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Journal Articles

Abstract 670: Targeting PI3K/mTOR leads to MEK/ERK over-activation in pancreatic cancer through suppression of mTORC2

Heloisa P. Soares, Ming Ming, Michelle Mellon, Steven H. Young, Liang Han, James Sinnet-Smith, Enrique Rozengurt

Cancer Res (2015) 75 (15_Supplement): 670.

https://doi.org/10.1158/1538-7445.AM2015-670

Published: 01 August 2015

View article titled, Abstract 670: Targeting PI3K/mTOR leads to MEK/ERK over-activation in pancreatic cancer through suppression of mTORC2

Journal Articles

Abstract 1028: Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/calcium-mediated mechanisms in human pancreatic carcinoma cells

Hui-Hua Chang, Steven Young, James Sinnett-Smith, Caroline Ei Ne Chou, Oscar Joe Hines, Enrique Rozengurt, Guido Eibl

Cancer Res (2015) 75 (15_Supplement): 1028.

https://doi.org/10.1158/1538-7445.AM2015-1028

Published: 01 August 2015

View article titled, Abstract 1028: Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/calcium-mediated mechanisms in human pancreatic carcinoma cells

Journal Articles

Abstract A109: Dual mTOR/PI3K inhibitors induce compensatory MEK/ERK activation in human pancreatic cancer cells: A mechanism contributing to drug resistance

Heloisa P. Soares, Ming Ming, James Sinnett-Smith, Michelle Mellon, Enrique Rozengurt

Cancer Res (2015) 75 (13_Supplement): A109.

https://doi.org/10.1158/1538-7445.PANCA2014-A109

Published: 30 June 2015

View article titled, Abstract A109: Dual mTOR/PI3K inhibitors induce compensatory MEK/ERK activation in human pancreatic cancer cells: A mechanism contributing to drug resistance

Journal Articles

Abstract 5453: Dual mTOR/PI3K inhibitors induce ERK pathway overactivation in pancreatic cell lines: Rationale for combinatory therapy

Heloisa P. Soares, Ming Ming, Michelle Mellon, James Sinnet-Smith, Enrique Rozengurt

Cancer Res (2014) 74 (19_Supplement): 5453.

https://doi.org/10.1158/1538-7445.AM2014-5453

Published: 01 October 2014

View article titled, Abstract 5453: Dual mTOR/PI3K inhibitors induce ERK pathway overactivation in pancreatic cell lines: Rationale for combinatory therapy

Journal Articles

Abstract B79: A diet high in fats and calories leads to obesity and metabolic disturbances and accelerates pancreatic cancer development in the conditional KrasG12D mouse model.

Aune Moro, Aurelia Lugea, David Dawson, Steven Pandol, Anna Gukovskaya, Enrique Rozengurt, Vay-Liang Go, Guido Eibl

Cancer Res (2012) 72 (14_Supplement): B79.

https://doi.org/10.1158/1538-7445.PANCA2012-B79

Published: 03 April 2014

View article titled, Abstract B79: A diet high in fats and calories leads to obesity and metabolic disturbances and accelerates pancreatic cancer development in the conditional KrasG12D mouse model.

Journal Articles

Abstract 4007: Different patterns of Akt and ERK feedback activation in response to allosteric and active-site mTOR inhibitors in comparison to metformin in pancreatic cancer cells.

Heloisa P. Soares, Ni Yang, James Sinnett-Smith, Robert Kui, Enrique Rozengurt

Cancer Res (2013) 73 (8_Supplement): 4007.

https://doi.org/10.1158/1538-7445.AM2013-4007

Published: 15 April 2013

View article titled, Abstract 4007: Different patterns of Akt and ERK feedback activation in response to allosteric and active-site mTOR inhibitors in comparison to metformin in pancreatic cancer cells.

Journal Articles

Metformin Disrupts Crosstalk between G Protein–Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Krisztina Kisfalvi, Guido Eibl, James Sinnett-Smith, Enrique Rozengurt

Cancer Res (2009) 69 (16): 6539–6545.

https://doi.org/10.1158/0008-5472.CAN-09-0418

Published: 12 August 2009

View article titled, Metformin Disrupts Crosstalk between G Protein–Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Includes: Supplementary data

Journal Articles

Loss of basal prostaglandins in intestinal epithelial cells eliminates PYK2 expression and constitutive FAK [Y397] phosphorylation

Hung pham, Steve Wu, Richard Waldron, Romina Vincenti, Enrique Rozengurt, Lee Slice

Cancer Res (2008) 68 (9_Supplement): 3420.

