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Journal Articles

XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance

Available to Purchase
Tulasigeri M. Totiger, Wannasiri Chiraphapphaiboon, Yasmine Baca, Sana Chaudhry, Ryan Q. Notti, Skye Montoya, Monika Chojnacka, Gabriel Gaidosh, Jumana Afaghani, Maurizio Affer, Christopher Armstrong, Paul M. Kavanaugh, Efe Karaca, Jenna Zabroski, Michael Lewis, Alyssa Maye, Jacob Jahn, Rajesh K. Soni, Daniel Bilbao, Phil Walker, Andrew Elliott, Emil Lou, Wafik S. El-Deiry, Jose Antonio Rodriguez, Hai Dang Nguyen, Justin Taylor
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-3112
Published: 18 June 2025
View articletitled, XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance
Open the PDF for XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance in another window
Includes: Supplementary data
Journal Articles

Abstract CT269: First-in-human trial in patients with metastatic colorectal cancer using CRISPR-engineered tumor infiltrating lymphocytes in which the intracellular immune checkpoint CISH is inhibited

Free
Emil Lou, Modassir S. Choudhry, Timothy K. Starr, Timothy Folsom, Jason Bell, Blaine Rathmann, Anthony P. DeFeo, Ji Hyun Kim, Nicholas Slipek, Zhaohui Jin, Darin Sumstad, Christopher A. Klebanoff, Katherine Ladner, Akshat Sarkari, R Scott McIvor, Thomas A. Murray, Jeffrey Miller, Madhuri Rao, Eric Jensen, Jacob Ankeny, Mahmoud A. Khalifa, Anil Chauhan, Benjamin Spilseth, Ajay Dixit, Paolo P. Provenzano, Wenjing Pan, Daniel Weber, Miranda Byrne-Steele, Tom Henley, David H. McKenna, Matthew J. Johnson, Beau R. Webber, Branden S. Moriarity
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT269.
https://doi.org/10.1158/1538-7445.AM2025-CT269
Published: 25 April 2025
View articletitled, Abstract CT269: First-in-human trial in patients with metastatic colorectal cancer using CRISPR-engineered tumor infiltrating lymphocytes in which the intracellular immune checkpoint CISH is inhibited
Journal Articles

Abstract 2026: Comprehensive molecular and immunological characterization of CLDN18.2 in pancreatic cancer

Free
Midhun Malla, Sachin Deshmukh, Timothy Samec, Sharon Wu, Joanne Xiu, Mehmet Akce, Garima Gupta, Qasim Hussaini, Darryl Outlaw, Rebecca Arrend, Aakash Desai, Arnab Basu, Purnachandra N. Ganji, Mark Evans, Heinz-Joseph Lenz, Emil Lou, Dani Castillo, Rachna Schroff, David Spetzler, Bassel El-Rayes
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2026.
https://doi.org/10.1158/1538-7445.AM2025-2026
Published: 21 April 2025
View articletitled, Abstract 2026: Comprehensive molecular and immunological characterization of CLDN18.2 in pancreatic cancer
Journal Articles

Abstract 6470: Real-world analysis of insurance status and survival in patients with selected GI cancers

Free
Rebecca AbuAyed, Joshua Schwanke, Brooke Patterson, McKenzie White, Schelomo Marmor, Eric Jensen, Christopher Tignanelli, Emil Lou, Ajay Prakash
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6470.
https://doi.org/10.1158/1538-7445.AM2024-6470
Published: 22 March 2024
View articletitled, Abstract 6470: Real-world analysis of insurance status and survival in patients with selected GI cancers
Journal Articles

Abstract 2300: AI enabled whole exome& transcriptome liquid biopsy addressing MCED, MRD, and therapy selection on a single platform

Free
Jim Abraham, Valeriy Domenyuk, Maria Perdigones Borderias, Takayuki Yoshino, Elisabeth I. Heath, Emil Lou, Stephen Liu, John Marshall, Wafik S. El-Deiry, Anthony Shields, Martin Dietrich, Yoshiaki Nakamura, Takao Fujisawa, David D. Halbert, Dominic Sacchetti, Seth Stahl, Adam Stark, Sergey Klimov, Sourabh Antani, Chadi Nabhan, Jeffrey Swensen, George Poste, Matt Oberley, Milan Radovich, George W. Sledge, David Spetzler
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2300.
https://doi.org/10.1158/1538-7445.AM2024-2300
Published: 22 March 2024
View articletitled, Abstract 2300: AI enabled whole exome& transcriptome liquid biopsy addressing MCED, MRD, and therapy selection on a single platform
Journal Articles

Abstract 6851: The genomic, transcriptomic, and immunologic landscape of TEM8 (ANTXR1) in neuroendocrine neoplasms (NENs)

