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Emiliano Cocco
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Journal Articles

Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer

Srushti Kittane, Erik Ladewig, Taibo Li, Jillian Love, Amaia Arruabarrena-Aristorena, Xinyu Guo, Mirna Sallaku, Liliana Garcia-Martinez, Ryan Blawski, Javier Carmona Sanz, Christopher Simpkins, Wanlu Chen, Bujamin Vokshi, Peihua Zhao, Nachiket Kelkar, Laura Baldino, Ingrid Kalemi, Pau Castel, Emiliano Cocco, Lluis Morey, Charles Sawyers, Hongkai Ji, Maurizio Scaltriti, Alexis Battle, Christina Leslie, Wouter Karthaus, Eneda Toska
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1245.
https://doi.org/10.1158/1538-7445.AM2024-1245
Published: 22 March 2024
View articletitled, Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer
Journal Articles

Abstract 1452: A PIK3CA-driven mouse model of metaplastic breast carcinoma to assess potential therapeutic strategies

Paola Roa, Valentina Foglizzo, Michelle R. de Marchena, Shraddha Chandthakuri, Emiliano Cocco, Pau Castel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM2024-1452
Published: 22 March 2024
View articletitled, Abstract 1452: A PIK3CA-driven mouse model of metaplastic breast carcinoma to assess potential therapeutic strategies
Journal Articles

Abstract 3931: BRD4, BRD3, NSD3, and ZNF532 fusions in histologies beyond NUT carcinomas: Investigation of a large pan-cancer cohort

Ian R. Nykaza, Christopher A. Febres-Aldana, Sabrina T. Lin, Ryma Benayed, Kerry Mullaney, Emiliano Cocco, Alexia Iasonos, Marc Ladanyi, Alexander E. Drilon, Yonina R. Murciano-Goroff
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3931.
https://doi.org/10.1158/1538-7445.AM2023-3931
Published: 04 April 2023
View articletitled, Abstract 3931: BRD4, BRD3, NSD3, and ZNF532 fusions in histologies beyond NUT carcinomas: Investigation of a large pan-cancer cohort
Journal Articles

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Erik Ladewig, Flavia Michelini, Komal Jhaveri, Pau Castel, Javier Carmona, Lauren Fairchild, Adler G. Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina Leslie, Maurizio Scaltriti, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2269–2280.
https://doi.org/10.1158/0008-5472.CAN-22-0446
Published: 15 June 2022
View articletitled, The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Open the PDF for The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation in another window
Includes: Supplementary data
Journal Articles

Abstract 5239: Switching inhibitor class overcomes crizotinib resistance in a MET fusion-positive NSCLC with a novel acquired MET G1090A mutation

Yonina R. Murciano-Goroff, Srinivasaraghavan Kannan, Jason C. Chang, Ryma Benayed, Ilya Blokhin, Natasha Rekhtman, Ann Elizabeth Sisk, Jaime Gibson, Lia Judka, Lauren Kaplanis, Madeline Merrill, Erica Sgroe, Chandra S. Verma, Alexander Drilon, Emiliano Cocco
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5239.
https://doi.org/10.1158/1538-7445.AM2022-5239
Published: 15 June 2022
View articletitled, Abstract 5239: Switching inhibitor class overcomes crizotinib resistance in a MET fusion-positive NSCLC with a novel acquired MET G1090A mutation
Journal Articles

Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer

Amaia Arruabarrena-Aristorena, Jesper LV Maag, Srushti Kittane, Yanyan Cai, Jane Park, Pedram Razavi, Lorenzo Ferrando, Pier Selenica, Wouter R. Karthaus, Srinivasaraghavan Kannan, Emiliano Cocco, Sik Y. Ho, Daisylyn Senna Tan, Mirna Sallaku, Charles L. Sawyers, Jorge S. Reis-Fihlo, Chandra S. Verma, Ralf Jauch, Richard Koche, José Baselga, Eneda Toska, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3439.
https://doi.org/10.1158/1538-7445.AM2020-3439
Published: 15 August 2020
View articletitled, Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer
Journal Articles

Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M. Schram, Helen H. Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Sabrina Arena, Benedetta Mussolin, Ram Kannan, Neil Vasan, Alexander N. Gorelick, Michael F. Berger, Yi Liao, Uwe Rix, Alberto Bardelli, Jacklyn Hechtman, Elisa de Stanchina, David M. Hyman, Chandra Verma, Andrea Ventura, Alexander Drilon, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5680.
https://doi.org/10.1158/1538-7445.AM2020-5680
Published: 15 August 2020
View articletitled, Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors
Journal Articles

Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer

Eneda Toska, Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Jordan Otto, Yanyan Cai, Carmen Chan, Drew R. D' Avino, Clayton Collings, Ross L. Levine, Maurizo Scaltriti, Jorge S. Reis-Filho, Cigall Kadoch, Christina Leslie, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 949.
https://doi.org/10.1158/1538-7445.AM2019-949
Published: 01 July 2019
View articletitled, Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer
Journal Articles

Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

Emiliano Cocco, Amanda Kulick, Sandra Misale, Rona Yaeger, Pedram Razavi, Helen H. Won, Ryan Ptashkin, Jaclyn F. Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B. Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J. Nagy, Richard B. Lanman, Michael F. Berger, Marc Ladanyi, David M. Hyman, Alexander Drilon, Maurizio Scaltriti, Alison M. Schram
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-118.
https://doi.org/10.1158/1538-7445.AM2019-LB-118
Published: 01 July 2019
View articletitled, Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation
Journal Articles

Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions

Emiliano Cocco, Jamal Benhamida, Sumit Middha, Ahmet Zehir, Kerry Mullaney, Jinru Shia, Rona Yaeger, Liying Zhang, Donna Wong, Liliana Villafania, Khedoudja Nafa, Maurizio Scaltriti, Alexander Drilon, Leonard Saltz, Alison M. Schram, Zsofia K. Stadler, David M. Hyman, Ryma Benayed, Marc Ladanyi, Jaclyn F. Hechtman
Journal: Cancer Research
Cancer Res (2019) 79 (6): 1047–1053.
https://doi.org/10.1158/0008-5472.CAN-18-3126
Published: 15 March 2019
View articletitled, Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions
Open the PDF for Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions in another window
Journal Articles

Abstract LB-042: Successful tumor formation following xenotransplantation of primary human ovarian cancer cells into severe combined immunodeficient (SCID) pigs

Adeline N. Boettcher, Matti Kiupel, Malavika Adur, Emiliano Cocco, Alessandro Santin, Sara Charley, John Risinger, Christopher Tuggle, Erik Shapiro
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-042.
https://doi.org/10.1158/1538-7445.AM2018-LB-042
Published: 01 July 2018
View articletitled, Abstract LB-042: Successful tumor formation following xenotransplantation of primary human ovarian cancer cells into severe combined immunodeficient (SCID) pigs
Journal Articles

Abstract 135: Mutational landscape of uterine and ovarian carcinosarcomas reveals new recurrently-mutated histone core genes as drivers of epithelial-mesenchymal transition

Gulden Menderes, Siming Zhao, Carlton L. Schwab, Salvatore Lopez, Jonathan D. Black, Emiliano Cocco, Stefania Bellone, Dan-Arin Silasi, Elena Ratner, Masoud Azodi, Babak Litkouhi, Peter E. Schwartz, Joseph Schlossinger, Richard Lifton, Alessandro Santin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 135.
https://doi.org/10.1158/1538-7445.AM2016-135
Published: 15 July 2016
View articletitled, Abstract 135: Mutational landscape of uterine and ovarian carcinosarcomas reveals new recurrently-mutated histone core genes as drivers of epithelial-mesenchymal transition
Journal Articles

Abstract 3103: Cyclin E amplification predicts sensitivity of primary Uterine Serous Carcinoma (USC) cell lines to the cdk2 inhibitor CYC065

Emiliano Cocco, Stefania Bellone, Salvatore Lopez, Elena Bonazzoli, Federica Predolini, Jonathan D. Black, Alessandro D. Santin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3103.
https://doi.org/10.1158/1538-7445.AM2015-3103
Published: 01 August 2015
View articletitled, Abstract 3103: Cyclin E amplification predicts sensitivity of primary Uterine Serous Carcinoma (USC) cell lines to the cdk2 inhibitor CYC065
Journal Articles

Abstract 2461: SYD985, a novel HER2-targeting antibody-drug conjugate, shows strong antitumor activity in primary USC cell lines with low (1+) and moderate (2+) HER2/Neu expression

Jonathan D. Black, Salvatore Lopez, Emiliano Cocco, Stefania Bellone, Elena Bonazzoli, Carlton Schwab, Diana English, Peter Goedings, Patrick Beusker, Miranda van der Lee, Marco Timmers, Wim Dokter, Thomas Rutherfor, Peter Schwartz, Alessandro Santin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2461.
https://doi.org/10.1158/1538-7445.AM2015-2461
Published: 01 August 2015
View articletitled, Abstract 2461: SYD985, a novel HER2-targeting antibody-drug conjugate, shows strong antitumor activity in primary USC cell lines with low (1+) and moderate (2+) HER2/Neu expression
Journal Articles