Published: 01 May 2008

View article titled, Loss of basal prostaglandins in intestinal epithelial cells eliminates PYK2 expression and constitutive FAK [Y397] phosphorylation

Journal Articles

Generation of transient calcium oscillations by the calcium sensing receptor: Role of the TRPC1 cation channel

Osvaldo Rey, Steven Young, Romeo Papazyan, Enrique Rozengurt

Cancer Res (2008) 68 (9_Supplement): 3495.

Published: 01 May 2008

View article titled, Generation of transient calcium oscillations by the calcium sensing receptor: Role of the TRPC1 cation channel

Journal Articles

Molecular determinants mediating the intracellular calcium oscillations produced by the calcium-sensing receptor

Osvaldo A. Rey, Steven H. Young, Jingzhen Yuan, Enrique Rozengurt

Cancer Res (2006) 66 (8_Supplement): 1002.

Published: 15 April 2006

View article titled, Molecular determinants mediating the intracellular calcium oscillations produced by the calcium-sensing receptor

Journal Articles

PGE2 induces sustained activation of Erk signaling in erlotinib-resistant proliferation of NSCLC cells.

Kostyantyn Krysan, Nora Rozengurt, Brian Escuadro, Karen L. Reckamp, Enrique Rozengurt, Steven M. Dubinett

Cancer Res (2006) 66 (8_Supplement): 1194.

Published: 15 April 2006

View article titled, PGE2 induces sustained activation of Erk signaling in erlotinib-resistant proliferation of NSCLC cells.

Journal Articles

Prostaglandin E₂ Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non–Small Cell Lung Cancer Cells in an Epidermal Growth Factor Receptor–Independent Manner

Kostyantyn Krysan, Karen L. Reckamp, Harnisha Dalwadi, Sherven Sharma, Enrique Rozengurt, Mariam Dohadwala, Steven M. Dubinett

Cancer Res (2005) 65 (14): 6275–6281.

https://doi.org/10.1158/0008-5472.CAN-05-0216

Published: 15 July 2005

View article titled, Prostaglandin E2 Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non–Small Cell Lung Cancer Cells in an Epidermal Growth Factor Receptor–Independent Manner

Journal Articles

Broad-Spectrum G Protein–Coupled Receptor Antagonist, [D-Arg¹,D-Trp^5,7,9,Leu¹¹]SP: A Dual Inhibitor of Growth and Angiogenesis in Pancreatic Cancer

Sushovan Guha, Guido Eibl, Krisztina Kisfalvi, Robert S. Fan, Marie Burdick, Howard Reber, Oscar J. Hines, Robert Strieter, Enrique Rozengurt

Cancer Res (2005) 65 (7): 2738–2745.

https://doi.org/10.1158/0008-5472.CAN-04-3197

Published: 01 April 2005

View article titled, Broad-Spectrum G Protein–Coupled Receptor Antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: A Dual Inhibitor of Growth and Angiogenesis in Pancreatic Cancer

Includes: Supplementary data

Journal Articles

Inhibition of PKCε translocation prevents protein kinase D activation loop phosphorylation

Osvaldo A. Rey, Joseph Reeve, Enrique Rozengurt

Cancer Res (2004) 64 (7_Supplement): 1187.

Published: 01 April 2004

View article titled, Inhibition of PKCε translocation prevents protein kinase D activation loop phosphorylation

Journal Articles

Neurotensin Stimulates Protein Kinase C-dependent Mitogenic Signaling in Human Pancreatic Carcinoma Cell Line PANC-1

Sushovan Guha, J. Adrian Lunn, Chintda Santiskulvong, Enrique Rozengurt

Cancer Res (2003) 63 (10): 2379–2387.

Published: 15 May 2003

View article titled, Neurotensin Stimulates Protein Kinase C-dependent Mitogenic Signaling in Human Pancreatic Carcinoma Cell Line PANC-1

Journal Articles

Neurotensin Induces Protein Kinase C-dependent Protein Kinase D Activation and DNA Synthesis in Human Pancreatic Carcinoma Cell Line PANC-1

Sushovan Guha, Osvaldo Rey, Enrique Rozengurt

Cancer Res (2002) 62 (6): 1632–1640.

Published: 15 March 2002

View article titled, Neurotensin Induces Protein Kinase C-dependent Protein Kinase D Activation and DNA Synthesis in Human Pancreatic Carcinoma Cell Line PANC-1

Journal Articles

Protein Kinase D in Small Cell Lung Cancer Cells: Rapid Activation through Protein Kinase C

Lina Paolucci, Enrique Rozengurt

Cancer Res (1999) 59 (3): 572–577.

Published: 01 February 1999

View article titled, Protein Kinase D in Small Cell Lung Cancer Cells: <subtitle>Rapid Activation through Protein Kinase C</subtitle>

Journal Articles

[d-Arg¹,d-Trp^5,7,9,Leu¹¹]Substance P: A Novel Potent Inhibitor of Signal Transduction and Growth in Vitro and in Vivo in Small Cell Lung Cancer Cells

Michael J. Seckl, Theresa Higgins, Fred Widmer, Enrique Rozengurt

Cancer Res (1997) 57 (1): 51–54.

Published: 01 January 1997

View article titled, [<sc>d</sc>-Arg1,<sc>d</sc>-Trp5,7,9,Leu11]Substance P: A Novel Potent Inhibitor of Signal Transduction and Growth in Vitro and in Vivo in Small Cell Lung Cancer Cells

Journal Articles

Galanin, Neurotensin, and Phorbol Esters Rapidly Stimulate Activation of Mitogen-activated Protein Kinase in Small Cell Lung Cancer Cells

Thomas Seufferlein, Enrique Rozengurt

Cancer Res (1996) 56 (24): 5758–5764.

Published: 01 December 1996

View article titled, Galanin, Neurotensin, and Phorbol Esters Rapidly Stimulate Activation of Mitogen-activated Protein Kinase in Small Cell Lung Cancer Cells

Journal Articles

Rapamycin Inhibits Constitutive p70^s6k Phosphorylation, Cell Proliferation, and Colony Formation in Small Cell Lung Cancer Cells

Thomas Seufferlein, Enrique Rozengurt

Cancer Res (1996) 56 (17): 3895–3897.

Published: 01 September 1996

View article titled, Rapamycin Inhibits Constitutive p70s6k Phosphorylation, Cell Proliferation, and Colony Formation in Small Cell Lung Cancer Cells

NARROW

Abstract 670: Targeting PI3K/mTOR leads to MEK/ERK over-activation in pancreatic cancer through suppression of mTORC2

Abstract 1028: Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/calcium-mediated mechanisms in human pancreatic carcinoma cells

Abstract A109: Dual mTOR/PI3K inhibitors induce compensatory MEK/ERK activation in human pancreatic cancer cells: A mechanism contributing to drug resistance

Abstract 5453: Dual mTOR/PI3K inhibitors induce ERK pathway overactivation in pancreatic cell lines: Rationale for combinatory therapy

Abstract B79: A diet high in fats and calories leads to obesity and metabolic disturbances and accelerates pancreatic cancer development in the conditional KrasG12D mouse model.

Abstract 4007: Different patterns of Akt and ERK feedback activation in response to allosteric and active-site mTOR inhibitors in comparison to metformin in pancreatic cancer cells.

Metformin Disrupts Crosstalk between G Protein–Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Loss of basal prostaglandins in intestinal epithelial cells eliminates PYK2 expression and constitutive FAK [Y397] phosphorylation

Generation of transient calcium oscillations by the calcium sensing receptor: Role of the TRPC1 cation channel

Molecular determinants mediating the intracellular calcium oscillations produced by the calcium-sensing receptor

PGE2 induces sustained activation of Erk signaling in erlotinib-resistant proliferation of NSCLC cells.

Prostaglandin E₂ Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non–Small Cell Lung Cancer Cells in an Epidermal Growth Factor Receptor–Independent Manner

Broad-Spectrum G Protein–Coupled Receptor Antagonist, [D-Arg¹,D-Trp^5,7,9,Leu¹¹]SP: A Dual Inhibitor of Growth and Angiogenesis in Pancreatic Cancer

Inhibition of PKCε translocation prevents protein kinase D activation loop phosphorylation

Neurotensin Stimulates Protein Kinase C-dependent Mitogenic Signaling in Human Pancreatic Carcinoma Cell Line PANC-1

Neurotensin Induces Protein Kinase C-dependent Protein Kinase D Activation and DNA Synthesis in Human Pancreatic Carcinoma Cell Line PANC-1

Protein Kinase D in Small Cell Lung Cancer Cells: Rapid Activation through Protein Kinase C

[d-Arg¹,d-Trp^5,7,9,Leu¹¹]Substance P: A Novel Potent Inhibitor of Signal Transduction and Growth in Vitro and in Vivo in Small Cell Lung Cancer Cells

Galanin, Neurotensin, and Phorbol Esters Rapidly Stimulate Activation of Mitogen-activated Protein Kinase in Small Cell Lung Cancer Cells

Rapamycin Inhibits Constitutive p70^s6k Phosphorylation, Cell Proliferation, and Colony Formation in Small Cell Lung Cancer Cells

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