati Sarcar, Anurima Majumder, Yonghong Zhang, Uwe Rix, Andriy Marusyk, Mallika Singh, Ida Aronchik, Eric B. Haura
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5512.
https://doi.org/10.1158/1538-7445.AM2025-5512
Published: 21 April 2025
View articletitled, Abstract 5512: Combining RAS(ON) G12C-selective and RAS(ON) multi-selective inhibitors overcomes sotorasib resistance driven byKRASG12C amplification or NRASG13R mutation
Journal Articles

Abstract 5509: Mechanisms regulating resistance to KRAS inhibitor driven by DNp63/YAP regulation of tissue stiffness and metabolic alterations in lung adenocarcinoma

Free
Santanu Adhikary, Marco Napoli, Suehelay Acevedo, Christina L. Carr, Jaden R. Baldwin, Nicole Hackel, Hitendra S. Solanki, Yaakov E. Stern, Laxmi Swetha Karanam, Duy T. Nguyen, Eric B. Haura, Elsa R. Flores
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5509.
https://doi.org/10.1158/1538-7445.AM2025-5509
Published: 21 April 2025
View articletitled, Abstract 5509: Mechanisms regulating resistance to KRAS inhibitor driven by DNp63/YAP regulation of tissue stiffness and metabolic alterations in lung adenocarcinoma
Journal Articles

Abstract 1924: RTK signaling and WT RAS activity as vulnerabilities in tumors with acquired resistance to GDP-state selective KRASG12C inhibitors in preclinical models

Free
Hitendra S. Solanki, Harshit Shah, Denis Imbody, Bina Desai, Paul A. Stewart, Bin Fang, Yaakov Stern, Lancia N. Darville, John M. Koomen, Andriy Marusyk, Ethan Ahler, Ida Aronchik, Mallika Singh, Eric B. Haura
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1924.
https://doi.org/10.1158/1538-7445.AM2024-1924
Published: 22 March 2024
View articletitled, Abstract 1924: RTK signaling and WT RAS activity as vulnerabilities in tumors with acquired resistance to GDP-state selective KRASG12C inhibitors in preclinical models
Journal Articles

Abstract 3264: Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment immunotherapy response

Free
Mohammed L. Ibrahim, Dana Foresman, Hong Zheng, Eric B. Haura, Daniel Abate-Daga, Xiaoqing Yu, Amer A. Beg
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3264.
https://doi.org/10.1158/1538-7445.AM2023-3264
Published: 04 April 2023
View articletitled, Abstract 3264: Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment immunotherapy response
Journal Articles

Abstract 6642: Rapid tissue donation identifies LAG3 as a potential therapeutic target for ALK fusion positive lung cancer

Free
Hilal Ozakinci, Gina Nazario, Karina Colossi Furlan, Dung-Tsa Chen, Trevor Rose, Matthew B. Schabath, Eric B. Haura, Bruna Pellini, Amer Beg, Theresa A. Boyle
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6642.
https://doi.org/10.1158/1538-7445.AM2023-6642
Published: 04 April 2023
View articletitled, Abstract 6642: Rapid tissue donation identifies LAG3 as a potential therapeutic target for ALK fusion positive lung cancer
Journal Articles

Abstract 3839: Discovery of GSTZ1 as a novel target for drug refractory non-small cell lung cancer by using fragment-based chemical proteomics

Free
Yi Liao, Sean Chin Chan, Eric A. Welsh, Bin Fang, Luxin Sun, Ernst Schönbrunn, John M. Koomen, Derek R. Duckett, Eric B. Haura, Andrii Monastyrskyi, Uwe Rix
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3839.
https://doi.org/10.1158/1538-7445.AM2023-3839
Published: 04 April 2023
View articletitled, Abstract 3839: Discovery of GSTZ1 as a novel target for drug refractory non-small cell lung cancer by using fragment-based chemical proteomics
Journal Articles

