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Emma Lees
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Journal Articles

Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Darrin D. Stuart, Wenlin Shao, Yuji Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacey Rivera, Fang Shen, Joshua Korn, Lesley A. Mathews Griner, Giselle Nishiguchi, Benjamin Taft, Lifeng Wan, Sharadha Subramanian, Yan Lou, Lina Setti, Matthew Burger, Victor Tamez, Alice Rico, Robert Aversa, John Tellew, Jacob R. Haling, Valery Polyakov, Amy Lambert, Richard Zang, Ann Van Abbema, Mohamad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, William R. Sellers, Savithri Ramurthy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): DDT01-04.
https://doi.org/10.1158/1538-7445.AM2018-DDT01-04
Published: 01 July 2018
View article titled, Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor
Journal Articles

Abstract 1685: Genomics based studies of gastric tumors identify ICOS as potential target for therapeutic intervention

Heather A. Hirsch, Jason Reeves, Tong Zi, Alexander Needham, Edward Stack, David Lee, Emma Lees, Deborah A. Law, Elizabeth Trehu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2018-1685
Published: 01 July 2018
View article titled, Abstract 1685: Genomics based studies of gastric tumors identify ICOS as potential target for therapeutic intervention
Journal Articles

Abstract 1678: Integrated genomics and histology based studies of triple negative breast cancer identify ICOS as potential target for therapeutic intervention

Heather A. Hirsch, Tong Zi, Rachel Fontana, Yun Wu, Jason Reeves, Alexander Needham, Edward Stack, David Lee, Emma Lees, Deborah A. Law, Elizabeth Trehu, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1678.
https://doi.org/10.1158/1538-7445.AM2018-1678
Published: 01 July 2018
View article titled, Abstract 1678: Integrated genomics and histology based studies of triple negative breast cancer identify ICOS as potential target for therapeutic intervention
Journal Articles

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Wenlin Shao, Yuji M. Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacy Rivera, Yingyun Wang, Fang Shen, Joshua M. Korn, Lesley A. Mathews Griner, Gisele Nishiguchi, Alice Rico, John Tellew, Jacob R. Haling, Robert Aversa, Valery Polyakov, Richard Zang, Mohammad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, Savithri Ramurthy, William R. Sellers, Darrin D. Stuart
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1537–1548.
https://doi.org/10.1158/0008-5472.CAN-17-2033
Published: 14 March 2018
View article titled, Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Open the PDF for Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF in another window
Includes: Supplementary data
Journal Articles

Abstract LB-017: Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5

Konstantinos Mavrakis, E Robert McDonald, III, Michael R. Schlabach, Eric Billy, Gregory R. Hoffman, Antoine deWeck, David A. Ruddy, Kavitha Venkatesan, Greg McAllister, Rosalie deBeaumont, Samuel Ho, Yue Liu, Yan Yan-Neale, Guizhi Yang, Fallon Lin, Hong Yin, Hui Gao, David Randal Kipp, Songping Zhao, Joshua T. McNamara, Elizabeth R. Sprague, Young Shin Cho, Justin Gu, Ken Crawford, Vladimir Capka, Kristen Hurov, Jeffrey A. Porter, John Tallarico, Craig Mickanin, Emma Lees, Raymond Pagliarini, Nicholas Keen, Tobias Schmelzle, Francesco Hofmann, Frank Stegmeier, William R. Sellers
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-017.
https://doi.org/10.1158/1538-7445.AM2016-LB-017
Published: 15 July 2016
View article titled, Abstract LB-017: Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5
Journal Articles

Abstract 872: In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial

Carl U. Bialucha, Scott D. Collins, Yeonju Shim, Xiamei Zhang, Roberto Velazquez, Colleen Kowal, Caroline Bullock, Hongbo Cai, Stacy M. Rivera, Julie M. Goldovitz, Esther Kurth, Alice T. Loo, Guizhi Yang, John Green, Lance Ostrom, Matthew J. Meyer, Rebecca Mosher, Hui Gao, Juliet Williams, Emma Lees
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 872.
https://doi.org/10.1158/1538-7445.AM2016-872
Published: 15 July 2016
View article titled, Abstract 872: In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial
Journal Articles

Abstract 2974: Targeting cadherin-6 (CDH6) with an antibody-drug conjugate for the treatment of ovarian and renal cancer

Scott D. Collins, Parmita Saxena, Xiao Y. Li, Yeonju Shim, Lance Ostrom, Nicholas C. Yoder, Kalli C. Catcott, Molly A. McShea, Xiuxia Sun, Sanela Bilic, William R. Tschantz, Meghan Flaherty, Keith Mansfield, Tiancen Hu, Vladimir Capka, Markus Kurz, Ivana Liric Rajlic, Anne Serdakowski London, Duc Nguyen, Rebecca Mosher, Matthew J. Meyer, Aaron Bourret, Jamal Saeh, Scott Cameron, Emma Lees, Carl U. Bialucha
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2974.
https://doi.org/10.1158/1538-7445.AM2016-2974
Published: 15 July 2016
View article titled, Abstract 2974: Targeting cadherin-6 (CDH6) with an antibody-drug conjugate for the treatment of ovarian and renal cancer
Journal Articles

Abstract 1695: Development of a novel antibody-drug conjugate for the treatment of c-Kit expressing solid tumors and AML

