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Elizabeth M. Swisher
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Journal Articles

Abstract 4716: Functional precision medicine: Uncovering high actionability in rare cancers beyond genomics

Free
Rachele Rosati, Payel Chatterjee, Alex C. Rajewski, Marwah Al-Aloosi, Lauren R. Appleyard, Vaishnavi Pallem, Shalini Pereira, Robert L. Diaz, Christopher J. Kemp, Ryan Jones, Brady Bernard, Pashtoon M. Kasi, Kiran Turaga, Michael Castro, Tara Seery, Arun Singh, Sameek Roychowdhury, Melind Javle, Jill Alldredge, Soledad Jorge, Kathryn Pennington, Barbara A. Goff, Heidi J. Gray, Elizabeth M. Swisher, Carla Grandori
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4716.
https://doi.org/10.1158/1538-7445.AM2025-4716
Published: 21 April 2025
View articletitled, Abstract 4716: Functional precision medicine: Uncovering high actionability in rare cancers beyond genomics
Journal Articles

Abstract 3615: Clonal hematopoiesis in ovarian cancer survivors: Correlation with carboplatin and PARP inhibitor exposure

Free
Marc R. Radke, Nithisha Khasnavis, Carly Mondoy, Mayumi Rubin-Saika, Enna Manhardt, Jennifer Ochoa, Melanie R. Dillon, Roseanne J. Gamboa, David Wu, Siobán Keel, Sergei Doulatov, Elizabeth M. Swisher
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3615.
https://doi.org/10.1158/1538-7445.AM2025-3615
Published: 21 April 2025
View articletitled, Abstract 3615: Clonal hematopoiesis in ovarian cancer survivors: Correlation with carboplatin and PARP inhibitor exposure
Journal Articles

Abstract LB416: IncreasedTP53somatic evolution in the fallopian tubes of individuals at high risk of ovarian cancer

Free
CoohleenAnn Coombes, Brendan F. Kohrn, Jeanne U. Fredrickson, Elena Latorre-Esteves, Emma Hazard, Shreya Suresh, Marc R. Radke, Melanie Dillon, Anh P. Vo, Katherine Lai, Ronit Katz, Barbara M. Norquist, Elizabeth M. Swisher, Elizabeth U. Parker, Rosana Risques
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB416.
https://doi.org/10.1158/1538-7445.AM2024-LB416
Published: 05 April 2024
View articletitled, Abstract LB416: IncreasedTP53somatic evolution in the fallopian tubes of individuals at high risk of ovarian cancer
Journal Articles

Abstract LB232: Implementation of population-based risk assessment for hereditary cancer in primary care: Results from the Early Detection of Genetic Risk (EDGE) Trial

Free
Elizabeth M. Swisher, Heather M. Harris, Barbara M. Norquist, Jeannine Brant, Brian Shirts, Sarah Knerr, Emerson J. Dusic, Faith Beers, Tesla N. Theoryn, DaLaina Cameron, Howard Cabral, Laurie A. Riemann, Michael Raff, Beth Devine, Deborah J. Bowen, Catharine Wang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB232.
https://doi.org/10.1158/1538-7445.AM2024-LB232
Published: 05 April 2024
View articletitled, Abstract LB232: Implementation of population-based risk assessment for hereditary cancer in primary care: Results from the Early Detection of Genetic Risk (EDGE) Trial
Journal Articles

