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Elizabeth E. Evans
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Journal Articles

Abstract 3975: Regulating dendritic cells to promote mature tertiary lymphoid structures and enhance anti-tumor immunity

Free
Elizabeth E. Evans, Crystal Mallow, Terrence L. Fisher, Elaine Gersz, Holm Bussler, Maria Scrivens, Vuyani Matsenjwa, Ellen Giampoli, Saurabh K. Garg, Colin W. Snyder, Brian Czerniecki, Conor Steuer, Nabil Saba, Michael Lowe, Gregory B. Lesinski, Chrystal Paulos, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3975.
https://doi.org/10.1158/1538-7445.AM2025-3975
Published: 21 April 2025
View articletitled, Abstract 3975: Regulating dendritic cells to promote mature tertiary lymphoid structures and enhance anti-tumor immunity
Journal Articles

Abstract 6007: Neoadjuvant pepinemab enhances DC function associated with mature tertiary lymphoid structures and activity of immune checkpoint blockade in patients with metastatic melanoma

Free
Elizabeth E. Evans, Crystal Mallow, Terrence L. Fisher, Ayana Ruffin, Elaine Gersz, Maria Scrivens, Elizabeth Tuttle, Vuyani Matsenjwa, Ellen Giampoli, Manoj Chelvanambi, Brenda Melendez, Florentia Dimitrou, Alexander J. Lazar, Jennifer Wargo, Michael Lowe, Chrystal M. Paulos, Gregory B. Lesinski, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6007.
https://doi.org/10.1158/1538-7445.AM2025-6007
Published: 21 April 2025
View articletitled, Abstract 6007: Neoadjuvant pepinemab enhances DC function associated with mature tertiary lymphoid structures and activity of immune checkpoint blockade in patients with metastatic melanoma
Journal Articles

Abstract A004: A Phase 1B/2 trial of second line immunotherapy with pepinemab and avelumab for patients with metastatic pancreatic adenocarcinoma

Free
Luis I Ruffolo, Matthew Byrne, Bailey Hilty, Brian A Belt, Yatee Dave, Paul Burchard, Terrence Fisher, Elizabeth E. Evans, Crystal Mallow, Megan Boise, Darren Carpizo, Jen Jen Yeh, David C Linehan, Daniel Mulkerin
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A004.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A004
Published: 15 September 2024
View articletitled, Abstract A004: A Phase 1B/2 trial of second line immunotherapy with pepinemab and avelumab for patients with metastatic pancreatic adenocarcinoma
Journal Articles

Abstract B025: MHC class II and CD1d expressing conventional dendritic cells with immunoglobulin therapy drives anti-tumor abscopal effect by recruiting Natural Killer T cells to the tumor microenvironment

Free
Saurabh K Garg, Colin Snyder, Ganesan Ramamoorthi, Elizabeth E Evans, Amy L Aldrich, Namrata Gautam, Doris Wiener, Marie C Lee, Hyo S Han, Koski K Gary, Brian J Czerniecki
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B025.
https://doi.org/10.1158/1538-7445.ADVBC23-B025
Published: 01 February 2024
View articletitled, Abstract B025: MHC class II and CD1d expressing conventional dendritic cells with immunoglobulin therapy drives anti-tumor abscopal effect by recruiting Natural Killer T cells to the tumor microenvironment
Journal Articles

Abstract CT111: Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE B84)

Free
Terrence L. Fisher, Elizabeth E. Evans, Crystal Mallow, Amber Foster, Megan Boise, Ernest Smith, John E. Leonard, Marya F. Chaney, J. Thaddeus Beck, Steven Hager, Nabil F. Saba, Conor Steuer, Douglas Adkins, Barbara Burtness, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT111.
https://doi.org/10.1158/1538-7445.AM2022-CT111
Published: 15 June 2022
View articletitled, Abstract CT111: Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE B84)
Journal Articles

Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy

Available to Purchase
Shalu Sharma Kharkwal, Christopher T. Johndrow, Natacha Veerapen, Himanshu Kharkwal, Noemi A. Saavedra-Avila, Leandro J. Carreño, Samantha Rothberg, Jinghang Zhang, Scott J. Garforth, Peter J. Jervis, Lianjun Zhang, Alena Donda, Amareeta K. Besra, Liam R. Cox, Steven C. Almo, Alan Howell, Elizabeth E. Evans, Maurice Zauderer, Gurdyal S. Besra, Steven A. Porcelli
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1788–1801.
https://doi.org/10.1158/0008-5472.CAN-20-2219
Published: 01 April 2021
View articletitled, Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy
Open the PDF for Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy in another window
Includes: Supplementary data
Journal Articles