Abstract B028: CDK12/13 inhibition antagonizes resistance to KRASG12C inhibitors

Free
Yaakov E. Stern, Pompom Ghosh, Hannah L. Walker-Mimms, John W. Mosior, Denis Imbody, Hitendra S. Solanki, Andrii Monastyrskyi, Derek R. Duckett, Eric B. Haura
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B028.
https://doi.org/10.1158/1538-7445.CancEpi22-B028
Published: 01 December 2022
View articletitled, Abstract B028: CDK12/13 inhibition antagonizes resistance to KRASG12C inhibitors
Journal Articles

Abstract 1101: CTNNB1 mutation can mediate resistance to EGFR, ALK and KRAS targeted therapies

Free
Anurima Majumder, Benjamin S. Meyer, J Kevin Hicks, Theresa A. Boyle, Eric B. Haura
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1101.
https://doi.org/10.1158/1538-7445.AM2022-1101
Published: 15 June 2022
View articletitled, Abstract 1101: CTNNB1 mutation can mediate resistance to EGFR, ALK and KRAS targeted therapies
Journal Articles

Abstract 3911: Proteomic and transcriptomic subtypes of KRASG12C mutant lung cancer

Free
Hitendra Singh Solanki, Paul A. Stewart, Eric A. Welsh, Victoria Izumi, Bin Fang, Sean J. Yoder, John M. Koomen, Eric B. Haura
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3911.
https://doi.org/10.1158/1538-7445.AM2022-3911
Published: 15 June 2022
View articletitled, Abstract 3911: Proteomic and transcriptomic subtypes of KRASG12C mutant lung cancer
Journal Articles

Abstract LB121: Multiplexed targeted proteomics of biomarkers for lung cancer treatment selection

Free
Sudhir Putty Reddy, Aileen Alontaga, Paul A. Stewart, Eric Welsh, Lamees Saeed, Lancia N.F. Darville, Bin Fang, Steven A. Eschrich, Eric B. Haura, Theresa A. Boyle, John M. Koomen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB121.
https://doi.org/10.1158/1538-7445.AM2022-LB121
Published: 15 June 2022
View articletitled, Abstract LB121: Multiplexed targeted proteomics of biomarkers for lung cancer treatment selection
Journal Articles

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Open Access
Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken, Jenevieve Kuang, Judy C. Boughey, Liewei Wang, Jodi M. Carter, Eric B. Haura, Matthew P. Goetz, Jann N. Sarkaria, Forest M. White
Journal: Cancer Research
Cancer Res (2021) 81 (14): 3930–3941.
https://doi.org/10.1158/0008-5472.CAN-21-0214
Published: 15 July 2021
View articletitled, Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks
Open the PDF for Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks in another window
Includes: Supplementary data
Journal Articles

Abstract 1865: Phosphoproteomic analyses identify EGFR as a critical cooperative kinase for ALK

Free
Nan Chen, Anh T. Le, Andrea E. Doak, Guolin Zhang, Bin Fang, Eric B. Haura, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1865.
https://doi.org/10.1158/1538-7445.AM2020-1865
Published: 15 August 2020
View articletitled, Abstract 1865: Phosphoproteomic analyses identify EGFR as a critical cooperative kinase for ALK
Journal Articles

Abstract 3410: Adaptive resistance mechanisms to KRASG12C specific inhibitors

Free
Hitendra Singh Solanki, Bin Fang, Eric A. Welsh, Aik C. Tan, Fumi Kinose, Uwe Rix, Eric B. Haura
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3410.
https://doi.org/10.1158/1538-7445.AM2020-3410
Published: 15 August 2020
View articletitled, Abstract 3410: Adaptive resistance mechanisms to KRASG12C specific inhibitors
Journal Articles

MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer

Free
Mengyu Xie, Hong Zheng, Ranjna Madan-Lala, Wenjie Dai, Nicholas T. Gimbrone, Zhihua Chen, Fumi Kinose, Sarah A. Blackstone, Keiran S.M. Smalley, W. Douglas Cress, Eric B. Haura, Uwe Rix, Amer A. Beg
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5812–5825.
https://doi.org/10.1158/0008-5472.CAN-19-0698
Published: 15 November 2019
View articletitled, MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
Open the PDF for MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4543: Proteomic characterization of AXL kinase inhibitors and signaling pathways

Free
Anurima Majumder, Guolin Zhang, Emma Adhikari, Bin Fang, Eric A. Welsh, John M. Koomen, Eric B. Haura
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4543.
https://doi.org/10.1158/1538-7445.AM2019-4543
Published: 01 July 2019
View articletitled, Abstract 4543: Proteomic characterization of AXL kinase inhibitors and signaling pathways
Journal Articles

Abstract 2708: Imputation-free analysis of high throughput TMT proteomics of 116 lung squamous samples

Free
Eric A. Welsh, Paul A. Stewart, Matthew C. Chambers, Guolin Zhang, Bin Fang, Steven A. Eschrich, John M. Koomen, Eric B. Haura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2708.
https://doi.org/10.1158/1538-7445.AM2018-2708
Published: 01 July 2018
View articletitled, Abstract 2708: Imputation-free analysis of high throughput TMT proteomics of 116 lung squamous samples
Journal Articles

Abstract 1616: Novel caged hapten proximity assay platform enables detection of oncogenic signaling-associated complexes in the clinical pathology laboratory setting

Free
Brian D. Kelly, Nathan W. Polaske, Yuri Belosludtsev, Matthew A. Smith, Theresa Boyle, Y. Ann Chen, Eric B. Haura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1616.
https://doi.org/10.1158/1538-7445.AM2018-1616
Published: 01 July 2018
View articletitled, Abstract 1616: Novel caged hapten proximity assay platform enables detection of oncogenic signaling-associated complexes in the clinical pathology laboratory setting
Journal Articles

Abstract 1308: Post translational crosstalk networks identify strategies to overcome EMT-mediated resistance to EGFR inhibitors

Free
Guolin Zhang, Karen Ross, Bin Fang, Jun-Min Zhou, Paul A. Stewart, Emma Adhikari, Eric A. Welsh, Xuefeng Wang, John M. Koomen, Cathy H. Wu, Eric B. Haura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1308.
https://doi.org/10.1158/1538-7445.AM2018-1308
Published: 01 July 2018
View articletitled, Abstract 1308: Post translational crosstalk networks identify strategies to overcome EMT-mediated resistance to EGFR inhibitors
Journal Articles

EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases

Free
Aria Vaishnavi, Laura Schubert, Uwe Rix, Lindsay A. Marek, Anh T. Le, Stephen B. Keysar, Magdalena J. Glogowska, Matthew A. Smith, Severine Kako, Natalia J. Sumi, Kurtis D. Davies, Kathryn E. Ware, Marileila Varella-Garcia, Eric B. Haura, Antonio Jimeno, Lynn E. Heasley, Dara L. Aisner, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3551–3563.
https://doi.org/10.1158/0008-5472.CAN-17-0109
Published: 02 July 2017
View articletitled, EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases
Open the PDF for EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases in another window
Includes: Supplementary data
Journal Articles

Abstract 205: Underlying mechanisms of genome-proteome discordance in squamous cell lung cancer

Free
Paul A. Stewart, Robbert J. Slebos, Eric A. Welsh, Ling Cen, Yonghong Zhang, Zhihua Chen, Chia-Ho Cheng, Fredrik Pettersson, Anders Berglund, Guolin Zhang, Bin Fang, Victoria Izumi, Sean Yoder, Katherine Fellows, Ann Chen, Jamie K. Teer, Steven A. Eschrich, John M. Koomen, Eric B. Haura
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 205.
https://doi.org/10.1158/1538-7445.AM2017-205
Published: 01 July 2017
View articletitled, Abstract 205: Underlying mechanisms of genome-proteome discordance in squamous cell lung cancer