R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts

Available to Purchase
Zhiyan Silvia Liu, Sayantani Sinha, Maxwell Bannister, Axia Song, Erica Arriaga-Gomez, Alexander J. McKeeken, Elizabeth A. Bonner, Benjamin K. Hanson, Martina Sarchi, Kouhei Takashima, Dawei Zong, Victor M. Corral, Evan Nguyen, Jennifer Yoo, Wannasiri Chiraphapphaiboon, Cassandra Leibson, Matthew C. McMahon, Sumit Rai, Elizabeth M. Swisher, Zohar Sachs, Srinivas Chatla, Derek L. Stirewalt, H. Joachim Deeg, Tomasz Skorski, Eirini P. Papapetrou, Matthew J. Walter, Timothy A. Graubert, Sergei Doulatov, Stanley C. Lee, Hai Dang Nguyen
Journal: Cancer Research
Cancer Res (2024) 84 (4): 577–597.
https://doi.org/10.1158/0008-5472.CAN-23-3239
Published: 15 February 2024
View articletitled, R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts
Open the PDF for R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts in another window
Includes: Supplementary data
Journal Articles

Abstract CT160: Phase 1b/2a clinical trial of the oral BET inhibitor PLX2853 as monotherapy for ARID1A mutated gynecologic cancers and in combination with carboplatin for platinum resistant ovarian cance

Free
Elizabeth M. Swisher, Linda R. Duska, Erika P. Hamilton, Amit M. Oza, Gini Fleming, Oladapo O. Yeku, Alexander I. Spira, Debra L. Richardson, Robin Guo, Jackie Walling, Kerry Inokuchi, Dmitriy Zamarin
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT160.
https://doi.org/10.1158/1538-7445.AM2023-CT160
Published: 14 April 2023
View articletitled, Abstract CT160: Phase 1b/2a clinical trial of the oral BET inhibitor PLX2853 as monotherapy for ARID1A mutated gynecologic cancers and in combination with carboplatin for platinum resistant ovarian cance
Journal Articles

Abstract 966: Exploration of a novel HRD signature (HRDsig) as a biomarker for rucaparib benefit in ARIEL2

Free
Ethan S. Sokol, Russell W. Madison, Dexter X. Jin, Kuei Ting Chen, Zoe Fleischmann, Justin Newberg, Alexa Shrock, David Fabrizio, Jie He, Neeru Bhardwaj, Kevin K. Lin, Iain A. McNeish, Elizabeth M. Swisher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 966.
https://doi.org/10.1158/1538-7445.AM2023-966
Published: 04 April 2023
View articletitled, Abstract 966: Exploration of a novel HRD signature (HRDsig) as a biomarker for rucaparib benefit in ARIEL2
Journal Articles

Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma

Free
Ksenija Nesic, Olga Kondrashova, Rachel M. Hurley, Cordelia D. McGehee, Cassandra J. Vandenberg, Gwo-Yaw Ho, Elizabeth Lieschke, Genevieve Dall, Nirashaa Bound, Kristy Shield-Artin, Marc Radke, Ashan Musafer, Zi Qing Chai, Mohammad Reza Eftekhariyan Ghamsari, Maria I. Harrell, Damien Kee, Inger Olesen, Orla McNally, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D.L. Bowtell, Elizabeth M. Swisher, S. John Weroha, Katia Nones, Nicola Waddell, Scott H. Kaufmann, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4709–4722.
https://doi.org/10.1158/0008-5472.CAN-21-0774
Published: 15 September 2021
View articletitled, Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma
Open the PDF for Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1074: Improving efficacy of microtubule inhibitors in the treatment of high-grade serous ovarian cancer and ovarian carcinosarcoma

Free
Cassandra J. Vandenberg, Gwo-Yaw Ho, Ksenija Nesic, Elizabeth M. Swisher, Sean M. Grimmond, Matthew J. Wakefield, Holly E. Barker, David D. Bowtell, Clare L. Scott
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1074.
https://doi.org/10.1158/1538-7445.AM2021-1074
Published: 01 July 2021
View articletitled, Abstract 1074: Improving efficacy of microtubule inhibitors in the treatment of high-grade serous ovarian cancer and ovarian carcinosarcoma
Journal Articles

Abstract LB047: Uterine lavage for the detection of ovarian cancer using an expanded gene panel