Tinya J. Abrams, Xiaohong Niu, Millicent Embry, Janine Kline, Montesa Patawaran, Christie Fanton, Marjorie Ison-Dugenny, Tracy Schneider, Kathy Miller, Zhen Wang, Majid Ghoddusi, Steven Cohen, E. Erica Hong, Emma Lees, Siew Schleyer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1695.
https://doi.org/10.1158/1538-7445.AM2015-1695
Published: 01 August 2015
View article titled, Abstract 1695: Development of a novel antibody-drug conjugate for the treatment of c-Kit expressing solid tumors and AML
Journal Articles

Abstract 1682: Development and activity of a novel antibody-drug conjugate for the treatment of P-cadherin expressing cancers

Daniel Menezes, Tinya J. Abrams, Christopher Karim, Yan Tang, Chi Ying, Kathy Miller, Christie Fanton, Majid Ghoddusi, Zhen Wang, Montesa Patawaran, Nancy Pryer, Emma Lees, Jason Damiano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1682.
https://doi.org/10.1158/1538-7445.AM2015-1682
Published: 01 August 2015
View article titled, Abstract 1682: Development and activity of a novel antibody-drug conjugate for the treatment of P-cadherin expressing cancers
Journal Articles

Abstract 1680: In vitro and in vivo activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate

Matthew J. Meyer, David Jenkins, David Batt, Rebecca Mosher, Randi Isaacs, Tiancen Hu, Vladimir Capka, Xiamei Zhang, Dongshu Chen, Lujia Tang, Mike Daley, Patrycja Nowakowski, Yeonju Shim, Wei Jiang, Seth Ettenberg, Emma Lees
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1680.
https://doi.org/10.1158/1538-7445.AM2015-1680
Published: 01 August 2015
View article titled, Abstract 1680: <em>In vitro</em> and <em>in vivo</em> activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate
Journal Articles

Abstract 2785: Modulating the interaction between cdk2 and cyclin A: Screening, synthesis and characterization of a quinoline-based inhibitor

William T. Windsor, Yongqi Deng, Gerald W. Shipps, Lianyun Zhao, Arshad Siddiqui, Janeta Popovici-Muller, Patrick Curran, Thierry Fischmann, Jose S. Duca, Alan Hruza, Rumin Zhang, Charles McNemar, Todd Mayhood, Rosalinda Syto, David A. Parry, Emma Lees, Paul Kirschmeier
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2785.
https://doi.org/10.1158/1538-7445.AM2011-2785
Published: 15 April 2011
View article titled, Abstract 2785: Modulating the interaction between cdk2 and cyclin A: Screening, synthesis and characterization of a quinoline-based inhibitor
Journal Articles

SCH 727965, a novel cyclin-dependent kinase inhibitor, has potent anti-tumor acitivity in a wide-spectrum of human tumor xenograft models

Yaolin Wang, Xiaoying Wang, Lipari Philip, Bo Yaremko, Ming Liu, Lingling Wu, Martin Oft, Satya Medicherla, David Parry, Emma Lees, Dan Hicklin, Paul Kirschmeier
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1594.
Published: 01 May 2008
View article titled, SCH 727965, a novel cyclin-dependent kinase inhibitor, has potent anti-tumor acitivity in a wide-spectrum of human tumor xenograft models
Journal Articles

In vitro and in vivo characterization of SCH727965 a novel potent cyclin dependent kinase inhibitor

David Parry, Timothy Guzi, Wolfgang Seghezzi, Kamil Paruch, Ronald Doll, Amin Nomeir, Yaolin Wang, Martin Oft, Paul Kirschmeier, Taiying Chen, Emma Lees
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4371.
Published: 01 May 2007
View article titled, In vitro and in vivo characterization of SCH727965 a novel potent cyclin dependent kinase inhibitor
Journal Articles

BRG1, a Component of the SWI-SNF Complex, Is Mutated in Multiple Human Tumor Cell Lines

Alexander K. C. Wong, Frances Shanahan, Yuan Chen, Lubing Lian, Phuong Ha, Kristin Hendricks, Siavash Ghaffari, Diana Iliev, Brandon Penn, Anne-Marie Woodland, Richard Smith, Grant Salada, Arlene Carillo, Kirsten Laity, Jamila Gupte, Brad Swedlund, Sean V. Tavtigian, David H-F. Teng, Emma Lees
Journal: Cancer Research
Cancer Res (2000) 60 (21): 6171–6177.
Published: 01 November 2000
View article titled, <em>BRG1,</em> a Component of the SWI-SNF Complex, Is Mutated in Multiple Human Tumor Cell Lines
Open the PDF for <em>BRG1,</em> a Component of the SWI-SNF Complex, Is Mutated in Multiple Human Tumor Cell Lines in another window
Journal Articles

Cyclin E, a Potential Prognostic Marker for Breast Cancer

Khandan Keyomarsi, Nuala O'Leary, Gyongyi Molnar, Emma Lees, Howard J. Fingert, Arthur B. Pardee
Journal: Cancer Research
Cancer Res (1994) 54 (2): 380–385.
Published: 01 January 1994
View article titled, Cyclin E, a Potential Prognostic Marker for Breast Cancer
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