Free
Samuel A. Kareff, Harris Krause, Andrew Elliott, Peter Hosein, Emil Lou, Heloisa Soares, Matthew Oberley, Aman Chauhan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6851.
https://doi.org/10.1158/1538-7445.AM2024-6851
Published: 22 March 2024
View articletitled, Abstract 6851: The genomic, transcriptomic, and immunologic landscape of TEM8 (ANTXR1) in neuroendocrine neoplasms (NENs)
Journal Articles

Abstract 3890: Comprehensive molecular and immunological characterization of early-onset esophagogastric cancer

Free
Lawrence W. Wu, Sachin K. Deshmukh, Sharon Wu, Joanne Xiu, Alex Farrell, Vincent Lam, Emil Lou, Sanjay Goel, Chadi Nabhan, Ryan H. Moy
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3890.
https://doi.org/10.1158/1538-7445.AM2024-3890
Published: 22 March 2024
View articletitled, Abstract 3890: Comprehensive molecular and immunological characterization of early-onset esophagogastric cancer
Journal Articles

Abstract 4253: Pan-cancer analysis of XPO1 R749Q mutations across 217,570 patients reveals association with high tumor mutational burden and therapy resistance

Free
Tulasigeri M. Totiger, Yasmine Baca, Wannasiri Chiraphapphaiboon, Sana Chaudhry, Skye Montoya, Monika Chojnacka, Gabriel Gaidosh, Jumana Afaghani, Maurizio Affer, Christopher D. Armstrong, Ryan Notti, Jenna Zabroski, Jacob Jahn, Vindhya Nawaratne, Ramiro Verdun, Hai Dang Nguyen, Chadi Nabhan, Thomas J. Herzog, Phil Walker, Andrew Elliott, Emil Lou, Wafik S. El-Deiry, Edith Mitchell, Jose Antonio Rodriguez, Justin Taylor
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4253.
https://doi.org/10.1158/1538-7445.AM2023-4253
Published: 04 April 2023
View articletitled, Abstract 4253: Pan-cancer analysis of XPO1 R749Q mutations across 217,570 patients reveals association with high tumor mutational burden and therapy resistance
Journal Articles

Abstract P4-08-06: Clock Genes in Breast Cancer

Free
Priya Jayachandran, Yasmine Baca, Joanne Xiu, Yuanzhong Pan, Phil Walker, Francesca Battaglin, Hiroyuki Arai, Moh’d Khushman, Janice Lu, Darcy Spicer, Shannon Mumenthaler, Richard Goldberg, Benjamin Weinberg, Emil Lou, Michael Hall, Arielle L. Heeke, W. Michael Korn, Steve A. Kay, Heinz-Josef Lenz, Evanthia T. Roussos Torres
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-06.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-06
Published: 01 March 2023
View articletitled, Abstract P4-08-06: Clock Genes in Breast Cancer
Journal Articles

The Mechanisms of Action of Tumor Treating Fields

Open Access
Justin C. Moser, Ellaine Salvador, Karina Deniz, Kenneth Swanson, Jack Tuszynski, Kristen W. Carlson, Narasimha Kumar Karanam, Chirag B. Patel, Michael Story, Emil Lou, Carsten Hagemann
Journal: Cancer Research
Cancer Res (2022) 82 (20): 3650–3658.
https://doi.org/10.1158/0008-5472.CAN-22-0887
Published: 17 October 2022
View articletitled, The Mechanisms of Action of Tumor Treating Fields
Open the PDF for The Mechanisms of Action of Tumor Treating Fields in another window
Includes: Supplementary data
Journal Articles

Abstract 1231: Prognostic and predictive drug-induced gene signatures for colorectal cancer patients personalized based on p53 status and treatment with FOLFOX, 5-FU, oxaliplatin, or irinotecan

Free
Lindsey Carlsen, Andrew Elliott, Marzia Capelletti, Micheal Hall, Philip A. Philip, Heinz-Josef Lenz, Howard Safran, Khaldoun Almhanna, Rimini Breakstone, Alexander G. Raufi, Emil Lou, John L. Marshall, W. Michael Korn, Wafik S. El-Deiry
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1231.
https://doi.org/10.1158/1538-7445.AM2022-1231
Published: 15 June 2022
View articletitled, Abstract 1231: Prognostic and predictive drug-induced gene signatures for colorectal cancer patients personalized based on p53 status and treatment with FOLFOX, 5-FU, oxaliplatin, or irinotecan
Journal Articles

Abstract 5699: Overexpression of KMT2A is associated with worse prognosis and specific immune signatures in patients with TP53-mutated hepatocellular carcinomas

Free
Liang Sha, Jun Yin, Sungming Kim, Woojin An, Jian Zhang, Alex Farrell, Joanne Xiu, David Spetzler, Shuanzeng Wei, Dave S. Hoon, Stephen V. Liu, Emil Lou, Misako Nagasaka, Wafik S. El-Deiry, Benedito A. Carneiro, Wolfgang Michael Korn, Heinz-Josef Lenz, Yali Dou
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5699.
https://doi.org/10.1158/1538-7445.AM2022-5699
Published: 15 June 2022
View articletitled, Abstract 5699: Overexpression of KMT2A is associated with worse prognosis and specific immune signatures in patients with TP53-mutated hepatocellular carcinomas
Journal Articles

Abstract 2037: Spatial omic changes of malignant pleural mesothelioma following treatment using tumor-treating fields

Free
Emil Lou, Katherine Ladner, Kerem Wainer-Katsir, Karina Deniz, Yaara Porat, Boris Brant, Shiri Davidi, Yuki Padmanabhan, Phillip Wong, Amrinder Nain, Clifford J. Steer, Moshe Giladi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2037.
https://doi.org/10.1158/1538-7445.AM2022-2037
Published: 15 June 2022
View articletitled, Abstract 2037: Spatial omic changes of malignant pleural mesothelioma following treatment using tumor-treating fields
Journal Articles

Abstract 2011: Tumor treating fields induce cellular and morphologic changes including disruption of intercellular communication networks in malignant pleural mesothelioma

Free
Akshat Sarkari, Sophie Korenfeld, Katherine Ladner, Phillip Wong, Antonia Martinez, Eyal Dor-On, Moshe Giladi, Amrinder Nain, Emil Lou
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2011.
https://doi.org/10.1158/1538-7445.AM2021-2011
Published: 01 July 2021
View articletitled, Abstract 2011: Tumor treating fields induce cellular and morphologic changes including disruption of intercellular communication networks in malignant pleural mesothelioma
Journal Articles

Abstract 5156: In vitro application of tumor-treating fields to suppress tunneling nanotubes in mesothelioma

Free
Akshat Sarkari, Michal Munster, Einav Zeevi, Moshe Giladi, Emil Lou
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5156.
https://doi.org/10.1158/1538-7445.AM2019-5156
Published: 01 July 2019
View articletitled, Abstract 5156: In vitro application of tumor-treating fields to suppress tunneling nanotubes in mesothelioma
Journal Articles

Abstract 929: Tunneling nanotube conduits facilitate the bystander effect after oncolytic viral infection

Free
Emil Lou, Justin Ady, Venugopal Thayanithy, Kelly Mojica, Joshua Carson, Prassanna Rao, Yuman Fong
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 929.
https://doi.org/10.1158/1538-7445.AM2016-929
Published: 15 July 2016
View articletitled, Abstract 929: Tunneling nanotube conduits facilitate the bystander effect after oncolytic viral infection
Journal Articles

Abstract 3189: Tunneling nanotube formation is significantly upregulated in invasive cancer cells

Free
Snider Desir, Subbaya Subramanian, Clifford Steer, Emil Lou
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3189.
https://doi.org/10.1158/1538-7445.AM2015-3189
Published: 01 August 2015
View articletitled, Abstract 3189: Tunneling nanotube formation is significantly upregulated in invasive cancer cells
Journal Articles

Abstract 3599: Long-distance intercellular transport of microRNAs via tunneling nanotubes: Role in tumor-stroma interactions and malignant potential

Free
Venugopal Thayanithy, Elizabeth L. Dickson, Subbaya Subramanian, Clifford J. Steer, Emil Lou
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3599.
https://doi.org/10.1158/1538-7445.AM2014-3599
Published: 01 October 2014
View articletitled, Abstract 3599: Long-distance intercellular transport of microRNAs via tunneling nanotubes: Role in tumor-stroma interactions and malignant potential
Journal Articles

Abstract 1528: Tunneling Nanotubes: a new approach to studying intercellular communication in aggressive solid tumor malignancies.

Free
Emil Lou, Victor Babatunde, Sho Fujisawa, Afsar Barlas, Andre L. Moreira, Venugopal Thayanithy, Subbaya Subramanian, Robert Downey, Katia Manova-Todorova, Malcolm A.S. Moore
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1528.
https://doi.org/10.1158/1538-7445.AM2013-1528
Published: 15 April 2013
View articletitled, Abstract 1528: Tunneling Nanotubes: a new approach to studying intercellular communication in aggressive solid tumor malignancies.
Journal Articles

Abstract 5660: Vaccinia virus GLV-1h153 in combination with 131I-iodine shows increased efficiency in treating triple-negative breast cancer in vivo

Free
Sepideh Gholami, Chun-Hao Chen, Emil Lou, Andrew A. Marano, Kelly M. Mojica, Nanhai G. Chen, Richard J. Aguilar, Laurence J. Belin, Valerie A. Longo, Pat Zanzonico, Aladar A. Szalay, Yuman Fong
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5660.
https://doi.org/10.1158/1538-7445.AM2012-5660
Published: 15 April 2012
View articletitled, Abstract 5660: Vaccinia virus GLV-1h153 in combination with 131I-iodine shows increased efficiency in treating triple-negative breast cancer in vivo