Abstract CT016: Integrated biomarker trials of VX15/2503 (pepinemab) in combination with checkpoint inhibitors in window of opportunity studies in solid tumors

Free
Gregory B. Lesinski, Terrence L. Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Pastore, Crystal Mallow, Ernest Smith, Maurice Zauderer, Conor Steuer, Nabil F. Saba, Michael Lowe, Ragini R. Kudchadkar, Brian Olson, Christina Wu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT016.
https://doi.org/10.1158/1538-7445.AM2019-CT016
Published: 01 July 2019
View articletitled, Abstract CT016: Integrated biomarker trials of VX15/2503 (pepinemab) in combination with checkpoint inhibitors in window of opportunity studies in solid tumors
Journal Articles

Abstract CT086: Interim results from CLASSICAL-Lung, a Phase Ib/II study of VX15/2503 (pepinemab) in combination with avelumab in advanced NSCLC

Free
Michael Shafique, Terrence L. Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Pastore, Crystal Mallow, Ernest Smith, Maurice Zauderer, Andreas Schröeder, Kevin Chin, Thaddeus Beck, Megan Baumgart, Rachel E. Sanborn, Jonathan W. Goldman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT086.
https://doi.org/10.1158/1538-7445.AM2019-CT086
Published: 01 July 2019
View articletitled, Abstract CT086: Interim results from CLASSICAL-Lung, a Phase Ib/II study of VX15/2503 (pepinemab) in combination with avelumab in advanced NSCLC
Journal Articles

Abstract 1545: Altered myeloid and lymphoid composition of tumor microenvironment following anti-SEMA4D and immune checkpoint combination therapies

Free
Elizabeth E. Evans, Terrence L. Fisher, Holm Bussler, Crystal Mallow, Christine Reilly, Sebold Torno, Desa Rae Pastore, Maria Scrivens, Alan Howell, Leslie Balch, John E. Leonard, Clint Allen, Paul E. Clavijo, Gregory Lesinski, Christina Wu, Conor Steuer, Nabil F. Saba, Brian Olson, Siwen Hu-Lieskovan, Antoni Ribas, Emily G. Greengard, Ernest S. Smith, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1545.
https://doi.org/10.1158/1538-7445.AM2019-1545
Published: 01 July 2019
View articletitled, Abstract 1545: Altered myeloid and lymphoid composition of tumor microenvironment following anti-SEMA4D and immune checkpoint combination therapies
Journal Articles

Abstract 1762: Shifting the tumor microenvironment with first-in-class semaphorin 4D mab for combination immunotherapy

Free
Elizabeth E. Evans, Holm Bussler, Crystal Mallow, Christine Reilly, Sebold Torno, Maria Scrivens, Alan Howell, Leslie Balch, John E. Leonard, Terrence Fisher, Clint Allen, Paul E. Clavijo, Gregory Lesinski, Christina Wu, Siwen Hu-Lieskovan, Antoni Ribas, Emily G. Greengard, Ernest S. Smith, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1762.
https://doi.org/10.1158/1538-7445.AM2018-1762
Published: 01 July 2018
View articletitled, Abstract 1762: Shifting the tumor microenvironment with first-in-class semaphorin 4D mab for combination immunotherapy
Journal Articles

Abstract 3661: Breaking down the barrier restricting infiltration and differentiation of APC in the tumor microenvironment with a first-in-class antibody targeting Semaphorin4D, and rational combination therapies

Free
Elizabeth E. Evans, Holm Bussler, Crystal Mallow, Christine Reilly, Sebold Torno, Maria Scrivens, Cathie Foster, Alan Howell, Stephen R. Comeau, Leslie Balch, Alyssa Knapp, John E. Leonard, Terrence L. Fisher, Siwen Hu-Lieskovan, Antoni Ribas, Ernest S. Smith, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3661.
https://doi.org/10.1158/1538-7445.AM2017-3661
Published: 01 July 2017
View articletitled, Abstract 3661: Breaking down the barrier restricting infiltration and differentiation of APC in the tumor microenvironment with a first-in-class antibody targeting Semaphorin4D, and rational combination therapies
Journal Articles

Abstract 4888: Antibody blockade of semaphorin 4D breaks down stromal barriers to enhance tumoricidal immune infiltration, supporting rational immunotherapy combinations

Free
Elizabeth E. Evans, Holm Bussler, Sebold Torno, Crystal Mallow, Christine Reilly, Maria Scrivens, Ekaterina Klimatcheva, Laurie A. Winter, Renee Kirk, Alan Howell, Leslie Balch, John E. Leonard, Mark Paris, Terrence L. Fisher, Siwen Hu-Lieskovan, Antoni Ribas, Ernest S. Smith, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4888.
https://doi.org/10.1158/1538-7445.AM2016-4888
Published: 15 July 2016
View articletitled, Abstract 4888: Antibody blockade of semaphorin 4D breaks down stromal barriers to enhance tumoricidal immune infiltration, supporting rational immunotherapy combinations
Journal Articles

