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Journal Articles

Abstract 5218: Breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) transport ibrutinib and may restrict its oral availability and brain accumulation, whereas CYP3A4 limits ibrutinib oral availability

Stephanie van Hoppe, Gert-Jan Rood, Els Wagenaar, Rolf Sparidans, Jos Beijnen, Alfred Schinkel
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5218.
https://doi.org/10.1158/1538-7445.AM2017-5218
Published: 01 July 2017
View articletitled, Abstract 5218: Breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) transport ibrutinib and may restrict its oral availability and brain accumulation, whereas CYP3A4 limits ibrutinib oral availability
Journal Articles

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Aksana Vasilyeva, Selvi Durmus, Lie Li, Els Wagenaar, Shuiying Hu, Alice A. Gibson, John C. Panetta, Sridhar Mani, Alex Sparreboom, Sharyn D. Baker, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2015) 75 (13): 2729–2736.
https://doi.org/10.1158/0008-5472.CAN-15-0280
Published: 30 June 2015
View articletitled, Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Open the PDF for Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b in another window
Includes: Supplementary data
Journal Articles

Abstract 4419: The role of ABC transporters in PhIP-induced colon carcinogenesis

Selvi Durmus, M.A. van der Valk, S.F. Teunissen, Els Wagenaar, Jos Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4419.
https://doi.org/10.1158/1538-7445.AM2012-4419
Published: 15 April 2012
View articletitled, Abstract 4419: The role of ABC transporters in PhIP-induced colon carcinogenesis
Journal Articles

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Robert A.B. van Waterschoot, Jurjen S. Lagas, Els Wagenaar, Cornelia M.M. van der Kruijssen, Antonius E. van Herwaarden, Ji-Ying Song, Rogier W. Rooswinkel, Olaf van Tellingen, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8996–9002.
https://doi.org/10.1158/0008-5472.CAN-09-2915
Published: 30 November 2009
View articletitled, Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity
Open the PDF for Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity in another window
Includes: Supplementary data
Journal Articles

Functional interaction of the ABC transporters Bcrp1 (Abcg2) and Mrp2 (Abcc2) in methotrexate elimination

Maria Vlaming, Anita van Esch, Zeliha Pala, Els Wagenaar, Olaf van Tellingen, Alfred Schinkel
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2293.
Published: 01 May 2007
View articletitled, Functional interaction of the ABC transporters Bcrp1 (Abcg2) and Mrp2 (Abcc2) in methotrexate elimination
Journal Articles

Mice deficient for the breast cancer resistance protein (Bcrp1/Abcg2): Biological and pharmacological implications.

Johan W. Jonker, Ellen Bolscher, Els Wagenaar, Trevor C. Dale, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 567–568.
Published: 01 April 2004
View articletitled, Mice deficient for the breast cancer resistance protein (Bcrp1/Abcg2): Biological and pharmacological implications.
Journal Articles

The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Restricts Exposure to the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Antonius E. van Herwaarden, Johan W. Jonker, Els Wagenaar, Remco F. Brinkhuis, Jan H. M. Schellens, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2003) 63 (19): 6447–6452.
Published: 14 October 2003
View articletitled, The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Restricts Exposure to the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Open the PDF for The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Restricts Exposure to the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in another window
Journal Articles

Mammary Tumor Virus DNA as a Marker for Genotypic Variance within Hormone-responsive GR Mouse Mammary Tumors

Rob Michalides, Els Wagenaar, Mels Sluyser
Journal: Cancer Research
Cancer Res (1982) 42 (3): 1154–1158.
Published: 01 March 1982
View articletitled, Mammary Tumor Virus DNA as a Marker for Genotypic Variance within Hormone-responsive GR Mouse Mammary Tumors
Open the PDF for Mammary Tumor Virus DNA as a Marker for Genotypic Variance within Hormone-responsive GR Mouse Mammary Tumors in another window