Free
Talayeh Ghezelayagh, Jeanne Fredrickson, Enna Manhardt, Marc R. Radke, Brendan Kohrn, Heidi J. Gray, Renata R. Urban, Kathryn P. Pennington, John B. Liao, Kemi M. Doll, Elise J. Simons, Jennifer K. Burzawa, Barbara A. Goff, Paul Speiser, Elizabeth M. Swisher, Rosa Ana Risques, Barbara M. Norquist
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB047.
https://doi.org/10.1158/1538-7445.AM2021-LB047
Published: 01 July 2021
View articletitled, Abstract LB047: Uterine lavage for the detection of ovarian cancer using an expanded gene panel
Journal Articles

Abstract 744: Progesterone receptors promote quiescence & ovarian cancer cell phenotypes via modulation of DREAM in p53-mutant fallopian tube models

Free
Laura J. Mauro, Megan I. Seibel, Caroline H. Diep, Angela Spartz, Carlos Perez Kerkvliet, Hari Singhal, Elizabeth M. Swisher, Lauren E. Schwartz, Ronny Drapkin, Siddharth Saini, Fatmata Seesay, Larisa Litovchick, Carol A. Lange
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 744.
https://doi.org/10.1158/1538-7445.AM2021-744
Published: 01 July 2021
View articletitled, Abstract 744: Progesterone receptors promote quiescence & ovarian cancer cell phenotypes via modulation of DREAM in p53-mutant fallopian tube models
Journal Articles

Abstract 2057: BRCA1 D11q isoform expression impacts PARP inhibitor responses in high grade serous ovarian carcinoma patient derived xenografts

Free
Ksenija Nesic, Cassandra J. Vandenberg, Olga Kondrashova, John J. Krais, Neil Johnson, Elizabeth M. Swisher, Matthew J. Wakefield, Clare L. Scott
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2057.
https://doi.org/10.1158/1538-7445.AM2021-2057
Published: 01 July 2021
View articletitled, Abstract 2057: BRCA1 D11q isoform expression impacts PARP inhibitor responses in high grade serous ovarian carcinoma patient derived xenografts
Journal Articles

Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer

Free
Cassandra L. Moyer, Jennifer Ivanovich, Jessica L. Gillespie, Rachel Doberstein, Marc R. Radke, Marcy E. Richardson, Scott H. Kaufmann, Elizabeth M. Swisher, Paul J. Goodfellow
Journal: Cancer Research
Cancer Res (2020) 80 (4): 857–867.
https://doi.org/10.1158/0008-5472.CAN-19-1991
Published: 14 February 2020
View articletitled, Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer
Open the PDF for Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4487: Association of the tumor-immune microenvironment with response to niraparib and pembrolizumab in relapsed, platinum-resistant ovarian cancer

Free
Anniina Farkkila, Jia R. Lin, Julia Casado, Huy Nguyen, Yinghui Zhou, Julie R. Graham, Bruce J. Dezube, Steven Waggoner, Pamela Munster, Gini F. Fleming, Sandro Santagata, Ursula A. Matulonis, Peter K. Sorger, Elizabeth M. Swisher, Alan D. D’Andrea, Panagiotis Konstantinopoulos
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4487.
https://doi.org/10.1158/1538-7445.AM2019-4487
Published: 01 July 2019
View articletitled, Abstract 4487: Association of the tumor-immune microenvironment with response to niraparib and pembrolizumab in relapsed, platinum-resistant ovarian cancer
Journal Articles

Abstract 139: DNA damage and immunoprofiling with highly multiplexed tissue immunofluorescence (t-CycIF) in high-grade serous ovarian cancer

Free
Anniina Farkkila, Sameer S. Chopra, Jia-Ren Lin, Zoltan Maliga, Bose Koruchupakkal, Kyle C. Strickland, Brooke E. Howitt, Sandro Santagata, Ursula A. Matulonis, Kevin Elias, Elizabeth M. Swisher, Panagiotis A. Konstantinopoulos, Peter Sorger, Alan D. D'Andrea
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 139.
https://doi.org/10.1158/1538-7445.AM2018-139
Published: 01 July 2018
View articletitled, Abstract 139: DNA damage and immunoprofiling with highly multiplexed tissue immunofluorescence (t-CycIF) in high-grade serous ovarian cancer
Journal Articles

Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance

Free
Rachel M. Hurley, Ksenija Nesic, Cordelia McGehee, Olga Kondrashova, Maria I. Harrell, Paula A. Schneider, Xiaonan Hou, Cristina Correia, Karen S. Flatten, Giada V. Zapparoli, Alexander Dobrovic, Kevin K. Lin, Thomas C. Harding, Andrea E. Wahner Hendrickson, Elizabeth M. Swisher, Matthew Wakefield, S. John Weroha, Clare L. Scott, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5885.
https://doi.org/10.1158/1538-7445.AM2018-5885
Published: 01 July 2018
View articletitled, Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance
Journal Articles

Abstract 410: Genome-wide and focused CRISPR screens to study PARP inhibitor resistance mediated by mutations in PARP1

Free
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Maria I. Harrell, Rachel Brough, Jessica Frankum, Jung-Min Lee, Elizabeth M. Swisher, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 410.
https://doi.org/10.1158/1538-7445.AM2018-410
Published: 01 July 2018
View articletitled, Abstract 410: Genome-wide and focused CRISPR screens to study PARP inhibitor resistance mediated by mutations in PARP1
Journal Articles

Abstract 4676: DNA repair protein expression and response of homologous recombination deficient ovarian cancer to the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in the ARIEL2 Part 1 study

Free
Andrea E. Wahner Hendrickson, Kevin K. Lin, Daniel W. Visscher, Rachel M. Hurley, Mitch Raponi, Thomas C. Harding, Linda M. Murphy, Jill M. Wagner, Heidi Giordano, Iain McNeish, Elizabeth M. Swisher, Scott Kaufmann
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4676.
https://doi.org/10.1158/1538-7445.AM2017-4676
Published: 01 July 2017
View articletitled, Abstract 4676: DNA repair protein expression and response of homologous recombination deficient ovarian cancer to the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in the ARIEL2 Part 1 study
Journal Articles

Abstract CT008: Phase I study of the alpha specific PI3-Kinase inhibitor BYL719 and the poly (ADP-Ribose) polymerase (PARP) inhibitor olaparib in recurrent ovarian and breast cancer: Analysis of the dose escalation and ovarian cancer expansion cohort

Free
Panagiotis A. Konstantinopoulos, William T. Barry, Michael Birrer, Shannon N. Westin, Sarah Farooq, Karen Cadoo, Christin Whalen, Weixiu Luo, Hui Liu, Carol Aghajanian, David B. Solit, Gordon B. Mills, Barry S. Taylor, Helen Won, Michael F. Berger, Sangeetha Palakurthi, Joyce F. Liu, Lew Cantley, Scott H. Kaufmann, Elizabeth M. Swisher, Alan D. D'Andrea, Eric Winer, Gerburg M. Wulf, Ursula A. Matulonis
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT008.
https://doi.org/10.1158/1538-7445.AM2017-CT008
Published: 01 July 2017
View articletitled, Abstract CT008: Phase I study of the alpha specific PI3-Kinase inhibitor BYL719 and the poly (ADP-Ribose) polymerase (PARP) inhibitor olaparib in recurrent ovarian and breast cancer: Analysis of the dose escalation and ovarian cancer expansion cohort
Journal Articles

Abstract 445: Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues

Free
Jeffrey D. Krimmel, Michael W. Schmitt, Scott R. Kennedy, Maribel I. Harrell, Kathy J. Agnew, Larry A. Loeb, Elizabeth M. Swisher, Rosa Ana Risques
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 445.
https://doi.org/10.1158/1538-7445.AM2016-445
Published: 15 July 2016
View articletitled, Abstract 445: Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues