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Journal Articles

Abstract 1181: Combined inhibition of KAT6 and menin reverses estrogen receptor-driven gene expression programs in breast cancer

Sarah Naomi Olsen, Bryn Anderson, Charles Hatton, Myles Brown, Rinath Jeselsohn, Eneda Toska, Scott Armstrong
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1181.
https://doi.org/10.1158/1538-7445.AM2025-1181
Published: 21 April 2025
View articletitled, Abstract 1181: Combined inhibition of KAT6 and menin reverses estrogen receptor-driven gene expression programs in breast cancer
Journal Articles

Abstract PO5-15-05: Clinical and genomic landscape of ERBB2 and ERBB3 mutated breast cancer

Nadeem Bilani, Jacqueline Tao, Anton Safonov, Dana Casey, Joshua Drago, Mehnaj Ahmed, Barbara Acevedo, Komal Jhaveri, Jorge Reis-Filho, Mark Robson, Eneda Toska, Ariella Hanker, Carlos Arteaga, Sarat Chandarlapaty, Hanna Y Wen, Pedram Razavi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO5-15-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO5-15-05
Published: 02 May 2024
View articletitled, Abstract PO5-15-05: Clinical and genomic landscape of ERBB2 and ERBB3 mutated breast cancer
Journal Articles

Abstract 3936: Altered endosomal pH regulation: molecular mechanisms of oncogenesis and therapeutic dependencies

Higinio Dopeso, Yingjie Zhu, Laxmi Gusain, Thais Basili, David Brown, Fatemeh Derakhshan, Edaise M. da Silva, Richard Koche, Pierre-Jacques Hamard, Xinyu Guo, Eneda Toska, Elisa DeStanchina, Hong Zhang, Jorge Reis-Filho, Britta Weigelt, Fresia Pareja
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3936.
https://doi.org/10.1158/1538-7445.AM2024-3936
Published: 22 March 2024
View articletitled, Abstract 3936: Altered endosomal pH regulation: molecular mechanisms of oncogenesis and therapeutic dependencies
Journal Articles

Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer

Srushti Kittane, Erik Ladewig, Taibo Li, Jillian Love, Amaia Arruabarrena-Aristorena, Xinyu Guo, Mirna Sallaku, Liliana Garcia-Martinez, Ryan Blawski, Javier Carmona Sanz, Christopher Simpkins, Wanlu Chen, Bujamin Vokshi, Peihua Zhao, Nachiket Kelkar, Laura Baldino, Ingrid Kalemi, Pau Castel, Emiliano Cocco, Lluis Morey, Charles Sawyers, Hongkai Ji, Maurizio Scaltriti, Alexis Battle, Christina Leslie, Wouter Karthaus, Eneda Toska
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1245.
https://doi.org/10.1158/1538-7445.AM2024-1245
Published: 22 March 2024
View articletitled, Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer
Journal Articles

A Unique FOXA1-Associated Chromatin State Dictates Therapeutic Resistance in Lobular Breast Cancer

Ryan Blawski, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (20): 3668–3670.
https://doi.org/10.1158/0008-5472.CAN-22-2594
Published: 17 October 2022
View articletitled, A Unique FOXA1-Associated Chromatin State Dictates Therapeutic Resistance in Lobular Breast Cancer
Open the PDF for A Unique FOXA1-Associated Chromatin State Dictates Therapeutic Resistance in Lobular Breast Cancer in another window
Journal Articles

Abstract 2955: SMYD2 regulates chromatin modifier KMT2D in ER+/PIK3CA mutant breast cancer

Ryan Blawski, Mirna Sallaku, Xinyu Guo, Srushti Kittane, Maurizio Scaltriti, Minkui Luo, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2955.
https://doi.org/10.1158/1538-7445.AM2022-2955
Published: 15 June 2022
View articletitled, Abstract 2955: SMYD2 regulates chromatin modifier KMT2D in ER+/PIK3CA mutant breast cancer
Journal Articles

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Erik Ladewig, Flavia Michelini, Komal Jhaveri, Pau Castel, Javier Carmona, Lauren Fairchild, Adler G. Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina Leslie, Maurizio Scaltriti, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2269–2280.
https://doi.org/10.1158/0008-5472.CAN-22-0446
Published: 15 June 2022
View articletitled, The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Open the PDF for The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation in another window
Includes: Supplementary data
Journal Articles

Abstract NG05: Epigenetic mechanisms of endocrine therapy response in breast cancer

Eneda Toska, Guotai Xu, Amaia Arruabarrena-Aristorena, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG05.
https://doi.org/10.1158/1538-7445.AM2021-NG05
Published: 01 July 2021
View articletitled, Abstract NG05: Epigenetic mechanisms of endocrine therapy response in breast cancer
Journal Articles

Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

Yanyan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Pau Castel, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S. Reis-Filho, Pedram Razavi, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2470–2480.
https://doi.org/10.1158/0008-5472.CAN-20-3232
Published: 01 May 2021
View articletitled, Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors
Open the PDF for Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract NG16: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Neil Vasan, Pedram Razavi, Jared L. Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Frauke Schimmoller, Timothy R. Wilson, Lori S. Friedman, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG16.
https://doi.org/10.1158/1538-7445.AM2020-NG16
Published: 15 August 2020
View articletitled, Abstract NG16: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Journal Articles

Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M. Schram, Helen H. Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Sabrina Arena, Benedetta Mussolin, Ram Kannan, Neil Vasan, Alexander N. Gorelick, Michael F. Berger, Yi Liao, Uwe Rix, Alberto Bardelli, Jacklyn Hechtman, Elisa de Stanchina, David M. Hyman, Chandra Verma, Andrea Ventura, Alexander Drilon, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5680.
https://doi.org/10.1158/1538-7445.AM2020-5680
Published: 15 August 2020
View articletitled, Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors
Journal Articles

Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer

Amaia Arruabarrena-Aristorena, Jesper LV Maag, Srushti Kittane, Yanyan Cai, Jane Park, Pedram Razavi, Lorenzo Ferrando, Pier Selenica, Wouter R. Karthaus, Srinivasaraghavan Kannan, Emiliano Cocco, Sik Y. Ho, Daisylyn Senna Tan, Mirna Sallaku, Charles L. Sawyers, Jorge S. Reis-Fihlo, Chandra S. Verma, Ralf Jauch, Richard Koche, José Baselga, Eneda Toska, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3439.
https://doi.org/10.1158/1538-7445.AM2020-3439
Published: 15 August 2020
View articletitled, Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer
Journal Articles

Abstract 1470: UGP2 is a critical regulator of protein glycosylation in pancreatic cancer

Andrew L. Wolfe, Jacqueline Galeas, Eneda Toska, Qing Zhou, Angel Ku, Richard P. Koche, Sourav Bandyopadhyay, Carlito B. Lebrilla, Maurizio Scaltriti, Frank McCormick, Sung Eun Kim
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1470.
https://doi.org/10.1158/1538-7445.AM2020-1470
Published: 15 August 2020
View articletitled, Abstract 1470: UGP2 is a critical regulator of protein glycosylation in pancreatic cancer
Journal Articles

Abstract P3-03-01: Double PIK3CA mutations in cis drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer

Neil Vasan, Pedram Razavi, Jared L Johnson, Hong Shao, Timothy Wilson, Frauke Schimmoller, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raul Rabadan, Ed Reznik, Melissa L Smith, Robert Sebra, Lori Friedman, Lewis C Cantley, Maurizio Scaltriti, José Baselga
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-03-01.
https://doi.org/10.1158/1538-7445.SABCS19-P3-03-01
Published: 15 February 2020
View articletitled, Abstract P3-03-01: Double PIK3CA mutations in cis drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer
Journal Articles

Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

Emiliano Cocco, Amanda Kulick, Sandra Misale, Rona Yaeger, Pedram Razavi, Helen H. Won, Ryan Ptashkin, Jaclyn F. Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B. Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J. Nagy, Richard B. Lanman, Michael F. Berger, Marc Ladanyi, David M. Hyman, Alexander Drilon, Maurizio Scaltriti, Alison M. Schram
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-118.
https://doi.org/10.1158/1538-7445.AM2019-LB-118
Published: 01 July 2019
View articletitled, Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation
Journal Articles

Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers

Erik Ladewig, Lauren Fairchild, Maurizio Scaltriti, Christina Leslie, Eneda Toska, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4346.
https://doi.org/10.1158/1538-7445.AM2019-4346
Published: 01 July 2019
View articletitled, Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers
Journal Articles

Abstract 3917: Double PIK3CA mutations in cis enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer

Neil Vasan, Pedram Razavi, Jared Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3917.
https://doi.org/10.1158/1538-7445.AM2019-3917
Published: 01 July 2019
View articletitled, Abstract 3917: Double PIK3CA mutations in cis enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer
Journal Articles

Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer

Eneda Toska, Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Jordan Otto, Yanyan Cai, Carmen Chan, Drew R. D' Avino, Clayton Collings, Ross L. Levine, Maurizo Scaltriti, Jorge S. Reis-Filho, Cigall Kadoch, Christina Leslie, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 949.
https://doi.org/10.1158/1538-7445.AM2019-949
Published: 01 July 2019
View articletitled, Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer
Journal Articles

Abstract 2107: PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition

Pau Castel, Haley Ellis, Ruzica Bago, Eneda Toska, Kannan Srinivasaraghavan, F Javier Carmona, Pedram Razavi, Chandra Verma, Maura Dickler, Sarat Chandarlapaty, Edi Brogi, Dario Alessi, José Baselga, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2107.
https://doi.org/10.1158/1538-7445.AM2016-2107
Published: 15 July 2016
View articletitled, Abstract 2107: PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition
Journal Articles

Abstract 781: Modeling the impact of somatic alterations across human cancers

Hatice U. Osmanbeyoglu, Eneda Toska, José Baselga, Christina Leslie
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 781.
https://doi.org/10.1158/1538-7445.AM2016-781
Published: 15 July 2016
View articletitled, Abstract 781: Modeling the impact of somatic alterations across human cancers