Abstract 278: Antibody blockade of semaphorin 4D promotes infiltration of activated tumor infiltrating leukocytes and reverses tumor growth

Free
Elizabeth E. Evans, Holm Bussler, Sebold Torno, Crystal Mallow, Laurie A. Winters, Christine Reilly, Katya Klimatcheva, Janaki Veeraraghavan, Alan S. Jonason, Maria Scrivens, Renee Kirk, Sue Giralico, Alan Howell, John E. Leonard, Mark Paris, Terrence L. Fisher, Ernest S. Smith, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 278.
https://doi.org/10.1158/1538-7445.AM2015-278
Published: 01 August 2015
View articletitled, Abstract 278: Antibody blockade of semaphorin 4D promotes infiltration of activated tumor infiltrating leukocytes and reverses tumor growth
Journal Articles

Abstract 5030: Antibody blockade of Semaphorin 4D promotes tumor rejection and improves response to immune checkpoint blockade and chemotherapy

Free
Elizabeth E. Evans, Holm Bussler, Sebold Torno, Janaki Veeraraghavan, Alan S. Jonason, Michael A. Doherty, Christine Reilly, Crystal Mallow, Jennifer Seils, Mark Paris, Terrence L. Fisher, William J. Bowers, Maria Scrivens, Leslie Balch, Renee Kirk, Alan Howell, Valerie Iddison, John E. Leonard, Ernest S. Smith, Maurice Zauderer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5030.
https://doi.org/10.1158/1538-7445.AM2014-5030
Published: 01 October 2014
View articletitled, Abstract 5030: Antibody blockade of Semaphorin 4D promotes tumor rejection and improves response to immune checkpoint blockade and chemotherapy
Journal Articles

Abstract 1245: Reduction of tumor growth and metastasis by a humanized IgG4 monoclonal antibody to SEMA4D (VX15/2503).

Free
Elizabeth E. Evans, Alan S. Jonason, Mark Paris, Terrence L. Fisher, Sebold Torno, Holm Bussler, Jessica Decker, Maria Scrivens, He Huang, Laurie A. Winter, Tracy Pandina, Leslie Balch, Michael A. Doherty, Renee Kirk, Alan Howell, Jennifer Seils, Christine Reilly, Maurice Zauderer, John E. Leonard, Ernest S. Smith
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1245.
https://doi.org/10.1158/1538-7445.AM2013-1245
Published: 15 April 2013
View articletitled, Abstract 1245: Reduction of tumor growth and metastasis by a humanized IgG4 monoclonal antibody to SEMA4D (VX15/2503).
Journal Articles

Abstract 2531: Reduction of In Vivo Tumor Growth and Angiogenesis by a Humanized IgG4 Monoclonal Antibody to SEMA4D

Free
Alan S. Jonason, Terrence L. Fisher, Sebold Torno, Holm Bussler, Michael A. Doherty, Laurie A. Winter, Christine Reilly, Renee Kirk, Alan Howell, He Huang, Jeff Caplan, Patrick Kenney, Maria Scrivens, Tracy Pandina, Leslie Croy, Elizabeth E. Evans, Mark Paris, Raymond Watkins, Maurice Zauderer, John E. Leonard, Ernest S. Smith
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2531.
https://doi.org/10.1158/1538-7445.AM2012-2531
Published: 15 April 2012
View articletitled, Abstract 2531: Reduction of In Vivo Tumor Growth and Angiogenesis by a Humanized IgG4 Monoclonal Antibody to SEMA4D
Journal Articles

Abstract 3667: Reduction of in vivo tumor growth and angiogenesis by a humanized IgG4 monoclonal antibody to SEMA4D

Free
Alan S. Jonason, Terrence L. Fisher, Sebold Torno, Holm Bussler, Laurie A. Winter, Renee Kirk, Alan Howell, Jeff Caplan, Patrick Kenney, Christine Reilly, Maria Scrivens, He Huang, Leslie Croy, Elizabeth E. Evans, Mark Paris, Raymond Watkins, Maurice Zauderer, John E. Leonard, Ernest S. Smith
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3667.
https://doi.org/10.1158/1538-7445.AM2011-3667
Published: 15 April 2011
View articletitled, Abstract 3667: Reduction of in vivo tumor growth and angiogenesis by a humanized IgG4 monoclonal antibody to SEMA4D