Abstract 4937: Fluorescence imaging using Clostridium Perfringens Enterotoxin carboxi-terminal fragment (c-CPE) to target metastatic chemotherapy-resistant human ovarian cancer in xenograft mice

Emiliano Cocco, Sara Gasparrini, Erik M. Shapiro, Carlton Schwab, Stefania Bellone, Ileana Bortolomai, Salvatore Lopez, Natalia J. Sumi, Elena Bonazzoli, Roberta Nicoletti, Yang Deng, William M. Saltzman, Caroline J. Zeiss, Dan-Arin Silasi, Thomas J. Rutherford, Peter E. Schwartz, Alessandro D. Santin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4937.
https://doi.org/10.1158/1538-7445.AM2014-4937
Published: 01 October 2014
View articletitled, Abstract 4937: Fluorescence imaging using Clostridium Perfringens Enterotoxin carboxi-terminal fragment (c-CPE) to target metastatic chemotherapy-resistant human ovarian cancer in xenograft mice
Journal Articles

Abstract 4498: Afatinib, an irreversible ErbB family inhibitor, demonstrates activity against HER2 mutated cervical cancer in vitro

Salvatore Lopez, Emiliano Cocco, Bellone Stefania, Ileana Bortolomai, Elena Bonazzoli, Roberta Nicoletti, Carlton Schwab, Diana P. English, Corrado Terranova, Roberto Angioli, Alessandro D. Santin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4498.
https://doi.org/10.1158/1538-7445.AM2014-4498
Published: 01 October 2014
View articletitled, Abstract 4498: Afatinib, an irreversible ErbB family inhibitor, demonstrates activity against HER2 mutated cervical cancer in vitro
Journal Articles

Abstract 732: Iron oxide nanoparticles functionalized with the Clostridium Perfringens Enterotoxin carboxi-terminal fragment peptide: A novel diagnostic and therapeutic approach to specifically target ovarian cancer.

Emiliano Cocco, Ileana Bortolomai, Stefania Bellone, Sara Gasparrini, Diana English, Erik Shapiro, Sergio Pecorelli, Dan-Arin Silasi, Masoud Azodi, Elena Ratner, Thomas Rutherford, Peter Schwartz, Alessandro Santin
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 732.
https://doi.org/10.1158/1538-7445.AM2013-732
Published: 15 April 2013
View articletitled, Abstract 732: Iron oxide nanoparticles functionalized with the Clostridium Perfringens Enterotoxin carboxi-terminal fragment peptide: A novel diagnostic and therapeutic approach to specifically target ovarian cancer.
Journal Articles

Abstract 364: In vivo targeting of CD44+ ovarian cancer stem cells (CSC) by Clostridium Perfringens Enterotoxin binding domain (CPE-peptide) conjugated to poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP)

Emiliano Cocco, Stefania Bellone, Dana Roque, Federica Guzzo, Sara Gasparrini, Sergio Pecorelli, Dan-Arin Silasi, Masoud Azodi, Elena Ratner, Thomas Ruterford, Peter Schwartz, Caroline E. Weller, W. Mark Saltzman, Alessandro D. Santin
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 364.
https://doi.org/10.1158/1538-7445.AM2012-364
Published: 15 April 2012
View articletitled, Abstract 364: In vivo targeting of CD44+ ovarian cancer stem cells (CSC) by Clostridium Perfringens Enterotoxin binding domain (CPE-peptide) conjugated to poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP)
Journal Articles

Abstract 4369: Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in C.B-17/SCID mice by intraperitoneal administration of Clostridium Perfringens Enterotoxin (CPE)

Alessandro D. Santin, Emiliano Cocco, Stefania Bellone, Francesca Casagrande, Marta Bellone, Paola Todeschini, Joyce Varughese, Dan-Arin Silasi, Masoud Azodi, Thomas Rutherford, Peter Schwartz, Sergio Pecorelli
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4369.
https://doi.org/10.1158/1538-7445.AM2011-4369
Published: 15 April 2011
View articletitled, Abstract 4369: Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in C.B-17/SCID mice by intraperitoneal administration of Clostridium Perfringens Enterotoxin (CPE)
Journal Articles

Abstract 699: Uterine serous papillary carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody

Alessandro D. Santin, Emiliano Cocco, Joyce Varughese, Christine E. Richter, Francesca Casagrande, Stefania Bellone, Karim El-Sahwi, Marta Bellone, Paola Todeschini, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 699.
https://doi.org/10.1158/1538-7445.AM10-699
Published: 15 April 2010
View articletitled, Abstract 699: Uterine serous papillary carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody